tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Angioedema D000799 6 associated lipids
Anus Diseases D001004 3 associated lipids
Apraxias D001072 1 associated lipids
Arm Injuries D001134 1 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Ascites D001201 25 associated lipids
Ataxia D001259 20 associated lipids
Ataxia Telangiectasia D001260 6 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Autonomic Nervous System Diseases D001342 4 associated lipids
Bacterial Infections D001424 21 associated lipids
Balanitis D001446 4 associated lipids
Beckwith-Wiedemann Syndrome D001506 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Biliary Fistula D001658 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Authors Title Published Journal PubMed Link
König S et al. Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:24056904
Ogino A et al. Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17644576
Giordano A et al. Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16428340
Kraiss LW et al. Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10775131
Tang WX et al. Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11893565
Sasamori K et al. Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:14990397
Lum H et al. Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11504680
Yaghi A and Sims SM Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16055480
Bouvier N et al. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death. 2009 Am. J. Physiol. Renal Physiol. pmid:18987109
Ren H et al. Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. 2016 Am. J. Physiol. Renal Physiol. pmid:27488997
Thai TL et al. ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. 2007 Am. J. Physiol. Renal Physiol. pmid:17652368
Peherstorfer E et al. Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. 2002 Am. J. Physiol. Renal Physiol. pmid:12060601
Axelsson J et al. Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. 2013 Am. J. Physiol. Renal Physiol. pmid:23657856
Mohebbi N et al. The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. 2009 Am. J. Physiol. Renal Physiol. pmid:19439519
Cho SG et al. Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. 2010 Am. J. Physiol. Renal Physiol. pmid:20410216
De Miguel C et al. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. 2011 Am. J. Physiol. Renal Physiol. pmid:21159736
Rojas-Vega L et al. Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. 2015 Am. J. Physiol. Renal Physiol. pmid:26336164
Edinger RS et al. Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. 2002 Am. J. Physiol. Renal Physiol. pmid:12110508
Ilori TO et al. Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. 2012 Am. J. Physiol. Renal Physiol. pmid:22205230
Amberg GC et al. Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. 2001 Am. J. Physiol., Cell Physiol. pmid:11698261
Ahn HS et al. Calcineurin-independent inhibition of KV1.3 by FK-506 (tacrolimus): a novel pharmacological property. 2007 Am. J. Physiol., Cell Physiol. pmid:17166943
Wang YX et al. FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. 2004 Am. J. Physiol., Cell Physiol. pmid:14592808
Sans MD and Williams JA Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. 2004 Am. J. Physiol., Cell Physiol. pmid:15044154
Bayguinov O et al. Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. 2001 Am. J. Physiol., Cell Physiol. pmid:11171588
Angus LM et al. Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 2005 Am. J. Physiol., Cell Physiol. pmid:15930144
Zhang Y et al. K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. 2008 Am. J. Physiol., Cell Physiol. pmid:18184875
Yue G et al. The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. 2000 Am. J. Physiol., Cell Physiol. pmid:10898719
Nam JH et al. Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells. 2011 Am. J. Physiol., Cell Physiol. pmid:21307343
Nakagawa K et al. Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. 2015 Am. J. Reprod. Immunol. pmid:25394810
Nakagawa K et al. Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. 2017 Am. J. Reprod. Immunol. pmid:28466977
Saito S et al. Role of Paternal Antigen-Specific Treg Cells in Successful Implantation. 2016 Am. J. Reprod. Immunol. pmid:26706630
Kofod L et al. Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. 2017 Am. J. Reprod. Immunol. pmid:28440588
Tabata C et al. Calcineurin/NFAT pathway: a novel regulator of parturition. 2009 Am. J. Reprod. Immunol. pmid:19527231
Goldthorpe H et al. Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25879383
Fujiki M et al. Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10572064
Deuse T et al. Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. 2010 Am. J. Respir. Cell Mol. Biol. pmid:19880819
Rolfe FG et al. Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. 1997 Am. J. Respir. Cell Mol. Biol. pmid:9271313
Yerkovich ST et al. Survival after bronchiolitis obliterans syndrome. 2011 Am. J. Respir. Crit. Care Med. pmid:21325085
Bhorade S et al. Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. 2011 Am. J. Respir. Crit. Care Med. pmid:20833822
Koshika T et al. Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury. 2001 Am. J. Respir. Crit. Care Med. pmid:11208629
Saeki K et al. Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. 2017 Am. J. Respir. Crit. Care Med. pmid:28199133
Joshi MS et al. Calcineurin regulates myocardial function during acute endotoxemia. 2006 Am. J. Respir. Crit. Care Med. pmid:16424445
Fauvel H et al. Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. 2002 Am. J. Respir. Crit. Care Med. pmid:11850335
Spiekerkoetter E et al. Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. 2015 Am. J. Respir. Crit. Care Med. pmid:26177174
Raofi V et al. A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. 1999 Am. J. Surg. pmid:10326847
Tanaka K et al. Living related liver transplantation in children. 1994 Am. J. Surg. pmid:7517649
Li X et al. Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts. 2007 Am. J. Surg. pmid:17618815
Rabkin JM et al. Immunosuppression impact on long-term cardiovascular complications after liver transplantation. 2002 Am. J. Surg. pmid:12034401
Jurim O et al. Living-donor liver transplantation at UCLA. 1995 Am. J. Surg. pmid:7538267
Lee KK et al. Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. 1993 Am. J. Surg. pmid:7678188
Finn L et al. Epstein-Barr virus infections in children after transplantation of the small intestine. 1998 Am. J. Surg. Pathol. pmid:9500771
Randhawa PS et al. The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. 1993 Am. J. Surg. Pathol. pmid:7680544
Minervini MI et al. Acute renal allograft rejection with severe tubulitis (Banff 1997 grade IB). 2000 Am. J. Surg. Pathol. pmid:10757402
Randhawa PS et al. Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. 1996 Am. J. Surg. Pathol. pmid:8772784
Ciancio G et al. The use of daclizumab, tacrolimus and mycophenolate mofetil in african-american and Hispanic first renal transplant recipients. 2003 Am. J. Transplant. pmid:12859538
Xu H et al. The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 2014 Am. J. Transplant. pmid:24472192
Abdelmalek MF et al. Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial. 2012 Am. J. Transplant. pmid:22233522
Boudjema K et al. Reduced-dose tacrolimus with mycophenolate mofetil vs. standard-dose tacrolimus in liver transplantation: a randomized study. 2011 Am. J. Transplant. pmid:21466650
Coghill AE et al. Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. 2016 Am. J. Transplant. pmid:26824445
Knechtle SJ Guidance for liver transplant immunosuppression. 2011 Am. J. Transplant. pmid:21466652
Saikali JA et al. Sirolimus may promote thrombotic microangiopathy. 2003 Am. J. Transplant. pmid:12603218
Budde K et al. Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. 2014 Am. J. Transplant. pmid:25278376
Duncan FJ et al. Clinically relevant immunosuppressants influence UVB-induced tumor size through effects on inflammation and angiogenesis. 2007 Am. J. Transplant. pmid:17941958
Suszynski TM et al. Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. 2013 Am. J. Transplant. pmid:23432755
Ferguson R et al. Immunosuppression with belatacept-based, corticosteroid-avoiding regimens in de novo kidney transplant recipients. 2011 Am. J. Transplant. pmid:21114656
McKenna G and Trotter JF Does early (CNI) conversion lead to eternal (renal) salvation? 2010 Am. J. Transplant. pmid:20928938
Koefoed-Nielsen PB et al. Blood tacrolimus levels and calcineurin phosphatase activity early after renal transplantation. 2002 Am. J. Transplant. pmid:12099520
Shemesh E et al. The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. 2017 Am. J. Transplant. pmid:28321975
Forns X and Navasa M Cyclosporine A or tacrolimus for hepatitis C recurrence? An old debate. 2011 Am. J. Transplant. pmid:21797970
Bryan CF et al. Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. 2007 Am. J. Transplant. pmid:17359511
Vincenti F et al. Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. 2007 Am. J. Transplant. pmid:17359512
Diaz-Siso JR et al. Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. 2015 Am. J. Transplant. pmid:25777324
Klintmalm GB et al. Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. 2014 Am. J. Transplant. pmid:25041339
TruneÄŒka P et al. Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. 2015 Am. J. Transplant. pmid:25707487
Adam R et al. Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. 2015 Am. J. Transplant. pmid:25703527
Oetting WS et al. Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. 2016 Am. J. Transplant. pmid:26485092
De Simone P et al. Everolimus with reduced tacrolimus in liver transplantation. 2013 Am. J. Transplant. pmid:23601137
Badri P et al. Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir. 2015 Am. J. Transplant. pmid:25708713
Chodoff L and Hamberg KJ Response to 'Different preparations of tacrolimus and medication errors'. 2009 Am. J. Transplant. pmid:19392982
Cherukuri A et al. An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation. 2012 Am. J. Transplant. pmid:22390816
Barth RN et al. Vascularized bone marrow-based immunosuppression inhibits rejection of vascularized composite allografts in nonhuman primates. 2011 Am. J. Transplant. pmid:21668624
Chen G et al. A synergistic effect between PG490-88 and tacrolimus prolongs renal allograft survival in monkeys. 2006 Am. J. Transplant. pmid:16539628
Guirado L et al. Efficacy and safety of conversion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients. 2011 Am. J. Transplant. pmid:21668633
Maes BD et al. Differential effect of diarrhea on FK506 versus cyclosporine A trough levels and resultant prevention of allograft rejection in renal transplant recipients. 2002 Am. J. Transplant. pmid:12484345
Heller T et al. Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients. 2007 Am. J. Transplant. pmid:17532750
Schrepfer S et al. Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease. 2007 Am. J. Transplant. pmid:17532751
Grenda R et al. A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. 2010 Am. J. Transplant. pmid:20420639
Asberg A et al. Effects of the intensity of immunosuppressive therapy on outcome of treatment for CMV disease in organ transplant recipients. 2010 Am. J. Transplant. pmid:20486914
Hautz T et al. Molecular markers and targeted therapy of skin rejection in composite tissue allotransplantation. 2010 Am. J. Transplant. pmid:20353468
Schussler T et al. Severe hepatitis C infection in a renal transplant recipient following hepatitis C genotype mismatch transplant. 2004 Am. J. Transplant. pmid:15268744
Toso C et al. Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. 2006 Am. J. Transplant. pmid:16611343
Lacaille F et al. Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation. 2006 Am. J. Transplant. pmid:16611346
Chamie K et al. The effect of sirolimus on prostate-specific antigen (PSA) levels in male renal transplant recipients without prostate cancer. 2008 Am. J. Transplant. pmid:18853950
Lefaucheur C et al. Renal histopathological lesions after lung transplantation in patients with cystic fibrosis. 2008 Am. J. Transplant. pmid:18671673
Pech T et al. Intestinal regeneration, residual function and immunological priming following rescue therapy after rat small bowel transplantation. 2012 Am. J. Transplant. pmid:22974463
Kaplan B and Kirk AD Tacrolimus and sirolimus: when bad things happen to good drugs. 2006 Am. J. Transplant. pmid:16827845
McAlister VC et al. Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: a meta-analysis. 2006 Am. J. Transplant. pmid:16827858
Gallon L et al. Long-term renal allograft function on a tacrolimus-based, pred-free maintenance immunosuppression comparing sirolimus vs. MMF. 2006 Am. J. Transplant. pmid:16827862
Grenda R et al. A prospective, randomized, multicenter trial of tacrolimus-based therapy with or without basiliximab in pediatric renal transplantation. 2006 Am. J. Transplant. pmid:16827869
Lake JR et al. Addition of MMF to dual immunosuppression does not increase the risk of malignant short-term death after liver transplantation. 2005 Am. J. Transplant. pmid:16303011