| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Patel NP et al. | Treatment of eosinophilic pustulosis of infancy with topical tacrolimus. | 2012 | Br. J. Dermatol. | pmid:22563626 |
| Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
| Kyllönen H et al. | Effects of 1-year intermittent treatment with topical tacrolimus monotherapy on skin collagen synthesis in patients with atopic dermatitis. | 2004 | Br. J. Dermatol. | pmid:15214906 |
| Meingassner JG et al. | Pimecrolimus does not affect Langerhans cells in murine epidermis. | 2003 | Br. J. Dermatol. | pmid:14616380 |
| Wilsmann-Theis D et al. | Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment. | 2004 | Br. J. Dermatol. | pmid:15214910 |
| Lerbaek A and Agner T | Facial eruption of molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15214914 |
| Edmonds EV et al. | Nodular prurigo responding to topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15214918 |
| Murrell DF et al. | A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids. | 2007 | Br. J. Dermatol. | pmid:17935515 |
| Liao YH et al. | Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(-1) ointment and tacrolimus 0.3 mg g(-1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17935517 |
| Schauber J et al. | Topical treatment of perianal eczema with tacrolimus 0.1%. | 2009 | Br. J. Dermatol. | pmid:19575757 |
| Rustin MH | The safety of tacrolimus ointment for the treatment of atopic dermatitis: a review. | 2007 | Br. J. Dermatol. | pmid:17854353 |
| Bunker CB | Male genital lichen sclerosus and tacrolimus. | 2007 | Br. J. Dermatol. | pmid:17854373 |
| Wu CS et al. | FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: implication for new therapeutic approach. | 2012 | Br. J. Dermatol. | pmid:22540338 |
| Tennis P et al. | Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors. | 2011 | Br. J. Dermatol. | pmid:21466537 |
| Afshar M et al. | The effect of pimecrolimus on innate immunity in subjects with atopic dermatitis: a double-blind, randomized, vehicle-controlled study. | 2013 | Br. J. Dermatol. | pmid:22577776 |
| Vidal D and Alomar A | Successful treatment of periostomal pyoderma gangrenosum using topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:14996128 |
| Carroll CL et al. | Better medication adherence results in greater improvement in severity of psoriasis. | 2004 | Br. J. Dermatol. | pmid:15491434 |
| Wenzel J et al. | Successful treatment of recalcitrant Wegener's granulomatosis of the skin with tacrolimus (Prograf). | 2004 | Br. J. Dermatol. | pmid:15491443 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Kabashima K et al. | Treatment of eosinophilic pustular folliculitis (Ofuji's disease) with tacrolimus ointment. | 2004 | Br. J. Dermatol. | pmid:15491457 |
| Aguilar-Bernier M et al. | Successful treatment of pruritus with topical tacrolimus in a patient with primary biliary cirrhosis. | 2005 | Br. J. Dermatol. | pmid:15840123 |
| Higgins E and Collins P | Recurrent bullous erythema multiforme treated with topical tacrolimus 0·1% ointment. | 2011 | Br. J. Dermatol. | pmid:21114481 |
| Pitt M et al. | A cost-utility analysis of pimecrolimus vs. topical corticosteroids and emollients for the treatment of mild and moderate atopic eczema. | 2006 | Br. J. Dermatol. | pmid:16704646 |
| Hashizume H et al. | Comparable risk of herpes simplex virus infection between topical treatments with tacrolimus and corticosteroids in adults with atopic dermatitis. | 2006 | Br. J. Dermatol. | pmid:16704659 |
| Walker SL et al. | The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus. | 2002 | Br. J. Dermatol. | pmid:12174136 |
| Simon D et al. | Successful treatment of pityriasis lichenoides with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15149526 |
| Mrowietz U et al. | The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. | 1998 | Br. J. Dermatol. | pmid:9990361 |
| Jain S and Stephens CJ | Successful treatment of disseminated granuloma annulare with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15149532 |
| Ghislain PD et al. | Efficacy and systemic absorption of topical tacrolimus used in pyoderma gangrenosum. | 2004 | Br. J. Dermatol. | pmid:15149540 |
| Katoh N et al. | Cutaneous sarcoidosis successfully treated with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12100200 |
| McElwee KJ et al. | Topical FK506: a potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. | 1997 | Br. J. Dermatol. | pmid:9390322 |
| Hoeger PH et al. | The treatment of facial atopic dermatitis in children who are intolerant of, or dependent on, topical corticosteroids: a randomized, controlled clinical trial. | 2009 | Br. J. Dermatol. | pmid:19067708 |
| Fujimoto N et al. | Facial lichen striatus: successful treatment with tacrolimus ointment. | 2003 | Br. J. Dermatol. | pmid:12653755 |
| Fricain JC et al. | Long-term efficacy of topical tacrolimus on oral lesions of chronic graft-versus-host disease. | 2007 | Br. J. Dermatol. | pmid:17300261 |
| Volz T et al. | Pimecrolimus cream 1% in erosive oral lichen planus--a prospective randomized double-blind vehicle-controlled study. | 2008 | Br. J. Dermatol. | pmid:18647310 |
| Nissi R et al. | Altered p53 and Bcl-2 expression in keratinocytes of vulvar lichen sclerosus during pimecrolimus treatment. | 2009 | Br. J. Dermatol. | pmid:19659469 |
| Lan CC et al. | FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. | 2005 | Br. J. Dermatol. | pmid:16120133 |
| Alomar A et al. | The role of topical calcineurin inhibitors in atopic dermatitis. | 2004 | Br. J. Dermatol. | pmid:15548171 |
| Ständer S et al. | Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. | 2007 | Br. J. Dermatol. | pmid:17388925 |
| Mashayekhi S et al. | The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic. | 2017 | Br. J. Dermatol. | pmid:28244087 |
| Barbier N et al. | Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme. | 2004 | Br. J. Dermatol. | pmid:14746622 |
| Rubegni P et al. | A case of reticular erythematous mucinosis treated with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:14746650 |
| Abe R et al. | Severe refractory chronic actinic dermatitis successfully treated with tacrolimus ointment. | 2002 | Br. J. Dermatol. | pmid:12452891 |
| Taher ZA et al. | Analysis of interleukin-10 levels in lesions of vitiligo following treatment with topical tacrolimus. | 2009 | Br. J. Dermatol. | pmid:19438859 |
| Lonsdale-Eccles AA and Velangi S | Topical pimecrolimus in the treatment of genital lichen planus: a prospective case series. | 2005 | Br. J. Dermatol. | pmid:16086755 |
| Undre NA et al. | Skin and systemic pharmacokinetics of tacrolimus following topical application of tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:19076975 |
| Caproni M et al. | The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. | 2007 | Br. J. Dermatol. | pmid:17223872 |
| Bilenchi R et al. | Human papillomavirus reactivation following topical tacrolimus therapy of anogenital lichen sclerosus. | 2007 | Br. J. Dermatol. | pmid:17223903 |
| Mashiko M et al. | A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment. | 2006 | Br. J. Dermatol. | pmid:16536847 |
| Brouard MC et al. | Erosive pustular dermatosis of the leg: report of three cases. | 2002 | Br. J. Dermatol. | pmid:12366427 |
| Hengge UR et al. | Multicentre, phase II trial on the safety and efficacy of topical tacrolimus ointment for the treatment of lichen sclerosus. | 2006 | Br. J. Dermatol. | pmid:17034535 |
| Kang HY and Choi YM | FK506 increases pigmentation and migration of human melanocytes. | 2006 | Br. J. Dermatol. | pmid:17034537 |
| Clayton TH et al. | Topical tacrolimus for facial psoriasis. | 2003 | Br. J. Dermatol. | pmid:12932257 |
| Lübbe J and Sorg O | Tacrolimus ointment and skin carcinogenesis in the DMBA/TPA model in mice. | 2004 | Br. J. Dermatol. | pmid:15606530 |
| Burkhart CG and Burkhart CN | Tacrolimus and topical steroids: which is more effective? | 2004 | Br. J. Dermatol. | pmid:15606537 |
| Tzung TY et al. | Tacrolimus vs. clobetasol propionate in the treatment of facial cutaneous lupus erythematosus: a randomized, double-blind, bilateral comparison study. | 2007 | Br. J. Dermatol. | pmid:17199600 |
| Lee DH et al. | Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial. | 2008 | Br. J. Dermatol. | pmid:18363758 |
| Moreno-Arias GA et al. | Plasma cell balanitis treated with tacrolimus 0.1%. | 2005 | Br. J. Dermatol. | pmid:16307659 |
| Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
| Pereira U et al. | Mechanisms of the sensory effects of tacrolimus on the skin. | 2010 | Br. J. Dermatol. | pmid:20302583 |
| Grassberger M et al. | A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. | 1999 | Br. J. Dermatol. | pmid:10468798 |
| Williams HC | Preventing eczema flares with topical corticosteroids or tacrolimus: which is best? | 2011 | Br. J. Dermatol. | pmid:21271989 |
| Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |
| Chohan R et al. | Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity. | 2003 | Br. J. Haematol. | pmid:14510951 |
| Mehta RS et al. | Post-transplantation cyclophosphamide versus conventional graft-versus-host disease prophylaxis in mismatched unrelated donor haematopoietic cell transplantation. | 2016 | Br. J. Haematol. | pmid:26947769 |
| Pulsipher MA et al. | A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL). | 2009 | Br. J. Haematol. | pmid:19744131 |
| Murata M et al. | A new preconditioning regimen with melphalan, busulphan and total body irradiation followed by low-dose immunosuppressant in allogeneic haemopoietic stem cell transplantation. | 1999 | Br. J. Haematol. | pmid:10354150 |
| Armand P et al. | The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. | 2016 | Br. J. Haematol. | pmid:26729448 |
| Wong R et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome after allogeneic haematopoietic stem cell transplantation. | 2003 | Br. J. Haematol. | pmid:12823354 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Couriel DR et al. | Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease. | 2005 | Br. J. Haematol. | pmid:16042691 |
| Mollee P et al. | Combination therapy with tacrolimus and anti-thymocyte globulin for the treatment of steroid-resistant acute graft-versus-host disease developing during cyclosporine prophylaxis. | 2001 | Br. J. Haematol. | pmid:11328304 |
| Kida A et al. | Calcineurin-inhibitor pain syndrome following haematopoietic stem cell transplantation. | 2004 | Br. J. Haematol. | pmid:15257699 |
| Boulad F et al. | Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. | 2000 | Br. J. Haematol. | pmid:11167755 |
| Dusting GJ et al. | Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms. | 1999 | Br. J. Pharmacol. | pmid:10510443 |
| Quintá HR and Galigniana MD | The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation. | 2012 | Br. J. Pharmacol. | pmid:22091865 |
| Gil V et al. | Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility. | 2011 | Br. J. Pharmacol. | pmid:21486289 |
| Klettner A and Herdegen T | The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. | 2003 | Br. J. Pharmacol. | pmid:12642403 |
| Magari K et al. | Calcineurin inhibitors exert rapid reduction of inflammatory pain in rat adjuvant-induced arthritis. | 2003 | Br. J. Pharmacol. | pmid:12839866 |
| Simon N et al. | Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria. | 2003 | Br. J. Pharmacol. | pmid:12540528 |
| Øzbay LA et al. | Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. | 2011 | Br. J. Pharmacol. | pmid:20825407 |
| Bader A et al. | Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions. | 2000 | Br. J. Pharmacol. | pmid:10694240 |
| Price RD et al. | FK506 potentiates NGF-induced neurite outgrowth via the Ras/Raf/MAP kinase pathway. | 2003 | Br. J. Pharmacol. | pmid:14559856 |
| Hortelano S et al. | Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. | 1999 | Br. J. Pharmacol. | pmid:10205001 |
| Eum SY et al. | Inhibition by the immunosuppressive agent FK-506 of antigen-induced airways eosinophilia and bronchial hyperreactivity in mice. | 1997 | Br. J. Pharmacol. | pmid:9117088 |
| Yasutsune T et al. | Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery. | 1999 | Br. J. Pharmacol. | pmid:10188984 |
| Deters M et al. | Sirolimus/cyclosporine/tacrolimus interactions on bile flow and biliary excretion of immunosuppressants in a subchronic bile fistula rat model. | 2002 | Br. J. Pharmacol. | pmid:12055139 |
| MacMillan D and McCarron JG | Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR. | 2009 | Br. J. Pharmacol. | pmid:19785652 |
| Waschulewski IH et al. | Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. | 1993 | Br. J. Pharmacol. | pmid:7683567 |
| Weidelt T and Isenberg G | Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle. | 2000 | Br. J. Pharmacol. | pmid:10742283 |
| Bas E et al. | Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses. | 2012 | Br. J. Pharmacol. | pmid:22320124 |
| Gardiner SM et al. | Regional haemodynamic effects of cyclosporine A, tacrolimus and sirolimus in conscious rats. | 2004 | Br. J. Pharmacol. | pmid:14744807 |
| Pahl A et al. | Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. | 2002 | Br. J. Pharmacol. | pmid:11959794 |
| Sakuma S et al. | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | 2000 | Br. J. Pharmacol. | pmid:10928971 |
| Seidel ER and Ragan VL | Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture. | 1997 | Br. J. Pharmacol. | pmid:9051292 |
| Harrison CA et al. | Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506. | 2007 | Br. J. Pharmacol. | pmid:17200674 |
| Zuany-Amorim C et al. | Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. | 1993 | Br. J. Pharmacol. | pmid:7694762 |
| Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
| Li J et al. | Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. | 2005 | Br. J. Pharmacol. | pmid:15821752 |
| Macfarlane SR et al. | The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes. | 2005 | Br. J. Pharmacol. | pmid:15821758 |