| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Boughton O et al. | A published pharmacogenetic algorithm was poorly predictive of tacrolimus clearance in an independent cohort of renal transplant recipients. | 2013 | Br J Clin Pharmacol | pmid:23305195 |
| Li Q et al. | Development and validation of a sensitive LC-MS/MS method for determination of tacrolimus on dried blood spots. | 2013 | Biomed. Chromatogr. | pmid:22893355 |
| Tsapepas D et al. | Sublingual tacrolimus: a pharmacokinetic evaluation pilot study. | 2013 | Pharmacotherapy | pmid:23307542 |
| Zhou YN et al. | Effect of amlodipine on the pharmacokinetics of tacrolimus in rats. | 2013 | Xenobiotica | pmid:23312000 |
| Landy J and Hart AL | Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336680 |
| Chen G et al. | Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. | 2013 | Mol. Immunol. | pmid:23357789 |
| Heavner MS et al. | Clinical outcomes associated with conversion from brand-name to generic tacrolimus in hospitalized kidney transplant recipients. | 2013 | Am J Health Syst Pharm | pmid:23943182 |
| Hautz T et al. | Targeting the Kv1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study. | 2013 | Transpl. Int. | pmid:23489391 |
| Becker S et al. | Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay. | 2013 | Ther Drug Monit | pmid:23188181 |
| Narayanan M et al. | Outcomes in African American kidney transplant patients receiving tacrolimus and mycophenolic acid immunosuppression. | 2013 | Transplantation | pmid:23423268 |
| Øzbay LA et al. | The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans. | 2013 | Transpl. Int. | pmid:23190385 |
| Afshar M et al. | The effect of pimecrolimus on innate immunity in subjects with atopic dermatitis: a double-blind, randomized, vehicle-controlled study. | 2013 | Br. J. Dermatol. | pmid:22577776 |
| Gaber AO et al. | Acute rejection characteristics from a prospective, randomized, double-blind, placebo-controlled multicenter trial of early corticosteroid withdrawal. | 2013 | Transplantation | pmid:23423269 |
| Levitsky J et al. | Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. | 2013 | Hepatology | pmid:22234876 |
| Giannelli V et al. | Conversion from twice-daily to once-daily Tacrolimus administration in liver transplant patient: results of long term follow-up. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24174352 |
| Doesch AO et al. | Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation. | 2013 | Drug Des Devel Ther | pmid:24174870 |
| White M et al. | Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. | 2013 | J. Heart Lung Transplant. | pmid:24263023 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Silva HT et al. | Planned randomized conversion from tacrolimus to sirolimus-based immunosuppressive regimen in de novo kidney transplant recipients. | 2013 | Am. J. Transplant. | pmid:24266969 |
| Khanmoradi K et al. | Evaluating safety and efficacy of rabbit antithymocyte globulin induction in elderly kidney transplant recipients. | 2013 | Exp Clin Transplant | pmid:23432665 |
| Aoun B et al. | Protocol biopsies in pediatric renal transplant recipients on cyclosporine versus tacrolimus-based immunosuppression. | 2013 | Pediatr. Nephrol. | pmid:23111894 |
| Ricciardelli I et al. | Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. | 2013 | Am. J. Transplant. | pmid:24266973 |
| Suszynski TM et al. | Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. | 2013 | Am. J. Transplant. | pmid:23432755 |
| Takahashi Y et al. | Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood. | 2013 | Brain Dev. | pmid:23433490 |
| Chen D et al. | FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation. | 2013 | J. Bacteriol. | pmid:23435975 |
| Schmidt KJ et al. | Short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - experience in 130 patients. | 2013 | Aliment. Pharmacol. Ther. | pmid:23121200 |
| TruneÄka P | [Immunosuppression after liver transplant, now and in future]. | 2013 | Vnitr Lek | pmid:24007221 |
| De Simone C et al. | Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open-label study. | 2013 | J Eur Acad Dermatol Venereol | pmid:22788697 |
| Bendezú GarcÃa RA et al. | Biological therapy for Crohn's disease in a liver transplant patient. | 2013 | J Dig Dis | pmid:23437819 |
| Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
| Zuo XC et al. | Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine. | 2013 | Drug Metab. Pharmacokinet. | pmid:23438946 |
| Liu YY et al. | The effect of ABCB1 C3435T polymorphism on pharmacokinetics of tacrolimus in liver transplantation: a meta-analysis. | 2013 | Gene | pmid:24042126 |
| Miwa Y et al. | Depression is improved when low-dose tacrolimus is given to rheumatoid arthritis patients showing an inadequate response to biologic agents. | 2013 | Mod Rheumatol | pmid:22990336 |
| Li Y et al. | Low-concentration topical tacrolimus for the treatment of anogenital lichen sclerosus in childhood: maintenance treatment to reduce recurrence. | 2013 | J Pediatr Adolesc Gynecol | pmid:24049806 |
| Sayegh J et al. | A case of severe osteomalacia secondary to phosphate diabetes in a renal transplant recipient. | 2013 | Int Urol Nephrol | pmid:22990413 |
| Annesley TM et al. | Standardization of LC-MS for therapeutic drug monitoring of tacrolimus. | 2013 | Clin. Chem. | pmid:23902823 |
| Yates CJ et al. | Screening for new-onset diabetes after kidney transplantation: limitations of fasting glucose and advantages of afternoon glucose and glycated hemoglobin. | 2013 | Transplantation | pmid:23902993 |
| Ma MK et al. | Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant recipients with or without concomitant diltiazem treatment. | 2013 | Ren Fail | pmid:23815459 |
| Kim BR et al. | A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation. | 2013 | Sao Paulo Med J | pmid:23903271 |
| Arnold R et al. | Association between calcineurin inhibitor treatment and peripheral nerve dysfunction in renal transplant recipients. | 2013 | Am. J. Transplant. | pmid:23841745 |
| Carmona A et al. | Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide. | 2013 | Biol. Blood Marrow Transplant. | pmid:23845694 |
| Mizuno S et al. | Combination assays for evaluation of immune function and CYP3A5 genotype to identify the risk of infectious complications and mortality in living donor liver transplant patients. | 2013 | Ann. Transplant. | pmid:23845965 |
| Sánchez Ferreiro AV and Muñoz Bellido L | [Tacrolimus in the treatment of atopic kerato-conjunctivitis]. | 2013 | Arch Soc Esp Oftalmol | pmid:23886369 |
| Min SI et al. | Therapeutic equivalence and pharmacokinetics of generic tacrolimus formulation in de novo kidney transplant patients. | 2013 | Nephrol. Dial. Transplant. | pmid:24084327 |
| Kapoor K et al. | Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70. | 2013 | J. Biol. Chem. | pmid:24064216 |
| van Boekel GA et al. | Treatment satisfaction in renal transplant patients taking tacrolimus once daily. | 2013 | Clin Ther | pmid:24135441 |
| Sun W et al. | [Association factors analysis of diarrhea in patients receiving kidney transplantation]. | 2013 | Beijing Da Xue Xue Bao | pmid:24136278 |
| Maguire O et al. | Nuclear translocation of nuclear factor of activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus. | 2013 | Cytometry A | pmid:24136923 |
| Nishimura R et al. | Tacrolimus inhibits the revascularization of isolated pancreatic islets. | 2013 | PLoS ONE | pmid:23613708 |
| Namkoong S et al. | Topical tacrolimus does not negatively impact acute skin wound healing. | 2013 | Exp. Dermatol. | pmid:23614749 |
| Thin LW et al. | Oral tacrolimus for the treatment of refractory inflammatory bowel disease in the biologic era. | 2013 | Inflamm. Bowel Dis. | pmid:23615528 |
| Chapin RW et al. | Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS). | 2013 | Skeletal Radiol. | pmid:23615775 |
| Radu CD et al. | Cotton-made cellulose support for anti-allergic pajamas. | 2013 | Carbohydr Polym | pmid:23618296 |
| Harikishore A et al. | Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. | 2013 | ACS Med Chem Lett | pmid:24900611 |
| Madeleine MM et al. | HPV-related cancers after solid organ transplantation in the United States. | 2013 | Am. J. Transplant. | pmid:24119294 |
| Lehner GM and Linek M | A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. | 2013 | Vet. Dermatol. | pmid:24118370 |
| Santoro AB et al. | CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients. | 2013 | Clin. Pharmacol. Ther. | pmid:23588314 |
| Poi MJ et al. | Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease. | 2013 | Clin Pharmacokinet | pmid:23588536 |
| Guy-Viterbo V et al. | Population pharmacokinetic analysis of tacrolimus in the first year after pediatric liver transplantation. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23588560 |
| Kumar AJ et al. | Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation. | 2013 | Biol. Blood Marrow Transplant. | pmid:23635453 |
| Ogata H | Response to Roblin and Del Tedesco. | 2013 | Inflamm. Bowel Dis. | pmid:23538853 |
| Ucak H et al. | Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis. | 2013 | J Dermatolog Treat | pmid:23638997 |
| Ho ET et al. | Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: a systematic review. | 2013 | Transplantation | pmid:23542469 |
| Ma L et al. | Comparison of release and penetration of tacrolimus ointment reference and trial formulation after dermal application to pigs by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2013 | Biomed. Chromatogr. | pmid:23657920 |
| Zhu L et al. | A limited sampling strategy for tacrolimus in liver transplant patients. | 2013 | Int J Clin Pharmacol Ther | pmid:23547852 |
| MartÃn-Cano FE et al. | mTOR pathway and Ca²⺠stores mobilization in aged smooth muscle cells. | 2013 | Aging (Albany NY) | pmid:23661091 |
| de Jonge H and Kuypers DR | Response to "CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients". | 2013 | Clin. Pharmacol. Ther. | pmid:23665867 |
| Saint-Marcoux F et al. | Lessons from routine dose adjustment of tacrolimus in renal transplant patients based on global exposure. | 2013 | Ther Drug Monit | pmid:23666572 |
| Viana RA et al. | Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast. | 2013 | Genetics | pmid:23934882 |
| Li Y et al. | Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus. | 2013 | Transplant. Proc. | pmid:23769050 |
| Dufty NE et al. | Pharmacokinetic interaction of maraviroc with tacrolimus in a patient coinfected with HIV and hepatitis B virus following hepatic transplant due to hepatocellular carcinoma. | 2013 | J. Antimicrob. Chemother. | pmid:23249840 |
| Szabó L et al. | Effects of tacrolimus on action potential configuration and transmembrane ion currents in canine ventricular cells. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23250339 |
| Ueno T et al. | Conversion to prolonged-release tacrolimus for pediatric living related donor liver transplant recipients. | 2013 | Transplant. Proc. | pmid:23769087 |
| Kimelman M and Brandacher G | Trends in immunosuppression after pancreas transplantation: what is in the pipeline? | 2013 | Curr Opin Organ Transplant | pmid:23254700 |
| Fuchs U et al. | Clinical outcome in cardiac transplant recipients receiving tacrolimus retard. | 2013 | Transplant. Proc. | pmid:23769094 |
| Gauthier AS et al. | [Galenic and analytic development of tacrolimus 0.06% eye drops]. | 2013 | J Fr Ophtalmol | pmid:23218600 |
| Koc-Zorawska E et al. | Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients. | 2013 | Transplant. Proc. | pmid:23769096 |
| Akhi SN et al. | Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus. | 2013 | Fertil. Steril. | pmid:23218920 |
| Kymionis GD et al. | Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. | 2013 | Cornea | pmid:23770977 |
| Yan L et al. | Immunomodulatory effectiveness of tacrolimus in preventing epidural scar adhesion after laminectomy in rat model. | 2013 | Eur. J. Pharmacol. | pmid:23220162 |
| Miyauchi T et al. | Therapeutic targeting of the axonal and microvascular change associated with repetitive mild traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23796228 |
| Mourer JS et al. | Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid intima media thickness in renal transplant recipients. | 2013 | Transplantation | pmid:23715049 |
| Jakes AD et al. | Case report: Guillain-BarreÌ syndrome following renal transplantation--a diagnostic dilemma. | 2013 | Nephron Clin Pract | pmid:24503667 |
| Gaber AO et al. | Conversion from twice-daily tacrolimus capsules to once-daily extended-release tacrolimus (LCPT): a phase 2 trial of stable renal transplant recipients. | 2013 | Transplantation | pmid:23715050 |
| Musso CG et al. | Furosemide test in stage III-chronic kidney disease and kidney transplant patients on tacrolimus. | 2013 | Int Urol Nephrol | pmid:23233031 |
| Goldust M et al. | Treatment of seborrheic dermatitis: comparison of sertaconazole 2 % cream versus pimecrolimus 1 % cream. | 2013 | Ir J Med Sci | pmid:23715821 |
| Im BH et al. | The effects of 8-arm-PEG-catechol/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets. | 2013 | Biomaterials | pmid:23261215 |
| Nakane S et al. | Successful treatment of stiff person syndrome with sequential use of tacrolimus. | 2013 | J. Neurol. Neurosurg. Psychiatr. | pmid:23715915 |
| Swartz DJ et al. | P-glycoprotein is fully active after multiple tryptophan substitutions. | 2013 | Biochim. Biophys. Acta | pmid:23261390 |
| Mehta SJ et al. | Review article: strategies for the management of chronic unremitting ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23718288 |
| Kurasawa T et al. | Successful treatment of class IV+V lupus nephritis with combination therapy of high-dose corticosteroids, tacrolimus and intravenous cyclophosphamide. | 2013 | Intern. Med. | pmid:23676603 |
| Peng Y et al. | Donor-derived mesenchymal stem cells combined with low-dose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study. | 2013 | Transplantation | pmid:23263506 |
| Kuypers DR et al. | Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring. | 2013 | Transplantation | pmid:23263559 |
| Lee KY et al. | Endothelin-1 enhances the proliferation of normal human melanocytes in a paradoxical manner from the TNF-α-inhibited condition, but tacrolimus promotes exclusively the cellular migration without proliferation: a proposed action mechanism for combination therapy of phototherapy and topical tacrolimus in vitiligo treatment. | 2013 | J Eur Acad Dermatol Venereol | pmid:22404745 |
| Noll BD et al. | Validation of an LC-MS/MS method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies. | 2013 | Ther Drug Monit | pmid:23921430 |
| Snell GI et al. | Evolution to twice daily bolus intravenous tacrolimus: optimizing efficacy and safety of calcineurin inhibitor delivery early post lung transplant. | 2013 | Ann. Transplant. | pmid:23921892 |
| Barbarino JM et al. | PharmGKB summary: cyclosporine and tacrolimus pathways. | 2013 | Pharmacogenet. Genomics | pmid:23922006 |
| Wojtusciszyn A et al. | Continuous glucose monitoring after kidney transplantation in non-diabetic patients: early hyperglycaemia is frequent and may herald post-transplantation diabetes mellitus and graft failure. | 2013 | Diabetes Metab. | pmid:23999231 |
| Martina MR et al. | The precise chemical-physical nature of the pharmacore in FK506 binding protein inhibition: ElteX, a New class of nanomolar FKBP12 ligands. | 2013 | J. Med. Chem. | pmid:23301792 |
| Herzer K et al. | [HCV reinfection after liver transplantation - management and first experiences with telaprevir-based triple therapy]. | 2013 | Dtsch. Med. Wochenschr. | pmid:24002874 |