Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Charlton M et al. | Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. | 2017 | Transplantation | pmid:28817434 |
Mentzer RM et al. | Tacrolimus as a rescue immunosuppressant after heart and lung transplantation. The U.S. Multicenter FK506 Study Group. | 1998 | Transplantation | pmid:9448154 |
Levy G et al. | Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. | 2004 | Transplantation | pmid:15201658 |
O'Grady J | C(2) monitoring: out of the blocks but with some way to go! | 2004 | Transplantation | pmid:15201659 |
First MR | Transplantation in the nineties. | 1992 | Transplantation | pmid:1370734 |
Ajiki T et al. | Generation of donor hematolymphoid cells after rat-limb composite grafting. | 2003 | Transplantation | pmid:12640301 |
Rush DN et al. | Factors associated with progression of interstitial fibrosis in renal transplant patients receiving tacrolimus and mycophenolate mofetil. | 2009 | Transplantation | pmid:19935461 |
Misra S et al. | Red cell aplasia in children on tacrolimus after liver transplantation. | 1998 | Transplantation | pmid:9500636 |
Butani L et al. | Effect of felodipine on tacrolimus pharmacokinetics in a renal transplant recipient. | 2002 | Transplantation | pmid:11793001 |
Leung W et al. | Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplant. | 1999 | Transplantation | pmid:10385092 |
Yang Z et al. | Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506. | 2003 | Transplantation | pmid:12589149 |
Naesens M et al. | Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients. | 2006 | Transplantation | pmid:17060857 |
Guo Z et al. | In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. | 1997 | Transplantation | pmid:9075844 |
Platz KP et al. | Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518975 |
Carroll PB et al. | Effect of the immunosuppressant FK506 on glucose-induced insulin secretion from adult rat islets of Langerhans. | 1991 | Transplantation | pmid:1702911 |
Nashan B et al. | Clinical validation studies of Neoral C(2) monitoring: a review. | 2002 | Transplantation | pmid:12023607 |
Stojanovic J et al. | Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation. | 2017 | Transplantation | pmid:27463537 |
Sarwal MM et al. | Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. | 2001 | Transplantation | pmid:11468528 |
Camirand G et al. | Combined immunosuppression of mycophenolate mofetil and FK506 for myoblast transplantation in mdx mice. | 2001 | Transplantation | pmid:11468532 |
Levitsky J et al. | Allospecific regulatory effects of sirolimus and tacrolimus in the human mixed lymphocyte reaction. | 2011 | Transplantation | pmid:21239962 |
Paramesh AS et al. | Thrombotic microangiopathy associated with combined sirolimus and tacrolimus immunosuppression after intestinal transplantation. | 2004 | Transplantation | pmid:14724447 |
Jain AB et al. | Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data. | 1998 | Transplantation | pmid:9825817 |
Franz M et al. | Posttransplant hemolytic uremic syndrome in adult retransplanted kidney graft recipients: advantage of FK506 therapy? | 1998 | Transplantation | pmid:9825827 |
Mathis AS et al. | Sex and ethnicity may chiefly influence the interaction of fluconazole with calcineurin inhibitors. | 2001 | Transplantation | pmid:11374405 |
Chan K et al. | Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trial. | 2011 | Transplantation | pmid:21836540 |
Kovarik JM et al. | Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients. | 2011 | Transplantation | pmid:21157403 |
Jugie M et al. | Study of the impact of liver transplantation on the outcome of intestinal grafts in children. | 2006 | Transplantation | pmid:16612274 |
Iwata H et al. | Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506. | 1993 | Transplantation | pmid:7687396 |
Roelen DL et al. | Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506. | 1993 | Transplantation | pmid:7687397 |
Song L et al. | Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. | 2014 | Transplantation | pmid:24992357 |
Panz VR et al. | Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation1. | 2002 | Transplantation | pmid:11889436 |
Charney DA et al. | Plasma cell-rich acute renal allograft rejection. | 1999 | Transplantation | pmid:10515379 |
Shivaswamy V et al. | Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats. | 2013 | Transplantation | pmid:23250335 |
Xu H et al. | Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance. | 2013 | Transplantation | pmid:23250336 |
Randhawa PS et al. | Clinical significance of renal biopsies showing concurrent acute rejection and tacrolimus-associated tubular vacuolization. | 1999 | Transplantation | pmid:9921801 |
Oike F et al. | A 12-day course of FK506 allows long-term acceptance of semi-identical liver allograft in inbred miniature swine. | 2000 | Transplantation | pmid:10868630 |
Yamani MH et al. | The impact of routine mycophenolate mofetil drug monitoring on the treatment of cardiac allograft rejection. | 2000 | Transplantation | pmid:10868634 |
Gloor JM et al. | Subclinical rejection in tacrolimus-treated renal transplant recipients. | 2002 | Transplantation | pmid:12131699 |
Johnson C et al. | Randomized trial of tacrolimus (Prograf) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral) with mycophenolate mofetil after cadaveric kidney transplantation. | 2000 | Transplantation | pmid:10755536 |
Ochiai T et al. | Studies of the effects of FK506 on renal allografting in the beagle dog. | 1987 | Transplantation | pmid:2447688 |
Deuse T et al. | Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. | 2012 | Transplantation | pmid:22971540 |
Cohen JB et al. | Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study. | 2017 | Transplantation | pmid:27941427 |
Gruessner RW et al. | Portal donor-specific blood transfusion and mycophenolate mofetil allow steroid avoidance and tacrolimus dose reduction with sustained levels of chimerism in a pig model of intestinal transplantation. | 2004 | Transplantation | pmid:15239611 |
Dean PG et al. | Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. | 2004 | Transplantation | pmid:15239621 |
Chavin KD et al. | Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or rapamycin to induce tolerance. | 1994 | Transplantation | pmid:7511258 |
Ricordi C et al. | In vivo effect of FK506 on human pancreatic islets. | 1991 | Transplantation | pmid:1716797 |
Katz IA et al. | Comparison of the effects of FK506 and cyclosporine on bone mineral metabolism in the rat. A pilot study. | 1991 | Transplantation | pmid:1716801 |
Margreiter R et al. | A double-hand transplant can be worth the effort! | 2002 | Transplantation | pmid:12134104 |
Tian L et al. | Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft. | 2002 | Transplantation | pmid:12134113 |
Hodak SP et al. | QT prolongation and near fatal cardiac arrhythmia after intravenous tacrolimus administration: a case report. | 1998 | Transplantation | pmid:9734501 |