tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prescott TA et al. | A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. | 2014 | FEBS Lett. | pmid:24374339 |
| Perlman RL and Rao PS | Quality of life of older patients undergoing renal transplantation: finding the right immunosuppressive treatment. | 2014 | Drugs Aging | pmid:24399579 |
| Tanaka K et al. | Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. | 2014 | J. Hum. Genet. | pmid:24352002 |
| Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
| Erdinest N and Solomon A | Topical immunomodulators in the management of allergic eye diseases. | 2014 | Curr Opin Allergy Clin Immunol | pmid:25054831 |
| Mo D et al. | In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. | 2014 | Mycopathologia | pmid:25052248 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Ünlüsoy Aksu A et al. | Immune thrombocytopenic purpura in a liver transplant patient. | 2014 | Exp Clin Transplant | pmid:24635822 |
| Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
| Bakkour W et al. | Successful use of dapsone for the management of circinate balanitis. | 2014 | Clin. Exp. Dermatol. | pmid:24635073 |
| Venkat VL et al. | Recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients. | 2014 | Liver Transpl. | pmid:24634351 |
| Kapoor K et al. | Lip hypertrophy due to cyclosporine therapy. | 2014 | Clin. Exp. Nephrol. | pmid:23615783 |
| Alloway RR et al. | Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): phase 2 trial of stable liver transplant recipients. | 2014 | Liver Transpl. | pmid:24493215 |
| Hartmann A et al. | Treatment of generalised vitiligo with tacrolimus 0.1% ointment vs. UVB intense pulsed light phototherapy: a pilot study. | 2014 | Acta Derm. Venereol. | pmid:24473666 |
| Xu H et al. | The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. | 2014 | Am. J. Transplant. | pmid:24472192 |
| Tsuchimoto A et al. | Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. | 2014 | PLoS ONE | pmid:25329716 |
| Lankarani KB et al. | Response to: Comment on: New-onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:24471728 |
| Qi H et al. | The antiaging activity and cerebral protection of rapamycin at micro-doses. | 2014 | CNS Neurosci Ther | pmid:25327787 |
| Kabir A | Comment on: New-onset diabetes and impaired fasting glucose after a liver transplant: risk analysis and the effect of tacrolimus dosage. | 2014 | Exp Clin Transplant | pmid:24471727 |
| Kuypers DR et al. | Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients. | 2014 | Pharmacogenet. Genomics | pmid:25322286 |
| Balato A et al. | Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes. | 2014 | Mycoses | pmid:24512536 |
| Kim H et al. | Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. | 2014 | Clin Mol Hepatol | pmid:25320733 |
| Li CJ et al. | Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients. | 2014 | PLoS ONE | pmid:24465960 |
| Curtin BF et al. | Unusually late-onset mycophenolate mofetil-related colitis. | 2014 | Am J Health Syst Pharm | pmid:25320135 |
| Silva-Cunha A et al. | Evaluation of the pharmacokinetics and ocular tolerance of a microemulsion containing tacrolimus. | 2014 | J Ocul Pharmacol Ther | pmid:24199740 |
| Diémé B et al. | Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling. | 2014 | Transplantation | pmid:24598938 |
| Grillo E et al. | Necrobiosis lipoidica. | 2014 | Aust Fam Physician | pmid:24600675 |
| Kimura Y et al. | Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. | 2014 | Toxicol In Vitro | pmid:24603311 |
| Shilbayeh S | The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625991 |
| Wang XZ et al. | Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients. | 2014 | Transpl. Immunol. | pmid:24211610 |
| Daher Abdi Z et al. | Exposure to mycophenolic acid better predicts immunosuppressive efficacy than exposure to calcineurin inhibitors in renal transplant patients. | 2014 | Clin. Pharmacol. Ther. | pmid:24968086 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Kato H et al. | Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Bone Marrow Transplant. | pmid:24317130 |
| Tischer S and Fontana RJ | Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting. | 2014 | J. Hepatol. | pmid:24280292 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Urbanowicz T et al. | Induction therapy, tacrolimus plasma concentration, and duration if intensive care unit stay are risk factors for peripheral leucopenia following heart transplantation. | 2014 | Ann. Transplant. | pmid:25274118 |
| Stifft F et al. | Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation. | 2014 | Transplantation | pmid:24686426 |
| Funaro D et al. | A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in patients with vulvar lichen sclerosus. | 2014 | J. Am. Acad. Dermatol. | pmid:24704090 |
| Demmers MW et al. | Limited efficacy of immunosuppressive drugs on CD8+ T cell-mediated and natural killer cell-mediated lysis of human renal tubular epithelial cells. | 2014 | Transplantation | pmid:24704664 |
| Størset E et al. | Importance of hematocrit for a tacrolimus target concentration strategy. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24071959 |
| Peloso LJ et al. | The serum concentration of tacrolimus after ingesting omeprazole: a pilot study. | 2014 | Transplantation | pmid:25221905 |
| Posadas Salas MA and Srinivas TR | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2014 | Drug Des Devel Ther | pmid:25210441 |
| Arduino PG et al. | Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. | 2014 | J Eur Acad Dermatol Venereol | pmid:23451852 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Keniya MV et al. | Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. | 2014 | Mol. Pharm. | pmid:25115303 |
| Sun Z et al. | Co-administration of Wuzhi capsules and tacrolimus in patients with idiopathic membranous nephropathy: clinical efficacy and pharmacoeconomics. | 2014 | Int Urol Nephrol | pmid:25145781 |
| Dannhorn E et al. | De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | 2014 | Clin Transplant | pmid:25142496 |
| Chatterjea A et al. | Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats. | 2014 | J. Cell. Mol. Med. | pmid:24237965 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Ko SF et al. | Therapeutic potential of tacrolimus on acute myocardial infarction in minipigs: analysis with serial cardiac magnetic resonance and changes at histological and protein levels. | 2014 | Biomed Res Int | pmid:25114905 |
| Grossman J et al. | Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. | 2014 | Biol. Blood Marrow Transplant. | pmid:25111582 |
| Grafals M et al. | Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. | 2014 | PLoS ONE | pmid:25111080 |
| Sethna CB and Gipson DS | Treatment of FSGS in Children. | 2014 | Adv Chronic Kidney Dis | pmid:24602468 |
| Bercaw-Pratt JL et al. | Clinical recommendation: pediatric lichen sclerosus. | 2014 | J Pediatr Adolesc Gynecol | pmid:24602304 |
| Kaieda S et al. | Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus. | 2014 | Mod Rheumatol | pmid:24593214 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Bica L et al. | Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. | 2014 | PLoS ONE | pmid:24587210 |
| Little JA et al. | The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood. | 2014 | J. Rheumatol. | pmid:24085549 |
| Hostettler KE et al. | Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. | 2014 | Eur. Respir. J. | pmid:23645405 |
| Bergmann TK et al. | Population pharmacokinetics of tacrolimus in adult kidney transplant patients: impact of CYP3A5 genotype on starting dose. | 2014 | Ther Drug Monit | pmid:24089074 |
| Aelvoet SA et al. | Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters. | 2014 | J. Neurosci. | pmid:25471588 |
| Oh CK et al. | Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation. | 2014 | Yonsei Med. J. | pmid:25048494 |
| Matin M et al. | The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. | 2014 | J Cosmet Laser Ther | pmid:25046236 |
| de la Fuente V et al. | Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation. | 2014 | Hippocampus | pmid:25043904 |
| Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
| Kluk J et al. | Follicular mucinosis treated with topical 0.1% tacrolimus ointment. | 2014 | Clin. Exp. Dermatol. | pmid:24252117 |
| Ohe M et al. | Successful treatment with tacrolimus of refractory adult-onset Still's disease. | 2014 | Korean J. Intern. Med. | pmid:24648814 |
| Friedrich RB et al. | Nanoencapsulation of tacrolimus in lipid-core nanocapsules showed similar immunosuppressive activity after oral and intraperitoneal administrations. | 2014 | J Biomed Nanotechnol | pmid:25016659 |
| Rostaing L et al. | The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. | 2014 | Ann. Transplant. | pmid:25017487 |
| Qi H et al. | Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24965502 |
| Jannot M et al. | Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. | 2014 | Ann. Transplant. | pmid:24999809 |
| Zhao J et al. | FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB. | 2014 | J. Neurol. Sci. | pmid:24954089 |
| Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
| Sureshkumar KK and Chopra B | In search of an optimal induction agent in kidney transplantation. | 2014 | Transplantation | pmid:24978038 |
| Welberry Smith MP and Baker RJ | The author's reply. | 2014 | Transplantation | pmid:24978039 |
| Toniutto P et al. | Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated. | 2014 | Int J Surg | pmid:25219480 |
| Boonyapredee M et al. | Increased BK viremia and progression to BK-virus nephropathy following high-dose intravenous immunoglobulin for acute cellular rejection. | 2014 | Mil Med | pmid:24902140 |
| Langone A et al. | Long-term dosing patterns of enteric-coated mycophenolate sodium or mycophenolate mofetil with tacrolimus after renal transplantation. | 2014 | Clin Transplant | pmid:24893821 |
| Nafar M et al. | Prevalence and risk factors of recurrent cytomegalovirus infection in kidney transplant recipients. | 2014 | Iran J Kidney Dis | pmid:24878947 |
| van Gelder T | Within-patient variability in immunosuppressive drug exposure as a predictor for poor outcome after transplantation. | 2014 | Kidney Int. | pmid:24875549 |
| Lalan S et al. | Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population. | 2014 | Pediatr. Nephrol. | pmid:24875272 |
| Tümgör G et al. | A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment. | 2014 | Turk J Gastroenterol | pmid:25599790 |
| Korbel L et al. | Clinically relevant pharmacogenomic testing in pediatric practice. | 2014 | Clin Pediatr (Phila) | pmid:24803633 |
| Kallash M and Aviles D | Efficacy of tacrolimus in the treatment of children with focal segmental glomerulosclerosis. | 2014 | World J Pediatr | pmid:24801235 |
| Maeda H et al. | Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine. | 2014 | PLoS ONE | pmid:24796859 |
| Du W et al. | Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24788378 |
| Agrawal YP et al. | Transplant patient classification and tacrolimus assays: more evidence of the need for assay standardization. | 2014 | Ther Drug Monit | pmid:24784024 |
| Sageshima J et al. | Everolimus with low-dose tacrolimus in simultaneous pancreas and kidney transplantation. | 2014 | Clin Transplant | pmid:24779669 |
| Nkongolo S et al. | Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. | 2014 | J. Hepatol. | pmid:24295872 |
| Parashos SA et al. | Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. | 2014 | JAMA Neurol | pmid:24711047 |
| Gillard P et al. | Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy. | 2014 | Transplantation | pmid:24770614 |
| Pandey S et al. | Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines. | 2014 | J. Neurochem. | pmid:25113668 |
| Mitsides N et al. | Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. | 2014 | Transpl Infect Dis | pmid:24215452 |
| Chung BH et al. | Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression. | 2014 | Transpl. Immunol. | pmid:24709525 |
| Al-Kadhimi Z et al. | High incidence of severe acute graft-versus-host disease with tacrolimus and mycophenolate mofetil in a large cohort of related and unrelated allogeneic transplantation patients. | 2014 | Biol. Blood Marrow Transplant. | pmid:24709007 |
| Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
| Indriolo A and Ravelli P | Clinical management of inflammatory bowel disease in the organ recipient. | 2014 | World J. Gastroenterol. | pmid:24707135 |
| Huang W et al. | Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis. | 2014 | PLoS ONE | pmid:25464008 |
| Nair S and Waters B | Telaprevir in treatment of recurrent hepatitis C infection in liver transplant recipients. | 2014 | Exp Clin Transplant | pmid:24702143 |
| Navas-López VM et al. | Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. | 2014 | Clin J Gastroenterol | pmid:26185880 |