tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gonzalez Molina M et al. | Renal function in patients with cadaveric kidney transplants treated with tacrolimus or cyclosporine. | 2007 | Transplant. Proc. | pmid:17889126 |
| Murase N et al. | FK 506 prevents spontaneous diabetes in the BB rat. | 1991 | Transplant. Proc. | pmid:1703705 |
| Manzanares C et al. | Influence of hepatitis C virus infection on FK 506 blood levels in renal transplant patients. | 1998 | Transplant. Proc. | pmid:9636513 |
| Gavela E et al. | Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715842 |
| Cherala G et al. | Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation. | 2011 | Transplant. Proc. | pmid:22172831 |
| Spinelli GA et al. | Lipid profile changes during the first year after kidney transplantation: risk factors and influence of the immunosuppressive drug regimen. | 2011 | Transplant. Proc. | pmid:22172836 |
| Latorre A et al. | Clinical management of renal transplant patients with hepatitis C virus infection treated with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:11959186 |
| Stringa P et al. | Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study. | Transplant. Proc. | pmid:26915870 | |
| Soda M et al. | Association Between Tacrolimus Pharmacokinetics and Cytochrome P450 3A5 and Multidrug Resistance Protein 1 Exon 21 Polymorphisms. | Transplant. Proc. | pmid:28736028 | |
| Mac Guad R et al. | Effects of CYP3A5 Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:26915847 | |
| Venkataramanan R et al. | Pharmacokinetics of FK 506: preclinical and clinical studies. | 1990 | Transplant. Proc. | pmid:1689899 |
| Jain AB et al. | Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations. | 1990 | Transplant. Proc. | pmid:1689900 |
| Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
| Zeevi A et al. | Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. | 1993 | Transplant. Proc. | pmid:7679843 |
| McMichael J et al. | Evaluation of a novel "intelligent" dosing system for optimizing FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721275 |
| Ali Shah I et al. | Effects of FK 506 on human hepatic microsomal cytochrome P-450-dependent drug metabolism in vitro. | 1991 | Transplant. Proc. | pmid:1721276 |
| Valdivia LA et al. | Prolonged survival of hearts obtained from chimeric donors in a mouse to rat xenotransplant model. | 1996 | Transplant. Proc. | pmid:8623371 |
| Ringe B et al. | Tacrolimus and mycophenolate mofetil in clinical liver transplantation: experience with a steroid-sparing concept. | 1998 | Transplant. Proc. | pmid:9636573 |
| Shimizu T et al. | Risk factors of acute tacrolimus nephrotoxicity in renal allografts. | 2000 | Transplant. Proc. | pmid:11119998 |
| Wakizaka Y et al. | Xenotransplantation of hamster liver into Gunn rats reserves congenital hyperbilirubinemia. | 1996 | Transplant. Proc. | pmid:8623372 |
| Rudich SM et al. | Immunosuppression using tacrolimus, mycophenolate, and prednisone following orthotopic liver transplantation: a single-center experience. | 1998 | Transplant. Proc. | pmid:9636574 |
| Chueh SC et al. | Drug fever caused by mycophenolate mofetil in a renal transplant recipient--a case report. | 2000 | Transplant. Proc. | pmid:11120003 |
| Ueno T et al. | Renal dysfunction following adult intestinal transplant under tacrolimus-based immunosuppression. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908274 |
| Bora F et al. | Drug interaction between tacrolimus and ertapenem in renal transplantation recipients. | 2012 | Transplant. Proc. | pmid:23195020 |
| Crespo-Leiro MG | Calcineurin inhibitors in heart transplantation. | 2005 | Transplant. Proc. | pmid:16386614 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Zeevi A et al. | In vitro assessment of FK 506 immunosuppressive activity in transplant patients. | 1991 | Transplant. Proc. | pmid:1721307 |
| Schneeberger H et al. | Tacrolimus as a primary immunosuppressive therapy in cadaveric renal transplantation: five years' experience at a single center. | 1998 | Transplant. Proc. | pmid:9636642 |
| Hairhara Y et al. | Effect of fluconazole on blood levels of tacrolimus. | 1999 | Transplant. Proc. | pmid:10578284 |
| Jain A et al. | Tacrolimus for primary liver transplantation: 12 to 15 years actual follow-up with safety profile. | 2005 | Transplant. Proc. | pmid:15848671 |
| Florman S et al. | Conversion of stable liver transplant recipients from a twice-daily Prograf-based regimen to a once-daily modified release tacrolimus-based regimen. | 2005 | Transplant. Proc. | pmid:15848672 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Chen J et al. | Observation of efficacy and safety of converting the calcineurin inhibitor to sirolimus in renal transplant recipients with chronic allograft nephropathy. | 2008 | Transplant. Proc. | pmid:18589119 |
| Chen JW et al. | Ten-year results of a randomised prospective study of FK506 versus cyclosporine in management of primary orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176460 |
| Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
| Marcén R et al. | Conversion from cyclosporine microemulsion to tacrolimus in stable kidney transplant patients with hypercholesterolemia is related to an improvement in cardiovascular risk profile: a prospective study. | 2006 | Transplant. Proc. | pmid:17097957 |
| Rucay P et al. | FK 506 rescue therapy for refractory acute rejection in five liver recipients. | 1991 | Transplant. Proc. | pmid:1721340 |
| Mortensen DM et al. | Calcineurin activity in tacrolimus-treated renal transplant patients early after and 5 years after transplantation. | 2006 | Transplant. Proc. | pmid:17098028 |
| Borrows R et al. | Steroid sparing in renal transplantation with tacrolimus and mycophenolate mofetil: three-year results. | 2005 | Transplant. Proc. | pmid:15919468 |
| Malyszko J et al. | A possible role of hepcidin in the pathogenesis of anemia among kidney allograft recipients. | 2009 | Transplant. Proc. | pmid:19857675 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Lo CM et al. | Use of FK506 as primary or rescue therapy after liver transplantation in Hong Kong. | 1998 | Transplant. Proc. | pmid:9838571 |
| Wijnen RM et al. | Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels. | 1991 | Transplant. Proc. | pmid:1721371 |
| Hung CM et al. | Tacrolimus to rescue refractory hepatic allograft rejection: a collaborative study in Taiwan. | 1998 | Transplant. Proc. | pmid:9838572 |
| Venkataramanan R et al. | Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1703355 |
| Fung JJ et al. | Adverse effects associated with the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721372 |
| Reichenspurner H et al. | Tacrolimus-based immunosuppressive protocols in lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083062 |
| Omar G et al. | FK 506 inhibition of cyclosporine metabolism by human liver microsomes. | 1991 | Transplant. Proc. | pmid:1703356 |
| Miller J | Tacrolimus and mycophenolate mofetil in renal transplant recipients: one year results of a multicenter, randomized dose ranging trial. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083106 |
| Mange KC and Bloom RD | Rates of acute rejection by recipient race and type of calcineurin inhibitor with mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12493393 |
| Domenech N et al. | Neither acute rejection nor immunosuppressant drug therapy (cyclosporine or tacrolimus) correlates with expression of either CD40 or CD154 on peripheral blood cells among human cardiac transplant patients. | 2003 | Transplant. Proc. | pmid:12962873 |
| Boots JM et al. | Pretransplant pharmacokinetics: does it predict the dose of tacrolimus after renal transplantation? | 2002 | Transplant. Proc. | pmid:12493409 |
| Peraira JR et al. | High incidence of severe infections in heart transplant recipients receiving tacrolimus. | 2003 | Transplant. Proc. | pmid:12962875 |
| Khanna A et al. | Cardiac changes at autopsy in adult liver transplant recipients under tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123118 |
| Busuttil RW and Holt CD | Tacrolimus (FK506) is superior to cyclosporine in liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123119 |
| Villanueva ME et al. | Alemtuzumab induction with tacrolimus monotherapy in de novo renal transplantation. | 2008 | Transplant. Proc. | pmid:18790198 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Wayman MR et al. | Two-year outcome in renal allograft recipients comparing neoral-led with tacrolimus-led therapy. | 2002 | Transplant. Proc. | pmid:12176526 |
| Cho WH et al. | Basiliximab does not reduce the early rejection incidence in high-risk kidney recipients under tacrolimus-based immunosuppression. | 2008 | Transplant. Proc. | pmid:18790201 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Okamoto M et al. | Tacrolimus-based immunosuppression in renal transplantation: 78 experiences in a single Japanese center. | 2002 | Transplant. Proc. | pmid:12176527 |
| Limsrichamrern S et al. | Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320581 |
| Mor E et al. | Homocysteine levels among transplant recipients: effect of immunosuppressive protocols. | 2001 | Transplant. Proc. | pmid:11543802 |
| Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
| Kokado Y et al. | Low-dose tacrolimus (FK 506)-based immunosuppressive protocol in living donor renal transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083515 |
| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Jacobs TW et al. | The effect of FK 506, cyclosporine A, and cyclosporine G on serum 1,25-dihydroxyvitamin D levels. | 1991 | Transplant. Proc. | pmid:1721403 |
| Yoshimura R et al. | A comparative study of cyclosporine vs FK 506: role of kidney microsomal cytochrome P-450. | 1992 | Transplant. Proc. | pmid:1379755 |
| Baruch Y et al. | Anasarca and hypertrophic cardiomyopathy in a liver transplant patient on FK506: relieved after a switch to Neoral. | 1996 | Transplant. Proc. | pmid:8769215 |
| Kuroki H et al. | Experimental studies of vascularized allogeneic limb transplantation in the rat using a new immunosuppressive agent, FK-506: morphological and immunological analysis. | 1989 | Transplant. Proc. | pmid:2468255 |
| Arai K et al. | Prolonged limb allograft survival with short-term treatment with FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468256 |
| Matsumiya G et al. | Serum interleukin-6 level after cardiac xenotransplantation in primates. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123586 |
| Schweizer RT and Meisterling LD | Tolerability of mycophenolate mofetil in organ transplant recipients. | 2001 | Transplant. Proc. | pmid:11377540 |
| Pham SM et al. | Sirolimus and tacrolimus in clinical cardiac transplantation. | 2002 | Transplant. Proc. | pmid:12176597 |
| Zhou J et al. | Sirolimus-based immunosuppression therapy in liver transplantation for patients with hepatocellular carcinoma exceeding the Milan criteria. | 2008 | Transplant. Proc. | pmid:19100435 |
| van den Berg AP et al. | Prediction of the inhibition of IL-2 production by calcineurin inhibitors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267197 |
| Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
| Kobayashi N et al. | Effect of FK 506 on abdominal organ cluster transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1721434 |
| Wada H et al. | An attempt to induce tolerance to skin grafts in congenic mice with FK 506. | 1991 | Transplant. Proc. | pmid:1721435 |
| Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
| Ghio L et al. | Conversion from tacrolimus to cyclosporine for a non-dose-dependent tacrolimus-induced toxicity, a pediatric kidney transplant recipient case report. | 2004 | Transplant. Proc. | pmid:15251325 |
| Calne R et al. | Observations about FK-506 in primates. | 1987 | Transplant. Proc. | pmid:2445078 |
| Grabczewska Z et al. | Neither cyclosporine nor tacrolimus deteriorate endothelial function in renal transplant recipients assessed with reactive hyperernia index. | 2013 | Transplant. Proc. | pmid:23726621 |
| Halloran PF et al. | Calcineurin and the biological effect of cyclosporine and tacrolimus. | 1998 | Transplant. Proc. | pmid:9723430 |
| Renner FC et al. | The risk of polyomavirus-associated graft nephropathy is increased by a combined suppression of CD8 and CD4 cell-dependent immune effects. | 2013 | Transplant. Proc. | pmid:23726630 |
| Walgenbach KJ et al. | Upregulation of basic fibroblast growth factor during chronic rejection of rat intestinal allografts and its downregulation by FK 506. | 1998 | Transplant. Proc. | pmid:9745501 |
| Laftavi MR et al. | The role of antibiotic prophylaxis in the new era of immunosuppression. | 2011 | Transplant. Proc. | pmid:21440753 |
| Treede H et al. | Incidence and spectrum of infections in lung transplanted patients: comparison of four different immunosuppressive protocols. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267444 |
| Fu Q et al. | Risk Factors for Acute Rejection After Deceased Donor Kidney Transplantation in China. | 2018 | Transplant. Proc. | pmid:30316380 |
| Chen H et al. | FK 506 and rapamycin in combination are not antagonistic but produce extended small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9636419 |
| Konno O et al. | Early Outcomes of Living-Donor Kidney Transplantation With Immunosuppression Therapy Induction With Tacrolimus Extended-Release: A Comparison With Cyclosporine. | 2018 | Transplant. Proc. | pmid:30316378 |
| Li S et al. | Intrathymic inoculation of donor bone marrow at the time of transplantation plus a short course of tacrolimus induce long-term acceptance to rat lung allografts. | 1998 | Transplant. Proc. | pmid:9636431 |
| Pinho-Apezzato ML et al. | Multiple clinical presentations of lymphoproliferative disorders in pediatric liver transplant recipients: a single-center experience. | 2010 | Transplant. Proc. | pmid:20620519 |
| Suarez Benjumea A et al. | Hepatitis C Virus in Kidney Transplant Recipients: A Problem on the Path to Eradication. | 2016 | Transplant. Proc. | pmid:27932111 |
| Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
| Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
| Pridöhl O et al. | Low-dose immunosuppression with FK 506 and sirolimus after liver transplantation: 1-year results. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750384 |