Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rivelli RF et al. | Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant. | 2015 | Nephrology (Carlton) | pmid:25404086 |
Cury Martins J et al. | Topical tacrolimus for atopic dermatitis. | 2015 | Cochrane Database Syst Rev | pmid:26132597 |
Argudo A et al. | Liver Transplant Patient Carriers of Polymorphism Cyp3a5*1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation. | 2015 | Transplant. Proc. | pmid:26518936 |
van Boekel GA et al. | Limited sampling strategy for prolonged-release tacrolimus in renal transplant patients by use of the dried blood spot technique. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25980838 |
de Jonge H et al. | The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients. | 2015 | Pharmacogenomics J. | pmid:25287072 |
Hategan A and Bourgeois JA | Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system. | 2015 | J Neuropsychiatry Clin Neurosci | pmid:25923858 |
Josephson MA et al. | American society of Nephrology Quiz and Questionnaire 2014: transplantation. | 2015 | Clin J Am Soc Nephrol | pmid:25862775 |
Abe Y et al. | Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus. | 2015 | Intern. Med. | pmid:26568012 |
Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
Wang Y et al. | Justification of noninferiority margin: methodology considerations in an exposure-response analysis. | 2015 | Clin. Pharmacol. Ther. | pmid:25670256 |
Dai DS et al. | Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. | 2015 | Am. J. Nephrol. | pmid:26439819 |
Chakraborty S et al. | Prediction of in vivo drug performance using in vitro dissolution coupled with STELLA: a study with selected drug products. | 2015 | Drug Dev Ind Pharm | pmid:25494535 |
Ramachandran R et al. | Tacrolimus combined with corticosteroids versus Modified Ponticelli regimen in treatment of idiopathic membranous nephropathy: Randomized control trial. | 2016 | Nephrology (Carlton) | pmid:26205759 |
Hurabielle C et al. | Certolizumab pegol - A new therapeutic option for refractory disseminated pyoderma gangrenosum associated with Crohn's disease. | 2016 | J Dermatolog Treat | pmid:25909366 |
Mercuri A et al. | In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions. | 2016 | Int J Pharm | pmid:27737809 |
Muduma G et al. | Systematic Review and Meta-Analysis of Tacrolimus versus Ciclosporin as Primary Immunosuppression After Liver Transplant. | 2016 | PLoS ONE | pmid:27812112 |
Prókai à et al. | Calcineurin-inhibition Results in Upregulation of Local Renin and Subsequent Vascular Endothelial Growth Factor Production in Renal Collecting Ducts. | 2016 | Transplantation | pmid:26502369 |
Unver Dogan N et al. | Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone. | 2016 | Regul. Toxicol. Pharmacol. | pmid:26993750 |
Garcovich S et al. | First report of hereditary Christ-Siemens-Touraine syndrome and non-segmental vitiligo association in a young adult: contraindication for vitiligo treatment. | 2016 | J Eur Acad Dermatol Venereol | pmid:25339629 |
Ferjani H et al. | Combination of tacrolimus and mycophenolate mofetil induces oxidative stress and genotoxicity in spleen and bone marrow of Wistar rats. | 2016 | Mutat. Res. | pmid:27776691 |
Klein OR et al. | Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders. | 2016 | Biol. Blood Marrow Transplant. | pmid:26860634 |
Deng S et al. | Mechanism of tacrolimus-induced chronic renal fibrosis following transplantation is regulated by ox-LDL and its receptor, LOX-1. | 2016 | Mol Med Rep | pmid:27633115 |
Jahnukainen T et al. | The second report of the Nordic Pediatric Renal Transplantation Registry 1997-2012: More infant recipients and improved graft survivals. | 2016 | Pediatr Transplant | pmid:26857893 |
Fathy M et al. | Impact of CYP3A5 and MDR-1 gene polymorphisms on the dose and level of tacrolimus among living-donor liver transplanted patients: single center experience. | 2016 | Biomarkers | pmid:26856709 |
Størset E et al. | Low-target tacrolimus in de novo standard risk renal transplant recipients: A single-centre experience. | 2016 | Nephrology (Carlton) | pmid:26854648 |
Chen YF et al. | Tacrolimus inhibits vasoconstriction by increasing Ca(2+) sparks in rat aorta. | 2016 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:26838733 |
Novosel MK and Bistrup C | Discontinuation of steroids in ABO-incompatible renal transplantation. | 2016 | Transpl. Int. | pmid:26706618 |
Kanda Y et al. | A randomized controlled trial of cyclosporine and tacrolimus with strict control of blood concentrations after unrelated bone marrow transplantation. | 2016 | Bone Marrow Transplant. | pmid:26437063 |
Stocki P et al. | Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. | 2016 | Mol. Biol. Cell | pmid:26764098 |
Kawamura A et al. | Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice. | 2016 | Sci Rep | pmid:26763872 |
Suh SW et al. | Risk Factors for the Adverse Events after Conversion from Twice-Daily to Once-Daily Tacrolimus in Stable Liver Transplantation Patients. | 2016 | J. Korean Med. Sci. | pmid:27709847 |
Yamamoto T et al. | Tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis: a retrospective observational study. | 2016 | Aliment. Pharmacol. Ther. | pmid:26762838 |
Witt LJ et al. | Benefit of adjunctive tacrolimus in connective tissue disease-interstitial lung disease. | 2016 | Pulm Pharmacol Ther | pmid:26762710 |
Dayal S et al. | Treatment of Childhood Vitiligo Using Tacrolimus Ointment with Narrowband Ultraviolet B Phototherapy. | 2016 | Pediatr Dermatol | pmid:27699846 |
Bakardzhiev I et al. | Unilateral unique Lupus tumidus: pathogenetic mystery and diagnostic problem. | 2016 | Wien Med Wochenschr | pmid:26762262 |
Kim JM et al. | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection. | 2016 | Clin Mol Hepatol | pmid:27729628 |
Michael M et al. | Outcomes of two-drug maintenance immunosuppression for pediatric renal transplantation: 10-yr follow-up in a single center. | 2016 | Pediatr Transplant | pmid:26916966 |
Ueda Y et al. | Interstitial cystitis associated with primary Sjögren's syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review. | 2016 | Mod Rheumatol | pmid:24720552 |
Kabat-Koperska J et al. | The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats. | 2016 | Apoptosis | pmid:27586504 |
Singh JA et al. | Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis. | 2016 | J. Rheumatol. | pmid:27585688 |
Jones-Hughes T et al. | Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model. | 2016 | Health Technol Assess | pmid:27578428 |
Schmutz JL | [No increased risk of cancer under pimecrolimus]. | 2016 | Ann Dermatol Venereol | pmid:26708204 |
Saito S et al. | Role of Paternal Antigen-Specific Treg Cells in Successful Implantation. | 2016 | Am. J. Reprod. Immunol. | pmid:26706630 |
Tamaki M et al. | Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. | 2016 | Transpl Infect Dis | pmid:27258644 |
Georgiou GK et al. | Calcineurin inhibitors and male fertility after renal transplantation - a review. | 2016 | Andrologia | pmid:26341518 |
Miyata Y et al. | Pharmacokinetics of a Once-Daily Dose of Tacrolimus Early After Liver Transplantation: With Special Reference to CYP3A5 and ABCB1 Single Nucleotide Polymorphisms. | 2016 | Ann. Transplant. | pmid:27503662 |
Orr C et al. | Quantifying Insulin Therapy Requirements to Preserve Islet Graft Function Following Islet Transplantation. | 2016 | Cell Transplant | pmid:25853639 |
Herden U et al. | Early Initiation of Everolimus After Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:26842532 |
Thomas KS et al. | Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. | 2016 | J. Am. Acad. Dermatol. | pmid:27502313 |
Yaowakulpatana K et al. | Impact of CYP3A5 polymorphism on trough concentrations and outcomes of tacrolimus minimization during the early period after kidney transplantation. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26635230 |
Yamaguchi Y et al. | Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. | 2016 | Eur J Dermatol | pmid:27502182 |
Shuker N et al. | Pretransplant Tacrolimus Dose Requirements Predict Early Posttransplant Dose Requirements in Blood Group AB0-Incompatible Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26630539 |
Turrión-Merino L et al. | A Case Series of 4 Patients With Peristomal Pyoderma Gangrenosum: Review of Risk Factors and Treatment Response. | 2016 | Actas Dermosifiliogr | pmid:26626501 |
Uemoto S et al. | Advantage of tacrolimus/mycophenolate mofetil regimen for cytotoxic T cell-mediated defence and its inhibition by additive steroid administration in high-risk liver transplant recipients. | 2016 | Clin. Exp. Immunol. | pmid:26560892 |
Niioka T et al. | Influence of everolimus on the pharmacokinetics of tacrolimus in Japanese renal transplant patients. | 2016 | Int. J. Urol. | pmid:26990259 |
Gastaca M et al. | Favorable longterm outcomes of liver transplant recipients treated de novo with once-daily tacrolimus: Results of a single-center cohort. | 2016 | Liver Transpl. | pmid:27434676 |
Genvigir FD et al. | Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients. | 2016 | Pharmacogenet. Genomics | pmid:27434656 |
Ogura Y et al. | Early Conversion From Twice-Daily Tacrolimus to Prolonged-Release Tacrolimus in Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:27432248 |
Shijo T et al. | A mismatch between MRI lesions and SPECT hypoperfusion in tacrolimus-related encephalopathy. | 2016 | J. Neurol. Sci. | pmid:27423609 |
Hermans C et al. | Atypical discrete papular lichen myxedematosus associated with monoclonal gammopathy: report of four cases and review of the literature. | 2016 | J Eur Acad Dermatol Venereol | pmid:27422288 |
Qi XM et al. | FK506 reduces albuminuria through improving podocyte nephrin and podocin expression in diabetic rats. | 2016 | Inflamm. Res. | pmid:26566632 |
Miura K et al. | Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine. | 2016 | Transplant. Proc. | pmid:27320612 |
Lee HK et al. | Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes. | 2016 | Transplant. Proc. | pmid:27320607 |
Asavakarn S et al. | Systematic Pharmaceutical Educational Approach to Enhance Drug Adherence in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320587 |
Limsrichamrern S et al. | Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320581 |
Kim JD et al. | Single-Center Experience of ABO-Incompatible Living-Donor Liver Transplantation With a New Simplified Intravenous Immunoglobulin Protocol: A Propensity Score-Matching Analysis. | 2016 | Transplant. Proc. | pmid:27320573 |
Federico S et al. | Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration. | 2016 | Eur. J. Clin. Invest. | pmid:27240092 |
Mo S et al. | Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach. | 2016 | J. Microbiol. Biotechnol. | pmid:26502733 |
Yesilipek MA et al. | Haploidentical hematopoietic stem cell transplantation with post-transplant high-dose cyclophosphamide in high-risk children: A single-center study. | 2016 | Pediatr Transplant | pmid:26707539 |
Sobiak J et al. | Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25663618 |
Sharma P et al. | Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. | 2016 | Diabetes | pmid:27246912 |
Prytuła A et al. | Factors associated with 1,25-dihydroxyvitamin D3 concentrations in liver transplant recipients: a prospective observational longitudinal study. | 2016 | Endocrine | pmid:26433738 |
Lazelle RA et al. | Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. | 2016 | J. Am. Soc. Nephrol. | pmid:26432904 |
Medeiros M et al. | Are Tacrolimus Pharmacokinetics Affected by Nephrotic Stage? | 2016 | Ther Drug Monit | pmid:27167176 |
Nitta D et al. | Successful Pregnancy and Delivery in a Heart Transplantation Recipient. | 2016 | Int Heart J | pmid:27150004 |
Jovanović M and Golušin Z | Nonsteroidal Topical Immunomodulators in Allergology and Dermatology. | 2016 | Biomed Res Int | pmid:27144167 |
Ban YH et al. | The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26342319 |
Romano C et al. | Management of Acute Severe Colitis in Children With Ulcerative Colitis in the Biologics Era. | 2016 | Pediatrics | pmid:27244779 |
Abud TB et al. | A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease. | 2016 | Ophthalmology | pmid:27086024 |
Nijhoff MF et al. | Glycemic Stability Through Islet-After-Kidney Transplantation Using an Alemtuzumab-Based Induction Regimen and Long-Term Triple-Maintenance Immunosuppression. | 2016 | Am. J. Transplant. | pmid:26288226 |
Anuradha D and Parsad | FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes. | 2016 | Dermatol Ther | pmid:27093927 |
Fujii S et al. | Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. | 2016 | Learn. Mem. | pmid:27084928 |
Shin J et al. | Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. | 2016 | Skelet Muscle | pmid:26949511 |
Han SS et al. | Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function. | 2016 | PLoS ONE | pmid:27082871 |
Bianic F et al. | Cost-effectiveness of everolimus plus reduced tacrolimus in de novo liver-recipients in the Italian setting. | 2016 | J Med Econ | pmid:27081739 |
Tannuri AC et al. | Prognostic factors for the evolution and reversibility of chronic rejection in pediatric liver transplantation. | 2016 | Clinics (Sao Paulo) | pmid:27166772 |
Mok CC et al. | Tacrolimus versus mycophenolate mofetil for induction therapy of lupus nephritis: a randomised controlled trial and long-term follow-up. | 2016 | Ann. Rheum. Dis. | pmid:25550339 |
Tariciotti L et al. | Everolimus and Advagraf Ab Initio in Combined Liver and Kidney Transplant With Donor-Specific Antibodies: A Case Report. | 2016 | Transplant. Proc. | pmid:27932158 |
Ikeda M et al. | Successful Second Allogeneic Stem Cell Transplantation From a Sibling Donor for Relapse of Myelodysplastic Syndrome in a Recipient of a Renal Transplant From His Mother: Case Report. | 2016 | Transplant. Proc. | pmid:27932152 |
Suarez Benjumea A et al. | Hepatitis C Virus in Kidney Transplant Recipients: A Problem on the Path to Eradication. | 2016 | Transplant. Proc. | pmid:27932111 |
Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
Kolonko A et al. | Successful Preemptive Kidney Transplantation With Rituximab Induction in a Patient With Focal Segmental Glomerulosclerosis and Massive Nephrotic Syndrome: A Case Report. | 2016 | Transplant. Proc. | pmid:27932154 |
Rodriguez Cubillo B et al. | Risk Factors of Recurrence of Diabetic Nephropathy in Renal Transplants. | 2016 | Transplant. Proc. | pmid:27932117 |
Thölking G et al. | Tacrolimus Concentration/Dose Ratio is Associated with Renal Function After Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27003330 |
Krämer BK et al. | Efficacy and safety of tacrolimus compared with ciclosporin-A in renal transplantation: 7-year observational results. | 2016 | Transpl. Int. | pmid:26565071 |
Janicki JJ et al. | Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction. | 2016 | Toxins (Basel) | pmid:26999210 |
Pallet N et al. | Long-Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype. | 2016 | Am. J. Transplant. | pmid:26990694 |
Awdishu L and Joy MS | Role of Pharmacogenomics in Kidney Disease and Injury. | 2016 | Adv Chronic Kidney Dis | pmid:26979149 |
Song GW et al. | A Pilot Study of the Pharmacokinetics of the Modified-Release Once-Daily Tacrolimus Formulation Administered to Living-Donor Liver Transplant Recipients. | 2016 | Exp Clin Transplant | pmid:26976646 |
Stockwell J et al. | Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. | 2016 | Neuropharmacology | pmid:26626486 |