tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Christians U et al. | High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients. | 1991 | Transplant. Proc. | pmid:1721262 |
| Beysens AJ et al. | FK 506: monitoring in plasma or in whole blood? | 1991 | Transplant. Proc. | pmid:1721263 |
| Regazzi MB et al. | Interaction between FK 506 and diltiazem in an animal model. | 1996 | Transplant. Proc. | pmid:8623215 |
| Shapiro R et al. | Outcome after steroid withdrawal in renal transplant patients receiving tacrolimus-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636557 |
| Okamoto M et al. | Beneficial effect of multiple drug therapy including tacrolimus in clinical renal transplantation. | 2000 | Transplant. Proc. | pmid:11119905 |
| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Grewal HP et al. | Corticosteroid cessation 1 week following renal transplantation using tacrolimus/mycophenolate mofetil based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636558 |
| Tanabe K et al. | Malabsorption of tacrolimus in kidney transplant recipients: a Japanese single center experience. | 2000 | Transplant. Proc. | pmid:11119906 |
| Ochiai M et al. | Islet toxicity of FK506 measured in canine autografts. | 1998 | Transplant. Proc. | pmid:9532224 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Vilalta R et al. | Rapamycin use and rapid withdrawal of calcineurin inhibitors in pediatric renal transplantation. | 2003 | Transplant. Proc. | pmid:12644102 |
| Monden M et al. | A potent immunosuppressive effect of FK 506 in orthotopic liver transplantation in primates. | 1990 | Transplant. Proc. | pmid:1689904 |
| Rath T and Küpper M | Comparison of inosine-monophosphate-dehydrogenase activity in patients with enteric-coated mycophenolate sodium or mycophenolate mofetil after renal transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715967 |
| Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
| Morell Ginestà M et al. | Histology and immunopathology of heart and liver xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959305 |
| Ullman KS et al. | Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes. | 1991 | Transplant. Proc. | pmid:1721294 |
| McAlister VC et al. | Cost of liver transplantation using tacrolimus. | 1998 | Transplant. Proc. | pmid:9636611 |
| Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunologic risk". | 2000 | Transplant. Proc. | pmid:11120281 |
| Woodle ES et al. | Corticosteroid withdrawal under tacrolimus primary and rescue therapy in renal transplantation: the Chicago experience. | 1999 | Transplant. Proc. | pmid:10576053 |
| Sathyan S et al. | A case of recurrent immunotactoid glomerulopathy in an allograft treated with rituximab. | 2009 | Transplant. Proc. | pmid:19917422 |
| Kaminska D et al. | Mycophenolate mofetil but not the type of calcineurin inhibitor (cyclosporine vs tacrolimus) influences the intragraft mRNA expression of cytokines in human kidney allograft biopsies by in situ RT-PCR analysis. | 2005 | Transplant. Proc. | pmid:15848526 |
| Woodle ES | A prospective, randomized, multicenter, double-blind study of early corticosteroid cessation versus long-term maintenance of corticosteroid therapy with tacrolimus and mycophenolate mofetil in primary renal transplant recipients: one year report. | 2005 | Transplant. Proc. | pmid:15848538 |
| Marzoa-Rivas R et al. | Conversion of heart transplant patients from standard to sustained-release tacrolimus requires a dosage increase. | 2010 | Transplant. Proc. | pmid:20970591 |
| López-Montenegro Soria MA et al. | Genetic polymorphisms and individualized tacrolimus dosing. | 2010 | Transplant. Proc. | pmid:20970601 |
| Lodewijk L et al. | Effect of liver regeneration on the pharmacokinetics of immunosuppressive drugs. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249561 |
| Nowacka-Cieciura E et al. | Late conversion to everolimus complicated with necrotizing glomerulonephritis in a renal allograft recipient: case report. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249576 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
| Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
| Hisanaga M et al. | Successful combination therapy with FK 506 and 15-deoxyspergualin in pancreatic islet xenografting. | 1992 | Transplant. Proc. | pmid:1376513 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Didlake R and Grogan J | Effect of FK 506 on rat leukocyte chemotaxis. | 1991 | Transplant. Proc. | pmid:1721327 |
| Akioka K et al. | Abdominal pain is a critical complication of mycophenolate mofetil in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591411 |
| Takeuchi H et al. | Optimal dose and target trough level in cyclosporine and tacrolimus conversion in renal transplantation as evaluated by lymphocyte drug sensitivity and pharmacokinetic parameters. | 2005 | Transplant. Proc. | pmid:15919452 |
| Sarvary E et al. | De novo Prograf versus de novo Advagraf: are trough level profile curves similar? | Transplant. Proc. | pmid:25131131 | |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| EscartÃn A et al. | Analysis of pig-MAP after small bowel transplantation in pigs. | 1998 | Transplant. Proc. | pmid:9865377 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in adult cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721358 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
| Nalesnik MA et al. | Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population. | 1991 | Transplant. Proc. | pmid:1703335 |
| Oğütmen B et al. | Transforming growth factor-beta1, vascular endothelial growth factor, and bone morphogenic protein-7 expression in tacrolimus-induced nephrotoxicity in rats. | 2006 | Transplant. Proc. | pmid:16549155 |
| Emiroglu R et al. | Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience. | 2006 | Transplant. Proc. | pmid:16549190 |
| Prates LC et al. | Pain syndrome induced by calcineurin inhibitor and resolved by conversion to sirolimus in a child after kidney transplantation: a case report. | 2012 | Transplant. Proc. | pmid:23026634 |
| Sánchez-Fructuoso AI et al. | Daclizumab induction as an immunosuppressive regimen for renal transplant recipients from non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12962759 |
| Martin Garcia D et al. | Tacrolimus-Basiliximab versus Cyclosporine-Basiliximab in renal transplantation "de novo": acute rejection and complications. | 2003 | Transplant. Proc. | pmid:12962761 |
| Zhu Y et al. | Prolongation of canine renal allograft survival by combining tacrolimus with antimetabolic agents. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123011 |
| Naraghi RM et al. | Long-term follow-up of tacrolimus rescue therapy for renal allograft rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123013 |
| Miyazawa H et al. | Graft immunomodulation by donor irradiation and recipient-specific bone marrow cells in rat small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12072357 |
| Nishi K et al. | The expression of intestinal CYP3A4 in the piglet model. | 2004 | Transplant. Proc. | pmid:15050159 |
| Platz KP et al. | Immunosuppressive power and limitations of FK 506 for prevention and treatment of graft-vs-host disease after small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907933 |
| Coupes BM et al. | Tacrolimus monotherapy in renal transplantation: four-year data. | 2002 | Transplant. Proc. | pmid:12176506 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Sonnenday CJ et al. | Preemptive therapy with plasmapheresis/intravenous immunoglobulin allows successful live donor renal transplantation in patients with a positive cross-match. | 2002 | Transplant. Proc. | pmid:12176507 |
| Di Benedetto F et al. | University of Modena experience in HIV-positive patients undergoing liver transplantation. | 2011 | Transplant. Proc. | pmid:21620066 |
| Guy S et al. | Successful treatment of acute severe graft-versus-host-disease in a pancreas-after-kidney transplant recipient: case report. | 2014 | Transplant. Proc. | pmid:25179161 |
| Stratta RJ | Optimal immunosuppression in pancreas transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083263 |
| Arita C et al. | Effect of FK 506 (FR 900506) on collagen arthritis in rats: a preliminary report. | 1989 | Transplant. Proc. | pmid:2468206 |
| Tze WJ et al. | Effect of FK 506 on glucose metabolism and insulin secretion in normal rats. | 1991 | Transplant. Proc. | pmid:1721391 |
| Walgenbach KJ et al. | Immunocytes of composite tissue allografts express elevated levels of TGF beta mRNA and protein during chronic rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123418 |
| Hesse CJ et al. | The value of routine monitoring of mycophenolic acid plasma levels after clinical heart transplantation. | 2001 | Transplant. Proc. | pmid:11377487 |
| Platz KP et al. | Incidence and outcome of chronic rejection in CyA- and FK 506-treated patients. | 1996 | Transplant. Proc. | pmid:8962235 |
| Uchida K et al. | Usefulness of monitoring of AUC(0-4h) during the induction period of immunosuppressive therapy with tacrolimus after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176556 |
| Iwamoto H et al. | Early steroid withdrawal in adult kidney transplantation at a single center. | 2012 | Transplant. Proc. | pmid:22310609 |
| Mao PC et al. | Trends in the use of immunosuppressive agents by outpatients after renal transplantation at a medical center in southern Taiwan. | 2012 | Transplant. Proc. | pmid:22310611 |
| Vincenti F | Tacrolimus (FK 506) in kidney transplantation: five-year survival results of the U.S. multicenter, randomized, comparative trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267172 |
| Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
| Cooper MH et al. | Prolonged prevention of acute graft-versus-host disease after allogeneic bone marrow transplantation by donor pretreatment using FK 506. | 1991 | Transplant. Proc. | pmid:1721421 |
| Yoshida Y et al. | Effect of lipoprostaglandin E1 in concordant xenografts. | 1996 | Transplant. Proc. | pmid:8658716 |
| Ash MM and Jolly PS | A Case Report of the Resolution of Multiple Recalcitrant Verrucae in a Renal Transplant Recipient After a Mycophenolate Mofetil Dose Reduction. | Transplant. Proc. | pmid:28104140 | |
| Yoshimi F et al. | Canine total orthotopic small bowel transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721422 |
| Kawauchi M et al. | Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. | 1996 | Transplant. Proc. | pmid:8658719 |
| Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
| Nayeri A et al. | Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. | Transplant. Proc. | pmid:28104136 | |
| Sicilia-Castro D et al. | Reconstruction of a severe facial defect by allotransplantation in neurofibromatosis type 1: a case report. | 2011 | Transplant. Proc. | pmid:21911174 |
| Collier DS et al. | FK-506 in experimental renal allografts. | 1987 | Transplant. Proc. | pmid:2445063 |
| Kanatani T et al. | Donor leukocytes combine with immunosuppressive drug therapy to prolong limb allograft survival. | 2005 | Transplant. Proc. | pmid:15964421 |
| Lang M et al. | Combined liver-kidney transplantation: long-term follow-up in 18 patients. | 1998 | Transplant. Proc. | pmid:9723313 |
| Gnatta D et al. | Use of tacrolimus and the development of posttransplant diabetes mellitus: a Brazilian single-center, observational study. | 2010 | Transplant. Proc. | pmid:20304169 |
| Trotter JF | Sirolimus in liver transplantation. | 2003 | Transplant. Proc. | pmid:12742496 |
| Ventura E et al. | Calcineurin Inhibitor Determination in Whole Blood With the RXL Dimension Analyzer: A Useful Tool for Immunosuppressive Drug Monitoring. | 2009 | Transplant. Proc. | pmid:19328963 |
| Ojogho ON et al. | Mycophenolate mofetil without antibody induction in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12176641 |
| van der Laan LJ et al. | Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus. | 2010 | Transplant. Proc. | pmid:21168740 |
| Veroux M et al. | Caspofungin in the treatment of azole-refractory esophageal candidiasis in kidney transplant recipients. | 2006 | Transplant. Proc. | pmid:16757256 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Markus BH et al. | Daclizumab induction therapy in combination with tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267354 |
| Rao B et al. | Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. | 2016 | Transplant. Proc. | pmid:27109983 |
| Sainsbury TS et al. | Differential effects of FK 506 and cyclosporine on hair regrowth in the DEBR model of alopecia areata. | 1991 | Transplant. Proc. | pmid:1721453 |
| González MG et al. | Comparison of post-liver transplantation electrocardiographic alterations between cyclosporine- and tacrolimus-treated patients. | 1999 | Transplant. Proc. | pmid:10500652 |
| Wang M et al. | Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats. | 2007 Jan-Feb | Transplant. Proc. | pmid:17275526 |
| Carroll PB et al. | Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans. | 1991 | Transplant. Proc. | pmid:1703688 |
| Eghtesad B et al. | Use of tacrolimus as the primary immunosuppression after renal transplant in Native Americans and Hispanics. | 1998 | Transplant. Proc. | pmid:9636500 |
| Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |