Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
Nishikawa K et al. | Experimental studies of vascularized joint allografts in rats. | 1994 | Transplant. Proc. | pmid:7513482 |
Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
Fukuzawa M and Okada A | Analysis of mouse xenogeneic T-cell responses and the effect of FK 506 on these responses and on xeno-skin graft rejection. | 1994 | Transplant. Proc. | pmid:7513483 |
Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
Petuch BR et al. | Microbial transformation of immunosuppressive compounds. III. Glucosylation of immunomycin (FR 900520) and FK 506 by Bacillus subtilis ATCC 55060. | 1994 | J. Ind. Microbiol. | pmid:7513528 |
Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
Shaeffer MS et al. | Interaction between FK506 and erythromycin. | 1994 | Ann Pharmacother | pmid:7513563 |
Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
Lhöest GJ et al. | 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity. | 1994 | Clin. Chem. | pmid:7513627 |
Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
Tai J et al. | Effect of FK506 on rat Leydig cell function--in vivo and in vitro study. | 1994 | Metab. Clin. Exp. | pmid:7513780 |
Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
Cvetkovic M et al. | The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. | 1994 | Transplantation | pmid:7513912 |
Burkhalter EL et al. | Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. | 1994 | J. Hepatol. | pmid:7529272 |
Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
Hashimoto T et al. | Treatment with FK506 prevents rejection of rat colon allografts. | 1994 | Transplantation | pmid:7516586 |
Alamartine E et al. | In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7529381 |
Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
Shapiro R et al. | A prospective, randomized trial of FK-506 in renal transplantation--a comparison between double- and triple-drug therapy. | 1994 | Clin Transplant | pmid:7532475 |
Ludwig B et al. | Characterization of Mip proteins of Legionella pneumophila. | 1994 | FEMS Microbiol. Lett. | pmid:7516906 |
Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
Murthy JN et al. | Identification of a 14 kDa FK-506/rapamycin binding immunophilin from calf thymus. | 1994 | Clin. Biochem. | pmid:7532556 |
Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
Donnelly JG and Soldin SJ | Partial characterization of a 52 kDa CsA/FK506/rapamycin binding protein. | 1994 | Clin. Biochem. | pmid:7532557 |
High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
Yoshimura N et al. | The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro. | 1994 | Transplantation | pmid:7517078 |
Firdaous I et al. | Pediatric intravenous FK506--how much are we really infusing? | 1994 | Transplantation | pmid:7517079 |
Manez R et al. | Rejection and hepatitis in liver transplants. | 1994 | Transplantation | pmid:7517080 |
Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
Fujisaki S et al. | Effects of preformed antibodies induced by whole blood transfusion on small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518140 |
Spada M et al. | Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518141 |
Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
Laifer SA et al. | Pregnancy after cardiac transplantation. | 1994 | Am J Perinatol | pmid:7519426 |
Yoshikawa N et al. | Effect of FK-506 on xenografted human Graves' thyroid tissue is severe combined immunodeficient mice. | 1994 | Clin. Endocrinol. (Oxf) | pmid:7519528 |
Porayko MK et al. | Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. | 1994 | Mayo Clin. Proc. | pmid:7508536 |
Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
Martin MF | Nephrotoxic effects of immunosuppression. | 1994 | Mayo Clin. Proc. | pmid:7508537 |
Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
Connelly PR et al. | Enthalpy of hydrogen bond formation in a protein-ligand binding reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7510408 |
Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
Shiraga T et al. | Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. | 1994 | Biochem. Pharmacol. | pmid:7510480 |
Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
Kuwano K and Arai S | The inhibitory effect of FK506 on cytotoxic T-lymphocyte killing. | 1994 | Immunol. Lett. | pmid:7536706 |
Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
Okamoto S et al. | The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. | 1994 | J. Biol. Chem. | pmid:7510691 |
Metcalfe S et al. | FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. | 1994 | Cell. Immunol. | pmid:7522130 |
Nichols RA et al. | Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. | 1994 | J. Biol. Chem. | pmid:7522234 |
Nakagawa H et al. | Tacrolimus ointment for atopic dermatitis. | 1994 | Lancet | pmid:7522297 |
Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
Ueda K et al. | Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. | 1994 | Jpn. J. Physiol. | pmid:7538609 |
FDA approved new drug bulletin: aprotinin injection (trasylol), tacrolimus (prograf). | 1994 | RN | pmid:7524131 | |
Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
Holländer GA et al. | Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | 1994 | Transplantation | pmid:7526495 |
Ishioka M et al. | FK506 treatment of noninfectious uveitis. | 1994 | Am. J. Ophthalmol. | pmid:7526689 |
Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
Mayrleitner M et al. | The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor. | 1994 | Cell Calcium | pmid:7511990 |
Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
Hamajima E et al. | Effects of FK506, an immunosuppressive agent, on genesis of water-immersion stress-induced gastric lesions in rats. | 1994 | Dig. Dis. Sci. | pmid:7512015 |
Akamine S et al. | Monitoring canine lung allograft rejection using Ia antigen expression by bronchoalveolar lymphocytes. | 1994 | Surg. Today | pmid:7526914 |
Tsuchida M et al. | The effects of FK506 and dexamethasone on rat thymocyte differentiation. | 1994 | Ther Immunol | pmid:7584489 |
Matsumoto T et al. | Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. | 1994 | Dig. Dis. Sci. | pmid:7512017 |
Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
Griffith BP et al. | A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. | 1994 | Transplantation | pmid:7512292 |
Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
Devlin J et al. | FK 506 primary immunosuppression following emergency liver transplantation for fulminant hepatic failure. European FK 506 Study Liver Group. | 1994 | Transpl. Int. | pmid:11271328 |
Otto G et al. | Corticosteroids and concomitant medication in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271338 |
Wong P et al. | FK 506 rescue therapy for intractable liver allograft rejection. | 1994 | Transpl. Int. | pmid:11271339 |
Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |
Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |