Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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The discovery of FK-506 and U.S. development. | 1991 | Nephrol News Issues | pmid:1720512 | |
Zheng B et al. | Effects of the new and highly active immunosuppressant, rapamycin, on lymphoid tissues and cells in vivo. | 1991 | Transplant. Proc. | pmid:1703717 |
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Yabuuchi H et al. | Prominent prolongation of islet xenograft survival in combination therapy with FK 506 and 15-deoxyspergualin. | 1991 | Transplant. Proc. | pmid:1703718 |
First International Congress on FK 506. August 21-24, 1991, Pittsburgh, PA. | 1991 | Transplant. Proc. | pmid:1721253 | |
Farghali H et al. | A biochemical and 31P-NMR investigation of the effect of FK 506 and cyclosporine pretreatment on immobilized hepatocytes perifused with ethanol. | 1991 | Transplant. Proc. | pmid:1721284 |
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Matsuura T et al. | Beneficial immunosuppressive effect of combined use of FK 506 and cyclosporine assessed by proliferative responses of cloned human T cells. | 1991 | Transplant. Proc. | pmid:1721316 |
Jiang H et al. | Combined immunosuppressive effect of FK 506 and other immunosuppressive agents on PHA- and CD3-stimulated human lymphocyte proliferation in vitro. | 1991 | Transplant. Proc. | pmid:1721317 |
Jain AB et al. | Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant. | 1991 | Transplant. Proc. | pmid:1721347 |
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Tze WJ et al. | Long-term survival of islet allografts in diabetic rats treated with FK 506. | 1991 | Transplant. Proc. | pmid:1721411 |
Wang X et al. | Intraportal FK 506 improves intrahepatic islet allograft survival. | 1991 | Transplant. Proc. | pmid:1721412 |
Hasegawa S et al. | FK 506 and cyclosporine: effects and side effects in canine lung transplantation. | 1991 | Transplant. Proc. | pmid:1721443 |
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Metcalfe S and Milner J | Evidence that FK506 and rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and PP2A. | 1991 | Transplantation | pmid:1710844 |
Chang JY et al. | FK506 and rapamycin: novel pharmacological probes of the immune response. | 1991 | Trends Pharmacol. Sci. | pmid:1710854 |
Weaver JL et al. | Comparison of the in vitro and biophysical effects of cyclosporine A, FK-506, and mycophenolic acid on human peripheral blood lymphocytes. | 1991 | Immunopharmacol Immunotoxicol | pmid:1723084 |
DiLella AG and Craig RJ | Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. | 1991 | Biochemistry | pmid:1716149 |
Burres NS et al. | Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. III. Immunosuppressive activities of dunaimycins. | 1991 | J. Antibiot. | pmid:1723403 |
McKeon F | When worlds collide: immunosuppressants meet protein phosphatases. | 1991 | Cell | pmid:1716181 |
Christians U et al. | Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. | 1991 | Clin. Biochem. | pmid:1714802 |
Turka LA and Thompson CB | Structure-function relationship of immunosuppressive drugs: a cautionary tale. | 1991 | Hepatology | pmid:1714876 |
Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
Thomson AW et al. | FK 506, cardiac transplantation, and graft-vessel disease. | 1992 | Lancet | pmid:1370563 |
First MR | Transplantation in the nineties. | 1992 | Transplantation | pmid:1370734 |
Naito M et al. | Reversal of multidrug resistance by an immunosuppressive agent FK-506. | 1992 | Cancer Chemother. Pharmacol. | pmid:1370765 |
Yem AW et al. | The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. | 1992 | J. Biol. Chem. | pmid:1371107 |
Park ST et al. | PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism. | 1992 | J. Biol. Chem. | pmid:1371117 |
Bishop DK and Li W | Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo. | 1992 | J. Immunol. | pmid:1371128 |
Hatfield SM and Roehm NW | Cyclosporine and FK506 inhibition of murine mast cell cytokine production. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1371158 |
Takaya S et al. | The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. | 1992 | Transplantation | pmid:1371195 |
Francavilla A et al. | Inhibition of liver, kidney, and intestine regeneration by rapamycin. | 1992 | Transplantation | pmid:1371198 |
Kim YI et al. | Stimulation of liver regeneration by pretreatment with azathioprine as well as cyclosporine and FK506. | 1992 | Transplantation | pmid:1373539 |
Carobbi A et al. | Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. | 1992 | Transplant. Proc. | pmid:1373543 |
Ueno M et al. | Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1373546 |
Matsuzaki T et al. | Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats. | 1992 | Transplant. Proc. | pmid:1373547 |
Vincent SH et al. | In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. | 1992 | Arch. Biochem. Biophys. | pmid:1373595 |
Liu J et al. | Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. | 1992 | Biochemistry | pmid:1373650 |
Adachi A et al. | Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: change of T cell subsets. | 1992 | Intern. Med. | pmid:1373661 |
Fruman DA et al. | Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1373887 |
Lake JR et al. | Maintenance immunosuppression after liver transplantation. | 1992 | Semin. Liver Dis. | pmid:1373916 |
Taormina D et al. | Stability and sorption of FK 506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride, and polyolefin containers. | 1992 | Am J Hosp Pharm | pmid:1373936 |
Jegasothy BV et al. | Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. | 1992 | Arch Dermatol | pmid:1376102 |
Wiederrecht G et al. | Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1376117 |
Bernstein L and Daviss SR | Organic anxiety disorder with symptoms of akathisia in a patient treated with the immunosuppressant FK506. | 1992 | Gen Hosp Psychiatry | pmid:1376291 |
Hatfield SM et al. | Rapamycin and FK506 differentially inhibit mast cell cytokine production and cytokine-induced proliferation and act as reciprocal antagonists. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1376361 |
Ericzon BG et al. | The effect of FK506 treatment on pancreaticoduodenal allotransplantation in the primate. | 1992 | Transplantation | pmid:1376501 |
Tze WJ et al. | FK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats. | 1992 | Transplant. Proc. | pmid:1376509 |
Yasunami Y et al. | Induction of donor-specific unresponsiveness in rat islet allografts by FK 506. | 1992 | Transplant. Proc. | pmid:1376510 |
Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
Hisanaga M et al. | Successful combination therapy with FK 506 and 15-deoxyspergualin in pancreatic islet xenografting. | 1992 | Transplant. Proc. | pmid:1376513 |
Ogasa N et al. | Successful transplantation of newborn rat intestine as a free graft. | 1992 | Transplant. Proc. | pmid:1376514 |
Hirano Y et al. | The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. | 1992 | Transplantation | pmid:1279850 |
Takaya S et al. | Liver transplantation in positive cytotoxic crossmatch cases using FK506, high-dose steroids, and prostaglandin E1. | 1992 | Transplantation | pmid:1279851 |
Partaledis JA et al. | Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. | 1992 | Yeast | pmid:1279908 |
Ozawa K et al. | An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. | 1992 | Ann. Surg. | pmid:1280074 |
Akutsu I et al. | [Inhibitory effects of cyclosporin A and FK-506 on eosinophil chemotactic factor activity in culture supernatants of mononuclear cells from asthmatics]. | 1992 | Arerugi | pmid:1280086 |
Bergstrand H and Lundquist B | Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. | 1992 | Allergy | pmid:1280915 |
Barry JM | Immunosuppressive drugs in renal transplantation. A review of the regimens. | 1992 | Drugs | pmid:1281071 |
Stiff DD et al. | Metabolism of FK 506 in differentially induced rat liver microsomes. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1281332 |
Foor F et al. | Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. | 1992 | Nature | pmid:1281518 |
Goldfeld AE et al. | Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1281550 |
Morikawa K et al. | The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes. | 1992 | Transplantation | pmid:1281561 |
Tocci MJ and Sigal NH | Recent advances in the mechanism of action of cyclosporine and FK506. | 1992 | Curr. Opin. Nephrol. Hypertens. | pmid:1285380 |
Bavandi A et al. | Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506. | 1992 | Exp. Dermatol. | pmid:1285411 |
High KP and Handschumacher RE | Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? | 1992 | Infect Agents Dis | pmid:1285413 |
Akutsu I et al. | [Inhibitory effect of inhaled FK-506 on increased bronchial responsiveness and eosinophil infiltration in the airway mucosa]. | 1992 | Arerugi | pmid:1377905 |
Takaori K et al. | A comparative study on immunosuppressive effects of cyclosporin A and FK 506 on peripheral blood lymphocytes in dogs. | 1992 | Biotherapy | pmid:1377926 |
Murthy JN et al. | Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood. | 1992 | Clin. Chem. | pmid:1377995 |
Takai K et al. | Effects of FK506 on rat thymic epithelial cells; immunohistochemical study. | 1992 | Thymus | pmid:1378235 |
Dutz JP et al. | Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes. | 1992 | Int. Immunol. | pmid:1378297 |
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Mouzaki A et al. | Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes. | 1992 | Cytokine | pmid:1378764 |
Ramamoorthy S et al. | Selective impairment of taurine transport by cyclosporin A in a human placental cell line. | 1992 | Pediatr. Res. | pmid:1378960 |
Takada K et al. | Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A. | 1992 | Biopharm Drug Dispos | pmid:1379839 |
Kahan BD | Cyclosporin A, FK506, rapamycin: the use of a quantitative analytic tool to discriminate immunosuppressive drug interactions. | 1992 | J. Am. Soc. Nephrol. | pmid:1379841 |
Lauerma AI et al. | Inhibition of contact allergy reactions by topical FK506. | 1992 | Lancet | pmid:1380111 |
Steiner JP et al. | High brain densities of the immunophilin FKBP colocalized with calcineurin. | 1992 | Nature | pmid:1380130 |
Aperia A et al. | Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380157 |
Nielsen JB et al. | Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380159 |
Calvo V et al. | Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380162 |
Price DJ et al. | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. | 1992 | Science | pmid:1380182 |
Granelli-Piperno A | SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506. | 1992 | J. Autoimmun. | pmid:1380242 |
Fruman DA et al. | Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. | 1992 | Eur. J. Immunol. | pmid:1382988 |
Mittrücker HW and Fleischer B | Functional localization of an exocytosis-triggering G-protein in human cytotoxic T lymphocytes. | 1992 | Immunology | pmid:1383135 |
Yasutomi D et al. | Inhibition of programmed cell death by cyclosporin A; preferential blocking of cell death induced by signals via TCR/CD3 complex and its mode of action. | 1992 | Immunology | pmid:1383138 |
Ruff VA et al. | Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody. | 1992 | J. Biol. Chem. | pmid:1383222 |
Wiederrecht G et al. | Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. | 1992 | J. Biol. Chem. | pmid:1383226 |
Morris RE | Immunopharmacology of new xenobiotic immunosuppressive molecules. | 1992 | Semin. Nephrol. | pmid:1384096 |
Hendey B et al. | Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. | 1992 | Science | pmid:1384129 |
Roberti I et al. | Evidence that the systematic analysis of bile cytology permits monitoring of hepatic allograft rejection. | 1992 | Transplantation | pmid:1384182 |
Langrehr JM et al. | Evidence that indefinite survival of small bowel allografts achieved by a brief course of cyclosporine or FK506 is not due to systemic hyporesponsiveness. | 1992 | Transplantation | pmid:1384185 |
McCarthy SA et al. | The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. | 1992 | Transplantation | pmid:1384186 |
Dhar DK et al. | The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver. | 1992 | Transplantation | pmid:1384188 |