tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Tzakis AG et al. | Two-year experience with FK 506 in pediatric patients. | 1993 | Transplant. Proc. | pmid:7679822 |
| Ochiai T et al. | Effective and safe use of FK 506: combination treatment with rapamycin or RS-61443 in experimental organ transplantation. | 1991 | Transplant. Proc. | pmid:1721255 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Demetris AJ et al. | Pathologic observations in human allograft recipients treated with FK 506. | 1990 | Transplant. Proc. | pmid:1689891 |
| Undre NA et al. | Pharmacokinetics of FK 506 and mycophenolic acid after the administration of a FK 506-based regimen in combination with mycophenolate mofetil in kidney transplantation. | 1998 | Transplant. Proc. | pmid:9636527 |
| Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
| Sánchez-Fructuoso AI et al. | The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715905 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Gruessner RW et al. | Mycophenolate mofetil and tacrolimus for induction and maintenance therapy after pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532156 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
| Ichikawa Y et al. | Acute rejection and the therapeutic choice of drug. | 2000 | Transplant. Proc. | pmid:11119923 |
| Morales JM et al. | Ten years of treatment with tacrolimus is related to an excellent renal function, allowing monotherapy in a large proportion of cases: unicentric results of the tacrolimus versus cyclosporine A European Multicentric Study in kidney transplant patients. | 2005 | Transplant. Proc. | pmid:16386523 |
| Lopes CT et al. | Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice. | 2008 | Transplant. Proc. | pmid:18455036 |
| Charpentier B | An induction versus no-induction protocol in anticalcineurin-based immunosuppression using very low-dose steroids. | 2001 | Transplant. Proc. | pmid:11406262 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Francavilla A et al. | The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo. | 1991 | Transplant. Proc. | pmid:1721287 |
| Carobbi A et al. | Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. | 1992 | Transplant. Proc. | pmid:1373543 |
| Blanc P et al. | Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture. | 1991 | Transplant. Proc. | pmid:1721288 |
| Ueno M et al. | Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1373546 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Ghobrial RM et al. | Retransplantation for recurrent hepatitis C following tacrolimus or cyclosporine immunosuppression. | 1998 | Transplant. Proc. | pmid:9636597 |
| Barreto P et al. | Conversion From Twice-Daily to Once-Daily Tacrolimus in Stable Kidney Graft Recipients. | 2016 | Transplant. Proc. | pmid:27742278 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Resch B et al. | FK 506 and successful pregnancy in a patient after renal transplantation. | 1998 | Transplant. Proc. | pmid:9474990 |
| Basu A et al. | Reversal of acute cellular rejection after renal transplantation with Campath-1H. | 2005 | Transplant. Proc. | pmid:15848576 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK 506 with FK 506 (tacrolimus) with and without anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578277 |
| Töz H et al. | Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013324 |
| Bachetoni A et al. | Preliminary evaluation of the new TACR flex method versus MEIA method in the therapeutic monitoring of tacrolimus in organ transplantation. | 2007 Jul-Aug | Transplant. Proc. | pmid:17692678 |
| Pereira M et al. | Hyperacute Rejection in a Kidney Transplant With Negative Crossmatch: A Case Report. | 2016 | Transplant. Proc. | pmid:27742303 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Loss M et al. | Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. | 1995 | Transplant. Proc. | pmid:7533365 |
| Woo J et al. | Effects of FK 506, mycophenolic acid, and bredinin on OKT-3-, PMA-, and alloantigen-induced activation molecule expression on cultured CD4+ and CD8+ human lymphocytes. | 1991 | Transplant. Proc. | pmid:1721319 |
| Jin KB et al. | Effects of tacrolimus on antioxidant status and oxidative stress in glioma cells. | 2008 | Transplant. Proc. | pmid:18929850 |
| Yoshimura N et al. | Safety analysis after tacrolimus immunosuppression in renal transplant recipients in Japan: 5-year results in >1500 patients. | 2005 | Transplant. Proc. | pmid:15919458 |
| Sugitani A et al. | Long-term results of tacrolimus therapy for renal transplantation in patients with diabetic nephropathy in Japan. | 2005 | Transplant. Proc. | pmid:15919459 |
| Tzakis AG et al. | Campath-1H in intestinal and multivisceral transplantation: preliminary data. | 2002 | Transplant. Proc. | pmid:12034248 |
| Allers C et al. | Tacrolimus, daclizumab, sirolimus, and budesonide after small bowel transplantation in order to reduce nephrotoxicity. | 2002 | Transplant. Proc. | pmid:12034251 |
| Böttiger Y et al. | Effect of bile flow on the absorption of tacrolimus in liver allograft transplantation. | 2002 | Transplant. Proc. | pmid:12176476 |
| Hodge EE et al. | Use of mycophenolate mofetil in liver transplant recipients experiencing renal dysfunction on cyclosporine or tacrolimus-randomized, prospective, multicenter study results. | 2002 | Transplant. Proc. | pmid:12176477 |
| Shirakata Y et al. | The minimum graft size for successful orthotopic partial liver transplantation in the canine model. | 1995 | Transplant. Proc. | pmid:7533422 |
| Yuan-Xin L et al. | Preliminary experience with alemtuzumab induction therapy combined with maintenance low-dose tacrolimus monotherapy in small-bowel transplantation in China. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172275 |
| Alessiani M et al. | CMV infection in liver transplantation under cyclosporine or FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721351 |
| Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
| Ahlmén J et al. | Positive effects of tacrolimus in a case of CIDP. | 1998 | Transplant. Proc. | pmid:9865344 |
| Sánchez-Pérez B et al. | Influence of immunosuppression and effect of hepatitis C virus on new onset of diabetes mellitus in liver transplant recipients. | 2008 | Transplant. Proc. | pmid:19010171 |
| Gaber LW et al. | Renal histology with varying FK506 blood levels. | 1997 Feb-Mar | Transplant. Proc. | pmid:9122955 |
| Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
| Chamienia A et al. | One-year observation of kidney allograft recipients converted from cyclosporine microemulsion to tacrolimus. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504670 |
| Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Herrero JI et al. | Conversion from calcineurin inhibitors to mycophenolate mofetil in liver transplant recipients with diabetes mellitus. | 2003 | Transplant. Proc. | pmid:12962832 |
| Youseff N and Small S | A retrospective analysis of a sirolimus/prograf regimen for the prevention of acute rejection in recipients of primary mismatched renal allografts. | 2002 | Transplant. Proc. | pmid:12176522 |
| Moutabarrik A et al. | In vitro FK 506 kidney tubular cell toxicity. | 1991 | Transplant. Proc. | pmid:1721383 |
| McCauley J et al. | Changes in renal function after liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721385 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Kandaswamy R et al. | Vascular graft thrombosis after pancreas transplantation: comparison of the FK 506 and cyclosporine eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083254 |
| Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
| Tashiro H et al. | Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123287 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Balbontin FG et al. | Tacrolimus monitoring by simplified sparse sampling under the concentration time curve. | 2003 | Transplant. Proc. | pmid:14611982 |
| Bhaloo S and Prasad GV | Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. | 2003 | Transplant. Proc. | pmid:14611983 |
| Saber LT et al. | Posttransplantation conversion to sirolimus-based immunosuppression: a single center experience. | 2007 | Transplant. Proc. | pmid:18089330 |
| Migita K and Eguchi K | FK 506-mediated T-cell apoptosis induction. | 2001 | Transplant. Proc. | pmid:11377532 |
| Omoto K et al. | Adverse events in renal transplantation under tacrolimus/mycophnolate mofetil immunosuppression: a single-center experience. | 2002 | Transplant. Proc. | pmid:12176591 |
| Erickson LM et al. | Gene expression profiles of rat heart allografts with immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266960 |
| Yamashita T et al. | Prolongation of pancreaticoduodenal allograft survival in rats by treatment with FK 506. | 1991 | Transplant. Proc. | pmid:1721414 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Chung YW et al. | Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum-derived Calcium-dependent Caspases-3,-12 in Jurkat Cells. | 2018 | Transplant. Proc. | pmid:29731088 |
| Dopazo C et al. | Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient. | 2009 | Transplant. Proc. | pmid:19376416 |
| Peeters P et al. | Economic evaluation of Neoral versus Sandimmune maintenance therapy for de novo liver transplant patients: results from an International Randomized Controlled Trial. Milton Study Group. | 1998 | Transplant. Proc. | pmid:9723301 |
| Eun SC et al. | Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506. | 2013 | Transplant. Proc. | pmid:23769045 |
| Li Y et al. | Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus. | 2013 | Transplant. Proc. | pmid:23769050 |
| Liu W et al. | Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft. | 2012 | Transplant. Proc. | pmid:22664023 |
| Ishida S et al. | Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104127 | |
| Kandaswamy R et al. | Can we maintain immunosuppression avoiding nephrotoxic agents in pancreas transplantation? | 2008 | Transplant. Proc. | pmid:18374118 |
| Kanodia KV et al. | Study of acute antibody-mediated rejection in renal allograft biopsies. | 2008 | Transplant. Proc. | pmid:18555123 |
| Jain A et al. | Prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil: complete report on 350 primary adult liver transplantations. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267319 |
| Propper DJ et al. | Evidence that FK 506 may abrogate suppressor cell activity induced by blood transfusion. | 1991 | Transplant. Proc. | pmid:1721446 |
| Fabrega AJ et al. | FK 506 enhances the beneficial effects of donor-specific blood transfusion on allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1721447 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| GarcÃa Meseguer C et al. | The effect of different immunosuppression on the outcome of pediatric renal transplants. | 1999 | Transplant. Proc. | pmid:10500577 |
| Torregrosa JV et al. | Combined liver-kidney transplantation: our experience. | 1999 | Transplant. Proc. | pmid:10500591 |
| Morena M et al. | Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients. | 2000 | Transplant. Proc. | pmid:11134805 |
| Fischer S et al. | Initial experience of combined immunosuppressive induction therapy with polyclonal antithymocyte antibody, FK 506 (tacrolimus), and prednisolone in clinical liver transplantation. | 2000 | Transplant. Proc. | pmid:11134815 |
| Jensik SC | Tacrolimus (FK 506) in kidney transplantation: three-year survival results of the US multicenter, randomized, comparative trial. FK 506 Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636494 |
| Teng D et al. | Comparison of rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy. | 2006 | Transplant. Proc. | pmid:16980034 |
| Matsumoto S et al. | ET-Kyoto ductal injection and density-adjusted purification combined with potent anti-inflammatory strategy facilitated single-donor islet transplantation: case reports. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692433 |
| Bresci S et al. | Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692461 |
| Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
| Finni PE et al. | Is hepatitis C a risk factor to posttransplant diabetes mellitus after renal transplantation in patients using tacrolimus? | 2004 | Transplant. Proc. | pmid:15194303 |
| White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
| Sens YA et al. | Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus. | 2004 | Transplant. Proc. | pmid:15194304 |
| Nakamura A et al. | Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. | 2014 | Transplant. Proc. | pmid:24656020 |