tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rivelli RF et al. | Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant. | 2015 | Nephrology (Carlton) | pmid:25404086 |
| Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
| Cury Martins J et al. | Topical tacrolimus for atopic dermatitis. | 2015 | Cochrane Database Syst Rev | pmid:26132597 |
| Prinz V et al. | MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection. | 2015 | J. Cereb. Blood Flow Metab. | pmid:26126863 |
| Cantaluppi V et al. | Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. | 2015 | PLoS ONE | pmid:26125566 |
| Fukahori H et al. | Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation. | 2015 | Int. Immunopharmacol. | pmid:26122135 |
| Eidens M et al. | Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping. | 2015 | Clin. Lab. | pmid:25975003 |
| Safa K et al. | Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report. | 2015 | Clin. Nephrol. | pmid:24495904 |
| Gordon P and Gooptu B | Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders. | 2015 | Rheumatology (Oxford) | pmid:25342374 |
| Shi WL et al. | Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis. | 2015 | PLoS ONE | pmid:26039043 |
| Wozniak LJ et al. | Donor-specific HLA Antibodies Are Associated With Late Allograft Dysfunction After Pediatric Liver Transplantation. | 2015 | Transplantation | pmid:26038872 |
| Staatz CE and Tett SE | Clinical Pharmacokinetics of Once-Daily Tacrolimus in Solid-Organ Transplant Patients. | 2015 | Clin Pharmacokinet | pmid:26038096 |
| Migita K et al. | Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus. | 2015 | Arthritis Res. Ther. | pmid:26036592 |
| Argudo A et al. | Liver Transplant Patient Carriers of Polymorphism Cyp3a5*1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation. | 2015 | Transplant. Proc. | pmid:26518936 |
| van Boekel GA et al. | Limited sampling strategy for prolonged-release tacrolimus in renal transplant patients by use of the dried blood spot technique. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25980838 |
| de Jonge H et al. | The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients. | 2015 | Pharmacogenomics J. | pmid:25287072 |
| Jin S et al. | Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. | 2015 | Gastroenterology | pmid:25980752 |
| Wiseman AC | Induction Therapy in Renal Transplantation: Why? What Agent? What Dose? We May Never Know. | 2015 | Clin J Am Soc Nephrol | pmid:25979977 |
| Ratanatharathorn V et al. | Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. | 2015 | Bone Marrow Transplant. | pmid:25285804 |
| Tanriover B et al. | Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance. | 2015 | Clin J Am Soc Nephrol | pmid:25979971 |
| Kang YZ et al. | Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. | 2015 | World J. Gastroenterol. | pmid:25717264 |
| Hategan A and Bourgeois JA | Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system. | 2015 | J Neuropsychiatry Clin Neurosci | pmid:25923858 |
| Blasco-Morente G et al. | Long-Standing Presternal Plaque. | 2015 | Actas Dermosifiliogr | pmid:25917959 |
| Ferraresso M et al. | Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. | 2015 | Pharmacogenomics | pmid:25916520 |
| Nagaya M et al. | A new system to evaluate the influence of immunosuppressive drugs on pancreatic islets using epigenetic analysis in a 3-dimensional culture. | 2015 | Pancreas | pmid:25906448 |
| Wang M et al. | Enteric polymer based on pH-responsive aliphatic polycarbonate functionalized with vitamin E to facilitate oral delivery of tacrolimus. | 2015 | Biomacromolecules | pmid:25714622 |
| Peña C et al. | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. | 2015 | Rev Med Chil | pmid:25860370 |
| Selk A | A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. | 2015 | J Low Genit Tract Dis | pmid:25853633 |
| Hurst AL et al. | Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients. | 2015 | Pediatr Transplant | pmid:25850753 |
| Wang L et al. | Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients. | 2015 | Genet. Mol. Res. | pmid:26634478 |
| Romanowski M et al. | Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Pharmacogenomics | pmid:26282401 |
| Solomon SR et al. | Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors. | 2015 | Biol. Blood Marrow Transplant. | pmid:25797174 |
| Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
| Suzuki N et al. | In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. | 2015 | PLoS ONE | pmid:25790231 |
| Abe Y et al. | Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus. | 2015 | Intern. Med. | pmid:26568012 |
| Heneberg P et al. | Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro. | 2015 | PLoS ONE | pmid:26562153 |
| Yang CJ et al. | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 | Biochemistry | pmid:26561008 |
| Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
| Dias PH et al. | Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion. | 2015 | Acta Cir Bras | pmid:25714692 |
| San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
| Jóźwiak-Bębenista M et al. | The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. | 2015 | Pharmacol Rep | pmid:25712659 |
| Kadlub N et al. | The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism. | 2015 | J. Bone Miner. Res. | pmid:25491283 |
| Katayama K et al. | Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. | 2015 | Mod Rheumatol | pmid:24983407 |
| Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
| Dumortier T et al. | Estimating the contribution of everolimus to immunosuppressive efficacy when combined with tacrolimus in liver transplantation: a model-based approach. | 2015 | Clin. Pharmacol. Ther. | pmid:25669933 |
| Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
| Tanaka M et al. | Corticosteroid and tacrolimus treatment in neuromyelitis optica related disorders. | 2015 | Mult. Scler. | pmid:25662352 |
| Wu SC et al. | Identification of Circulating miRNAs in a Mouse Model of Nerve Allograft Transplantation under FK506 Immunosuppression by Illumina Small RNA Deep Sequencing. | 2015 | Dis. Markers | pmid:26435568 |
| Okechuku G et al. | Anorexia nervosa in a pediatric renal transplant recipient and its reversal with cyclosporine. | 2015 | Pediatr Transplant | pmid:25661468 |
| Xie X et al. | mTOR inhibitor versus mycophenolic acid as the primary immunosuppression regime combined with calcineurin inhibitor for kidney transplant recipients: a meta-analysis. | 2015 | BMC Nephrol | pmid:26126806 |
| Kume K et al. | Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25614218 |
| Garnock-Jones KP | Tacrolimus prolonged release (Envarsus®): a review of its use in kidney and liver transplant recipients. | 2015 | Drugs | pmid:25613762 |
| Oguni H and Hayashi M | [Topics for authorization of new intravenous antiepileptic drugs and tacrolimus for autoimmune epilepsy]. | 2015 | No To Hattatsu | pmid:26349372 |
| Dave CN et al. | Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. | 2015 | Int Urol Nephrol | pmid:26347076 |
| Wu J et al. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | 2015 | J. Clin. Invest. | pmid:26436650 |
| Overk CR et al. | Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. | 2015 | Neuroscience | pmid:26341908 |
| Bhadauria D et al. | Cryptosporidium infection after renal transplantation in an endemic area. | 2015 | Transpl Infect Dis | pmid:25620388 |
| Schnitzbauer AA et al. | Delayed bottom-up and amended simple method of dosing with once-daily tacrolimus application to achieve stable trough levels in liver transplantation. | 2015 | Ann. Transplant. | pmid:25553853 |
| Burke MT et al. | Genetics and nonmelanoma skin cancer in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:25616102 |
| Schnitzler F et al. | Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort. | 2015 | PLoS ONE | pmid:26288187 |
| Aruch DB and Renteria A | Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant. | 2015 | Blood | pmid:26287041 |
| Chakraborty S et al. | Prediction of in vivo drug performance using in vitro dissolution coupled with STELLA: a study with selected drug products. | 2015 | Drug Dev Ind Pharm | pmid:25494535 |
| Hauch A et al. | Generics: are all immunosuppression agents created equally? | 2015 | Surgery | pmid:26206317 |
| Gong N et al. | Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. | 2015 | Cell. Immunol. | pmid:26205091 |
| Chamani G et al. | Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta-analysis. | 2015 | Int. J. Dermatol. | pmid:26204904 |
| Türkoğlu O et al. | Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? | 2015 | Arch. Oral Biol. | pmid:25555253 |
| Rivinius R et al. | Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy. | 2015 | Drug Des Devel Ther | pmid:25552900 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Filler G and Smith N | The need for tacrolimus assay standardization. | 2014 | Ther Drug Monit | pmid:25390282 |
| Sachewsky N et al. | Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway. | 2014 | Dis Model Mech | pmid:25056698 |
| Erdinest N and Solomon A | Topical immunomodulators in the management of allergic eye diseases. | 2014 | Curr Opin Allergy Clin Immunol | pmid:25054831 |
| Yin Z et al. | Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin. | 2014 | Drug Des Devel Ther | pmid:25336924 |
| Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
| Balato A et al. | Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes. | 2014 | Mycoses | pmid:24512536 |
| Qin XL et al. | In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. | 2014 | Drug Metab. Dispos. | pmid:24195812 |
| Silva-Cunha A et al. | Evaluation of the pharmacokinetics and ocular tolerance of a microemulsion containing tacrolimus. | 2014 | J Ocul Pharmacol Ther | pmid:24199740 |
| Bruel A et al. | Early protocol biopsies in pediatric renal transplantation: interest for the adaptation of immunosuppression. | 2014 | Pediatr Transplant | pmid:24341571 |
| Teraki Y | [Atopic dermatitis in pregnancy]. | 2014 | Arerugi | pmid:24714179 |
| Casey MJ et al. | Prolonged immunosuppression preserves nonsensitization status after kidney transplant failure. | 2014 | Transplantation | pmid:24717218 |
| Jalil MH et al. | Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. | 2014 | Br J Clin Pharmacol | pmid:23738951 |
| Deng Z et al. | [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25224233 |
| Peloso LJ et al. | The serum concentration of tacrolimus after ingesting omeprazole: a pilot study. | 2014 | Transplantation | pmid:25221905 |
| Tanaka H et al. | Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis. | 2014 | Lupus | pmid:24651669 |
| Shah NP et al. | Treatment of a Crohn's disease-related cutaneous facial lesion with topical tacrolimus. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25151593 |
| Pichler R et al. | De novo renal cell carcinoma in a kidney allograft with focus on contrast-enhanced ultrasound. | 2014 | Urol. Int. | pmid:25115614 |
| Yan YH et al. | Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. | 2014 | Neurosci. Lett. | pmid:24607931 |
| Bogan JS | Endocytic cycling of glucose transporters and insulin resistance due to immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25279573 |
| Demmers MW et al. | Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus. | 2014 | Transplantation | pmid:24157471 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Hostettler KE et al. | Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. | 2014 | Eur. Respir. J. | pmid:23645405 |
| Kuramitsu S et al. | [Case report of introducing MMF and steroids as an immunosuppressive therapy after living-donor liver transplantation for a patient with the diabetic nephropathy]. | 2014 | Fukuoka Igaku Zasshi | pmid:25000660 |
| Wohlfahrtova M and Viklicky O | Recent trials in immunosuppression and their consequences for current therapy. | 2014 | Curr Opin Organ Transplant | pmid:24905020 |
| Reitamo S and Remitz A | An update on current pharmacotherapy options in atopic dermatitis. | 2014 | Expert Opin Pharmacother | pmid:24811606 |
| Stifft F et al. | Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24809233 |
| Yamanaka M et al. | Development and evaluation of a tacrolimus cream formulation using a binary solvent system. | 2014 | Int J Pharm | pmid:24456671 |
| Levy G et al. | REFINE: a randomized trial comparing cyclosporine A and tacrolimus on fibrosis after liver transplantation for hepatitis C. | 2014 | Am. J. Transplant. | pmid:24456049 |
| Miller EC et al. | Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. | 2014 | Eur. J. Neurosci. | pmid:24713000 |