Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Stienstra NA et al. | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | 2016 | Ther Drug Monit | pmid:27805928 |
Quist SR et al. | Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis. | 2016 | Acta Derm. Venereol. | pmid:26911315 |
Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
Wang X et al. | Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. | 2016 | Mol Nutr Food Res | pmid:27061233 |
Tang J et al. | ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. | 2016 | Cell. Physiol. Biochem. | pmid:27771715 |
Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
Sayar E et al. | The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor. | 2016 | J. Clin. Gastroenterol. | pmid:26828243 |
Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
Cortes X et al. | Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine. | 2016 | Int J Clin Pharmacol Ther | pmid:26754306 |
Vanhove T et al. | Clinical determinants of calcineurin inhibitor disposition: a mechanistic review. | 2016 | Drug Metab. Rev. | pmid:26912097 |
Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
Bessa AB et al. | Prospective Randomized Trial Investigating the Influence of Pharmaceutical Care on the Intra-Individual Variability of Tacrolimus Concentrations Early After Kidney Transplant. | 2016 | Ther Drug Monit | pmid:27414973 |
Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
Pastor-Clerigues A et al. | Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test. | 2016 | Curr. Eye Res. | pmid:26554729 |
Mittal A et al. | Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis. | 2016 | J Cutan Med Surg | pmid:26553734 |
Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
Dunyak BM and Gestwicki JE | Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. | 2016 | J. Med. Chem. | pmid:27409354 |
Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
Baek CH et al. | Usefulness of Tacrolimus without Basiliximab in Well-Matched Living-Donor Renal Transplant Recipients in Korea. | 2016 | Exp Clin Transplant | pmid:27228054 |
Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
Schmidt KJ et al. | Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues. | 2016 | J Crohns Colitis | pmid:26419459 |
Sommerer C and Giese T | Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:26418701 |
Yamamoto T et al. | Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27137731 |
Laharie D and Poullenot F | Letter: which patient profile for tacrolimus in ulcerative colitis? | 2016 | Aliment. Pharmacol. Ther. | pmid:27137730 |
Wowro SJ et al. | Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells. | 2016 | Int. Immunopharmacol. | pmid:26613512 |
Adler M et al. | A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | 2016 | J. Am. Soc. Nephrol. | pmid:26260164 |
Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
Brito-Costa A et al. | Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents. | 2016 | Transplantation | pmid:27136260 |
Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
Thervet É | [Applied pharmacogenetic]. | 2016 | Nephrol. Ther. | pmid:26972091 |
Tang T et al. | Roles of the tacrolimus-dependent transcription factor IRF4 in acute rejection after liver transplantation. | 2015 | Int. Immunopharmacol. | pmid:26093273 |
Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
Rahman S et al. | Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant. | 2015 | Chem. Biol. Interact. | pmid:25770929 |
Rossetto AM et al. | The full electron structure of the FKBP12/FK506 complex. | 2015 | J. Biomol. Struct. Dyn. | pmid:24471694 |
Li DW et al. | Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis. | 2015 | World J. Gastroenterol. | pmid:26034369 |
Ma R et al. | FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. | 2015 | Int J Clin Exp Pathol | pmid:26823720 |
Kaieda S et al. | Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis. | 2015 | Mod Rheumatol | pmid:24252010 |
Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
Ichimaru N et al. | Risk factors and incidence for lipid abnormalities in kidney transplant patients. | 2015 | Transplant. Proc. | pmid:25891708 |
Bruckmueller H et al. | Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus. | 2015 | Ther Drug Monit | pmid:25271728 |
Moscovici BK et al. | Treatment of Sjögren's syndrome dry eye using 0.03% tacrolimus eye drop: Prospective double-blind randomized study. | 2015 | Cont Lens Anterior Eye | pmid:25956572 |
Kim D et al. | Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells. | 2015 | Respir Physiol Neurobiol | pmid:25956223 |
Torres-EspÃn A et al. | Immunosuppression of allogenic mesenchymal stem cells transplantation after spinal cord injury improves graft survival and beneficial outcomes. | 2015 | J. Neurotrauma | pmid:25203134 |
Rojas L et al. | Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies. | 2015 | Pharmacogenomics J. | pmid:25201288 |
Chung YW et al. | Transcriptional activation of nuclear-related factor 2 by FK506 in Jurkat T cells. | 2015 | Transplant. Proc. | pmid:25891728 |
Daunton A et al. | A cutaneous presentation of a common condition. | 2015 | BMJ | pmid:26681202 |
Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
Hur J et al. | Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | 2015 | Chem. Res. Toxicol. | pmid:25811541 |
Malvezzi P and Rostaing L | The safety of calcineurin inhibitors for kidney-transplant patients. | 2015 | Expert Opin Drug Saf | pmid:26329325 |
Hempen CM et al. | Hematocrit-independent recovery of immunosuppressants from DBS using heated flow-through desorption. | 2015 | Bioanalysis | pmid:26327182 |
Pidala J et al. | Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease. | 2015 | Haematologica | pmid:25840599 |
Tsai MK et al. | B cells and immunoglobulin in ABO-incompatible renal transplant patients receiving rituximab and double filtration plasmapheresis. | 2015 | J. Formos. Med. Assoc. | pmid:25839769 |
Rajaganapathy BR et al. | Intravesical Liposomal Tacrolimus Protects against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation. | 2015 | J. Urol. | pmid:25839382 |
Furlan SN et al. | Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. | 2015 | Sci Transl Med | pmid:26606970 |
Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
Fujibayashi T et al. | Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry. | 2015 | Mod Rheumatol | pmid:25775147 |
Adotama P et al. | Patient satisfaction with different treatment modalities for vitiligo. | 2015 | J. Am. Acad. Dermatol. | pmid:25773415 |
Lehman N et al. | Left subconjunctival hemorrhage · renal dysfunction · international normalized ratio of 4.5 · Dx? | 2015 | J Fam Pract | pmid:26551480 |
Boloori A et al. | Characterization of Remitting and Relapsing Hyperglycemia in Post-Renal-Transplant Recipients. | 2015 | PLoS ONE | pmid:26551468 |
Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
Mahajan R et al. | Co-localization of agminated congenital melanocytic nevi with vitiligo vulgaris: an unusual presentation. | 2015 | Int. J. Dermatol. | pmid:25039486 |
TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
Yokoyama Y et al. | Corticosteroid-sparing effect of tacrolimus in the initial treatment of dermatomyositis and polymyositis. | 2015 | Mod Rheumatol | pmid:25775144 |
Asrani SK and O'Leary JG | Can one pill a day keep rejection away? | 2015 | Am. J. Transplant. | pmid:25703394 |
Chen QQ et al. | Kaposi's Varicelliform Eruption During Long-term Treatment of Rosacea with 0.03% Tacrolimus Ointment. | 2015 | Chin. Med. J. | pmid:26481759 |
Kim M et al. | Nail lichen striatus: report of seven cases and review of the literature. | 2015 | Int. J. Dermatol. | pmid:26474189 |
Peksa GD et al. | Dosing algorithm for concomitant administration of sirolimus, tacrolimus, and an azole after allogeneic hematopoietic stem cell transplantation. | 2015 | J Oncol Pharm Pract | pmid:24938293 |
Cen J et al. | The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus. | 2015 | Biochimie | pmid:25701551 |
Shengyou Y et al. | Influence of tacrolimus on podocyte injury inducted by angiotensin II. | 2015 | J Renin Angiotensin Aldosterone Syst | pmid:25650384 |
Carenco C et al. | Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | 2015 | Am. J. Transplant. | pmid:25648361 |
Mizokami D et al. | Tacrolimus prevents laryngotracheal stenosis in an acute-injury rat model. | 2015 | Laryngoscope | pmid:25647147 |
Coelho R et al. | Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? | 2015 | J Gastrointestin Liver Dis | pmid:26405712 |
Romanowski M et al. | Interleukin-17 gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26400516 |
Sato M et al. | Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature. | 2015 | Intern. Med. | pmid:26328659 |
Chittock J et al. | Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. | 2015 | Acta Derm. Venereol. | pmid:25594610 |
Knops N et al. | The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells. | 2015 | Mol. Pharm. | pmid:25590378 |
Ge Y et al. | The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis: a systematic review. | 2015 | Clin. Rheumatol. | pmid:26328518 |
Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
Demir T et al. | Cancer Screening of Renal Transplant Patients Undergoing Long-Term Immunosuppressive Therapy. | 2015 | Transplant. Proc. | pmid:26093731 |
Yang F et al. | A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases. | 2015 | Int Urol Nephrol | pmid:25539617 |
Webb NJ et al. | Corticosteroid-free Kidney Transplantation Improves Growth: 2-Year Follow-up of the TWIST Randomized Controlled Trial. | 2015 | Transplantation | pmid:25539467 |
Schaap MM et al. | A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015 | Arch. Toxicol. | pmid:25270620 |
Yoo MC et al. | Steroid-free Liver Transplantation Using Rabbit Antithymocyte Globulin Induction in 500 Consecutive Patients. | 2015 | Transplantation | pmid:25539464 |
Seeling W et al. | Knowledge-based immunosuppressive therapy for kidney transplant patients--from theoretical model to clinical integration. | 2015 | Stud Health Technol Inform | pmid:26262418 |
Wardhana EA and Datau | A patient with plaque type morphea mimicking systemic lupus erythematosus. | 2015 | Acta Med Indones | pmid:26260557 |
Kim SH et al. | Conversion of twice-daily to once-daily tacrolimus is safe in stable adult living donor liver transplant recipients. | 2015 | HBPD INT | pmid:26256081 |
Clift DE et al. | Effects of embryonic cyclosporine exposures on brain development and behavior. | 2015 | Behav. Brain Res. | pmid:25591474 |
Togashi M et al. | Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26184414 |
Inamoto Y et al. | Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:26033280 |
Regelmann MO et al. | New-onset diabetes mellitus after pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:26032592 |