tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morello RJ et al. | Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice. | 2016 | Acta Cir Bras | pmid:27828601 |
| Lee SG et al. | Enhanced topical delivery of tacrolimus by a carbomer hydrogel formulation with transcutol P. | 2016 | Drug Dev Ind Pharm | pmid:26925849 |
| Koura-Nishiura A et al. | Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. | 2016 | J Eur Acad Dermatol Venereol | pmid:25353715 |
| Lee SH et al. | Low-dose mycophenolate mofetil in tablet form or capsule form combined with tacrolimus in the early period after kidney transplantation: a prospective randomized trial
. | 2016 | Clin. Nephrol. | pmid:27781419 |
| Cortes M et al. | The use of temporary portocaval shunt as a technical aid in auxiliary orthotopic liver transplantation. | 2016 | Liver Transpl. | pmid:27357622 |
| Nascimento J and Machado S | Pediatric-onset necrobiosis lipoidica. | 2016 | Pediatr Int | pmid:26865027 |
| Ueno KI et al. | Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis. | 2016 | Int J Rheum Dis | pmid:27457756 |
| Barreto P et al. | Conversion From Twice-Daily to Once-Daily Tacrolimus in Stable Kidney Graft Recipients. | 2016 | Transplant. Proc. | pmid:27742278 |
| Robinson CL et al. | Posaconazole in lung transplant recipients: use, tolerability, and efficacy. | 2016 | Transpl Infect Dis | pmid:26781986 |
| RodrÃguez-Lago I et al. | Previous exposure to biologics and C-reactive protein are associated with the response to tacrolimus in inflammatory bowel disease. | 2016 | Rev Esp Enferm Dig | pmid:27604685 |
| Pereira M et al. | Hyperacute Rejection in a Kidney Transplant With Negative Crossmatch: A Case Report. | 2016 | Transplant. Proc. | pmid:27742303 |
| Rostaing L et al. | Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial. | 2016 | Am. J. Kidney Dis. | pmid:26717860 |
| Shuker N et al. | A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation. | 2016 | Am. J. Transplant. | pmid:26714287 |
| Spain L et al. | Management of toxicities of immune checkpoint inhibitors. | 2016 | Cancer Treat. Rev. | pmid:26874776 |
| Juvvadi PR et al. | Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. | 2016 | FEBS Lett. | pmid:26864964 |
| Solomon A | Allergic manifestations of contact lens wearing. | 2016 | Curr Opin Allergy Clin Immunol | pmid:27518840 |
| Navarro-Villarán E et al. | Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies. | 2016 | PLoS ONE | pmid:27518575 |
| Jung HJ et al. | Improved oral absorption of tacrolimus by a solid dispersion with hypromellose and sodium lauryl sulfate. | 2016 | Int. J. Biol. Macromol. | pmid:26642839 |
| Hirsch HH et al. | BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. | 2016 | Am. J. Transplant. | pmid:26639422 |
| Cassuto E et al. | Adherence to and Acceptance of Once-Daily Tacrolimus After Kidney and Liver Transplant: Results From OSIRIS, a French Observational Study. | 2016 | Transplantation | pmid:27653227 |
| Saliba F et al. | Corticosteroid-Sparing and Optimization of Mycophenolic Acid Exposure in Liver Transplant Recipients Receiving Mycophenolate Mofetil and Tacrolimus: A Randomized, Multicenter Study. | 2016 | Transplantation | pmid:27454919 |
| Butts AR et al. | Factors associated with optimized tacrolimus dosing in hematopoietic stem cell transplantation. | 2016 | J Oncol Pharm Pract | pmid:25802301 |
| Zhao CY et al. | External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients. | 2016 | Br J Clin Pharmacol | pmid:26574188 |
| Zhang X et al. | The effect of calcineurin inhibitors in the induction and maintenance treatment of lupus nephritis: a systematic review and meta-analysis. | 2016 | Int Urol Nephrol | pmid:26781720 |
| Vadcharavivad S et al. | Validation of a 2-Point Limited Sampling Strategy to Predict the Tacrolimus Area-Under-the-12-Hour-Curve in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:27328329 |
| Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
| Raja R et al. | A prospective study of collapsing focal segmental glomerulosclerosis. | 2016 | Ren Fail | pmid:27266801 |
| De Meyer M et al. | Pharmacogenetic-based strategy using de novo tacrolimus once daily after kidney transplantation: prospective pilot study. | 2016 | Pharmacogenomics | pmid:27266721 |
| Wilkes SR et al. | How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema? | 2016 | J. Invest. Dermatol. | pmid:27265005 |
| Bagherani N | Comparison of pimecrolimus with clobetasol propionate in the treatment of localized vitiligo. | 2016 | Dermatol Ther | pmid:26445411 |
| Gaynor JJ et al. | Lower tacrolimus trough levels are associated with subsequently higher acute rejection risk during the first 12 months after kidney transplantation. | 2016 | Transpl. Int. | pmid:26442829 |
| Ha DH et al. | Effects of tacrolimus on morphology, proliferation and differentiation of mesenchymal stem cells derived from gingiva tissue. | 2016 | Mol Med Rep | pmid:27177273 |
| Jin J et al. | Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway. | 2016 | Am. J. Nephrol. | pmid:27174564 |
| Bruns K et al. | Quantitative determination of four immunosuppressants by high resolution mass spectrometry (HRMS). | 2016 | Clin. Chem. Lab. Med. | pmid:26641969 |
| Zamorano-Leon JJ et al. | New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres. | 2016 | Transpl. Immunol. | pmid:27102446 |
| Dasgupta A et al. | Analytical Performance Evaluation of a New Cobas Tacrolimus Assay on Cobas e411 Analyzer: Comparison of Values Obtained by the CMIA Tacrolimus Assay and a Liquid Chromatography Combined with Tandem Mass Spectrometric Method. | 2016 | Ann. Clin. Lab. Sci. | pmid:27098629 |
| Watanabe H et al. | The efficacy of add-on tacrolimus for minor flare in patients with systemic lupus erythematosus: a retrospective study. | 2016 | Lupus | pmid:26296361 |
| Tang JT et al. | Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations. | 2016 | Expert Opin Drug Metab Toxicol | pmid:27010623 |
| Wakamatsu A et al. | Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm. | 2016 | Physiol Rep | pmid:27009276 |
| Rivelli RF et al. | Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant. | 2015 | Nephrology (Carlton) | pmid:25404086 |
| Birdwell KA et al. | Assessment of arterial stiffness using pulse wave velocity in tacrolimus users the first year post kidney transplantation: a prospective cohort study. | 2015 | BMC Nephrol | pmid:26133166 |
| Cury Martins J et al. | Topical tacrolimus for atopic dermatitis. | 2015 | Cochrane Database Syst Rev | pmid:26132597 |
| Prinz V et al. | MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection. | 2015 | J. Cereb. Blood Flow Metab. | pmid:26126863 |
| Gordon P and Gooptu B | Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders. | 2015 | Rheumatology (Oxford) | pmid:25342374 |
| Milam EC et al. | Treatment of Scarring Alopecia in Discoid Variant of Chronic Cutaneous Lupus Erythematosus With Tacrolimus Lotion, 0.3. | 2015 | JAMA Dermatol | pmid:26039539 |
| Shi WL et al. | Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis. | 2015 | PLoS ONE | pmid:26039043 |
| Argudo A et al. | Liver Transplant Patient Carriers of Polymorphism Cyp3a5*1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation. | 2015 | Transplant. Proc. | pmid:26518936 |
| Söderlund C and Rådegran G | Safety and efficacy of the switch to generic mycophenolate mofetil and tacrolimus in heart transplant patients. | 2015 | Clin Transplant | pmid:25981927 |
| van Boekel GA et al. | Limited sampling strategy for prolonged-release tacrolimus in renal transplant patients by use of the dried blood spot technique. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25980838 |
| de Jonge H et al. | The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients. | 2015 | Pharmacogenomics J. | pmid:25287072 |
| Jin S et al. | Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. | 2015 | Gastroenterology | pmid:25980752 |
| Wiseman AC | Induction Therapy in Renal Transplantation: Why? What Agent? What Dose? We May Never Know. | 2015 | Clin J Am Soc Nephrol | pmid:25979977 |
| Ratanatharathorn V et al. | Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. | 2015 | Bone Marrow Transplant. | pmid:25285804 |
| Kang YZ et al. | Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. | 2015 | World J. Gastroenterol. | pmid:25717264 |
| Murata M | Prophylactic and therapeutic treatment of graft-versus-host disease in Japan. | 2015 | Int. J. Hematol. | pmid:25864188 |
| Hategan A and Bourgeois JA | Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system. | 2015 | J Neuropsychiatry Clin Neurosci | pmid:25923858 |
| Blasco-Morente G et al. | Long-Standing Presternal Plaque. | 2015 | Actas Dermosifiliogr | pmid:25917959 |
| Ferraresso M et al. | Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. | 2015 | Pharmacogenomics | pmid:25916520 |
| Li JS et al. | Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. | 2015 | PLoS ONE | pmid:26352670 |
| Lin S et al. | Interleukin-2 receptor antagonist therapy leads to increased tacrolimus levels after kidney transplantation. | 2015 | Ther Drug Monit | pmid:25162212 |
| Josephson MA et al. | American society of Nephrology Quiz and Questionnaire 2014: transplantation. | 2015 | Clin J Am Soc Nephrol | pmid:25862775 |
| Peña C et al. | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. | 2015 | Rev Med Chil | pmid:25860370 |
| Liu S et al. | Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study. | 2015 | BMC Nephrol | pmid:26637482 |
| Watanabe K et al. | The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. | 2015 | Mol Brain | pmid:26637371 |
| Wang L et al. | Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients. | 2015 | Genet. Mol. Res. | pmid:26634478 |
| Solomon SR et al. | Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors. | 2015 | Biol. Blood Marrow Transplant. | pmid:25797174 |
| Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
| Furie R et al. | Lessons Learned From the Clinical Trials of Novel Biologics and Small Molecules in Lupus Nephritis. | 2015 | Semin. Nephrol. | pmid:26573553 |
| Abe Y et al. | Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus. | 2015 | Intern. Med. | pmid:26568012 |
| William BM and de Lima M | Sirolimus plus calcineurin inhibitors and methotrexate: is more necessarily better? | 2015 | Leuk. Lymphoma | pmid:25065702 |
| Gu L et al. | A retrospective study to compare the use of tacrolimus and cyclosporine in combination with adriamycin in post-transplant liver cancer patients. | 2015 | Cell Biochem. Biophys. | pmid:25287673 |
| Ambrosioni J et al. | Role of rhinovirus load in the upper respiratory tract and severity of symptoms in lung transplant recipients. | 2015 | J. Clin. Virol. | pmid:25728070 |
| Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
| Dias PH et al. | Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion. | 2015 | Acta Cir Bras | pmid:25714692 |
| Townamchai N et al. | A Simple Novel Technique to Estimate Tacrolimus Dosages During the Early Post Kidney Transplantation Period. | 2015 | Transplant. Proc. | pmid:26518946 |
| San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
| Kadlub N et al. | The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism. | 2015 | J. Bone Miner. Res. | pmid:25491283 |
| Katayama K et al. | Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. | 2015 | Mod Rheumatol | pmid:24983407 |
| Tavira B et al. | The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients. | 2015 | J. Hum. Genet. | pmid:25673014 |
| Wang Y et al. | Justification of noninferiority margin: methodology considerations in an exposure-response analysis. | 2015 | Clin. Pharmacol. Ther. | pmid:25670256 |
| Dumortier T et al. | Estimating the contribution of everolimus to immunosuppressive efficacy when combined with tacrolimus in liver transplantation: a model-based approach. | 2015 | Clin. Pharmacol. Ther. | pmid:25669933 |
| Kikuchi T et al. | Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma. | 2015 | Int. J. Hematol. | pmid:26440970 |
| Dai DS et al. | Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. | 2015 | Am. J. Nephrol. | pmid:26439819 |
| Xie X et al. | mTOR inhibitor versus mycophenolic acid as the primary immunosuppression regime combined with calcineurin inhibitor for kidney transplant recipients: a meta-analysis. | 2015 | BMC Nephrol | pmid:26126806 |
| Aouam K et al. | Development of Limited Sampling Strategies for the Estimation of Tacrolimus Area Under the Curve in Adult Kidney Transplant Recipients According to the Posttransplantation Time. | 2015 | Ther Drug Monit | pmid:25627405 |
| Oguni H and Hayashi M | [Topics for authorization of new intravenous antiepileptic drugs and tacrolimus for autoimmune epilepsy]. | 2015 | No To Hattatsu | pmid:26349372 |
| Dave CN et al. | Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. | 2015 | Int Urol Nephrol | pmid:26347076 |
| Wu J et al. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | 2015 | J. Clin. Invest. | pmid:26436650 |
| Bhadauria D et al. | Cryptosporidium infection after renal transplantation in an endemic area. | 2015 | Transpl Infect Dis | pmid:25620388 |
| Luger T et al. | Pimecrolimus in atopic dermatitis: consensus on safety and the need to allow use in infants. | 2015 | Pediatr Allergy Immunol | pmid:25557211 |
| Burke MT et al. | Genetics and nonmelanoma skin cancer in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:25616102 |
| Schnitzler F et al. | Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort. | 2015 | PLoS ONE | pmid:26288187 |
| Al-Harbi NO et al. | Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. | 2015 | J Renin Angiotensin Aldosterone Syst | pmid:24737642 |
| Lawrence MC et al. | NFAT targets signaling molecules to gene promoters in pancreatic β-cells. | 2015 | Mol. Endocrinol. | pmid:25496032 |
| Chakraborty S et al. | Prediction of in vivo drug performance using in vitro dissolution coupled with STELLA: a study with selected drug products. | 2015 | Drug Dev Ind Pharm | pmid:25494535 |
| Scholz FM et al. | Focal metatarsal fistulae syndrome affecting a greyhound dog successfully treated with topical 0.1% tacrolimus ointment. | 2015 | Vet. Dermatol. | pmid:26216245 |
| Hauch A et al. | Generics: are all immunosuppression agents created equally? | 2015 | Surgery | pmid:26206317 |
| Borda B et al. | [Frequency of T-cell mediated rejection in new-onset diabetes after kidney transplantation]. | 2015 | Orv Hetil | pmid:26039918 |
| Albring A et al. | Relationship between pharmacokinetics and pharmacodynamics of calcineurin inhibitors in renal transplant patients. | 2015 | Clin Transplant | pmid:25557538 |
| Türkoğlu O et al. | Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? | 2015 | Arch. Oral Biol. | pmid:25555253 |