tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Petuch BR et al. | Microbial transformation of immunosuppressive compounds. III. Glucosylation of immunomycin (FR 900520) and FK 506 by Bacillus subtilis ATCC 55060. | 1994 | J. Ind. Microbiol. | pmid:7513528 |
| Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
| Shaeffer MS et al. | Interaction between FK506 and erythromycin. | 1994 | Ann Pharmacother | pmid:7513563 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Lhöest GJ et al. | 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity. | 1994 | Clin. Chem. | pmid:7513627 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
| Asselin I et al. | Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. | 1994 | Transplant. Proc. | pmid:7527970 |
| Tai J et al. | Effect of FK506 on rat Leydig cell function--in vivo and in vitro study. | 1994 | Metab. Clin. Exp. | pmid:7513780 |
| Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
| Cvetkovic M et al. | The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. | 1994 | Transplantation | pmid:7513912 |
| Arakawa H et al. | Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7513996 |
| Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
| Alamartine E et al. | In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7529381 |
| Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
| Ludwig B et al. | Characterization of Mip proteins of Legionella pneumophila. | 1994 | FEMS Microbiol. Lett. | pmid:7516906 |
| Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
| Murthy JN et al. | Identification of a 14 kDa FK-506/rapamycin binding immunophilin from calf thymus. | 1994 | Clin. Biochem. | pmid:7532556 |
| Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
| Donnelly JG and Soldin SJ | Partial characterization of a 52 kDa CsA/FK506/rapamycin binding protein. | 1994 | Clin. Biochem. | pmid:7532557 |
| High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
| Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
| Yoshimura N et al. | The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro. | 1994 | Transplantation | pmid:7517078 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Firdaous I et al. | Pediatric intravenous FK506--how much are we really infusing? | 1994 | Transplantation | pmid:7517079 |
| Manez R et al. | Rejection and hepatitis in liver transplants. | 1994 | Transplantation | pmid:7517080 |
| Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
| Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
| Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
| Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Alessiani M et al. | Total orthotopic small bowel transplantation in swine under FK 506. | 1994 | Transplant. Proc. | pmid:7518148 |
| Jain A et al. | FK 506 in small bowel transplant recipients: pharmacokinetics and dosing. | 1994 | Transplant. Proc. | pmid:7518149 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Yoshikawa N et al. | Effect of FK-506 on xenografted human Graves' thyroid tissue is severe combined immunodeficient mice. | 1994 | Clin. Endocrinol. (Oxf) | pmid:7519528 |
| Porayko MK et al. | Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. | 1994 | Mayo Clin. Proc. | pmid:7508536 |
| Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
| Martin MF | Nephrotoxic effects of immunosuppression. | 1994 | Mayo Clin. Proc. | pmid:7508537 |
| Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
| Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
| Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
| Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
| Funauchi M et al. | Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. | 1994 | Neurosci. Res. | pmid:7520143 |
| Connelly PR et al. | Enthalpy of hydrogen bond formation in a protein-ligand binding reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7510408 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Shiraga T et al. | Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. | 1994 | Biochem. Pharmacol. | pmid:7510480 |
| Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
| Kuwano K and Arai S | The inhibitory effect of FK506 on cytotoxic T-lymphocyte killing. | 1994 | Immunol. Lett. | pmid:7536706 |
| Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
| Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
| Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
| Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
| Stancato LF et al. | The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. | 1994 | J. Biol. Chem. | pmid:7520912 |
| Hirano Y et al. | Mechanism of FK506-induced glucose intolerance in rats. | 1994 | J Toxicol Sci | pmid:7520947 |
| Tacrolimus (FK506) for organ transplants. | 1994 | Med Lett Drugs Ther | pmid:7520968 | |
| Bierer BE | Biology of cyclosporin A and FK506. | 1994 | Prog. Clin. Biol. Res. | pmid:7536944 |
| Okamoto S et al. | The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. | 1994 | J. Biol. Chem. | pmid:7510691 |
| Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
| Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
| Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
| Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Ueda K et al. | Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. | 1994 | Jpn. J. Physiol. | pmid:7538609 |
| Lebeau MC et al. | Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7522447 |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
| Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
| Kattner A et al. | Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption. | 1994 | Transplant. Proc. | pmid:7524225 |
| Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
| Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
| Akamine S et al. | Monitoring canine lung allograft rejection using Ia antigen expression by bronchoalveolar lymphocytes. | 1994 | Surg. Today | pmid:7526914 |
| Tsuchida M et al. | The effects of FK506 and dexamethasone on rat thymocyte differentiation. | 1994 | Ther Immunol | pmid:7584489 |
| Matsumoto T et al. | Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. | 1994 | Dig. Dis. Sci. | pmid:7512017 |
| Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
| Alnemri ES et al. | FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. | 1994 | J. Biol. Chem. | pmid:7527037 |
| Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Griffith BP et al. | A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. | 1994 | Transplantation | pmid:7512292 |
| Shaw LM and Brayman KL | FK-506 therapeutic drug monitoring. | 1994 | Clin. Chem. | pmid:7527305 |
| Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
| Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition. | 1994 | Biochemistry | pmid:7512379 |
| Mori A et al. | Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512393 |
| Otto G et al. | Corticosteroids and concomitant medication in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271338 |
| Wong P et al. | FK 506 rescue therapy for intractable liver allograft rejection. | 1994 | Transpl. Int. | pmid:11271339 |
| Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
| Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |
| Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |