tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sheiner PA et al. | Acute renal failure associated with the use of ibuprofen in two liver transplant recipients on FK506. | 1994 | Transplantation | pmid:7513099 |
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| Piekoszewski W et al. | Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7513355 |
| Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
| Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
| Hossain M et al. | Eosinophil viability-enhancing activity in mite-sensitive bronchial asthma. | 1994 | Intern. Med. | pmid:7528071 |
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| Burdmann EA et al. | Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs. | 1994 | Ren Fail | pmid:7514309 |
| Yli-Kauhaluoma J and Janda KD | Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: synthesis of the immunoconjugates. | 1994 | Bioorg. Med. Chem. | pmid:7528089 |
| Jindal RM et al. | Serum lipid changes in liver transplant recipients in a prospective trial of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7514317 |
| Stan R et al. | Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. | 1994 | J. Biol. Chem. | pmid:7528205 |
| Haddy A and Rusnak F | Overexpression and characterization of a recombinant form of rat calcineurin A. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7514397 |
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| Woerly G et al. | Demonstration of ternary immunophilin-calcineurin complexes with the immunosuppressants cyclosporin and macrolide FK506. | 1994 | Biochem. Pharmacol. | pmid:7514409 |
| Sugiyama E et al. | FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. | 1994 | J. Rheumatol. | pmid:7528280 |
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| Chen TS et al. | Microbial transformation of immunosuppressive compounds. IV. Hydroxylation and hemiketal formation of ascomycin (immunomycin) by Streptomyces sp. MA 6970 (ATCC No. 55281). | 1994 | J. Antibiot. | pmid:7531195 |
| Brillantes AB et al. | Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. | 1994 | Cell | pmid:7514503 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Miner Electrolyte Metab | pmid:7531274 |
| McCashland TM et al. | Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: differing effects of cyclosporine and FK 506. | 1994 | Hepatology | pmid:7514561 |
| Husi H et al. | Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin. | 1994 | J. Biol. Chem. | pmid:7514602 |
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| Tanaka K et al. | Living related liver transplantation in children. | 1994 | Am. J. Surg. | pmid:7517649 |
| Yu L et al. | NMR studies of the FK506 binding protein bound to a spin-labeled ascomycin analog. | 1994 | J Magn Reson B | pmid:7517786 |
| Aagaard-Tillery KM and Jelinek DF | Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. | 1994 | Cell. Immunol. | pmid:7517796 |
| Furue M et al. | Immunosuppressive effects of azelastine hydrochloride on contact hypersensitivity and T-cell proliferative response: a comparative study with FK-506. | 1994 | J. Invest. Dermatol. | pmid:7517981 |
| Suzuki S and Toledo-Pereyra LH | Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. | 1994 | J. Surg. Res. | pmid:7518017 |
| Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
| Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| D'Ambrosio R et al. | Improved procedures for enzyme immunoassay of tacrolimus (FK506) in whole blood. | 1994 | Clin. Chem. | pmid:7507007 |
| Bäckman L et al. | Chronic nephrotoxicity of FK 506 after liver transplantation. | 1994 | Transplant. Proc. | pmid:7518159 |
| Bäckman L et al. | Whole blood and plasma levels of FK 506 after liver transplantation: correlation with toxicity. | 1994 | Transplant. Proc. | pmid:7518160 |
| Duncan JI | Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and rapamycin. | 1994 | J. Invest. Dermatol. | pmid:7507155 |
| Engelbrecht ME et al. | The effect of immunosuppressants on human leukocyte NADPH oxidase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518204 |
| Reding R et al. | Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy, toxicity, and dose regimen in 23 children. | 1994 | Transplantation | pmid:7507272 |
| Zuany-Amorim C et al. | Modulation by rm interferon-gamma and CD4+ T-lymphocytes of allergic eosinophil accumulation in the mice peritoneal cavity. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518212 |
| Helekar SA et al. | Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels. | 1994 | Neuron | pmid:7507339 |
| Sabatini DM et al. | RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. | 1994 | Cell | pmid:7518356 |
| Parsons JN et al. | Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex. | 1994 | J. Biol. Chem. | pmid:7518461 |
| Wang T et al. | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. | 1994 | Science | pmid:7518616 |
| Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
| Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
| Sewell TJ et al. | Inhibition of calcineurin by a novel FK-506-binding protein. | 1994 | J. Biol. Chem. | pmid:7520438 |
| Oyanagui Y | Nitric oxide- and hydrogen peroxide-mediated gene expression by glucocorticoids and FK506 in histamine paw edema of mice. | 1994 | Life Sci. | pmid:7520521 |
| Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
| Nakata S et al. | Immunosuppressive mechanisms of deoxymethylspergualin and FK 506 on in vitro cytotoxic T lymphocytes. | 1994 | Transplant. Proc. | pmid:7520613 |
| Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
| Pai SY et al. | Cross-linking CD28 leads to activation of 70-kDa S6 kinase. | 1994 | Eur. J. Immunol. | pmid:7523138 |
| Schmidt B et al. | A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila. | 1994 | FEBS Lett. | pmid:7523184 |
| Hakamata Y et al. | Involvement of the brain type of ryanodine receptor in T-cell proliferation. | 1994 | FEBS Lett. | pmid:7523185 |
| Ahern GP et al. | Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506. | 1994 | FEBS Lett. | pmid:7523191 |
| Clipstone NA et al. | Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. | 1994 | J. Biol. Chem. | pmid:7523407 |
| Lemster B et al. | Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. | 1994 | Autoimmunity | pmid:7539635 |
| Karmann K et al. | Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. | 1994 | J. Immunol. | pmid:7523510 |
| Wakabayashi H et al. | The effect of FK506 on warm ischemia and reperfusion injury in the rat liver. | 1994 | Surg. Today | pmid:7539646 |
| Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
| Siekierka JJ | Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. | 1994 | Immunol. Res. | pmid:7539823 |
| Bierer BE | Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. | 1994 | Chem. Immunol. | pmid:7524531 |
| Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
| Yu L and Fesik SW | pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands. | 1994 | Biochim. Biophys. Acta | pmid:7524680 |
| Papaccio G et al. | The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. | 1994 | Cell Tissue Res. | pmid:7525068 |
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| Milan D et al. | The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. | 1994 | Cell | pmid:7525078 |
| Tamir H et al. | Secretogogue-induced gating of chloride channels in the secretory vesicles of parafollicular cells. | 1994 | Endocrinology | pmid:7525261 |
| Shafiee A et al. | Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858. | 1994 | Eur. J. Biochem. | pmid:7525282 |
| Ericzon B et al. | Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study. | 1994 | Transpl. Int. | pmid:11271178 |
| Undre N and Möller A | Pharmacokinetic interpretation of FK 506 levels in blood and in plasma during a European randomised study in primary liver transplant patients. The FK 506 European Study Group. | 1994 | Transpl. Int. | pmid:11271189 |
| Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
| Devlin J et al. | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. | 1994 | Transpl. Int. | pmid:11271207 |
| Two-year follow-up study of the efficacy and safety of FK 506 in kidney transplant patients. Japanese FK 506 Study Group. | 1994 | Transpl. Int. | pmid:11271216 | |
| Calmus Y | [Rejection of a liver allograft. Diagnosis and treatment]. | 1994 | Ann Radiol (Paris) | pmid:7527621 |
| Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
| Winkler M et al. | The use of plasma levels for FK 506 dosing in liver-grafted patients. | 1994 | Transpl. Int. | pmid:7527638 |
| Stark JH et al. | Sensitivity of baboon lymphocytes to cyclosporin A and FK 506: relative resistance of alloactivated cells to CyA. | 1994 | Transpl. Int. | pmid:7527639 |
| Lyons WE et al. | Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7512727 |
| Abdalla AH et al. | FK 506 as an alternative in cyclosporin-induced hemolytic uremic syndrome in a kidney transplant recipient. | 1994 | Transpl. Int. | pmid:7527640 |
| Cooper MH et al. | Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. | 1994 | Bone Marrow Transplant. | pmid:7527689 |
| Lea JP et al. | Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin. | 1994 | Kidney Int. | pmid:7527873 |
| Yasunami Y and Ikeda S | Induction of donor specific unresponsiveness in rat islet allografts by intraportal grafting and FK506. | 1994 | Cell Transplant | pmid:7512877 |
| Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
| Mor E et al. | Reversal of gastrointestinal toxicity associated with long-term FK506 immunosuppression by conversion to cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7513098 |
| Assan R et al. | FK 506/fluconazole interaction enhances FK 506 nephrotoxicity. | 1994 Jan-Feb | Diabete Metab | pmid:7520007 |
| Perotti BY et al. | FK 506 metabolism in male and female rat liver microsomes. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:7512020 |
| Akita K et al. | Effect of FK506 and anti-CD4 therapy on fetal pig pancreas xenografts and host lymphoid cells in nod/Lt, CBA, and BALB/c mice. | 1994 Jan-Feb | Cell Transplant | pmid:7512875 |
| Yasunami Y et al. | Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. | 1994 Jan-Feb | Cell Transplant | pmid:7512876 |
| Yoshida Y et al. | Comparison of cardiac rejection in heart and heart-lung concordant xenotransplantation. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:7518252 |
| Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
| von Asmuth EJ et al. | IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. | 1994 May-Jun | Eur. Cytokine Netw. | pmid:7524716 |
| Ryffel B et al. | Nephrotoxicity of immunosuppressants in rats: comparison of macrolides with cyclosporin. | 1994 Nov-Dec | Exp. Nephrol. | pmid:7532090 |
| Cacciarelli TV et al. | Influence of the timing of FK 506 (Tacrolimus) administration on recovery of renal function from warm ischemic injury in rats. | 1994 Oct-Dec | ASAIO J. | pmid:7532042 |
| Karanam BV et al. | FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7530623 |
| Monfar M et al. | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. | 1995 | Mol. Cell. Biol. | pmid:7528328 |
| Rebollo A et al. | Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2. | 1995 | Cytokine | pmid:7543780 |
| Tamura K et al. | Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. | 1995 | Transplantation | pmid:7539960 |