Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Carobbi A et al. | Effect of splenectomy in combination with FK 506 and 15-deoxyspergualin on cardiac xenograft survival. | 1991 | Transplant. Proc. | pmid:1703704 |
Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
Rostaing L et al. | Early posttransplantation renal hemodynamics in FK 506-treated kidney recipients with or without prior induction therapy. | 1998 | Transplant. Proc. | pmid:9636519 |
Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunological risk". | 2000 | Transplant. Proc. | pmid:11119893 |
Hu RH et al. | Clinical influencing factors for daily dose, trough level, and relative clearance of tacrolimus in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119894 |
Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
Marin-Gomez LM et al. | Evaluation of clinical safety of conversion to Advagraf therapy in liver transplant recipients: observational study. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715867 |
Montejo M et al. | Prophylactic therapy with valgancyclovir in high-risk (cytomegalovirus D+/R-) liver transplant recipients: a single-center experience. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715869 |
Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
Shoji T et al. | Long-term acceptance of porcine pulmonary allografts without chronic rejection. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808551 |
Yamamoto S et al. | FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808570 |
Ortiz de Urbina J et al. | Advagraf de novo in liver transplantation: a single-center experience. | 2011 | Transplant. Proc. | pmid:21486583 |
Pérez MJ et al. | Cardiovascular risk factors after liver transplantation: analysis of related factors. | 2011 | Transplant. Proc. | pmid:21486587 |
Jain AB et al. | Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations. | 1990 | Transplant. Proc. | pmid:1689900 |
Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
Jain AB et al. | Pharmacokinetics of cyclosporine and nephrotoxicity in orthotopic liver transplant patients rescued with FK 506. | 1991 | Transplant. Proc. | pmid:1721274 |
Namii Y et al. | Tetrahydropyranyladriamycin with FK 506 combination therapy for hamster-to-rat-concordant xenotransplantation. | 1996 | Transplant. Proc. | pmid:8623358 |
Hossain MA et al. | Effect of the immunosuppressants FK506 and D-allose on allogenic orthotopic liver transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120048 |
Liu WT et al. | In vitro generation of tacrolimus metabolites and their detection in whole blood. | 1998 | Transplant. Proc. | pmid:9636590 |
Jiang H and Kobayashi M | Differences between cyclosporin A and tacrolimus in organ transplantation. | 1999 | Transplant. Proc. | pmid:10455942 |
Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
Gonzalez-Molina M et al. | Mycophenolate mofetil and tacrolimus reduce mortality after deceased donor kidney transplantation. | 2012 | Transplant. Proc. | pmid:23146459 |
Yeung S et al. | Primary immunosuppression with tacrolimus and low-dose mycophenolate mofetil in renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518754 |
Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
Zeevi A et al. | In vitro assessment of FK 506 immunosuppressive activity in transplant patients. | 1991 | Transplant. Proc. | pmid:1721307 |
Tullius SG et al. | ATG versus basiliximab induction therapy in renal allograft recipients receiving a dual immunosuppressive regimen: one-year results. | 2003 | Transplant. Proc. | pmid:14529854 |
Manu MA et al. | Tacrolimus rescue for resistant rejection, chronic rejection, and immunoglobulin A nephropathy of renal allografts under primary cyclosporine A immunosuppression. | 1999 | Transplant. Proc. | pmid:10578313 |
Jacob DA et al. | Liver transplantation for primary biliary cirrhosis: influence of primary immunosuppression on survival. | 2005 | Transplant. Proc. | pmid:15919432 |
Wasilewski G et al. | Inadequate blood pressure control in orthotopic heart transplant: is there a role of kidney function and immunosuppressive regimen? | 2014 | Transplant. Proc. | pmid:25380929 |
Ciancio G et al. | Pilot Randomized Trial of Tacrolimus/Everolimus vs Tacrolimus/Enteric-Coated Mycophenolate Sodium in Adult, Primary Kidney Transplant Recipients at a Single Center. | Transplant. Proc. | pmid:27569936 | |
Chuang JP et al. | Does immunosuppressive pharmacotherapy affect isoagglutinin titers? | 2008 | Transplant. Proc. | pmid:18929836 |
Chung YW et al. | Transcriptional activation of nuclear-related factor 2 by FK506 in Jurkat T cells. | 2015 | Transplant. Proc. | pmid:25891728 |
Tannuri AC et al. | Effects of immunosuppressants on hepatocyte cell mitosis during liver regeneration in growing animal models of partial hepatectomy. | 2008 | Transplant. Proc. | pmid:18589165 |
Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
Shaw BW et al. | FK 506 for rescue treatment of acute and chronic rejection in liver allograft recipients. | 1991 | Transplant. Proc. | pmid:1721338 |
McDiarmid SV et al. | FK 506 rescue therapy in liver transplantation: outcome and complications. | 1991 | Transplant. Proc. | pmid:1721339 |
Lladó L et al. | Prospective study of a tacrolimus-based quadruple immunosuppressive regimen: evaluation of safety and efficacy. | 2002 | Transplant. Proc. | pmid:12176468 |
Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
Krämer BK et al. | Cardiovascular risk estimates and risk factors in renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919488 |
Wlodarczyk Z et al. | Lipid metabolism in renal transplant patients receiving tacrolimus/sirolimus combination therapy. | 2005 | Transplant. Proc. | pmid:15919489 |
Moro JA et al. | Randomized prospective study of the evolution of renal function depending on the anticalcineurin used. | 2008 | Transplant. Proc. | pmid:19010143 |
Fukuhara N et al. | Long-term outcome of tacrolimus in cadaveric kidney transplantation from non-heart-beating donors. | 2002 | Transplant. Proc. | pmid:12176492 |
Barrera-Pulido L et al. | Clinical relevance and prevalence of polymorphisms in CYP3A5 and MDR1 genes that encode tacrolimus biotransformation enzymes in liver transplant recipients. | 2008 | Transplant. Proc. | pmid:19010156 |
Gruttadauria S et al. | Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182762 |
Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
Iaria G et al. | Switch to tacrolimus for cyclosporine-induced gynecomastia in liver transplant recipients. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182769 |
Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
Fries D et al. | Development of renal dysfunction and renal histological lesions in two patients treated with FK 506 for acute rejection following liver transplantation. | 1991 | Transplant. Proc. | pmid:1721370 |
Jain AB et al. | Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1703354 |
Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
Molmenti E et al. | Noncompliance after pediatric liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083164 |
Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
Chien YS et al. | Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. | 2008 | Transplant. Proc. | pmid:18790250 |
Beaunoyer M et al. | Low-dose tacrolimus, trough-monitored mycophenolate mofetil, and planned steroid withdrawal for cadaveric kidney transplantation: a single center experience. | 2002 | Transplant. Proc. | pmid:12176540 |
Tashiro H et al. | Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123287 |
Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
Lee H et al. | Thymoglobulin Versus Basiliximab Induction Therapy in Low-Risk Kidney Transplant Recipients: A Single-Center Experience. | 2018 | Transplant. Proc. | pmid:29880348 |
Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
Kuroki H et al. | Experimental studies of vascularized allogeneic limb transplantation in the rat using a new immunosuppressive agent, FK-506: morphological and immunological analysis. | 1989 | Transplant. Proc. | pmid:2468255 |
Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
Nakao A et al. | Changes of allo-intestinal graft survival and intragraft cytokine expression by bone marrow augmentation with tacrolimus treatment in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266851 |
Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
Hoshino Y et al. | FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK 506 in rat allograft models. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083547 |
Kato Y et al. | Epidermal growth factor enhances the intestinal adaptation of small bowel allografts in the postoperative period. | 2000 | Transplant. Proc. | pmid:10995935 |
Kahan BD | High variability of drug exposure: a biopharmaceutic risk factor for chronic rejection. | 1998 | Transplant. Proc. | pmid:9723224 |
Keown PA and Primmett DR | Cyclosporine: the principal immunosuppressant for renal transplantation. | 1998 | Transplant. Proc. | pmid:9723252 |
Mendes J et al. | Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plasma levels of tacrolimus and cyclosporine in renal transplant recipients. | 2009 | Transplant. Proc. | pmid:19376366 |
Weir MR | Optimizing early de novo immunosuppression with sirolimus. | 2008 | Transplant. Proc. | pmid:19100903 |
Khwaja K et al. | Pancreas transplantation in cross-match-positive recipients using cyclosporine- or tacrolimus-based immunosuppression. | 2002 | Transplant. Proc. | pmid:12176621 |
Beckebaum S et al. | Impact of combined mycophenolate mofetil and low-dose calcineurin inhibitor therapy on renal function, cardiovascular risk factors, and graft function in liver transplant patients: preliminary results of an open prospective study. | 2004 | Transplant. Proc. | pmid:15621120 |
Rigotti P et al. | Antilymphocyte induction is no longer necessary in simultaneous pancreas and kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176623 |
Rintala JM et al. | The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. | 2006 | Transplant. Proc. | pmid:17175234 |
Wu GD et al. | FK 506 inhibits the development of transplant arteriosclerosis. | 1991 | Transplant. Proc. | pmid:1721433 |
Kobayashi N et al. | Effect of FK 506 on abdominal organ cluster transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1721434 |
Todo S et al. | Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. | 1987 | Transplant. Proc. | pmid:2445076 |
Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
Del Castillo D | Analysis of primary and recurrent rejection following renal transplantation in a large, comparative, multicentre trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267283 |
Fukuoka N et al. | Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. | 2010 | Transplant. Proc. | pmid:20832577 |
Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
Maroun T et al. | Rejection therapy with tacrolimus in renal transplantation: preliminary results of a collaborative multicenter study in 45 patients. Groupe Cooperatif de Transplantation D'ile de France (GCIF). | 1998 | Transplant. Proc. | pmid:9745576 |
Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
Ito Y et al. | Complete replacement of tracheal epithelia by the host promotes spontaneous acceptance of orthotopic tracheal allografts in rats. | 2004 | Transplant. Proc. | pmid:15561264 |
Owen ER et al. | Peripheral nerve regeneration in human hand transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267484 |
Molmenti EP et al. | Incidence, management, and outcome of posttransplant lymphoproliferative disease in pediatric liver transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267487 |
Barak S et al. | Alveolar bone height in patients after liver transplantation. | 2000 | Transplant. Proc. | pmid:10856558 |
Marcus N et al. | Medium-term outcome of tacrolimus immunosuppression following rejection or graft dysfunction in heart transplant patients. | 1998 | Transplant. Proc. | pmid:9636460 |
Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |
Girman P et al. | Similar early complication rate in simultaneous pancreas and kidney recipients on tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus immunosuppressive regimens. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692391 |
Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |