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Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. |
1995 |
Prog Cell Cycle Res |
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Functional and structural characteristics of experimental FK 506 nephrotoxicity. |
1995 |
Clin. Exp. Pharmacol. Physiol. |
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Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Rabbit-rat experiments. |
1995 |
Acta Orthop Scand |
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Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation. |
1995 |
Immunopharmacology |
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FK506 nephrotoxicity: morphologic and physiologic characterization of a rat model. |
1995 |
Lab. Invest. |
pmid:8558840
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Gjertson DW et al. |
The relative effects of FK506 and cyclosporine on short- and long-term kidney graft survival. |
1995 |
Transplantation |
pmid:8545861
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Shirakata Y et al. |
Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. |
1995 |
Transplantation |
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Aoyama H et al. |
Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. |
1995 |
Br. J. Dermatol. |
pmid:8547017
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Gharpure VS et al. |
Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. |
1995 |
Bone Marrow Transplant. |
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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. |
1995 |
Science |
pmid:7528941
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Hamasaki Y et al. |
Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells. |
1995 |
Pharmacology |
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Marx SO et al. |
Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. |
1995 |
Circ. Res. |
pmid:7532117
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Clardy J |
The chemistry of signal transduction. |
1995 |
Proc. Natl. Acad. Sci. U.S.A. |
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Kawai M et al. |
Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. |
1995 |
J. Immunol. |
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FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. |
1995 |
J. Exp. Med. |
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Grobecker HF et al. |
Cyclosporine A-induced hypertension in SHR and WKY: role of the sympatho-adrenal system. |
1995 |
Clin Exp Pharmacol Physiol Suppl |
pmid:9072458
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Loss M et al. |
Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. |
1995 |
Transplant. Proc. |
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Büttemeyer R et al. |
Peripheral nerve allograft transplantation with FK506: functional, histological, and immunological results before and after discontinuation of immunosuppression. |
1995 |
Ann Plast Surg |
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Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. |
1995 |
Transplant. Proc. |
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Takeda Y et al. |
Effect of FK 506 on the expression of endothelin receptor mRNA in the vasculature. |
1995 |
J. Cardiovasc. Pharmacol. |
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Recovery of delayed-type hypersensitivity following liver transplantation. |
1995 |
Transplant. Proc. |
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FK506-induced endothelin release by cultured rat mesangial cells. |
1995 |
J. Cardiovasc. Pharmacol. |
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Gaweco AS et al. |
Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression. |
1995 |
Transplant. Proc. |
pmid:7533370
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Soldin SJ |
Receptor (immunophilin-binding) assay for immunosuppressive drugs. |
1995 |
Ther Drug Monit |
pmid:8588223
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Armstrong VW et al. |
Metabolic liver function and lipoprotein metabolism after orthotopic liver transplantation in patients on immunosuppressive therapy with FK 506 or cyclosporine. |
1995 |
Transplant. Proc. |
pmid:7533371
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Thomson AW et al. |
Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. |
1995 |
Ther Drug Monit |
pmid:8588225
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Martinez OM et al. |
Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. |
1995 |
Transplant. Proc. |
pmid:7533372
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Fung JJ and Starzl TE |
FK506 in solid organ transplantation. |
1995 |
Ther Drug Monit |
pmid:8588226
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Langrehr JM et al. |
Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. |
1995 |
Transplant. Proc. |
pmid:7533373
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Jusko WJ |
Analysis of tacrolimus (FK 506) in relation to therapeutic drug monitoring. |
1995 |
Ther Drug Monit |
pmid:8588227
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Vargas V et al. |
Alpha-interferon for acute hepatitis C in liver transplant patients. |
1995 |
Transplant. Proc. |
pmid:7533374
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McMaster P et al. |
Therapeutic drug monitoring of tacrolimus in clinical transplantation. |
1995 |
Ther Drug Monit |
pmid:8588228
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Barkholt LM et al. |
New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. |
1995 |
Transplant. Proc. |
pmid:7533375
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Jusko WJ et al. |
Consensus document: therapeutic monitoring of tacrolimus (FK-506). |
1995 |
Ther Drug Monit |
pmid:8588229
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Shirakata Y et al. |
The minimum graft size for successful orthotopic partial liver transplantation in the canine model. |
1995 |
Transplant. Proc. |
pmid:7533422
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Kumano K et al. |
Role of endothelin in FK 506-induced renal hypoperfusion in rats. |
1995 |
Transplant. Proc. |
pmid:7533423
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Izutani H et al. |
Graft coronary arteriosclerosis in rat heart transplant model with FK 506 short-term administration. |
1995 |
Transplant. Proc. |
pmid:7533425
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Funayama Y et al. |
Changes in cell adhesion molecules after small bowel transplantation in rats. |
1995 |
Transplant. Proc. |
pmid:7533426
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Laskow DA et al. |
Phase II FK 506 multicenter concentration control study: one-year follow-up. |
1995 |
Transplant. Proc. |
pmid:7533431
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Shapiro R et al. |
A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. |
1995 |
Transplant. Proc. |
pmid:7533432
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Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. |
1995 |
Transplant. Proc. |
pmid:7533433
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Sakamoto K et al. |
Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. |
1995 |
Transplant. Proc. |
pmid:7533434
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Ochiai T et al. |
Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. |
1995 |
Transplant. Proc. |
pmid:7533435
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Grimmond S et al. |
Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1. |
1995 |
Hum. Genet. |
pmid:7535744
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Jiang H et al. |
Induction of anagen in telogen mouse skin by topical application of FK506, a potent immunosuppressant. |
1995 |
J. Invest. Dermatol. |
pmid:7535825
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Atkison P et al. |
Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients. |
1995 |
Lancet |
pmid:7535875
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Shaffer D et al. |
Normal pancreas allograft function following simultaneous pancreas kidney transplantation after rescue therapy with tacrolimus (FK506). |
1995 |
Transplantation |
pmid:7535958
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Bronster DJ et al. |
Demyelinating sensorimotor polyneuropathy after administration of FK506. |
1995 |
Transplantation |
pmid:7535959
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Sheppard KE |
Cyclosporin A and FK506 are potent activators of proopiomelanocortin-derived peptide secretion without affecting corticotrope glucocorticoid receptor function. |
1995 |
J. Neuroendocrinol. |
pmid:8748119
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Iwasaki K et al. |
Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. |
1995 |
Drug Metab. Dispos. |
pmid:7536652
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Miranker A and Karplus M |
An automated method for dynamic ligand design. |
1995 |
Proteins |
pmid:8749844
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Marumo T et al. |
Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. |
1995 |
Hypertension |
pmid:7536714
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Schwaninger M et al. |
Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. |
1995 |
J. Biol. Chem. |
pmid:7536740
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Kobayashi I et al. |
Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy. |
1995 |
Eur. J. Pediatr. |
pmid:7556338
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IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain. |
1995 |
FEBS Lett. |
pmid:7556630
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David M et al. |
[Occurrence of suspicious changes in cervix cytology in women after liver transplantation]. |
1995 |
Geburtshilfe Frauenheilkd |
pmid:7557217
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Mills RA et al. |
Topical FK-506 prevents experimental corneal allograft rejection. |
1995 |
Cornea |
pmid:7538061
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[Experimental and clinical studies on the effectiveness of new immunosuppressive agents used in heart transplantation and transplantation-related complications]. |
1995 |
Nihon Kyobu Geka Gakkai Zasshi |
pmid:7561285
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Yamamoto S et al. |
Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. |
1995 |
Jpn. J. Ophthalmol. |
pmid:8926639
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Lee TK et al. |
Postoperative selective bowel decontamination prevents gram-negative bacterial translocation in small-bowel graft recipients. |
1995 |
J. Surg. Res. |
pmid:7538186
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Asano K et al. |
Generation of effector T cells in Hymenolepis nana-infected, FK-506-treated BALB/c mice. |
1995 |
Immunol. Lett. |
pmid:7590919
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A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. |
1995 |
J. Biol. Chem. |
pmid:7592869
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Peptidylproline cis/trans isomerases. |
1995 |
Prog. Biophys. Mol. Biol. |
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Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. |
1995 |
Virology |
pmid:7538254
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Kanda T et al. |
Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. |
1995 |
J. Pharmacol. Exp. Ther. |
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Living-donor liver transplantation at UCLA. |
1995 |
Am. J. Surg. |
pmid:7538267
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Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. |
1995 |
J. Am. Soc. Nephrol. |
pmid:7542491
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Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. |
1995 |
Immunology |
pmid:7538492
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Garrett-Engele P et al. |
Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. |
1995 |
Mol. Cell. Biol. |
pmid:7542741
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Skeen MJ and Ziegler HK |
Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. |
1995 |
J. Immunol. |
pmid:7538532
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Columbo M et al. |
Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. |
1995 |
J. Immunol. |
pmid:7538541
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Pearlman DA and Connelly PR |
Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. |
1995 |
J. Mol. Biol. |
pmid:7538591
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Lochmüller H et al. |
Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice. |
1995 |
Biochem. Biophys. Res. Commun. |
pmid:7544122
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Deschler DG et al. |
Posttransplantation lymphoproliferative disorder in patients under primary tacrolimus (FK 506) immunosuppression. |
1995 |
Arch. Otolaryngol. Head Neck Surg. |
pmid:7544136
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1H and 15N assignment of NMR spectrum, secondary structure and global folding of the immunophilin-like domain of the 59-kDa FK506-binding protein. |
1995 |
Eur. J. Biochem. |
pmid:7544285
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Sakamoto K et al. |
A new assay method for immunosuppressants with a tacrolimus (FK506)-like mode of action. |
1995 |
J. Antibiot. |
pmid:7544337
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Immunosuppressive drugs and hypertrophic cardiomyopathy. |
1995 |
Lancet |
pmid:7540241
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Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation. |
1995 |
Immunopharmacol Immunotoxicol |
pmid:7544367
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Dhawan A et al. |
Immunosuppressive drugs and hypertrophic cardiomyopathy. |
1995 |
Lancet |
pmid:7540242
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Sauer P et al. |
In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion. |
1995 |
J. Hepatol. |
pmid:7544368
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Nielsen FT et al. |
Nephrotoxicity of FK-506 in the rat. Studies on glomerular and tubular function, and on the relationship between efficacy and toxicity. |
1995 |
Nephrol. Dial. Transplant. |
pmid:7540737
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Chang HY et al. |
Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. |
1995 |
Nature |
pmid:7544441
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Reichenspurner H et al. |
First experience with FK 506 for treatment of chronic pulmonary rejection. |
1995 |
Transplant. Proc. |
pmid:7540775
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Murio JE et al. |
Compassionate use of FK 506 in liver transplantation. |
1995 |
Transplant. Proc. |
pmid:7544501
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Yumiba T et al. |
Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. |
1995 |
Transplant. Proc. |
pmid:7540780
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Llull R et al. |
Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. |
1995 |
Transplant. Proc. |
pmid:7544504
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Horne SM and Young KD |
Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. |
1995 |
Arch. Microbiol. |
pmid:7540828
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Teutsch M et al. |
Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. |
1995 |
Int. Immunol. |
pmid:7540861
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Mori A et al. |
IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. |
1995 |
Int. Immunol. |
pmid:7540862
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Tashiro H et al. |
Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. |
1995 |
Cell Transplant |
pmid:7540919
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Okamoto M et al. |
In situ proliferating status of mononuclear cells in rat small bowel grafts. |
1995 |
Int J Exp Pathol |
pmid:7547442
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Zhu D et al. |
Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. |
1995 |
J. Biol. Chem. |
pmid:7559604
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Platz KP et al. |
Toxicity versus rejection--or why conversions between cyclosporine A and FK506 were performed after liver transplantation. |
1995 |
Clin Transplant |
pmid:7549052
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Mueller AR et al. |
The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? |
1995 |
Clin Transplant |
pmid:7549057
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Nagai H et al. |
Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. |
1995 |
Int. Arch. Allergy Immunol. |
pmid:7549508
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Ma J et al. |
Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein. |
1995 |
Biophys. J. |
pmid:8599646
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Jung-Testas I et al. |
Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. |
1995 |
C. R. Acad. Sci. III, Sci. Vie |
pmid:7583777
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Kissinger CR et al. |
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |
1995 |
Nature |
pmid:8524402
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Cardenas ME et al. |
Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. |
1995 |
Curr. Opin. Nephrol. Hypertens. |
pmid:8591053
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Lake KD and Canafax DM |
Important interactions of drugs with immunosuppressive agents used in transplant recipients. |
1995 |
J. Antimicrob. Chemother. |
pmid:8601538
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