Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen F et al. | [Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria]. | 2015 | Zhonghua Xue Ye Xue Za Zhi | pmid:26759101 |
Xie H et al. | [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. | 2002 | Zhonghua Yan Ke Za Zhi | pmid:11955293 |
Chen J et al. | [The study of FK506 eye drops preventing and treating immune rejection on limbal allograft transplantation]. | 2003 | Zhonghua Yan Ke Za Zhi | pmid:14766087 |
Xiang DM et al. | [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. | 2017 | Zhonghua Yan Ke Za Zhi | pmid:28412805 |
Sun YJ et al. | [Systematic review of penetrating keratoplasty rejection treated by immunosuppressants]. | 2010 | Zhonghua Yan Ke Za Zhi | pmid:21211228 |
Shi WY et al. | [Implantation of FK506 drug delivery system into the anterior chamber for inhibiting corneal rejection in high risk rabbit corneal allograft]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:16762204 |
Fei WL et al. | [The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:16762205 |
Lü L et al. | [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. | 1999 | Zhonghua Yan Ke Za Zhi | pmid:11835769 |
Lü L and Zhang W | [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. | 1998 | Zhonghua Yan Ke Za Zhi | pmid:11877144 |
Jin J et al. | Impact of multidrug resistance 1 gene polymorphism on tacrolimus dose and concentration-to-dose ratio in Chinese liver transplantation recipients. | 2005 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:16331555 |
Dong J et al. | [Osteoblastic differentiation and in vivo osteogenic activity of marrow-derived mesenchymal stem cells stimulated by Tacrolimus: experiment with rats]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17425851 |
Wang W et al. | [Relationship between MDR1 gene polymorphism and blood concentration of tacrolimus in renal transplant patients]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16409819 |
Lu AW et al. | [Dual, triple, and quadruple oral tacrolimus-based immunosuppression regimens after orthotopic liver transplantation: a randomised comparative study of regimens]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:17313848 |
Huang G et al. | [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26814103 |
Li YX et al. | [Preliminary experience with partial tolerance protocol in small bowel transplantation]. | 2009 | Zhonghua Yi Xue Za Zhi | pmid:20137270 |
Feng HY et al. | [Therapeutic efficacy and safety of tacrolimus for intractable myasthenia gravis: a report of 36 patients]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:22333101 |
Huang HF et al. | [Conversion from calcineurin inhibitors to sirolimus in chronic allograft nephropathy: a 4-year prospective study]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:22333250 |
Li YL et al. | [Measurement of tacrolimus in blood with the method of high performance liquid chromatography-mass spectrometry]. | 2008 | Zhonghua Yi Xue Za Zhi | pmid:19087682 |
Lü DC et al. | [Effect of FK506 on axonal regeneration of rat sciatic nerve in regeneration chamber: an experimental study]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16313776 |
Zhang WG et al. | [Favorable effect of chitosan sustained-release FK506 incorporated conduits on axonal regeneration in rat sciatic nerve]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16784713 |