Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lhöest GJ et al. | 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity. | 1994 | Clin. Chem. | pmid:7513627 |
Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
Tai J et al. | Effect of FK506 on rat Leydig cell function--in vivo and in vitro study. | 1994 | Metab. Clin. Exp. | pmid:7513780 |
Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
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Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
Yoshimura N et al. | The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro. | 1994 | Transplantation | pmid:7517078 |
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Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
Petros AM and Fesik SW | Nuclear magnetic resonance methods for studying protein-ligand complexes. | 1994 | Meth. Enzymol. | pmid:7530321 |
Dawson TM et al. | The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. | 1994 | Neuroscience | pmid:7530348 |
Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
Singh N et al. | Decreased incidence of viral infections in liver transplant recipients. Possible effects of FK506? | 1994 | Dig. Dis. Sci. | pmid:7506641 |
D'Ambrosio R et al. | Improved procedures for enzyme immunoassay of tacrolimus (FK506) in whole blood. | 1994 | Clin. Chem. | pmid:7507007 |
Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
Logan TM et al. | Structural characterization of the FK506 binding protein unfolded in urea and guanidine hydrochloride. | 1994 | J. Mol. Biol. | pmid:7508991 |
Cooper MH et al. | Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors. | 1994 | Transplantation | pmid:7509089 |
Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
Ueda K et al. | Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. | 1994 | Jpn. J. Physiol. | pmid:7538609 |
Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |
Burnett D et al. | Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. | 1994 | Biochem. Pharmacol. | pmid:7524504 |
Bierer BE | Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. | 1994 | Chem. Immunol. | pmid:7524531 |
Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
Matsumoto T et al. | Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. | 1994 | Dig. Dis. Sci. | pmid:7512017 |
Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
Griffith BP et al. | A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. | 1994 | Transplantation | pmid:7512292 |
Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
Chen SR et al. | Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7527548 |
Calmus Y | [Rejection of a liver allograft. Diagnosis and treatment]. | 1994 | Ann Radiol (Paris) | pmid:7527621 |
Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
Azhderian EM et al. | Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7679834 |
Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
Nelson PA et al. | Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. | 1993 | J. Immunol. | pmid:7680683 |
Krentz AJ et al. | Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients. | 1993 | Diabetes | pmid:7694879 |
Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
Ning YM and Sánchez ER | Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. | 1993 | J. Biol. Chem. | pmid:7681058 |
Reese JC et al. | The effect of FK506 on canine bile flow. | 1993 | Transplantation | pmid:7504342 |
Woodle ES et al. | FK506--reversal of humorally mediated cardiac allograft rejection in the presence of preformed anti-class I antibody. | 1993 | Transplantation | pmid:7504346 |
Jindal RM et al. | Effect of deoxyspergualin on the endocrine function of the rat pancreas. | 1993 | Transplantation | pmid:7504347 |
Distant DA and Gonwa TA | The kidney in liver transplantation. | 1993 | J. Am. Soc. Nephrol. | pmid:7691205 |
Muthukkumar S et al. | Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. | 1993 | Eur. J. Immunol. | pmid:7691606 |
Wesselborg S et al. | Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes. | 1993 | Eur. J. Immunol. | pmid:7691614 |
Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
Travis J | Making molecular matches in the cell. | 1993 | Science | pmid:7694368 |
Jusko WJ and Kobayashi M | Therapeutic monitoring of tacrolimus (FK 506) | 1993 | Ther Drug Monit | pmid:7694395 |
Kunz J and Hall MN | Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. | 1993 | Trends Biochem. Sci. | pmid:7694398 |
Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
Akamine S et al. | [Effect of FK-506 on bronchial healing of canine lung allografts]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7685803 |
Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
Sykes K et al. | Proline isomerases function during heat shock. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685914 |
Abu-Elmagd K et al. | Recent advances in hepatic transplantation at the University of Pittsburgh. | 1993 | Clin Transpl | pmid:7522528 |
Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
Pleyer U et al. | Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7688360 |
Machida M | [Effect of temperature on plasma concentration of FK506]. | 1993 | Nippon Hinyokika Gakkai Zasshi | pmid:7688443 |
Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
Zenke G et al. | Molecular mechanisms of immunosuppression by cyclosporins. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689806 |
Zuany-Amorim C et al. | Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. | 1993 | Br. J. Pharmacol. | pmid:7694762 |
Meadows RP et al. | Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. | 1993 | Biochemistry | pmid:7678499 |
Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |
Naito M et al. | Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. | 1993 | J. Natl. Cancer Inst. | pmid:7678867 |
Hirasé Y et al. | Transplantation of long-term cryopreserved allocutaneous tissue by skin graft or microsurgical anastomosis: experimental studies in the rat. | 1993 | Plast. Reconstr. Surg. | pmid:7679796 |