Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Carcas-Sansuán AJ | Limited sampling strategies for once daily tacrolimus exposure monitoring. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26939899 |
Vohra S et al. | Clinical and serological efficacy of topical calcineurin inhibitors in oral lichen planus: a prospective randomized controlled trial. | 2016 | Int. J. Dermatol. | pmid:26147635 |
Herz S et al. | Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient. | 2016 | Eur. J. Cancer | pmid:27614165 |
Hazama Y et al. | Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats. | 2016 | Biol. Pharm. Bull. | pmid:26934927 |
Anderson K et al. | A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor. | 2016 | J Dermatolog Treat | pmid:26138407 |
Nakajima A et al. | Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis. | 2016 | Mod Rheumatol | pmid:26934454 |
Iguchi A et al. | Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. | 2016 | Pediatr Transplant | pmid:26526424 |
Pan GH et al. | Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. | 2016 | Oncotarget | pmid:26933811 |
Moes DJ et al. | Response: Limited sampling strategies for once daily tacrolimus exposure monitoring. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26931555 |
Merino D et al. | Different in vitro proliferation and cytokine-production inhibition of memory T-cell subsets after calcineurin and mammalian target of rapamycin inhibitors treatment. | 2016 | Immunology | pmid:26931075 |
Doke T et al. | Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation. | 2016 | Intern. Med. | pmid:26875963 |
Fukuta T et al. | Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity. | 2016 | Sci Rep | pmid:27440054 |
Dugast E et al. | Failure of Calcineurin Inhibitor (Tacrolimus) Weaning Randomized Trial in Long-Term Stable Kidney Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27367750 |
Lim SW et al. | Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. | 2016 | Sci Rep | pmid:27436514 |
Knight SR | Intrapatient variability in tacrolimus exposure - a useful tool for clinical practice? | 2016 | Transpl. Int. | pmid:27283231 |
Shuker N et al. | A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation. | 2016 | Transpl. Int. | pmid:27188932 |
Rodrigues-Diez R et al. | Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling. | 2016 | Sci Rep | pmid:27295076 |
Wen X et al. | Comparison of Utilization and Clinical Outcomes for Belatacept- and Tacrolimus-Based Immunosuppression in Renal Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27137884 |
Arreola-Guerra JM et al. | Tacrolimus Trough Levels as a Risk Factor for Acute Rejection in Renal Transplant Patients. | 2016 | Ann. Transplant. | pmid:26879833 |
Nie F et al. | [Post-transplant kidney from C-III donation after cardiac death of children: a clinicopathologic study of 20 cases]. | 2016 | Zhonghua Bing Li Xue Za Zhi | pmid:26879429 |
Song JL et al. | Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation. | 2016 | World J. Gastroenterol. | pmid:26877618 |
Viesselmann CW et al. | Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection. | 2016 | Pharmacotherapy | pmid:26877191 |
Than NN et al. | Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy. | 2016 | Scand. J. Gastroenterol. | pmid:26458216 |
Dharnidharka VR et al. | Differential risks for adverse outcomes 3 years after kidney transplantation based on initial immunosuppression regimen: a national study. | 2016 | Transpl. Int. | pmid:27564782 |
Wang X et al. | Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model. | 2016 | PLoS ONE | pmid:27537683 |
Rostaing L et al. | Successful Transplantation in ABO- and HLA-Incompatible Living Kidney Transplant Patients: A Report on 12 Cases. | 2016 | Ther Apher Dial | pmid:27073167 |
Malik N et al. | A simple office-based procedure for patients with extensive vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27745651 |
Lee JH et al. | Stability of tacrolimus solutions in polyolefin containers. | 2016 | Am J Health Syst Pharm | pmid:26796907 |
Cruzado JM et al. | Controlled randomized study comparing the cardiovascular profile of everolimus with tacrolimus in renal transplantation. | 2016 | Transpl. Int. | pmid:27648523 |
Torrisi JS et al. | Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity. | 2016 | Sci Rep | pmid:26796537 |
Chatterjee S and Agrawal D | Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. | 2016 | Cornea | pmid:27310883 |
Yan L et al. | Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus. | 2016 | Pharmacogenomics | pmid:26784512 |
Ward I et al. | Digital Pulp Ulcerations and Inverse Gottron Papules in Melanoma Differentiation-Associated Gene 5-Related Dermatomyositis. | 2016 | J Clin Rheumatol | pmid:27464773 |
EriÅŸ E et al. | Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. | 2016 | Eye Contact Lens | pmid:25996419 |
First MR et al. | Use of low-dose tacrolimus and associated hypomagnesemia in the prevention of erectile dysfunction following prostatectomy for prostate cancer. | 2016 | Pharmacol Rep | pmid:27607363 |
Armand P et al. | The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. | 2016 | Br. J. Haematol. | pmid:26729448 |
Hanaoka K et al. | A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy. | 2016 | Transpl. Immunol. | pmid:27545900 |
Matsa E et al. | Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. | 2016 | Cell Stem Cell | pmid:27545504 |
Lee B et al. | Appropriate timing of tacrolimus concentration measurements in the emergency department. | 2016 | Am J Health Syst Pharm | pmid:27543574 |
Thao le Q et al. | Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues. | 2016 | Int J Pharm | pmid:26657273 |
Mokuda S and Oiwa H | Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. | 2016 | Scand. J. Rheumatol. | pmid:26652057 |
Komaki Y et al. | Efficacy and Safety of Tacrolimus Therapy for Active Ulcerative Colitis; A Systematic Review and Meta-analysis. | 2016 | J Crohns Colitis | pmid:26645641 |
Imai Y et al. | Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma. | 2016 | JCI Insight | pmid:27699258 |
Vadcharavivad S et al. | Population pharmacokinetics of tacrolimus in Thai kidney transplant patients: comparison with similar data from other populations. | 2016 | J Clin Pharm Ther | pmid:27191538 |
Elshatory YM et al. | Diagnostic and Therapeutic Challenges. | 2016 | Retina (Philadelphia, Pa.) | pmid:26225484 |
Yu H et al. | Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study. | 2016 | BMC Nephrol | pmid:27473469 |
Thevissen K | How promising are combinatorial drug strategies in combating Candida albicans biofilms? | 2016 | Future Med Chem | pmid:27463947 |
Li X and Sun S | Targeting the fungal calcium-calcineurin signaling network in overcoming drug resistance. | 2016 | Future Med Chem | pmid:27463738 |
Scalea JR et al. | Tacrolimus for the prevention and treatment of rejection of solid organ transplants. | 2016 | Expert Rev Clin Immunol | pmid:26588770 |
Ikeya K et al. | The Ulcerative Colitis Endoscopic Index of Severity More Accurately Reflects Clinical Outcomes and Long-term Prognosis than the Mayo Endoscopic Score. | 2016 | J Crohns Colitis | pmid:26581895 |
Gala-Lopez BL et al. | Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice. | 2016 | Diabetes | pmid:26581595 |
Sakai R et al. | A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey. | 2016 | Int. J. Hematol. | pmid:26800676 |
Milgrom SA et al. | Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports. | 2016 | J Med Case Rep | pmid:27465468 |
Jung H et al. | FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes. | 2016 | Pigment Cell Melanoma Res | pmid:26581186 |
Pouché L et al. | New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs. | 2016 | Pharmacogenomics | pmid:26799749 |
Constantinescu AA et al. | Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. | 2016 | Mol. Cell. Biochem. | pmid:27344165 |
Shao K et al. | Different Effects of Tacrolimus on Innate and Adaptive Immune Cells in the Allograft Transplantation. | 2016 | Scand. J. Immunol. | pmid:26524694 |
Cena T et al. | De novo noncutaneous malignancies after kidney transplantation are associated with an increased risk of graft failure: results from a time-dependent analysis on 672 patients. | 2016 | Transpl. Int. | pmid:27343849 |
Moes DJ et al. | Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26521259 |
Yeo L and Ormerod AD | Oral tacrolimus: a treatment option for recalcitrant erosive lichen planus. | 2016 | Clin. Exp. Dermatol. | pmid:27339859 |
Hashimoto K et al. | Pure red cell aplasia induced by anti-erythropoietin antibodies, well-controlled with tacrolimus. | 2016 | Int. J. Hematol. | pmid:27338269 |
Korobko IV and Lomonosov KM | A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo. | 2016 | Dermatol Ther | pmid:27329330 |
Wu H et al. | Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice. | 2016 | PLoS ONE | pmid:27606422 |
Binkhathlan Z et al. | Reutilization of Tacrolimus Extracted from Expired Prograf® Capsules: Physical, Chemical, and Pharmacological Assessment. | 2016 | AAPS PharmSciTech | pmid:26729529 |
Gardiner KM et al. | Multinational Evaluation of Mycophenolic Acid, Tacrolimus, Cyclosporin, Sirolimus, and Everolimus Utilization. | 2016 | Ann. Transplant. | pmid:26729299 |
Chacon A and Mercer J | Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution. | 2016 | G Ital Dermatol Venereol | pmid:25014586 |
Grześk E et al. | Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells. | 2016 | Pharmacol Rep | pmid:26721374 |
McShane AJ et al. | Therapeutic drug monitoring of immunosuppressants by liquid chromatography-mass spectrometry. | 2016 | Clin. Chim. Acta | pmid:26721314 |
Riegersperger M et al. | The Effect of ABCB1 Polymorphisms on Serial Tacrolimus Concentrations in Stable Austrian Long-Term Kidney Transplant Recipients. | 2016 | Clin. Lab. | pmid:28164520 |
Fernández de Castillo Torras L et al. | Treatment with ulipristal acetate (Esmya(®)) and plasma levels of tacrolimus: a case report. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:27282803 |
Levitsky J et al. | Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses. | 2016 | PLoS ONE | pmid:27275747 |
Schneider L et al. | Study of the Atopic March: Development of Atopic Comorbidities. | 2016 | Pediatr Dermatol | pmid:27273433 |
Kostereva NV et al. | IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation. | 2016 | PLoS ONE | pmid:27272754 |
Ferjani H et al. | The evaluate and compare the effects of the Tacrolimus and Sirolimus on the intestinal system using an intestinal cell culture model. | 2016 | Toxicol. Mech. Methods | pmid:26460985 |
Serrano-Mollar A et al. | Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis. | 2016 | Chest | pmid:27020420 |
Nerattini F et al. | II. Dissociation free energies in drug-receptor systems via nonequilibrium alchemical simulations: application to the FK506-related immunophilin ligands. | 2016 | Phys Chem Chem Phys | pmid:27193181 |
Seok J et al. | Recalcitrant steroid-induced rosacea successfully treated with 0.03% tacrolimus and 595-nm pulsed dye laser. | 2016 | Eur J Dermatol | pmid:27193042 |
Sisti A et al. | Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. | 2016 | An Bras Dermatol | pmid:27192518 |
Ramachandran R et al. | Cyclical cyclophosphamide and steroids is effective in resistant or relapsing nephrotic syndrome due to M-type phospholipase A2 receptor-related membranous nephropathy after tacrolimus therapy. | 2016 | Kidney Int. | pmid:27181781 |
Kim JM et al. | Conversion of once-daily extended-release tacrolimus is safe in stable liver transplant recipients: A randomized prospective study. | 2016 | Liver Transpl. | pmid:26360125 |
Bican Demir A et al. | Two Cases With Developing Neurologic Complications After Liver Transplant. | 2016 | Exp Clin Transplant | pmid:26643318 |
Al-Maawali AK et al. | Modern Treatments and Stem Cell Therapies for Perianal Crohn's Fistulas. | 2016 | Can J Gastroenterol Hepatol | pmid:28053967 |
Rao B et al. | Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. | 2016 | Transplant. Proc. | pmid:27109983 |
Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
Baraldo M | Meltdose Tacrolimus Pharmacokinetics. | 2016 | Transplant. Proc. | pmid:27109969 |
Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
Park OJ et al. | A combination of excimer laser treatment and topical tacrolimus is more effective in treating vitiligo than either therapy alone for the initial 6 months, but not thereafter. | 2016 | Clin. Exp. Dermatol. | pmid:26299799 |
Gomes RM et al. | Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. | 2016 | Expert Rev Clin Pharmacol | pmid:27181131 |
Felix MJ et al. | Time-Dependent and Immunosuppressive Drug-Associated Adverse Event Profiles in De Novo Kidney Transplant Recipients Converted from Tacrolimus to Sirolimus Regimens. | 2016 | Pharmacotherapy | pmid:26799522 |
Kishida N et al. | Increased Incidence of Thrombotic Microangiopathy After ABO-Incompatible Living Donor Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27956735 |
Jimbo H et al. | Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus. | 2016 | Eur J Dermatol | pmid:27033557 |
Shimizu K et al. | Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect. | 2016 | J Drug Target | pmid:27030163 |
Vanhove T et al. | High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients. | 2016 | Am. J. Transplant. | pmid:27013142 |
Kanazawa H et al. | Chemotherapy-induced B-cell depletion in hepatoblastoma patients undergoing ABO-incompatible living donor liver transplantation. | 2016 | Pediatr Transplant | pmid:27012966 |
Shipley CA and Spivakovsky S | Tacrolimus or clobetasol for treatment of oral lichen planus. | 2016 | Evid Based Dent | pmid:27012570 |
Yan Y et al. | Robust Axonal Regeneration in a Mouse Vascularized Composite Allotransplant Model Undergoing Delayed Tissue Rejection. | 2016 | Hand (N Y) | pmid:28149214 |
Ha DH et al. | Potential differentiation ability of gingiva originated human mesenchymal stem cell in the presence of tacrolimus. | 2016 | Sci Rep | pmid:27721434 |
Taşoğlu Ö et al. | Pregabalin: A New Adjunct in Calcineurin Inhibitor Pain Syndrome Treatment. | 2016 | Prog Transplant | pmid:27312682 |
Thomusch O et al. | Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial. | 2016 | Lancet | pmid:27871759 |
Tron C et al. | A high performance liquid chromatography tandem mass spectrometry for the quantification of tacrolimus in human bile in liver transplant recipients. | 2016 | J Chromatogr A | pmid:27837999 |