| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Nakajima K et al. | Effects of triple therapy of cyclosporine, FK 506, and RS-61443 on allogeneic small bowel transplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679821 |
| Ohtsuka S et al. | Hamster-to-rat xenotransplantation of whole pancreas by FK 506 combined with splenectomy. | 1994 | Transplant. Proc. | pmid:7513473 |
| Hu RH et al. | Clinical influencing factors for daily dose, trough level, and relative clearance of tacrolimus in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119894 |
| Tzakis AG et al. | Two-year experience with FK 506 in pediatric patients. | 1993 | Transplant. Proc. | pmid:7679822 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin. | 1994 | Transplant. Proc. | pmid:7513476 |
| Goto T et al. | FK 506: historical perspectives. | 1991 | Transplant. Proc. | pmid:1721254 |
| Ochiai T et al. | Effective and safe use of FK 506: combination treatment with rapamycin or RS-61443 in experimental organ transplantation. | 1991 | Transplant. Proc. | pmid:1721255 |
| Ciancio G et al. | Current advantage of FK 506 in cadaveric kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623207 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Van Buren D et al. | Renal function in primary liver transplant recipients receiving neoral (cyclosporine) versus prograf (tacrolimus). | 1998 | Transplant. Proc. | pmid:9636566 |
| Miyazaki T et al. | Two case reports of successful withdrawal of mycofenolate mofetil after living donor lobar lung transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375323 |
| Jain A et al. | Liver transplantation under tacrolimus in infants, children, adults, and seniors: long-term results, survival, and adverse events in 1000 consecutive patients. | 1998 | Transplant. Proc. | pmid:9636567 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Schenker P et al. | Modified release tacrolimus in de novo immunosuppression after simultaneous pancreas-kidney transplantation--a first single-center experience. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715977 |
| Matevossian E et al. | Liver transplantation in the rat: single-center experience with technique, long-term survival, and functional and histologic findings. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715990 |
| Garcia VD et al. | Corticosteroid reduction with tacrolimus (CORRETA) TRIAL: a prospective Brazilian multicenter, randomized trial of early corticosteroid reduction versus regular corticosteroid dosage maintenance on a tacrolimus (Prograf) and mycophenolate mofetil (Cellcept) immunosuppression regimen in kidney transplant recipients: interim analysis. | 2008 | Transplant. Proc. | pmid:18454988 |
| Nalesnik MA et al. | The effect of FK 506 and CyA on the Lewis rat renal ischemia model. | 1990 | Transplant. Proc. | pmid:1689911 |
| Müller H et al. | Immunosuppression with generic tacrolimus and mycophenolate mofetil in renal transplant recipients: preliminary report in Chile. | 2008 | Transplant. Proc. | pmid:18454992 |
| Hossain MA et al. | Effect of the immunosuppressants FK506 and D-allose on allogenic orthotopic liver transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120048 |
| Mañez R et al. | Association between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation. | 1993 | Transplant. Proc. | pmid:7680170 |
| Sekido H et al. | Successful conversion from cyclosporine to tacrolimus for immunosuppression. | 2000 | Transplant. Proc. | pmid:11120096 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
| Müller MK et al. | Inhibition of insulin release by FK 506 and its prevention by rioprostil, a stable prostaglandin E1 analogue. | 1991 | Transplant. Proc. | pmid:1721286 |
| Friemann S et al. | Conversion to tacrolimus in hyperlipidemic patients. | 1999 | Transplant. Proc. | pmid:10576042 |
| Francavilla A et al. | The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo. | 1991 | Transplant. Proc. | pmid:1721287 |
| Carobbi A et al. | Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. | 1992 | Transplant. Proc. | pmid:1373543 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Souto-RodrÃguez R et al. | Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol. | 2014 | Transplant. Proc. | pmid:25420839 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| Perrella A et al. | Cytomegalovirus infection after liver transplantation: prophylaxis and preemptive treatment--a single-center experience. | 2010 | Transplant. Proc. | pmid:20534267 |
| Alloway R et al. | Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. | 2005 | Transplant. Proc. | pmid:15848559 |
| Peddi VR et al. | Long-term kidney and pancreas function with tacrolimus immunosuppression following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636626 |
| Chen JS et al. | Effect of CYP3A5 genotype on renal allograft recipients treated with tacrolimus. | 2009 | Transplant. Proc. | pmid:19545678 |
| Cabello M et al. | Pharmacokinetics of once- versus twice-daily tacrolimus formulations in kidney transplant patients receiving expanded criteria deceased donor organs: a single-center, randomized study. | 2010 | Transplant. Proc. | pmid:20970603 |
| Woo J et al. | Flow cytometric analysis of lymphocyte populations and activation antigen expression in blood and lymphoid tissues of FK 506-treated rats. | 1990 | Transplant. Proc. | pmid:1697112 |
| Woo J et al. | Effects of FK 506 and low concentration cyclosporine on human lymphocyte activation antigen expression: a flow cytometric analysis. | 1990 | Transplant. Proc. | pmid:1697113 |
| Mueller AR et al. | Association between hepatitis and rejection: upregulation of cytokines and extracellular matrix parameters. | 1997 | Transplant. Proc. | pmid:9365585 |
| Deardon DJ et al. | Small bowel tonometry: a possible technique for detecting early small bowel allograft dysfunction. | 1993 | Transplant. Proc. | pmid:7505502 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Uchida H et al. | Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. | 1999 | Transplant. Proc. | pmid:10578297 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Loss M et al. | Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. | 1995 | Transplant. Proc. | pmid:7533365 |
| Woo J et al. | Effects of FK 506, mycophenolic acid, and bredinin on OKT-3-, PMA-, and alloantigen-induced activation molecule expression on cultured CD4+ and CD8+ human lymphocytes. | 1991 | Transplant. Proc. | pmid:1721319 |
| Tanabe K et al. | Synergistic effect of high-dose mizoribine and low-dose tacrolimus on renal allograft survival in nonhuman primates. | 2002 | Transplant. Proc. | pmid:12176425 |
| Sakai K et al. | The pathologic impact of tacrolimus on protocol biopsy in renal transplant patients with basiliximab-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919455 |
| Loucaidou M et al. | Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919456 |
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| Tashiro H et al. | Monitoring for engraftment of rat orthotopic liver transplantation by semiquantitative PCR. | 1995 | Transplant. Proc. | pmid:7533421 |
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| Felser I et al. | Changes in quality of life following conversion from CyA to FK 506 in orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721350 |
| Alessiani M et al. | CMV infection in liver transplantation under cyclosporine or FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721351 |
| Tanabe K et al. | Outcome of kidney transplantation from non-heart-beating donors followed by tacrolimus immunosuppression in japan. | 2002 | Transplant. Proc. | pmid:12176493 |
| Ramirez CB et al. | Early steroid withdrawal after liver transplantation. | 1998 | Transplant. Proc. | pmid:9838406 |
| Nishi K et al. | The colon displays an absorptive capacity of tacrolimus. | 2004 | Transplant. Proc. | pmid:15050160 |
| Gringeri E et al. | Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival. | 2011 | Transplant. Proc. | pmid:21620084 |
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| Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
| Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
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| Krzyżowska K et al. | No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. | Transplant. Proc. | pmid:30056895 | |
| Moons P et al. | Steroids may compromise quality of life of renal transplant recipients on a tacrolimus-based regimen. | 2002 | Transplant. Proc. | pmid:12176538 |
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| Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
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| Fernando ON et al. | Elective conversion of patients from cyclosporine to tacrolimus for hypertrichosis. | 1998 | Transplant. Proc. | pmid:9636505 |
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