Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zhang Y et al. | Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. | 2000 | J. Biol. Chem. | pmid:10950958 |
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Hashimoto M et al. | Short-course immunosuppression using FK506 for rat tracheal allografts. | 2000 | J Cardiovasc Surg (Torino) | pmid:10952347 |
Morton SJ and Powell RJ | Cyclosporin and tacrolimus: their use in a routine clinical setting for scleroderma. | 2000 | Rheumatology (Oxford) | pmid:10952740 |
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Blomberg B and Järnerot G | Clinical evaluation and management of acute severe colitis. | 2000 | Inflamm. Bowel Dis. | pmid:10961594 |
Mogi M et al. | Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. | 2000 | Neurosci. Lett. | pmid:10961655 |
Taylor DO | Immunosuppressive therapies after heart transplantation: best, better, and beyond. | 2000 | Curr. Opin. Cardiol. | pmid:10963148 |
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Sakamoto Y et al. | Correlation between neurotoxic events and intracerebral concentration of tacrolimus in rats. | 2000 | Biol. Pharm. Bull. | pmid:10963314 |
Teperman L | Case studies in orthotopic liver transplantation for hepatitis B: a panel discussion. | 2000 | Clin Transplant | pmid:10965964 |
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Königsrainer A et al. | Nonocclusive segmental mesenteric ischemia after combined pancreas kidney transplantation: mycophenolate mofetil as an etiological factor? | 2000 | Transplantation | pmid:10972233 |
Sasakawa Y et al. | FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells. | 2000 | Eur. J. Pharmacol. | pmid:10973631 |
Voggenreiter G et al. | Immunosuppression with FK506 increases bone induction in demineralized isogeneic and xenogeneic bone matrix in the rat. | 2000 | J. Bone Miner. Res. | pmid:10977002 |
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Nash RA et al. | Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. | 2000 | Blood | pmid:10979948 |
Zhang W and Victor RG | Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. | 2000 | Am. J. Hypertens. | pmid:10981550 |
Allen C et al. | PCL-b-PEO micelles as a delivery vehicle for FK506: assessment of a functional recovery of crushed peripheral nerve. | 2000 Jul-Sep | Drug Deliv | pmid:10989914 |
Lohmann T et al. | Diabetes mellitus and islet cell specific autoimmunity as adverse effects of immunsuppressive therapy by FK506/tacrolimus. | 2000 | Exp. Clin. Endocrinol. Diabetes | pmid:10989953 |
Kane GC and Lipsky JJ | Drug-grapefruit juice interactions. | 2000 | Mayo Clin. Proc. | pmid:10994829 |
Lote CJ et al. | The hypomagnesaemic action of FK506: urinary excretion of magnesium and calcium and the role of parathyroid hormone. | 2000 | Clin. Sci. | pmid:10995593 |
Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
Madariaga JR et al. | The long-term efficacy of multivisceral transplantation. | 2000 | Transplant. Proc. | pmid:10995918 |
Fishbein T et al. | Isolated intestinal transplantation in adults with nonreconstructible GI tracts. | 2000 | Transplant. Proc. | pmid:10995925 |
Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
Kato Y et al. | Epidermal growth factor enhances the intestinal adaptation of small bowel allografts in the postoperative period. | 2000 | Transplant. Proc. | pmid:10995935 |
Kimura O et al. | Influence of bombesin on the intestinal mucosal immunologic response under immunosuppression. | 2000 | Transplant. Proc. | pmid:10995942 |
Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
Chakrabarti P et al. | Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 2000 | Transplantation | pmid:11003353 |
Inoue T et al. | Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats. | 2000 | Transplantation | pmid:11003356 |
Marchetti P and Navalesi R | The metabolic effects of cyclosporin and tacrolimus. | 2000 Jul-Aug | J. Endocrinol. Invest. | pmid:11005276 |
Tsaroucha AK et al. | Levels of mycophenolic acid and its glucuronide derivative in the plasma of liver, small bowel and kidney transplant patients receiving tacrolimus and cellcept combination therapy. | 2000 | Transpl. Immunol. | pmid:11005321 |
Dambrin C et al. | Pharmacodynamics of immunosuppressive drugs. | 2000 | Curr. Opin. Immunol. | pmid:11007359 |
Pham PT et al. | Cyclosporine and tacrolimus-associated thrombotic microangiopathy. | 2000 | Am. J. Kidney Dis. | pmid:11007689 |
Revelo MP et al. | A 14-year-old boy with kidney allograft failure in the first month after transplantation. | 2000 | Am. J. Kidney Dis. | pmid:11007695 |
Ideura T et al. | Tacrolimus/itraconazole interactions: a case report of ABO-incompatible living-related renal transplantation. | 2000 | Nephrol. Dial. Transplant. | pmid:11007866 |
Springer JE et al. | Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. | 2000 | J. Neurosci. | pmid:11007881 |
Lorf T et al. | The effect of pantoprazole on tacrolimus and cyclosporin A blood concentration in transplant recipients. | 2000 | Eur. J. Clin. Pharmacol. | pmid:11009056 |
Bronster DJ et al. | Tacrolimus-associated mutism after orthotopic liver transplantation. | 2000 | Transplantation | pmid:11014653 |
Kaufman DB et al. | Simultaneous pancreas-kidney transplantation in the mycophenolate mofetil/tacrolimus era: evolution from induction therapy with bladder drainage to noninduction therapy with enteric drainage. | 2000 | Surgery | pmid:11015108 |
Miyake K et al. | [Tacrolimus administration to a patient with cyclosporine-induced encephalopathy after allogeneic bone marrow transplantation]. | 2000 | Rinsho Ketsueki | pmid:11020982 |
Hayashi T and Miyamori I | [Cyclosporine- and tacrolimus-induced hypertension]. | 2000 | Nippon Rinsho | pmid:11028414 |
Matsuura M et al. | Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats. | 2000 | Inflamm. Res. | pmid:11028757 |
Marsen TA et al. | Differential transcriptional regulation of endothelin-1 by immunosuppressants FK506 and cyclosporin A. | 2000 Jul-Aug | Fundam Clin Pharmacol | pmid:11030448 |
Toma H | [Neurologic disorders in renal transplantation]. | 2000 | Ryoikibetsu Shokogun Shirizu | pmid:11031921 |
Davis DL and Soldin SJ | Identification of ubiquitin as an immunophilin. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11032725 |
Taylor PJ et al. | Simultaneous quantification of tacrolimus and sirolimus, in human blood, by high-performance liquid chromatography-tandem mass spectrometry. | 2000 | Ther Drug Monit | pmid:11034268 |
van Gelder T et al. | Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 2000 | Ther Drug Monit | pmid:11034275 |
Mayer JM et al. | Single doses of FK506 and OKT3 reduce severity in early experimental acute pancreatitis. | 2000 | Eur J Surg | pmid:11034471 |
Shimoyama M et al. | Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. | 2000 | Circulation | pmid:11034951 |
Shiraishi S et al. | Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and rapamycin in bovine adrenal chromaffin cells. | 2000 | Neurosci. Lett. | pmid:11036198 |
Shapiro R et al. | Simultaneous pancreas-kidney transplantation at the University of Pittsburgh. | 1999 | Clin Transpl | pmid:11038640 |
Cronin DC et al. | Liver transplantation at the University of Chicago. | 1999 | Clin Transpl | pmid:11038642 |
Nakahama H et al. | Co-administration of furosemide augments tacrolimus-induced impairment in kidney function in rats. | 2000 | Ren Fail | pmid:11041285 |
Przepiorka D et al. | Tacrolimus clearance is age-dependent within the pediatric population. | 2000 | Bone Marrow Transplant. | pmid:11041564 |
Kantrow SP et al. | Regulation of tumor necrosis factor cytotoxicity by calcineurin. | 2000 | FEBS Lett. | pmid:11042265 |
Yano M et al. | Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. | 2000 | Circulation | pmid:11044432 |
Miyazawa N et al. | Protective effect of FK506 in the reperfusion model after short-term occlusion of middle cerebral artery in the rat: assessment by autoradiography using [125I]PK-11195. | 2000 | Neurol. Res. | pmid:11045029 |
Jiang H et al. | Distinct patterns of cytokine gene suppression by the equivalent effective doses of cyclosporine and tacrolimus in rat heart allografts. | 2000 | Immunobiology | pmid:11045663 |
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Bechstein WO | Neurotoxicity of calcineurin inhibitors: impact and clinical management. | 2000 | Transpl. Int. | pmid:11052266 |
Weimer R et al. | Switch from cyclosporine A to tacrolimus in renal transplant recipients: impact on Th1, Th2, and monokine responses. | 2000 | Hum. Immunol. | pmid:11053632 |
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Shitamukai A et al. | A positive screening for drugs that specifically inhibit the Ca2+-signaling activity on the basis of the growth promoting effect on a yeast mutant with a peculiar phenotype. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055400 |
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Sakata Y et al. | Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats. | 2000 | Circulation | pmid:11056104 |
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Paul C et al. | Ascomycins: promising agents for the treatment of inflammatory skin diseases. | 2000 | Expert Opin Investig Drugs | pmid:11060661 |
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Kuinose M et al. | Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions. | 2000 | Acta Med. Okayama | pmid:11061569 |
Bandyopadhyay A et al. | Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart. | 2000 | Biochem. J. | pmid:11062058 |
Mack-Shipman LR et al. | Reproductive hormones after pancreas transplantation. | 2000 | Transplantation | pmid:11063337 |
Chisholm MA et al. | Renal transplant patient compliance with free immunosuppressive medications. | 2000 | Transplantation | pmid:11063348 |
Dominguez J et al. | Conversion to rapamycin immunosuppression in renal transplant recipients: report of an initial experience. | 2000 | Transplantation | pmid:11063349 |
Hernández G et al. | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. | 2000 | J. Periodontol. | pmid:11063397 |
Abramowicz D et al. | Immunosuppressive strategies in renal transplantation at the beginning of the third millennium. | 2000 | Adv. Nephrol. Necker Hosp. | pmid:11068631 |
Bova D et al. | Delayed transient neurologic toxicity due to tacrolimus: CT and MRI. | 2000 | Neuroradiology | pmid:11071440 |
Miyamoto S et al. | Signal transduction pathways that contribute to increased protein synthesis during T-cell activation. | 2000 | Biochim. Biophys. Acta | pmid:11072066 |
Dale S and Shaw J | Clinical picture. Eosinophilic pustular folliculitis. | 2000 | Lancet | pmid:11072943 |
Shimizu K et al. | Tacrolimus (FK506) treatment of CD34+ hematopoietic progenitor cells promote the development of dendritic cells that drive CD4+ T cells toward Th2 responses. | 2000 | J. Leukoc. Biol. | pmid:11073101 |
Griffith EC et al. | Yeast three-hybrid system for detecting ligand-receptor interactions. | 2000 | Meth. Enzymol. | pmid:11075340 |
Soncin F et al. | Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. | 2000 | Int. J. Mol. Med. | pmid:11078832 |
Guo WH et al. | Recipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection. | 2000 | J. Pediatr. Surg. | pmid:11083432 |
Bathgate AJ et al. | Pretransplantation tumor necrosis factor-alpha production predicts acute rejection after liver transplantation. | 2000 | Liver Transpl. | pmid:11084058 |
Chang GJ et al. | Experience with the use of sirolimus in liver transplantation--use in patients for whom calcineurin inhibitors are contraindicated. | 2000 | Liver Transpl. | pmid:11084060 |