tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mazariegos GV et al. | Weaning of immunosuppression in liver transplant recipients. | 1997 | Transplantation | pmid:9020325 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal allograft rejection--five-year experience. | 1997 | Transplantation | pmid:9020321 |
| Villalba L and Adams EM | Update on therapy for refractory dermatomyositis and polymyositis. | 1996 | Curr Opin Rheumatol | pmid:9018458 |
| Sano Y et al. | Effect of a single injection of high-dose FK506 on lung transplantation in rats. | 1996 | Surg. Today | pmid:9017963 |
| Richardson D et al. | The successful conversion to Tacrolimus (FK506) of a renal transplant recipient with cyclosporin-induced haemolytic-uraemic syndrome. | 1996 | Nephrol. Dial. Transplant. | pmid:9017633 |
| Ishizuka T et al. | Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016789 |
| Noguchi N et al. | Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. | 1997 | J. Biol. Chem. | pmid:9013543 |
| DeCenzo MT et al. | FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes. | 1996 | Protein Eng. | pmid:9005438 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Becker G et al. | Rescue therapy with tacrolimus in simultaneous pancreas/kidney transplantation. | 1997 | Transpl. Int. | pmid:9002152 |
| Felldin M et al. | Rescue therapy with tacrolimus (FK 506) in renal transplant recipients--a Scandinavian multicenter analysis. | 1997 | Transpl. Int. | pmid:9002146 |
| Pirenne J et al. | Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model. | 1997 | Surgery | pmid:9001555 |
| Nair SC et al. | Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. | 1997 | Mol. Cell. Biol. | pmid:9001212 |
| Kelly PA et al. | Ciprofloxacin does not block the antiproliferative effect of tacrolimus. | 1997 | Transplantation | pmid:9000686 |
| Ericzon BG et al. | Secretion and composition of bile after human liver transplantation: studies on the effects of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9000664 |
| Rambusch EG and Manns MP | [Therapy of autoimmune hepatitis]. | 1996 | Dtsch. Med. Wochenschr. | pmid:8998922 |
| Przepiorka D et al. | Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus. | 1996 | Transplantation | pmid:8990368 |
| Shapiro R et al. | Tacrolimus in pediatric renal transplantation. | 1996 | Transplantation | pmid:8990356 |
| pmid:8986461 | ||||
| Yoshikai Y et al. | Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. | 1997 | J. Virol. | pmid:8985410 |
| High KP and Washburn RG | Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). | 1997 | J. Infect. Dis. | pmid:8985226 |
| Sempuku T et al. | Osteogenic potential of allogeneic rat marrow cells in porous hydroxyapatite ceramics: a histological study. | 1996 | J. Orthop. Res. | pmid:8982133 |
| Redmon JB et al. | Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. | 1996 | J. Clin. Invest. | pmid:8981925 |
| Nichterlein T et al. | Effects of FK-506 on the course of murine salmonellosis. | 1996 | J Chemother | pmid:8981186 |
| Odom A et al. | The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. | 1997 | Antimicrob. Agents Chemother. | pmid:8980772 |
| Blecher O et al. | A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression. | 1996 | Plant Mol. Biol. | pmid:8980498 |
| James DG | A new immunosuppressant: tacrolimus. | 1996 | Postgrad Med J | pmid:8977938 |
| Morris RE | Transplantation. Beware: shifting paradigms ahead. | 1996 Dec 21-28 | Lancet | pmid:8973504 |
| Corey HE et al. | Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy. | 1996 | Pediatr. Nephrol. | pmid:8971888 |
| Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
| Taler SJ et al. | Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. | 1996 | Transplantation | pmid:8970613 |
| Hedayat S et al. | Relationship of whole-blood FK506 concentrations to rejection and toxicity in liver and kidney transplants. | 1996 | J Biopharm Stat | pmid:8969977 |
| Sharkey J et al. | Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. | 1996 | Stroke | pmid:8969794 |
| Guérette B et al. | Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506. | 1996 | Muscle Nerve | pmid:8965835 |
| Teraoka S et al. | [Present status and problems in clinical application of tacrolimus(FK506)]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963787 |
| Kawasaki M et al. | [Immunosuppression and the problems in partial liver transplantation]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963785 |
| Jonas S et al. | Posttransplant malignancy and newer immunosuppressive protocols after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962257 |
| Mueller AR et al. | Long-term follow-up in hepatitis C patients with respect to immunosuppression. | 1996 | Transplant. Proc. | pmid:8962255 |
| Yokoyama I et al. | Decreased Fas antigen expression of cultured hepatocytes with FK 506. | 1996 | Transplant. Proc. | pmid:8962237 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Platz KP et al. | Incidence and outcome of chronic rejection in CyA- and FK 506-treated patients. | 1996 | Transplant. Proc. | pmid:8962235 |
| Golling M et al. | Tacrolimus reduction improves glucose metabolism and insulin secretion after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962234 |
| Yussim A et al. | Conversion from cyclosporine to tacrolimus in hepatic and renal transplantation. | 1996 | Transplant. Proc. | pmid:8962233 |
| Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
| Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
| Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
| Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
| Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| Williams R et al. | Two-year data from the European multicentre tacrolimus (FK506) liver study. | 1996 | Transpl. Int. | pmid:8959812 |
| Chambraud B et al. | FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. | 1996 | J. Biol. Chem. | pmid:8955134 |
| Ueda S et al. | In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices. | 1996 | J Pharm Biomed Anal | pmid:8951695 |
| Benelli U et al. | FK-506 delays corneal graft rejection in a model of corneal xenotransplantation. | 1996 | J Ocul Pharmacol Ther | pmid:8951679 |
| Iwata M et al. | Regulation of T cell apoptosis via T cell receptors and steroid receptors. | 1996 | Stem Cells | pmid:8948021 |
| Brunet M et al. | Comparative analysis of tacrolimus (FK506) in whole blood liver transplant recipients by PRO-TRAC enzyme-linked immunosorbent assay and microparticle enzyme immunoassay IMX methods. | 1996 | Ther Drug Monit | pmid:8946669 |
| MacFarlane G et al. | A simplified whole blood enzyme-linked immunosorbent assay (ProTrac II) for tacrolimus (FK506) using proteolytic extraction in place of organic solvents. | 1996 | Ther Drug Monit | pmid:8946668 |
| Winkler M et al. | Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. | 1996 | Ther Drug Monit | pmid:8946659 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation. | 1996 | Blood | pmid:8943876 |
| Adachi M et al. | Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. | 1996 | Blood | pmid:8943845 |
| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Poon M et al. | Rapamycin inhibits vascular smooth muscle cell migration. | 1996 | J. Clin. Invest. | pmid:8941644 |
| Freiberg RA et al. | Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. | 1996 | J. Biol. Chem. | pmid:8940187 |
| Cai W et al. | Transcription-modulating drugs: mechanism and selectivity. | 1996 | Curr. Opin. Biotechnol. | pmid:8939643 |
| Ide T et al. | An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil. | 1996 | Neurosci. Lett. | pmid:8938254 |
| Budde K et al. | Clinical pharmacokinetics of tacrolimus in rescue therapy after renal transplantation. | 1996 | Int J Clin Pharmacol Ther | pmid:8937932 |
| Andrews PA et al. | Racial variation in dosage requirements of tacrolimus. | 1996 | Lancet | pmid:8937292 |
| Soin AS and Jamieson NV | Lessons learnt from the multicentre randomized trials of tacrolimus in liver transplantation. | 1996 Sep-Oct | Natl Med J India | pmid:8937063 |
| Galat A | A large-scale processing of kinetic data files with derivation of the inhibitory constant Ki: an application to proline isomerases. | 1996 | Comput. Chem. | pmid:8936426 |
| Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
| Shuker SB et al. | Discovering high-affinity ligands for proteins: SAR by NMR. | 1996 | Science | pmid:8929414 |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Cumming DV et al. | Pharmacological preconditioning of primary rat cardiac myocytes by FK506. | 1996 Sep-Oct | Basic Res. Cardiol. | pmid:8922254 |
| Licitra EJ and Liu JO | A three-hybrid system for detecting small ligand-protein receptor interactions. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8917502 |
| Wang X et al. | Rapamycin inhibits aldolase A expression during human lymphocyte activation. | 1996 | J. Cell. Biochem. | pmid:8913875 |
| Yagita Y et al. | Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. | 1996 | Life Sci. | pmid:8913329 |
| Weigao C | [Limb allograft in rats: studies on optimal maintenance dose of FK506 and development of graft-versus-host-disease (GVHD)]. | 1996 | Fukuoka Igaku Zasshi | pmid:8913057 |
| Bell A et al. | The antiparasite effects of cyclosporin A: possible drug targets and clinical applications. | 1996 | Gen. Pharmacol. | pmid:8909976 |
| Rozen TD et al. | Treatment-refractory cyclosporine-associated headache: relief with conversion to FK-506. | 1996 | Neurology | pmid:8909459 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Reggiani P et al. | Oral administration of FK 506 in a swine model of liver-small bowel allotransplantation. | 1996 | Transplant. Proc. | pmid:8907965 |
| Cicalese L et al. | Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. | 1996 | Transplant. Proc. | pmid:8907959 |
| Costa A et al. | Stimulatory effect of FK506 and erythromycin on pig intestinal motility. | 1996 | Transplant. Proc. | pmid:8907957 |