tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morris RE | In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. | 1991 | Transplant. Proc. | pmid:1721257 |
| Kobayashi M et al. | FK 506 assay past and present--characteristics of FK 506 ELISA. | 1991 | Transplant. Proc. | pmid:1721258 |
| Warty VS et al. | Practical aspects of FK 506 analysis (Pittsburgh experience). | 1991 | Transplant. Proc. | pmid:1721259 |
| McCauley J et al. | Cyclosporine and FK 506 induced inhibition of renal epithelial cell proliferation. | 1991 | Transplant. Proc. | pmid:1721290 |
| McLachlan G et al. | Growth inhibition of the MOLT-4 human T-leukemia cell line. A comparison of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721291 |
| Takaori K et al. | Effects of FK 506 on in vivo immunity in comparison to cyclosporine. | 1991 | Transplant. Proc. | pmid:1721322 |
| Jordan ML et al. | Inhibition of T-cell function by FK 506 and cyclosporine is not accompanied by alterations in intracellular calcium. | 1991 | Transplant. Proc. | pmid:1721323 |
| Paul AA et al. | CMV retinitis and the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721354 |
| Keicho N et al. | Effects of an immunosuppressant, FK506, on interleukin 1 alpha production by human macrophages and a macrophage-like cell line, U937. | 1991 | Cell. Immunol. | pmid:1703047 |
| Reyes J et al. | Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721355 |
| White DJ | FK506: the promise and the paradox. | 1991 | Clin. Exp. Immunol. | pmid:1703053 |
| McCauley J et al. | Renal function after conversion from cyclosporine to FK 506 in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721387 |
| Hossein-Nia M et al. | Urinary proteins as a marker of drug-induced renal damage following treatment with cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721388 |
| Tzakis AG et al. | FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721416 |
| Masaoka T et al. | Phase II study of FK 506 for allogeneic bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721417 |
| Markus PM et al. | The effect of cyclosporine, rapamycin and FK 506 the survival following allogeneic bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721418 |
| Lim SM and White DJ | The pharmacology of immunosuppression. | 1991 | Ann. Acad. Med. Singap. | pmid:1709344 |
| Rosen MK et al. | Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. | 1991 | Biochemistry | pmid:1709363 |
| Sakr MF et al. | FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats. | 1991 | Hepatology | pmid:1709412 |
| Abu-Elmagd K et al. | FK 506: a new therapeutic agent for severe recalcitrant psoriasis. | 1991 | Transplant. Proc. | pmid:1721449 |
| Nikolaidis NL et al. | Metabolic effects of FK 506 in patients with severe psoriasis: short-term follow-up of seven cases. | 1991 | Transplant. Proc. | pmid:1721450 |
| Lodish HF and Kong N | Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum. | 1991 | J. Biol. Chem. | pmid:1714445 |
| Ellis D et al. | Phospholipase-C and Na-K ATPase activation by cyclosporine and FK506 in LLC-PK1, cells. Possible implications in blood pressure regulation. | 1991 | Transplantation | pmid:1714643 |
| Jiang H et al. | Effect of FK-506 on heart allograft survival in the highly sensitized recipient rats as compared with ciclosporin and 15-deoxyspergualin. | 1991 | Eur Surg Res | pmid:1723683 |
| Pezze JL and Whiteman K | Transplantation's newest weapon FK 506. | 1991 | Am J Nurs | pmid:1716857 |
| Fung JJ et al. | Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls. | 1991 | Transplant. Proc. | pmid:1703682 |
| Marquis-Omer D et al. | Stabilization of the FK506 binding protein by ligand binding. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1716886 |
| Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
| Bishop DK and Li W | Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo. | 1992 | J. Immunol. | pmid:1371128 |
| Hatfield SM and Roehm NW | Cyclosporine and FK506 inhibition of murine mast cell cytokine production. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1371158 |
| Takaya S et al. | The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. | 1992 | Transplantation | pmid:1371195 |
| Francavilla A et al. | Inhibition of liver, kidney, and intestine regeneration by rapamycin. | 1992 | Transplantation | pmid:1371198 |
| Liu J et al. | Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. | 1992 | Biochemistry | pmid:1373650 |
| Adachi A et al. | Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: change of T cell subsets. | 1992 | Intern. Med. | pmid:1373661 |
| Fruman DA et al. | Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1373887 |
| Yasunami Y et al. | Induction of donor-specific unresponsiveness in rat islet allografts by FK 506. | 1992 | Transplant. Proc. | pmid:1376510 |
| Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
| Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
| Barry JM | Immunosuppressive drugs in renal transplantation. A review of the regimens. | 1992 | Drugs | pmid:1281071 |
| Stiff DD et al. | Metabolism of FK 506 in differentially induced rat liver microsomes. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1281332 |
| Foor F et al. | Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. | 1992 | Nature | pmid:1281518 |
| Takai K et al. | Effects of FK506 on rat thymic epithelial cells; immunohistochemical study. | 1992 | Thymus | pmid:1378235 |
| Dutz JP et al. | Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes. | 1992 | Int. Immunol. | pmid:1378297 |
| Kenmochi T et al. | [The effect of FK506 on segmental pancreas allograft in mongrel dogs]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1378526 |
| Nielsen JB et al. | Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380159 |
| Calvo V et al. | Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380162 |
| Price DJ et al. | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. | 1992 | Science | pmid:1380182 |
| Hendey B et al. | Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. | 1992 | Science | pmid:1384129 |
| Roberti I et al. | Evidence that the systematic analysis of bile cytology permits monitoring of hepatic allograft rejection. | 1992 | Transplantation | pmid:1384182 |
| Langrehr JM et al. | Evidence that indefinite survival of small bowel allografts achieved by a brief course of cyclosporine or FK506 is not due to systemic hyporesponsiveness. | 1992 | Transplantation | pmid:1384185 |