Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
Friemann S et al. | Conversion to tacrolimus in hyperlipidemic patients. | 1999 | Transplant. Proc. | pmid:10576042 |
Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
Jordan ML et al. | Tacrolimus-based immunosuppression in pediatric renal transplantation. | 1999 | Transplant. Proc. | pmid:10576039 |
Mayer AD | Four-year follow-up of the European Tacrolimus Multicenter Renal Study. | 1999 | Transplant. Proc. | pmid:10576038 |
Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
Zhang Y et al. | Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites. | 1999 | J. Biol. Chem. | pmid:10574930 |
Rao SK et al. | Limbal allografting using FK-506. | 1999 | Br J Ophthalmol | pmid:10574824 |
Young AL et al. | Allo-limbal transplantation in patients with limbal stem cell deficiency. | 1999 | Br J Ophthalmol | pmid:10574823 |
Burke GW et al. | Microangiopathy in kidney and simultaneous pancreas/kidney recipients treated with tacrolimus: evidence of endothelin and cytokine involvement. | 1999 | Transplantation | pmid:10573073 |
Shiratori T et al. | [Immunosuppressive treatment of ulcerative colitis]. | 1999 | Nippon Rinsho | pmid:10572417 |
Fujiki M et al. | Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10572064 |
Asai A et al. | High level calcineurin activity predisposes neuronal cells to apoptosis. | 1999 | J. Biol. Chem. | pmid:10567426 |
Shaw LM et al. | Current opinions on therapeutic drug monitoring of immunosuppressive drugs. | 1999 | Clin Ther | pmid:10566561 |
Fansa H et al. | [Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK 506]. | 1999 | Handchir Mikrochir Plast Chir | pmid:10566134 |
Müschen A et al. | Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. | 1999 | Inflamm. Res. | pmid:10563471 |
Myers JN et al. | Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome. | 1999 | J. Heart Lung Transplant. | pmid:10561115 |
Gremillion RB et al. | Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: initial experience in 12 patients. | 1999 | J. Rheumatol. | pmid:10555886 |
Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
Mizuta K et al. | Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. | 1999 | Transpl. Int. | pmid:10551996 |