tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson MC et al. | QT prolongation and Torsades de Pointes after administration of FK506. | 1992 | Transplantation | pmid:1373538 |
| Tai PK et al. | Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. | 1992 | Science | pmid:1376003 |
| Mor E et al. | Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. | 1992 | Transplantation | pmid:1279849 |
| Natazuka T | FK506 reverses adriamycin resistance in a multidrug-resistant human leukemia cell line. | 1992 | Kobe J Med Sci | pmid:1284834 |
| Iwasaki K et al. | Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin. | 1992 | Arzneimittelforschung | pmid:1379812 |
| Christians U et al. | Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. | 1992 | Clin. Chem. | pmid:1382896 |
| Mizuno K et al. | Modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, FK506 and mizoribine. | 1992 Jan-Feb | Anticancer Res. | pmid:1373592 |
| Arai S et al. | The impact of FK506 on graft coronary disease of rat cardiac allograft--a comparison with cyclosporine. | 1992 Jul-Aug | J. Heart Lung Transplant. | pmid:1379829 |
| Fagiuoli S et al. | FK 506: a new immunosuppressive agent for organ transplantation. Pharmacology, mechanism of action and clinical applications. | 1992 Jul-Aug | Ital J Gastroenterol | pmid:1381245 |
| Tong J et al. | Effect of FK-506 and cyclosporin A on in vitro CFU-GM growth in severe aplastic anemia patients. | 1992 Jul-Aug | Haematologica | pmid:1385279 |
| Nazer H et al. | FK 506 associated disorders in liver transplantation. | 1992 May-Jun | J. Gastroenterol. Hepatol. | pmid:1377038 |
| Bowman H and Lennard TW | Immunosuppressive drugs. | 1992 Nov 4-17 | Br J Hosp Med | pmid:1282440 |
| Sattler M et al. | Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. | 1992 Sep-Oct | Drug Metab. Dispos. | pmid:1385058 |
| Nakajima K et al. | Effects of triple therapy of cyclosporine, FK 506, and RS-61443 on allogeneic small bowel transplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679821 |
| Tzakis AG et al. | Two-year experience with FK 506 in pediatric patients. | 1993 | Transplant. Proc. | pmid:7679822 |
| Gibbs JF et al. | Outcome analysis of FK 506 therapy for acute and chronic rejection. | 1993 | Transplant. Proc. | pmid:7679823 |
| Mañez R et al. | Association between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation. | 1993 | Transplant. Proc. | pmid:7680170 |
| McCauley J | The nephrotoxicity of FK506 as compared with cyclosporine. | 1993 | Curr. Opin. Nephrol. Hypertens. | pmid:7532089 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Krentz AJ et al. | Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients. | 1993 | Diabetes | pmid:7694879 |
| Reese JC et al. | The effect of FK506 on canine bile flow. | 1993 | Transplantation | pmid:7504342 |
| Woodle ES et al. | FK506--reversal of humorally mediated cardiac allograft rejection in the presence of preformed anti-class I antibody. | 1993 | Transplantation | pmid:7504346 |
| Jindal RM et al. | Effect of deoxyspergualin on the endocrine function of the rat pancreas. | 1993 | Transplantation | pmid:7504347 |
| Woodle ES et al. | Recurrent rejection following FK 506 rescue therapy for acute hepatic allograft rejection. | 1993 | Transplant. Proc. | pmid:7682358 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Meiser BM et al. | Simvastatin decreases accelerated graft vessel disease after heart transplantation in an animal model. | 1993 | Transplant. Proc. | pmid:7682363 |
| Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
| Quesniaux VF | Immunosuppressants: tools to investigate the physiological role of cytokines. | 1993 | Bioessays | pmid:7507316 |
| Schmitt J et al. | Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. | 1993 | Gene | pmid:7693550 |
| Shafiee A et al. | Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins). | 1993 | J. Antibiot. | pmid:7693638 |
| Keicho N et al. | Antilymphocytic activity of erythromycin distinct from that of FK506 or cyclosporin A. | 1993 | J. Antibiot. | pmid:7693639 |
| Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
| Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
| Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
| Wallemacq PE et al. | Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours. | 1993 | Clin. Chem. | pmid:7684956 |
| Mochizuki M et al. | A clinical trial of FK506 in refractory uveitis. | 1993 | Am. J. Ophthalmol. | pmid:7685147 |
| Renoir JM et al. | Immunological identification of a 50 kDa Mr FK506-binding immunophilin as a component of the non-DNA binding, hsp90 and hsp70 containing, heterooligomeric form of the chick oviduct progesterone receptor. | 1993 | C. R. Acad. Sci. III, Sci. Vie | pmid:7522118 |
| Nishizawa S et al. | Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. | 1993 | Neurosurgery | pmid:7687044 |
| Warty V et al. | FK506 measurement: comparison of different analytical methods. | 1993 | Ther Drug Monit | pmid:7687389 |
| Iwata H et al. | Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506. | 1993 | Transplantation | pmid:7687396 |
| Roelen DL et al. | Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506. | 1993 | Transplantation | pmid:7687397 |
| Jost U et al. | FK 506 treatment of intractable rejection after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689276 |
| Winkler M et al. | Plasma level-guided low-dose FK 506 therapy in patients with early liver dysfunction after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689277 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| Zuany-Amorim C et al. | Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. | 1993 | Br. J. Pharmacol. | pmid:7694762 |
| Lee KK et al. | Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. | 1993 | Am. J. Surg. | pmid:7678188 |
| Galvin F et al. | Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen. | 1993 | Eur. J. Immunol. | pmid:7678228 |
| Hirasé Y et al. | Transplantation of long-term cryopreserved allocutaneous tissue by skin graft or microsurgical anastomosis: experimental studies in the rat. | 1993 | Plast. Reconstr. Surg. | pmid:7679796 |