tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Persić-Vojinović S et al. | Disseminated Hailey-Hailey disease treated with topical tacrolimus and oral erythromycin: Case report and review of the literature. | 2006 | Acta Dermatovenerol Croat | pmid:17311740 |
| Louvain D et al. | Lichen sclerosus in the oral mucosa: a rare form of presentation. | 2012 | Acta Dermatovenerol Croat | pmid:22507475 |
| Lipozencić J | Pimecrolimus--a safe and effective local immunomodulator in the treatment of inflammatory skin diseases. | 2005 | Acta Dermatovenerol Croat | pmid:15788149 |
| Pustisek N et al. | Tacrolimus ointment: a new therapy for atopic dermatitis--review of the literature. | 2002 | Acta Dermatovenerol Croat | pmid:12137728 |
| Polastri L et al. | Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells. | 2002 | Acta Diabetol | pmid:12486498 |
| Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
| Pirenne J | Contribution of large animal models to the development of clinical intestinal transplantation. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427786 |
| Jamieson NV | Adult small intestinal transplantation in Europe. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427790 |
| Bonaccorsi-Riani E et al. | Impact of steroid-avoidance immunosuppression on long-term outcome after liver transplantation for HCV cirrhosis: the need for well documented long-term follow-up. | 2012 | Acta Gastroenterol. Belg. | pmid:23402084 |
| Reding R et al. | Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational tolerance. | 2005 Jul-Sep | Acta Gastroenterol. Belg. | pmid:16268418 |
| Varela E | [Small bowel transplantation]. | 1995 | Acta Gastroenterol. Latinoam. | pmid:7544939 |
| Okada M et al. | Successful treatment of chronic graft-versus-host disease with sulfasalazine in allogeneic bone marrow transplantation. | 1999 | Acta Haematol. | pmid:10529517 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Mesar I et al. | [Outcome of renal transplantation after tacrolimus switch to cyclosporine]. | 2011 | Acta Med Croatica | pmid:22359902 |
| Wardhana EA and Datau | A patient with plaque type morphea mimicking systemic lupus erythematosus. | 2015 | Acta Med Indones | pmid:26260557 |
| Kuinose M et al. | Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions. | 2000 | Acta Med. Okayama | pmid:11061569 |
| Takagi K et al. | Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation. | 2017 | Acta Med. Okayama | pmid:28238015 |
| Tanaka K et al. | Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. | 2000 | Acta Med. Okayama | pmid:11132921 |
| Setkowicz Z and Guzik R | Injections of vehicle, but not cyclosporin A or tacrolimus (FK506), afford neuroprotection following injury in the developing rat brain. | 2007 | Acta Neurobiol Exp (Wars) | pmid:18320718 |
| Luchowska E et al. | FK506 attenuates 1-methyl-4-phenylpyridinium- and 3-nitropropionic acid-evoked inhibition of kynurenic acid synthesis in rat cortical slices. | 2003 | Acta Neurobiol Exp (Wars) | pmid:12926536 |
| Yildirim FB et al. | Effect of FK506 administration after obturator nerve injury: a functional and ultrastructural study. | 2008 | Acta Neurobiol Exp (Wars) | pmid:19112470 |
| Ishikawa Y et al. | Search for novel gene markers of traumatic brain injury by time differential microarray analysis. | 2006 | Acta Neurochir. Suppl. | pmid:16671447 |
| Uchino H et al. | Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage. | 2003 | Acta Neurochir. Suppl. | pmid:14753416 |
| Katsura KI et al. | FK506 attenuates the post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors. | 2003 | Acta Neurochir. Suppl. | pmid:14753417 |
| Mitsui T et al. | The effects of FK506 on refractory inflammatory myopathies. | 2011 | Acta Neurol Belg | pmid:22141281 |
| Ogul H et al. | Severe toxic leukoencephalopathy associated with tacrolimus after living donor liver transplantation. | 2015 | Acta Neurol Belg | pmid:24854146 |
| Miura S et al. | Combined treatment with prednisolone and tacrolimus for myasthenia gravis with invasive thymoma. | 2010 | Acta Neurol Belg | pmid:20514937 |
| DÃaz-GarcÃa C et al. | First report on fertility after allogeneic uterus transplantation. | 2010 | Acta Obstet Gynecol Scand | pmid:20879912 |
| Kortekangas-Savolainen O and Kiilholma P | Treatment of vulvovaginal erosive and stenosing lichen planus by surgical dilatation and methotrexate. | 2007 | Acta Obstet Gynecol Scand | pmid:17364310 |
| Jongen VH et al. | Vaginal delivery after lung transplantation. | 2000 | Acta Obstet Gynecol Scand | pmid:11130101 |
| Helgesen AL et al. | Vaginal involvement in genital erosive lichen planus. | 2010 | Acta Obstet Gynecol Scand | pmid:20583940 |
| Hellström VC et al. | Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study. | 2016 | Acta Oncol | pmid:26824275 |
| Remitz A et al. | Tacrolimus ointment in atopic blepharoconjunctivitis does not seem to elevate intraocular pressure. | 2011 | Acta Ophthalmol | pmid:20064110 |
| Virtanen HM et al. | Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective study. | 2006 | Acta Ophthalmol Scand | pmid:16965503 |
| Shibatani M et al. | Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head. | 2008 | Acta Orthop | pmid:18839369 |
| Fukunaga T et al. | Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Rabbit-rat experiments. | 1995 | Acta Orthop Scand | pmid:8553828 |
| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Ikebe S et al. | Immunosuppressive effect of tacrolimus (FK-506). Bone xenografts in rabbits. | 1996 | Acta Orthop Scand | pmid:8792745 |
| Bas E et al. | An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss. | 2009 | Acta Otolaryngol. | pmid:19051071 |
| Azuma H et al. | Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. | 1997 | Acta Paediatr Jpn | pmid:9141259 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Bienemann K et al. | Topical tacrolimus is effective against eczema in Wiskott-Aldrich syndrome (WAS). | 2007 | Acta Paediatr. | pmid:17429928 |
| Sinha R and Marks SD | Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. | 2013 | Acta Paediatr. | pmid:23573873 |
| Isidor B et al. | Hyperzincemia and hypercalprotectinemia: unsuccessful treatment with tacrolimus. | 2009 | Acta Paediatr. | pmid:18983438 |
| Marlaka JR et al. | Tacrolimus without or with the addition of conventional immunosuppressive treatment in juvenile autoimmune hepatitis. | 2012 | Acta Paediatr. | pmid:22646819 |
| Gradman J and Wolthers OD | Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus. | 2007 | Acta Paediatr. | pmid:17590198 |
| Puzik A et al. | Effects of ciclosporin A, tacrolimus and sirolimus on cytokine production in neonatal immune cells. | 2007 | Acta Paediatr. | pmid:17880416 |
| Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
| Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |