Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tesi RJ et al. | Conversion of pancreas transplants to FK 506 from CsA. | 1995 | Transplant. Proc. | pmid:8539828 |
Kobayashi M et al. | HLA-DR matching effect in orthotopic liver transplantation under FK 506. | 1993 | Transplant. Proc. | pmid:7679812 |
Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
Miura S et al. | Long-term results of spousal renal donor transplants with donor-specific blood transfusions. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750463 |
Strasser S et al. | The effect of FK 506 on canine pancreatic islet cell function in beagle dogs. | 1991 | Transplant. Proc. | pmid:1703709 |
Borro JM et al. | Conversion from cyclosporine to tacrolimus stabilizes the course of lung function in lung transplant recipients with bronchiolitis obliterans syndrome. | 2007 | Transplant. Proc. | pmid:17889206 |
Ryu S and Yasunami Y | Prevention of immune rejection in rat islet allografts by continuous SC administration of FK 506 using a mini-osmotic pump. | 1991 | Transplant. Proc. | pmid:1703710 |
Christiaans M et al. | Effect of breakfast on the oral bioavailability of tacrolimus and changes in pharmacokinetics at different times posttransplant in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636516 |
Sato S et al. | Specificity of therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 1998 | Transplant. Proc. | pmid:9636517 |
Sancho Calabuig A et al. | Very low-grade proteinuria at 3 months posttransplantation is an earlier marker of graft survival. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715850 |
Kanter J et al. | Cytomegalovirus infection renal transplant recipients: risk factors and outcome. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715860 |
Herrero JC et al. | Role of immunosuppressive treatments based on mycophenolate mofetil in posttransplantation renal surgical complications. | 2002 | Transplant. Proc. | pmid:11959201 |
Facundo C et al. | Results of a triple induction regime with tacrolimus, mycophenolate mofetil, and prednisone in renal transplantation. | 2002 | Transplant. Proc. | pmid:11959203 |
Rafael-Valdivia L et al. | How long should initiation of calcineurin inhibitors be delayed to protect renal function in liver transplantation? | 2011 | Transplant. Proc. | pmid:21486577 |
Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
Murase N et al. | Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506. | 1990 | Transplant. Proc. | pmid:1689906 |
Bonet H et al. | Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. | 1993 | Transplant. Proc. | pmid:7680145 |
Melo MJ et al. | Impact of conversion from Advagraf to twice-daily generic tacrolimus in kidney transplant recipients: a single-center study. | 2015 | Transplant. Proc. | pmid:26036484 |
Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
Pichard L et al. | Effect of FK 506 on human hepatic cytochromes P-450: interaction with CyA. | 1991 | Transplant. Proc. | pmid:1721279 |
Takeda M et al. | Methotrexate in rescue therapy for xenotransplanted lungs in primates. | 1996 | Transplant. Proc. | pmid:8623402 |
Langrehr JM et al. | Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636583 |
Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
Viganó J et al. | Incidence of graft rejection in small bowel transplanted pigs after immunosuppression withdrawal. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908291 |
Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
Higuchi K et al. | FK506 induces the atrophy of enteric ganglia in small bowel transplantation, which can be prevented by the neuropeptide bombesin. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908293 |
Kaplinsky E et al. | Renal function improvement after conversion to proliferation signal inhibitors during long-term follow-up in heart transplant recipients. | 2012 | Transplant. Proc. | pmid:23146455 |
Yilmaz A et al. | Severe angioedema caused by banana allergy under tacrolimus immunosuppression. | 2005 | Transplant. Proc. | pmid:16387091 |
Lai WJ et al. | Is sirolimus a safe alternative to reduce or eliminate calcineurin inhibitors in chronic allograft nephropathy in kidney transplantation? | 2004 | Transplant. Proc. | pmid:15518744 |
Barten MJ et al. | Pharmacodynamic monitoring of the conversion of cyclosporine to tacrolimus in heart and lung transplant recipients. | 2005 | Transplant. Proc. | pmid:16387162 |
Chueh SC et al. | Pharmacokinetic variability of sirolimus in Taiwanese renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518745 |
Colak H et al. | Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation. | 2015 | Transplant. Proc. | pmid:25964218 |
Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
Ohtsuka S et al. | Effect of splenectomy on hamster-to-rat pancreas xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518109 |
Platz KP et al. | OKT3 vs FK 506 rescue management of acute steroid-resistant and chronic rejection. | 1995 | Transplant. Proc. | pmid:7533357 |
Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
Andersson J et al. | The effects of FK 506 on cytokine production are dependent on the mode of cell activation. | 1991 | Transplant. Proc. | pmid:1721311 |
Li D et al. | Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms. | 2006 | Transplant. Proc. | pmid:17112846 |
Wang SC et al. | FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. | 1991 | Transplant. Proc. | pmid:1721312 |
Abecassis MM et al. | Patient outcomes and economics of once-daily tacrolimus in renal transplant patients: results of a modeling analysis. | 2008 | Transplant. Proc. | pmid:18589126 |
Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
Oike F et al. | Complete withdrawal of immunosuppression in living donor liver transplantation. | 2002 | Transplant. Proc. | pmid:12176465 |
Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
Tzakis AG et al. | FK 506 versus cyclosporine in pediatric liver transplantation. | 1991 | Transplant. Proc. | pmid:1721343 |
Moffatt SD et al. | Comparative efficacy of liposomal FK506 with FK506. | 1998 | Transplant. Proc. | pmid:9865297 |
Mieles LA et al. | Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report. | 1991 | Transplant. Proc. | pmid:1721344 |
Marin M et al. | Factors influencing the onset of diabetes mellitus after kidney transplantation: a single French center experience. | 2005 | Transplant. Proc. | pmid:15919484 |
Jacques F et al. | Comparison of cyclosporine and tacrolimus in combination with rabbit antithymocyte immunoglobulins as induction therapy in cardiac transplantation. | 2009 | Transplant. Proc. | pmid:19857745 |
Bouchta NB et al. | Conversion from tacrolimus to cyclosporin is associated with a significant improvement of glucose metabolism in patients with new-onset diabetes mellitus after renal transplantation. | 2005 | Transplant. Proc. | pmid:15919485 |
Cardinal H et al. | The evolution of kidney function after lung transplantation: a retrospective cohort study. | 2009 | Transplant. Proc. | pmid:19857746 |
Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
Ronchetti F et al. | Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification. | 1997 | Transplant. Proc. | pmid:9142293 |
Rabkin JM et al. | Tacrolimus is associated with a lower incidence of cardiovascular complications in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176483 |
Langrehr JM et al. | First results from a prospective randomized trial comparing steroid-free induction therapy with tacrolimus and MMF versus tacrolimus and steroids in patients after liver transplantation for HCV. | 2002 | Transplant. Proc. | pmid:12176487 |
Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
Morris SM et al. | Disruption of renal function and gene expression by FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721375 |
Lagodziński Z et al. | Effect of FK 506 on B-cell responses. | 1991 | Transplant. Proc. | pmid:1703359 |
Tacrolimus in renal transplantation: a comparison of induction vs noninduction therapy (triple therapy): three-month results. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083131 | |
Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
Meiser BM et al. | Tacrolimus (FK506) proves superior to OKT3 for treating episodes of persistent rejection following intrathoracic transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123150 |
Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
Pirsch JD et al. | Pulmonary infiltrates and eosinophilia in an FK 506 liver transplant recipient. | 1991 | Transplant. Proc. | pmid:1721406 |
Wada H et al. | Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. | 1992 | Transplant. Proc. | pmid:1379758 |
Yamashita K et al. | Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083526 |
Alessiani M et al. | Pharmacokinetic study of intraarterial local intestinal infusion of tacrolimus. | 2000 | Transplant. Proc. | pmid:10995915 |
Shinozuka H et al. | Effect of FK 506 on experimental liver carcinogenesis. | 1991 | Transplant. Proc. | pmid:1721407 |
Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
Wu MS et al. | Cyclosporine, but not FK506 and rapamycin, enhances Na(+)-K(+)-CL- cotransport activity in cultured medullary thick ascending limb cells. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083527 |
Madariaga JR et al. | The long-term efficacy of multivisceral transplantation. | 2000 | Transplant. Proc. | pmid:10995918 |
Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
Ju MK et al. | Is the affinity column-mediated immunoassay method suitable as an alternative to the microparticle enzyme immunoassay method as a blood tacrolimus assay? | 2008 | Transplant. Proc. | pmid:19100463 |
McCarter JF et al. | FK 506 protects brain tissue in animal models of stroke. | 2001 | Transplant. Proc. | pmid:11377571 |
Baran DA et al. | Predictors of early renal insufficiency in cardiac transplant recipients initiated on tacrolimus. | 2002 | Transplant. Proc. | pmid:12176609 |
Franke GH et al. | Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. | 2006 | Transplant. Proc. | pmid:16797285 |
Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
DeValeria PA et al. | FK 506 fails to reverse moderate cardiac allograft rejection in a canine heterotopic model. | 1991 | Transplant. Proc. | pmid:1721438 |
Dikow R et al. | Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine. | 2004 | Transplant. Proc. | pmid:15251373 |
Murase N et al. | Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. | 1987 | Transplant. Proc. | pmid:2445081 |
Chu Z et al. | Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20832552 |
Jonas S et al. | Five-year follow-up of tacrolimus as primary immunosuppressant after liver transplantation. | 1998 | Transplant. Proc. | pmid:9723433 |
Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
Perego C et al. | Study of the immunosuppressive effect of SMS 201-995 and its synergic action with FK 506. | 1998 | Transplant. Proc. | pmid:9723434 |
Timmermann W et al. | Noninvasive videomicroscopic monitoring of rat small bowel rejection. | 1998 | Transplant. Proc. | pmid:9745537 |
Morales J et al. | Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells. | 2008 | Transplant. Proc. | pmid:19010240 |
Wang CH et al. | Efficacy and safety of tacrolimus versus cyclosporine microemulsion in primary cardiac transplant recipients: 6-month results in Taiwan. | 2004 | Transplant. Proc. | pmid:15561256 |
Wang CH et al. | Therapeutic drug monitoring of tacrolimus in cardiac transplant recipients: a comparison with cyclosporine neoral. | 2004 | Transplant. Proc. | pmid:15561257 |
McCauley J et al. | Long-term lipid metabolism in combined kidney-pancreas transplant recipients under tacrolimus immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267475 |
Undre NA et al. | Pharmacokinetics of tacrolimus (FK506) in primary orthotopic heart transplant patients. | 1998 | Transplant. Proc. | pmid:9636451 |
Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |