Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Summaries for patients. Multitarget therapy for induction treatment of lupus nephritis. | 2015 | Ann. Intern. Med. | pmid:25383607 | |
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Rossetto AM et al. | The full electron structure of the FKBP12/FK506 complex. | 2015 | J. Biomol. Struct. Dyn. | pmid:24471694 |
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Ma R et al. | FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. | 2015 | Int J Clin Exp Pathol | pmid:26823720 |
Liu Z et al. | Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. | 2015 | Ann. Intern. Med. | pmid:25383558 |
Bifano M et al. | An open-label investigation into drug-drug interactions between multiple doses of daclatasvir and single-dose cyclosporine or tacrolimus in healthy subjects. | 2015 | Clin Drug Investig | pmid:25896946 |
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Wang L et al. | Benefits of minimizing immunosuppressive dosage according to cytochrome P450 3A5 genotype in liver transplant patients: findings from a single-center study. | 2015 | Genet. Mol. Res. | pmid:25966085 |
Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
Colak H et al. | Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation. | 2015 | Transplant. Proc. | pmid:25964218 |
Kim YT et al. | Co-treatment effect of pulsed electromagnetic field (PEMF) with human dental pulp stromal cells and FK506 on the regeneration of crush injured rat sciatic nerve. | 2015 | Int. J. Neurosci. | pmid:25271799 |
Kogiso T et al. | Mycophenolate mofetil may induce prolonged severe anemia during pegylated-interferon/ribavirin/simeprevir therapy in liver transplant recipients. | 2015 | Clin J Gastroenterol | pmid:25963122 |
Bruckmueller H et al. | Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus. | 2015 | Ther Drug Monit | pmid:25271728 |
Moscovici BK et al. | Treatment of Sjögren's syndrome dry eye using 0.03% tacrolimus eye drop: Prospective double-blind randomized study. | 2015 | Cont Lens Anterior Eye | pmid:25956572 |
Kim D et al. | Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells. | 2015 | Respir Physiol Neurobiol | pmid:25956223 |
Antonini TM et al. | Therapy with boceprevir or telaprevir in HIV/hepatitis C virus co-infected patients to treat recurrence of hepatitis C virus infection after liver transplantation. | 2015 | AIDS | pmid:25387314 |
Tabchi S et al. | Successful treatment of Evans syndrome with Tacrolimus. | 2015 | Invest New Drugs | pmid:25209619 |
Papadopoulos-Köhn A et al. | Daily low-dose tacrolimus is a safe and effective immunosuppressive regimen during telaprevir-based triple therapy for hepatitis C virus recurrence after liver transplant. | 2015 | Transplantation | pmid:25208324 |
Torres-EspÃn A et al. | Immunosuppression of allogenic mesenchymal stem cells transplantation after spinal cord injury improves graft survival and beneficial outcomes. | 2015 | J. Neurotrauma | pmid:25203134 |
Bae JM et al. | Combination therapy with 308-nm excimer laser, topical tacrolimus, and short-term systemic corticosteroids for segmental vitiligo: A retrospective study of 159 patients. | 2015 | J. Am. Acad. Dermatol. | pmid:25956660 |
Weisenseel P and Reich K | [Inverse psoriasis]. | 2015 | Hautarzt | pmid:25896586 |
Ennaifer R et al. | Nodular hyperplasia of the gastrointestinal tract after liver transplantation: role of immunosuppressive therapy? A case report. | 2015 | Transplant. Proc. | pmid:25891739 |
Chung YW et al. | Transcriptional activation of nuclear-related factor 2 by FK506 in Jurkat T cells. | 2015 | Transplant. Proc. | pmid:25891728 |
Chen KH et al. | De novo cancer avoidance after renal transplantation: A case-control study on low-dose sirolimus combined with a calcineurin inhibitor. | 2015 | J. Formos. Med. Assoc. | pmid:25843527 |
Berro M et al. | Allogeneic hematopoietic stem cell transplantation in the elderly. Predicting the risk for non relapse mortality. | 2015 | Medicina (B Aires) | pmid:26339873 |
Hur J et al. | Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | 2015 | Chem. Res. Toxicol. | pmid:25811541 |
Malvezzi P and Rostaing L | The safety of calcineurin inhibitors for kidney-transplant patients. | 2015 | Expert Opin Drug Saf | pmid:26329325 |
Wang L et al. | Gq signaling causes glomerular injury by activating TRPC6. | 2015 | J. Clin. Invest. | pmid:25844902 |
Legendre L et al. | Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis. | 2015 | J. Am. Acad. Dermatol. | pmid:25840730 |
Manuyakorn W et al. | In vitro cytokine changes after pediatric liver transplantation. | 2015 | Asian Pac. J. Allergy Immunol. | pmid:25840634 |
Pidala J et al. | Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease. | 2015 | Haematologica | pmid:25840599 |
Aouam K et al. | Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post-transplant phase. | 2015 | Pharmacogenomics | pmid:26615671 |
Eaton KV et al. | Engineering macrophages to control the inflammatory response and angiogenesis. | 2015 | Exp. Cell Res. | pmid:26610863 |
Tavira B et al. | ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach. | 2015 | Clin. Chem. Lab. Med. | pmid:25781547 |
Burke MT et al. | Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients. | 2015 | Am. J. Clin. Pathol. | pmid:25780003 |
Plischke M et al. | Late Conversion of Kidney Transplant Recipients from Ciclosporin to Tacrolimus Improves Graft Function: Results from a Randomized Controlled Trial. | 2015 | PLoS ONE | pmid:26270340 |
Nouchi A et al. | [Treatment of angiolymphoid hyperplasia with eosinophilia (ALHE) using topical tacrolimus: Two cases]. | 2015 | Ann Dermatol Venereol | pmid:25778634 |
Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
Fujibayashi T et al. | Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry. | 2015 | Mod Rheumatol | pmid:25775147 |
Lehman N et al. | Left subconjunctival hemorrhage · renal dysfunction · international normalized ratio of 4.5 · Dx? | 2015 | J Fam Pract | pmid:26551480 |
Boloori A et al. | Characterization of Remitting and Relapsing Hyperglycemia in Post-Renal-Transplant Recipients. | 2015 | PLoS ONE | pmid:26551468 |
Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
Chen F et al. | [Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria]. | 2015 | Zhonghua Xue Ye Xue Za Zhi | pmid:26759101 |
Morales E et al. | A case of thrombotic micro-angiopathy after heart transplantation successfully treated with eculizumab. | 2015 | Transpl. Int. | pmid:25712140 |
Buschow SI et al. | To target or not to target viral antigens in HBV related HCC? | 2015 | J. Hepatol. | pmid:25711422 |
Qasim W et al. | Reply to: "To target or not to target viral antigens in HBV related HCC?". | 2015 | J. Hepatol. | pmid:25711420 |
TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
Kawano N et al. | Successful Secondary Umbilical Cord Blood Transplantation for Graft Failure in Acute Myelogenous Leukemia, Treated with Modified One-Day Conditioning Regimen, and Graft-Versus-Host Disease Prophylaxis Consisting of Mycophenolate and Tacrolimus. | 2015 | J Clin Exp Hematop | pmid:26490521 |
Li ZQ et al. | Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults. | 2015 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:26489612 |
Chen QQ et al. | Kaposi's Varicelliform Eruption During Long-term Treatment of Rosacea with 0.03% Tacrolimus Ointment. | 2015 | Chin. Med. J. | pmid:26481759 |
Badri P et al. | Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir. | 2015 | Am. J. Transplant. | pmid:25708713 |
Peksa GD et al. | Dosing algorithm for concomitant administration of sirolimus, tacrolimus, and an azole after allogeneic hematopoietic stem cell transplantation. | 2015 | J Oncol Pharm Pract | pmid:24938293 |
Stefanović NZ et al. | Potential role of tacrolimus in erythrocytes' antioxidative capacity in long-term period after renal transplantation. | 2015 | Eur J Pharm Sci | pmid:25657088 |
Park JH et al. | Comparative study of tacrolimus and bevacizumab on corneal neovascularization in rabbits. | 2015 | Cornea | pmid:25651492 |
Shengyou Y et al. | Influence of tacrolimus on podocyte injury inducted by angiotensin II. | 2015 | J Renin Angiotensin Aldosterone Syst | pmid:25650384 |
Carenco C et al. | Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | 2015 | Am. J. Transplant. | pmid:25648361 |
Petruzzo P et al. | Outcomes after bilateral hand allotransplantation: a risk/benefit ratio analysis. | 2015 | Ann. Surg. | pmid:24646555 |
Coelho R et al. | Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? | 2015 | J Gastrointestin Liver Dis | pmid:26405712 |
Polańska A et al. | Monitoring of therapy in atopic dermatitis--observations with the use of high-frequency ultrasonography. | 2015 | Skin Res Technol | pmid:24894324 |
Sahin G et al. | Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy. | 2015 | Nephrology (Carlton) | pmid:25650527 |
Oda K et al. | In vitro-in vivo extrapolations to evaluate the effect of concomitant drugs on tacrolimus (FK506) exposure. | 2015 | Biopharm Drug Dispos | pmid:25600613 |
Sato M et al. | Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature. | 2015 | Intern. Med. | pmid:26328659 |
Pérez-López I et al. | Koebner phenomenon in a patient with lichen sclerosus following a jellyfish sting: an exceptional morphology. | 2015 | Actas Dermosifiliogr | pmid:25597413 |
Niioka T et al. | Capability of utilizing CYP3A5 polymorphisms to predict therapeutic dosage of tacrolimus at early stage post-renal transplantation. | 2015 | Int J Mol Sci | pmid:25594874 |
Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
Chittock J et al. | Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. | 2015 | Acta Derm. Venereol. | pmid:25594610 |
Sánchez-Lázaro I et al. | Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation. | 2015 | Pharmacogenomics | pmid:26107754 |
Ling Q et al. | Donor PPARα Gene Polymorphisms Influence the Susceptibility to Glucose and Lipid Disorders in Liver Transplant Recipients: A Strobe-Compliant Observational Study. | 2015 | Medicine (Baltimore) | pmid:26334901 |
Koch M et al. | De novo mTOR inhibitor-based immunosuppression in ABO-incompatible kidney transplantation. | 2015 | Clin Transplant | pmid:26333844 |
Graham F et al. | Tacrolimus use in renal and cardiac pediatric transplantation: no increased risk of food allergies. | 2015 | Ann. Allergy Asthma Immunol. | pmid:26094803 |
Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
Teixeira Mdo C et al. | Influence of post-transplant immunosuppressive therapy on gastrointestinal transit using biomagnetic method: a pilot study. | 2015 | Dig. Dis. Sci. | pmid:25146844 |
Urquhart BL and Knauer MJ | Dried blood spots for therapeutic drug monitoring of tacrolimus and sirolimus in pediatric patients. | 2015 | Pediatr Transplant | pmid:25546506 |
Park J et al. | Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells. | 2015 | Toxicology | pmid:26318285 |
Shi RZ et al. | Rapid measurement of tacrolimus in whole blood by paper spray-tandem mass spectrometry (PS-MS/MS). | 2015 | Clin. Chim. Acta | pmid:25540885 |
Yang F et al. | A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases. | 2015 | Int Urol Nephrol | pmid:25539617 |
Coilly A et al. | Once-daily prolonged release tacrolimus in liver transplantation: Experts' literature review and recommendations. | 2015 | Liver Transpl. | pmid:26264233 |
Boluda ER | Pediatric small bowel transplantation. | 2015 | Curr Opin Organ Transplant | pmid:26262456 |
Seeling W et al. | Knowledge-based immunosuppressive therapy for kidney transplant patients--from theoretical model to clinical integration. | 2015 | Stud Health Technol Inform | pmid:26262418 |
Wardhana EA and Datau | A patient with plaque type morphea mimicking systemic lupus erythematosus. | 2015 | Acta Med Indones | pmid:26260557 |
Minami-Hori M et al. | Periorbital lupus profundus successfully treated with oral tacrolimus plus low-dose prednisolone. | 2015 | J. Dermatol. | pmid:25544984 |
Xing J et al. | Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25487141 |
van Boekel GA et al. | Delayed trough level measurement with the use of prolonged-release tacrolimus. | 2015 | Transpl. Int. | pmid:25474192 |
Niioka T et al. | Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. | 2015 | Xenobiotica | pmid:26189776 |
Gallagher HM et al. | Erratic tacrolimus exposure, assessed using the standard deviation of trough blood levels, predicts chronic lung allograft dysfunction and survival. | 2015 | J. Heart Lung Transplant. | pmid:26186804 |
Li Y et al. | Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients. | 2015 | Int. Immunopharmacol. | pmid:26186486 |
Togashi M et al. | Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. | 2015 | Eur. J. Clin. Pharmacol. | pmid:26184414 |
Toole B et al. | Evaluation of the New Cyclosporine and Tacrolimus Automated Electrochemiluminescence Immunoassays under Field Conditions. | 2015 | Clin. Lab. | pmid:26554251 |
Shen T et al. | Reversible sinusoidal obstruction syndrome associated with tacrolimus following liver transplantation. | 2015 | World J. Gastroenterol. | pmid:26034381 |
Cilião HL et al. | Cytotoxic and genotoxic effects of high concentrations of the immunosuppressive drugs cyclosporine and tacrolimus in MRC-5 cells. | 2015 | Exp. Toxicol. Pathol. | pmid:25541063 |