tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Carobbi A et al. | Effect of splenectomy in combination with FK 506 and 15-deoxyspergualin on cardiac xenograft survival. | 1991 | Transplant. Proc. | pmid:1703704 |
| Morris RE et al. | Comparative immunopharmacologic effects of FK 506 and CyA in in vivo models of organ transplantation. | 1990 | Transplant. Proc. | pmid:1689885 |
| Todo S et al. | Early trials with FK 506 as primary treatment in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689886 |
| Scheel AK et al. | Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: two case reports. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750573 |
| Morris-Stiff G et al. | Prospective randomized study comparing FK 506 (Prograft) and cyclosporine A (Neoral) as primary immunosuppression in cadaveric renal transplants at a single institution: interim report of the first 80 cases. | 1998 | Transplant. Proc. | pmid:9636525 |
| Wang XH et al. | Tacrolimus vs CyA Neoral in combination with MMF and steroids after cadaveric renal transplantation. | 2000 | Transplant. Proc. | pmid:11119899 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Aravot D et al. | A new immunosuppressive protocol for lung transplantation: early promising results. | 2003 | Transplant. Proc. | pmid:12644072 |
| Gallego-Valcarce E et al. | Conversion to tacrolimus extended-release formulation: short-term clinical results. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715909 |
| Mollevà DG et al. | Late xenograft rejection: comparison between liver and heart xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959212 |
| Cimsit B et al. | Successful treatment of fibrosing cholestatic hepatitis after liver transplantation. | 2011 | Transplant. Proc. | pmid:21486625 |
| Zhao Y et al. | Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808586 |
| Rajnoch J et al. | Regulators of angiogenesis in renal ischemia/reperfusion injury in normotensive and hypertensive rats: effect of tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808641 |
| Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
| Jain AB et al. | Pharmacokinetics of cyclosporine and nephrotoxicity in orthotopic liver transplant patients rescued with FK 506. | 1991 | Transplant. Proc. | pmid:1721274 |
| McMichael J et al. | Evaluation of a novel "intelligent" dosing system for optimizing FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721275 |
| Namii Y et al. | Tetrahydropyranyladriamycin with FK 506 combination therapy for hamster-to-rat-concordant xenotransplantation. | 1996 | Transplant. Proc. | pmid:8623358 |
| Charpentier B | An induction versus no-induction protocol in anticalcineurin-based immunosuppression using very low-dose steroids. | 2001 | Transplant. Proc. | pmid:11406262 |
| Ghobrial RM et al. | Retransplantation for recurrent hepatitis C following tacrolimus or cyclosporine immunosuppression. | 1998 | Transplant. Proc. | pmid:9636597 |
| Tashiro H et al. | Donor bone marrow perioperatively administered via portal vein induced prolongation of skin allograft survival and microchimerism in liver-transplanted rats. | 2000 | Transplant. Proc. | pmid:11120201 |
| Jurewicz WA | Immunological and nonimmunological risk factors with tacrolimus and Neoral in renal transplant recipients: an interim report. | 1999 | Transplant. Proc. | pmid:10576048 |
| Tarasewicz A et al. | Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex. | 2009 | Transplant. Proc. | pmid:19917366 |
| San Segundo D et al. | Study of B-cell subpopulations in lung transplant recipients with posttransplant infection. | 2012 | Transplant. Proc. | pmid:23146491 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Tanabe K et al. | Excellent outcome of ABO-incompatible living kidney transplantation under pretransplantation immunosuppression with tacrolimus, mycophenolate mofetil, and steroid. | 2004 | Transplant. Proc. | pmid:15518791 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Zeevi A et al. | In vitro assessment of FK 506 immunosuppressive activity in transplant patients. | 1991 | Transplant. Proc. | pmid:1721307 |
| Ziolkowski J et al. | Renal function after liver transplantation: calcineurin inhibitor nephrotoxicity. | 2003 | Transplant. Proc. | pmid:14529923 |
| Foroncewicz B et al. | Anti-CD25 and tacrolimus therapy may not prevent early primary biliary cirrhosis recurrence after liver transplantation: two case reports. | 2003 | Transplant. Proc. | pmid:14529924 |
| Ushigome H et al. | Pediatric living-related renal transplantation under tacrolimus as the primary immunosuppressive agent. | 2003 | Transplant. Proc. | pmid:12591350 |
| Kim SW et al. | Decreased formation of nitric oxide in rats treated with FK506. | 2003 | Transplant. Proc. | pmid:12591357 |
| Nakamura Y et al. | Evaluation of appropriate blood level in continuous intravenous infusion from trough concentrations after oral administration based on area under trough level in tacrolimus and cyclosporine therapy. | 2005 | Transplant. Proc. | pmid:15919445 |
| Masuda S et al. | Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients. | 2005 | Transplant. Proc. | pmid:15919446 |
| Ogino S et al. | Conversion from tacrolimus to cyclosporine microemulsion therapy in liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15041357 |
| Takaori K et al. | Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. | 1992 | Transplant. Proc. | pmid:1376531 |
| Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
| Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
| Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
| Shaw BW et al. | FK 506 for rescue treatment of acute and chronic rejection in liver allograft recipients. | 1991 | Transplant. Proc. | pmid:1721338 |
| McDiarmid SV et al. | FK 506 rescue therapy in liver transplantation: outcome and complications. | 1991 | Transplant. Proc. | pmid:1721339 |
| Böttiger Y et al. | Effect of bile flow on the absorption of tacrolimus in liver allograft transplantation. | 2002 | Transplant. Proc. | pmid:12176476 |
| Orlandi V et al. | Tacrolimus-associated myositis: a case report in a renal transplant patient. | 2004 | Transplant. Proc. | pmid:15110639 |
| Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
| de Oliveira Clark RM et al. | Evaluation of hemodynamic, metabolic, and electrolytic changes after graft reperfusion in a porcine model of intestinal transplantation. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172287 |
| Fischereder M et al. | Gynaecomastia following solid organ transplantation. | 2002 | Transplant. Proc. | pmid:12270376 |
| Hohage H et al. | Switching immunosuppression from cyclosporine to tacrolimus improves long-term kidney function: a 6-year study. | 2005 | Transplant. Proc. | pmid:15919497 |
| Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
| Budde K et al. | Five year outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176499 |
| Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
| Malaise J et al. | Corticosteroid withdrawal in simultaneous pancreas-kidney transplantation: a 3-year report. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182832 |
| Lorho R et al. | Improved liver function and decreased hepatitis C viral load after tacrolimus was replaced by cyclosporine. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182838 |
| Feitoza CQ et al. | A role for HO-1 in renal function impairment in animals subjected to ischemic and reperfusion injury and treated with immunosuppressive drugs. | 2007 | Transplant. Proc. | pmid:17362747 |
| Fries D et al. | Development of renal dysfunction and renal histological lesions in two patients treated with FK 506 for acute rejection following liver transplantation. | 1991 | Transplant. Proc. | pmid:1721370 |
| Jain AB et al. | Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1703354 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| Damotte D et al. | Morphologic features of large bowel biopsies in combined small and large bowel transplantations could predict clinical rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083252 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Kandaswamy R et al. | Vascular graft thrombosis after pancreas transplantation: comparison of the FK 506 and cyclosporine eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083254 |
| Tashiro H et al. | Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123287 |
| Ierardi E et al. | Long-term tacrolimus: a promising therapeutic approach for Crohn's disease. | 2001 | Transplant. Proc. | pmid:11377467 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Jørgensen KA et al. | Two-hour blood tacrolimus levels are not superior to trough levels as estimates of the area under the curve in tacrolimus-treated renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176551 |
| Hatakeyama S et al. | A switch from conventional twice-daily tacrolimus to once-daily extended-release tacrolimus in stable kidney transplant recipients. | 2012 | Transplant. Proc. | pmid:22310594 |
| Jiang Y et al. | Dyslipidemia in human kidney transplant recipients receiving cyclosporine and tacrolimus is associated with different expression of CD36 on peripheral blood monocytes. | 2011 | Transplant. Proc. | pmid:21693242 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Lauro A et al. | Rejection episodes and 3-year graft survival under sirolimus and tacrolimus treatment after adult intestinal transplantation. | 2007 | Transplant. Proc. | pmid:17580204 |
| Morrisett JD et al. | Effect of FK 506 and cyclosporine on plasma cholesterol levels in rabbits. | 1991 | Transplant. Proc. | pmid:1721402 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs receiving FK 506. | 1992 | Transplant. Proc. | pmid:1379754 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
| Kuroki H et al. | Experimental studies of vascularized allogeneic limb transplantation in the rat using a new immunosuppressive agent, FK-506: morphological and immunological analysis. | 1989 | Transplant. Proc. | pmid:2468255 |
| Ishibashi M et al. | Experimental study of tacrolimus immunosuppression on the mode of administration: efficacy of constant intravenous infusion avoiding C(max). | 2001 Feb-Mar | Transplant. Proc. | pmid:11266958 |
| Braun N et al. | Impairment of renal function following liver transplantation. | 2003 | Transplant. Proc. | pmid:12826191 |
| Van Buren D et al. | Impact of Sandimmune, Neoral, and Prograf on rejection incidence and renal function in primary liver transplant recipients. | 1998 | Transplant. Proc. | pmid:9723299 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| Morrissey PE et al. | Factors contributing to acute rejection in renal transplantation: the role of noncompliance. | 2005 | Transplant. Proc. | pmid:15964334 |
| El-Sabrout R et al. | Sirolimus in combination with tacrolimus or mycophenolate mofetil for minimizing acute rejection risk in renal transplant recipients--a single center experience. | 2003 | Transplant. Proc. | pmid:12742474 |
| Formica RN et al. | Sirolimus-based immunosuppression with reduce dose cyclosporine or tacrolimus after renal transplantation. | 2003 | Transplant. Proc. | pmid:12742475 |
| Testillano M et al. | Survival and hepatitis C virus recurrence after liver transplantation in HIV- and hepatitis C virus-coinfected patients: experience in a single center. | 2009 | Transplant. Proc. | pmid:19376421 |
| Polanco N et al. | Everolimus-based immunosuppression therapy for BK virus nephropathy. | Transplant. Proc. | pmid:25645770 | |
| Filler G et al. | One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion. | 2002 | Transplant. Proc. | pmid:12176634 |
| Hasegawa A et al. | Optimal use of tacrolimus in living donor renal transplantation in children. | 2002 | Transplant. Proc. | pmid:12176635 |
| Tinti F et al. | Improvement of graft function after conversion to once daily tacrolimus of stable kidney transplant patients. | 2010 | Transplant. Proc. | pmid:21168623 |
| Joo DJ et al. | Comparison of the affinity column-mediated immunoassay and microparticle enzyme immunoassay methods as a tacrolimus concentration assay in the early period after liver transplantation. | 2010 | Transplant. Proc. | pmid:21168645 |
| Staak A et al. | Immunoglobulin induction therapy in renal transplant recipients: Effects on immunoglobulin and regulatory antibody levels. | 2006 | Transplant. Proc. | pmid:17175311 |
| Wu GD et al. | FK 506 inhibits the development of transplant arteriosclerosis. | 1991 | Transplant. Proc. | pmid:1721433 |
| Kobayashi N et al. | Effect of FK 506 on abdominal organ cluster transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1721434 |
| Todo S et al. | Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. | 1987 | Transplant. Proc. | pmid:2445076 |
| Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
| MartÃn-Fernández M et al. | Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts. | 2017 | Transplant. Proc. | pmid:29149986 |
| Ott R et al. | Does conversion of immunosuppressive monotherapy from cyclosporine A to tacrolimus improve bone mineral density in long-term stable liver transplant recipients? | 2003 | Transplant. Proc. | pmid:14697971 |
| GarcÃa Meseguer C et al. | The effect of different immunosuppression on the outcome of pediatric renal transplants. | 1999 | Transplant. Proc. | pmid:10500577 |
| Morena M et al. | Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients. | 2000 | Transplant. Proc. | pmid:11134805 |
| Kanbay M et al. | Influence of cyclosporine and tacrolimus on serum uric acid levels in stable kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:16213325 |
| Wojarski J et al. | Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177108 |
| Preston R et al. | FK 506 as primary immunosuppressive therapy in renal transplantation. | 1998 | Transplant. Proc. | pmid:9636493 |
| Jensik SC | Tacrolimus (FK 506) in kidney transplantation: three-year survival results of the US multicenter, randomized, comparative trial. FK 506 Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636494 |
| Kanatani T et al. | Experimental limb transplantation, part III: induction of tolerance in the rigorous strain combination of Brown Norway donor to Lewis recipient. | 2004 | Transplant. Proc. | pmid:15686745 |
| Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
| Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |