tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tata PN et al. | Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506). | 2009 | Xenobiotica | pmid:19604035 |
| Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
| Jeong H and Chiou WL | Role of P-glycoprotein in the hepatic metabolism of tacrolimus. | 2006 | Xenobiotica | pmid:16507509 |
| Imamura R et al. | ABO-incompatible kidney transplantation with anti-CD20 monoclonal antibodies, intravenous immunoglobulin and plasmapheresis without splenectomy: a case report. | 2006 | Xenotransplantation | pmid:16623807 |
| Song Z et al. | Tacrolimus inhibits discordant islet xenograft rejection: a study in the pig-to-rat model. | 2003 | Xenotransplantation | pmid:14617270 |
| Balamurugan AN et al. | Effect of various immunosuppressive monotherapies on survival and histopathology of monkey islet xenografts in rats. | 2007 | Xenotransplantation | pmid:17669173 |
| Miki T et al. | Hamster-to-rat bone marrow xenotransplantation and humoral graft vs. host disease. | 2001 | Xenotransplantation | pmid:11472629 |
| Tachibana A et al. | Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes. | 2013 Jul-Aug | Xenotransplantation | pmid:23683097 |
| Li J et al. | [Regulatory effect of FK506 on the expression of CD152 and PD-1 in the liver allo-recipients]. | 2008 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:18177621 |
| He QH et al. | [The role of superantigen SEB-induced immunotolerance in the immune privileged site]. | 2003 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:15132898 |
| Bai YJ et al. | [Regulatory function of tacrolimus and CsA on CD4/CD8 T lymphocyte subgroups and costimulators on them in allo-liver recipients]. | 2008 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:18845086 |
| Pan ZX et al. | [IL-18 expression in whole blood cell cultures from active lupus nephritis and the inhibitory effects of FK506, cyclosporin A and dexamethasone]. | 2004 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:15555450 |
| Tayama Y et al. | [Influence of tacrolimus and ciprofloxacin on glucose metabolism]. | 2007 | Yakugaku Zasshi | pmid:17978565 |
| Nagao K et al. | [Drug development from natural fermentation products: establishing a manufacturing process which maximizes the potential of microorganisms]. | 2010 | Yakugaku Zasshi | pmid:21048405 |
| Fukudo M | [Individualized dosage regimen of immunosuppressive drugs based on pharmacokinetic and pharmacodynamic analysis]. | 2007 | Yakugaku Zasshi | pmid:17603267 |
| Tanaka H et al. | [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. | 1997 | Yakugaku Zasshi | pmid:9306728 |
| Muraki Y | [Factors affecting the pharmacokinetics after living donor liver transplant]. | 2012 | Yakugaku Zasshi | pmid:23023417 |
| Iwamoto T et al. | [Successful treatment by tacrolimus in two patients with Osserman's grade III intractable myasthenia gravis and elderly IIb]. | 2004 | Yakugaku Zasshi | pmid:15067188 |
| Niwa T et al. | Effect of cyclosporine and tacrolimus on cytochrome p450 activities in human liver microsomes. | 2007 | Yakugaku Zasshi | pmid:17202802 |
| Tanaka Y et al. | [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan]. | 2013 | Yakugaku Zasshi | pmid:23328499 |