tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Khalaf H et al. | Tacrolimus (FK 506) given three times daily after liver transplantation for minimizing nephrotoxicity and neurotoxicity. | 2003 | Transplant. Proc. | pmid:14612120 |
| Park K et al. | Efficacy of tacrolimus in primary kidney transplant patients: multicenter, open-label prospective study. | 2000 | Transplant. Proc. | pmid:11119901 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
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| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Ma A et al. | Immunological evaluation of combination therapy with tacrolimus and sirolimus on long-term allograft survival in nonhuman primates. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808578 |
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| Weiler N et al. | Tacrolimus effects and side effects after liver transplantation: is there a difference between immediate and extended release? | 2013 Jul-Aug | Transplant. Proc. | pmid:23953543 |
| Qu W et al. | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | Transplant. Proc. | pmid:27569951 | |
| Rudich SM et al. | Immunosuppression using tacrolimus, mycophenolate, and prednisone following orthotopic liver transplantation: a single-center experience. | 1998 | Transplant. Proc. | pmid:9636574 |
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| Ullman KS et al. | Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes. | 1991 | Transplant. Proc. | pmid:1721294 |
| Squifflet JP et al. | The Benelux experience with the combination of tacrolimus and mycophenolate mofetil. | 1999 | Transplant. Proc. | pmid:10576050 |
| Watarai Y et al. | Effect of tacrolimus and cyclosporine on renal microcirculation and nitric oxide production. | 2004 | Transplant. Proc. | pmid:15518773 |
| Sigal NH et al. | Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506? | 1991 | Transplant. Proc. | pmid:1721295 |
| Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
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| Nassar CA et al. | Effects of long-term FK 506 therapy on the alveolar bone and cementum of rats. | 2009 | Transplant. Proc. | pmid:19545747 |
| Moscicka M et al. | The effect of cyclosporine and tacrolimus on indigenous bacterial flora in human skin grafts. | 2003 | Transplant. Proc. | pmid:14529942 |
| Bahra M et al. | Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss. | 2005 | Transplant. Proc. | pmid:15919436 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
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| González-Pinto IM et al. | Five-year follow-up of a trial comparing Tacrolimus and cyclosporine microemulsion in liver transplantation. | 2005 | Transplant. Proc. | pmid:15919441 |
| Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in renal transplantation: a single center experience. | 2003 | Transplant. Proc. | pmid:12591370 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Cooper MH et al. | Evaluation of the influence of FK 506, rapamycin, and cyclosporine on processing and presentation of particulate antigen by macrophages: assessment of a drug "carry-over" effect. | 1991 | Transplant. Proc. | pmid:1721326 |
| Maes BD and Vanrenterghem YF | Cyclosporine: advantages versus disadvantages vis-Ã -vis tacrolimus. | 2004 | Transplant. Proc. | pmid:15041305 |
| Hesselink DA et al. | The use of cyclosporine in renal transplantation. | 2004 | Transplant. Proc. | pmid:15041316 |
| Chen JW et al. | Ten-year results of a randomised prospective study of FK506 versus cyclosporine in management of primary orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176460 |
| Figueras J et al. | Steroid-free regimen with daclizumab, mycophenolate mofetil, and tacrolimus in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176461 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Soin AS et al. | Complement activation during rejection in experimental intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142282 |
| Chmiel B et al. | Rheological properties of red blood cells in kidney transplant recipients: the role of lipid profile and type of immunosuppresion. | 2005 | Transplant. Proc. | pmid:15919493 |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in adult cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721358 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in pediatric cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721359 |
| Strassburg A et al. | Basiliximab reduces acute liver allograft rejection in pediatric patients. | 2002 | Transplant. Proc. | pmid:12270443 |
| Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
| Yoshimura N et al. | Safety analysis following tacrolimus immunosuppression in renal transplant recipients in Japan: 3-year results in over 1000 patients. | 2002 | Transplant. Proc. | pmid:12176501 |
| Kilinç M et al. | FK 506-induced fulminant leukoencephalopathy after kidney transplantation: case report. | 2002 | Transplant. Proc. | pmid:12072309 |
| Hung CM et al. | Tacrolimus to rescue refractory hepatic allograft rejection: a collaborative study in Taiwan. | 1998 | Transplant. Proc. | pmid:9838572 |
| Miller J | Tacrolimus and mycophenolate mofetil in renal transplant recipients: one year results of a multicenter, randomized dose ranging trial. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083106 |
| Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
| Busuttil RW and Holt CD | Tacrolimus (FK506) is superior to cyclosporine in liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123119 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Tze WJ et al. | Effect of FK 506 on glucose metabolism and insulin secretion in normal rats. | 1991 | Transplant. Proc. | pmid:1721391 |
| Bilbao I et al. | Comparison between tacrolimus and neoral cyclosporine administered by oral route in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377472 |
| van Duijnhoven EM et al. | Evidence that fasting does not significantly affect trough levels of tacrolimus in stable renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176552 |
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| Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
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| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Zuckermann A et al. | Benefit of mycophenolate mofetil in patients with cyclosporine A-induced nephropathy after lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083518 |
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| Mabuchi M et al. | Insulin-like growth factor-I enhances choleretic action of FK506 in rats. | 2003 | Transplant. Proc. | pmid:12826230 |
| McLaughlin GE et al. | Use of phenobarbital in the management of acute tacrolimus toxicity: a case report. | 2000 | Transplant. Proc. | pmid:10812158 |
| Yoshimi F et al. | Canine total orthotopic small bowel transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721422 |
| Kawauchi M et al. | Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. | 1996 | Transplant. Proc. | pmid:8658719 |
| Lo A et al. | Observations on the use of sirolimus and tacrolimus in high-risk renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12742477 |
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| Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
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| Sainsbury TS et al. | Differential effects of FK 506 and cyclosporine on hair regrowth in the DEBR model of alopecia areata. | 1991 | Transplant. Proc. | pmid:1721453 |
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| Mehra MR et al. | Corticosteroid weaning in the tacrolimus and mycophenolate era in heart transplantation: clinical and neurohormonal benefits. | 2004 | Transplant. Proc. | pmid:15686716 |
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