Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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St A Nunes FA and Lucey MR | Searching for a balance when applying immunosuppression after liver transplantation. | 2001 | Transplantation | pmid:11258425 |
Ringe B et al. | A novel management strategy of steroid-free immunosuppression after liver transplantation: efficacy and safety of tacrolimus and mycophenolate mofetil. | 2001 | Transplantation | pmid:11258429 |
Matsuda S et al. | Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. | 2000 | EMBO Rep. | pmid:11258483 |
Queille-Roussel C et al. | The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. | 2001 | Br. J. Dermatol. | pmid:11260007 |
Weir MR et al. | Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathy. | 2001 | Kidney Int. | pmid:11260422 |
Chand DH et al. | Tacrolimus: the good, the bad, and the ugly. | 2001 | Pediatr Transplant | pmid:11260486 |
Grotz WH et al. | Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. | 2001 | Transpl. Int. | pmid:11263551 |
Nikiforow S et al. | CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. | 2001 | J. Virol. | pmid:11264363 |
Vasquez E et al. | Clotrimazole increases tacrolimus blood levels: a drug interaction in kidney transplant patients. | 2001 | Clin Transplant | pmid:11264634 |
Nagashima N et al. | Decreased effect of immunosuppression on immunocompetence in African--Americans after kidney and liver transplantation. | 2001 | Clin Transplant | pmid:11264637 |
Ciancio G et al. | The use of intravenous tacrolimus and mycophenolate mofetil as induction and maintenance immunosuppression in simultaneous pancreas--kidney recipients with previous transplants. | 2001 | Clin Transplant | pmid:11264642 |
Utsugi R et al. | Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266727 |
Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
Nakao A et al. | Changes of allo-intestinal graft survival and intragraft cytokine expression by bone marrow augmentation with tacrolimus treatment in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266851 |
Janezic AL et al. | Alternatively spliced variants of IL-2 mRNA in sequential transplant kidney core needle biopsies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266873 |
Opelz G | New immunosuppressants and HLA matching. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266911 |
Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
Orsenigo R et al. | FK506 and SMS 201-995: effect on heterotopic heart transplantation in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266956 |
Ishibashi M et al. | Experimental study of tacrolimus immunosuppression on the mode of administration: efficacy of constant intravenous infusion avoiding C(max). | 2001 Feb-Mar | Transplant. Proc. | pmid:11266958 |
Erickson LM et al. | Gene expression profiles of rat heart allografts with immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266960 |
Reutzel-Selke A et al. | Donor pretreatment of grafts from marginal donors improves long-term graft outcome. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267150 |
Ettenger R | The practical problems of prednisone in pediatric renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267159 |
Berloco P et al. | Tacrolimus as cornerstone immunosuppressant in kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267161 |
Ciancio G et al. | Daclizumab induction for primary kidney transplant recipients using tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267169 |
Vincenti F | Tacrolimus (FK 506) in kidney transplantation: five-year survival results of the U.S. multicenter, randomized, comparative trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267172 |
Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
Kauffman HM et al. | Drug regimens affect cadaveric kidney graft survival. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267176 |
Dudley CR | Conversion at first rejection: a prospective trial comparing cyclosporine microemulsion with tacrolimus in renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267179 |
Wang W et al. | Effect of rapamycin and FK506 on mesangial cell proliferation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267180 |
Salazar A et al. | Sirolimus-tacrolimus combination for combined kidney-pancreas transplantation: effect on renal function. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267181 |
Zaltzman J et al. | Tacrolimus, MMF, steroid, and ALG immunotherapy for high immunological risk renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267183 |
Zamauskaite A et al. | FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267184 |
Aguirrezabalaga J et al. | Lipid profiles in liver transplantation in patients receiving tacrolimus or cyclosporin. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267192 |
Shishido S et al. | Pharmacokinetics of tacrolimus in pediatric renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267193 |
Glanemann M et al. | Mycophenolate mofetil is superior in combination with tacrolimus compared to cyclosporine for immunosuppressive therapy after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267194 |
van den Berg AP et al. | Prediction of the inhibition of IL-2 production by calcineurin inhibitors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267197 |
Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
Luke PP et al. | IVIG rescue therapy in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267206 |
Felipe CR et al. | Choosing the right dose of new immunossuppressive drugs for new populations: importance of pharmacokinetic studies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267207 |
Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
Cailhier JF et al. | CMV in kidney transplants in the tacrolimus-mycophenolate era. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267255 |
Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
Del Castillo D | Analysis of primary and recurrent rejection following renal transplantation in a large, comparative, multicentre trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267283 |
Busque S et al. | Canadian multicentre trial of tacrolimus/azathioprine/steroids versus tacrolimus/mycophenolate mofetil/steroids versus neoral/mycophenolate mofetil/steroids in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267285 |
Sperschneider H | A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267291 |
Mühlbacher F | Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267317 |
Peltekian K et al. | De novo use of low-dose tacrolimus and sirolimus in liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267318 |