| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Tai J et al. | In vivo function of pig islet xenografts in immunosuppressed diabetic mice. | 1995 | Transplant. Proc. | pmid:8539968 |
| Felldin M et al. | Rescue therapy with Tacrolimus (FK506) in renal transplant recipients--a multicenter analysis. | 1995 | Transplant. Proc. | pmid:8540032 |
| Bersztel A et al. | Deoxyspergualin is synergistic with cyclosporin A, but not with FK506 in a rat heart allograft transplantation model. | 1995 | Transplant. Proc. | pmid:8540095 |
| Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
| Chaudhuri B et al. | The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. | 1995 | FEBS Lett. | pmid:7528690 |
| Timerman AP et al. | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 | J. Biol. Chem. | pmid:7531689 |
| Richter A et al. | Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. | 1995 | Biochem. Pharmacol. | pmid:7531976 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Bäckman L et al. | Whole-blood and plasma levels of FK 506 after liver transplantation: results from the US Multicenter Trial. FK506 Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533361 |
| Söderdahl G et al. | FK 506 improves recovery of bile secretion following orthotopic liver transplantation in man. | 1995 | Transplant. Proc. | pmid:7533362 |
| Mor E et al. | Weight gain and lipid profile changes in liver transplant recipients: long-term results of the American FK506 Multicenter Study. | 1995 | Transplant. Proc. | pmid:7533363 |
| Hemenway CS et al. | vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. | 1995 | Genetics | pmid:8582630 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Shapiro R et al. | The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. | 1995 | Clin Transpl | pmid:8794266 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Bismuth H | Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533415 |
| Ochiai T et al. | Japanese multicenter studies of FK 506 in renal transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533419 |
| Saito S et al. | The pattern of rejection and susceptibility to different kinds of immunosuppression after combined liver, duodenum, and pancreas transplantation in swine--immunosuppressive drugs versus ex vivo immunomodulation of the allograft. | 1995 | Transplant. Proc. | pmid:7533420 |
| Hadley S et al. | Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. | 1995 | Transplantation | pmid:7535482 |
| Bakhtiar R and Stearns RA | Studies on non-covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:7535601 |
| McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
| Dix SP et al. | Re: Severe interaction between methotrexate and a macrolide-like antibiotic. | 1995 | J. Natl. Cancer Inst. | pmid:7563209 |
| Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
| Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
| Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
| MacDonald AS and Sketris IS | Tacrolimus in transplantation. | 1995 | Am J Health Syst Pharm | pmid:7552906 |
| Kawasaki M et al. | [Immunosuppression and the problems in partial liver transplantation]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963785 |
| Torii N et al. | An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. | 1995 | Neurosci. Lett. | pmid:7537357 |
| Holmes JA and Twentyman PR | The activity of deoxyspergualin in multidrug-resistant cells. | 1995 | Cancer Chemother. Pharmacol. | pmid:7554042 |
| Miyazawa H et al. | Hamster to rat kidney xenotransplantation. Effects of FK 506, cyclophosphamide, organ perfusion, and complement inhibition. | 1995 | Transplantation | pmid:7537396 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Furlan V et al. | Interactions between FK506 and rifampicin or erythromycin in pediatric liver recipients. | 1995 | Transplantation | pmid:7537398 |
| Mañez R et al. | Anomalous pattern of IgG antibody response to primary cytomegalovirus infection after solid organ retransplantation. | 1995 | Transplantation | pmid:7537400 |
| Van Thiel DH et al. | Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7537444 |
| Minamoto A et al. | Suppression of corneal graft rejection by subconjunctival injection of FK-506 in a rat model of penetrating keratoplasty. | 1995 | Jpn. J. Ophthalmol. | pmid:7543958 |
| Ueda M et al. | A proposal of FK506 optimal dosing in living related liver transplantations. | 1995 | Transplantation | pmid:7544035 |
| Muthukkumar S et al. | Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. | 1995 | Transplantation | pmid:7544036 |
| Muraki T et al. | Antithrombotic effect of FK506 versus prothrombotic effect of cyclosporine in vivo. | 1995 | Transplantation | pmid:7544038 |
| Nash RA et al. | Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. | 1995 | Blood | pmid:7540071 |
| Bennett WM | The nephrotoxicity of immunosuppressive drugs. | 1995 | Clin. Nephrol. | pmid:7540121 |
| Moro A et al. | Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. | 1995 | EMBO J. | pmid:7540135 |
| Zweifach A and Lewis RS | Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms. | 1995 | J. Biol. Chem. | pmid:7540169 |
| Han JW et al. | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. | 1995 | J. Biol. Chem. | pmid:7545671 |
| Ruff VA and Leach KL | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. | 1995 | J. Biol. Chem. | pmid:7545680 |
| Matsuo S and Okamoto K | Enhancement of FK-506 activities by ganglioside (GM3) in vivo. | 1995 | Life Sci. | pmid:7545772 |
| Jain AB et al. | Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. | 1995 | Transplantation | pmid:7545836 |
| Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
| Lake JR et al. | The impact of immunosuppressive regimens on the cost of liver transplantation--results from the U.S. FK506 multicenter trial. | 1995 | Transplantation | pmid:7482713 |
| Bolman RM | Advantage--FK 506: reduced chronic rejection for lung transplant recipients. | 1995 | Ann. Thorac. Surg. | pmid:7545888 |
| Mathew A et al. | Reversal of steroid-resistant rejection in renal allograft recipients using FK506. | 1995 | Transplantation | pmid:7482730 |
| Sakane T et al. | [A phase II study of FK506 (tacrolimus) on refractory uveitis associated with Behçet's disease and allied conditions]. | 1995 | Ryumachi | pmid:8594659 |
| Karanam BV et al. | FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7530623 |
| Cacciarelli TV et al. | Influence of the timing of FK 506 (Tacrolimus) administration on recovery of renal function from warm ischemic injury in rats. | 1994 Oct-Dec | ASAIO J. | pmid:7532042 |
| Ryffel B et al. | Nephrotoxicity of immunosuppressants in rats: comparison of macrolides with cyclosporin. | 1994 Nov-Dec | Exp. Nephrol. | pmid:7532090 |
| Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
| von Asmuth EJ et al. | IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. | 1994 May-Jun | Eur. Cytokine Netw. | pmid:7524716 |
| Yoshida Y et al. | Comparison of cardiac rejection in heart and heart-lung concordant xenotransplantation. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:7518252 |
| Assan R et al. | FK 506/fluconazole interaction enhances FK 506 nephrotoxicity. | 1994 Jan-Feb | Diabete Metab | pmid:7520007 |
| Perotti BY et al. | FK 506 metabolism in male and female rat liver microsomes. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:7512020 |
| Akita K et al. | Effect of FK506 and anti-CD4 therapy on fetal pig pancreas xenografts and host lymphoid cells in nod/Lt, CBA, and BALB/c mice. | 1994 Jan-Feb | Cell Transplant | pmid:7512875 |
| Yasunami Y et al. | Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. | 1994 Jan-Feb | Cell Transplant | pmid:7512876 |
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Ohtsuka S et al. | Hamster-to-rat xenotransplantation of whole pancreas by FK 506 combined with splenectomy. | 1994 | Transplant. Proc. | pmid:7513473 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin. | 1994 | Transplant. Proc. | pmid:7513476 |
| Douglas CM et al. | The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7528927 |
| Breuder T et al. | Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7515500 |
| Lhoëst G et al. | Isolation and identification of a FK-506 C36-C37 dihydrodiol from erythromycin-induced rabbit liver microsomes. | 1994 | J Pharm Biomed Anal | pmid:7516189 |
| Ohtsuka S et al. | Experimental rat pancreas transplant: surgical technique and immunological considerations. | 1994 | Surg. Today | pmid:7516209 |
| Raymond M et al. | Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520. | 1994 | Mol. Cell. Biol. | pmid:7505392 |
| Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Prasad TN et al. | FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7518966 |
| Dumont FJ et al. | Quantitative and temporal analysis of the cellular interaction of FK-506 and rapamycin in T-lymphocytes. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7507994 |
| Mueller AR et al. | Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518974 |
| Platz KP et al. | Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518975 |
| Kitamura Y et al. | Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. | 1994 | J. Neuroimmunol. | pmid:7509816 |
| Tze WJ et al. | Successful islet allotransplantation in diabetic rats immunosuppressed with FK506: a functional and immunological study. | 1994 | Metab. Clin. Exp. | pmid:7510012 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Jiang H et al. | FK 506 and deoxyspergualin: additive immunosuppressive effect on rat cardiac allograft rejection in vivo and mitogen-stimulated human lymphocyte responses in vitro. | 1994 | Transplant. Proc. | pmid:7520631 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Tsuchida M et al. | Effects of irradiation, glucocorticoid and FK506 on cell-surface antigen expression by rat thymocytes: a three-colour flow cytofluorometric analysis. | 1994 | Immunology | pmid:7530693 |
| Winkler M et al. | Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. | 1994 | Ther Drug Monit | pmid:7521978 |
| D'Ambrosio R et al. | Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction. | 1994 | Ther Drug Monit | pmid:7521979 |
| Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
| Calne RY | Immunosuppression in liver transplantation. | 1994 | N. Engl. J. Med. | pmid:7523947 |
| Kinoshita I et al. | Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. | 1994 | Muscle Nerve | pmid:7526208 |
| Cullen BR and Heitman J | Human immunodeficiency virus. Chaperoning a pathogen. | 1994 | Nature | pmid:7526224 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Ayres RC et al. | Peripheral neurotoxicity with tacrolimus. | 1994 | Lancet | pmid:7511197 |
| Bendahan J et al. | The effect of administration of FK506 on delayed regeneration in flushed partially hepatectomized livers. | 1994 | Transplantation | pmid:7511255 |
| Chavin KD et al. | Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or rapamycin to induce tolerance. | 1994 | Transplantation | pmid:7511258 |
| Ishii T et al. | Immunodepressants ameliorate normothermic ischemia injury to the rat liver by down-regulating tumor necrosis factor, not by alleviation of lipid peroxidative injury. | 1994 | Transpl. Int. | pmid:11271294 |
| Platz KP et al. | Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients. | 1994 | Transpl. Int. | pmid:11271297 |
| Metcalfe S et al. | FK 506 and cyclosporin each block antigen-induced T cell receptor signalling that is dependent on CD4 co-receptor and operates in the absence of detectable cytoplasmic calcium fluxes. | 1994 | Transpl. Int. | pmid:11271304 |