tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mycobacterium Infections D009164 7 associated lipids
Sarcoidosis D012507 13 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Wang C et al. Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. 2017 J. Ind. Microbiol. Biotechnol. pmid:28776273
Béland MA et al. Higher calcineurin inhibitor levels predict better kidney graft survival in patients with de novo donor-specific anti-HLA antibodies: a cohort study. 2017 Transpl. Int. pmid:28186642
Lim SW et al. Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. 2017 Cell Death Dis pmid:28771227
Colombo M et al. Influence of Drug Brittleness, Nanomilling Time, and Freeze-Drying on the Crystallinity of Poorly Water-Soluble Drugs and Its Implications for Solubility Enhancement. 2017 AAPS PharmSciTech pmid:28168626
Kumai Y et al. Reversible Cerebral Vasoconstriction Syndrome After Heart Transplantation: A Case Report. 2017 Transplant. Proc. pmid:29198694
Nazmul MN et al. Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. 2017 Transplant. Proc. pmid:29198681
Miyake M et al. Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice. 2017 PLoS ONE pmid:28644884
Song L et al. ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys. 2017 Am. J. Transplant. pmid:27598231
Zizzo AN et al. Second-line Agents in Pediatric Patients With Autoimmune Hepatitis: A Systematic Review and Meta-analysis. 2017 J. Pediatr. Gastroenterol. Nutr. pmid:28644343
Sopko NA et al. Ex Vivo Model of Human Penile Transplantation and Rejection: Implications for Erectile Tissue Physiology. 2017 Eur. Urol. pmid:27432525
Al-Uzri A et al. Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. 2017 Pediatr Transplant pmid:28635157
Ruiz S et al. Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology. 2017 Hum. Mol. Genet. pmid:28973643
Saburi M et al. Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation. 2017 Int. J. Hematol. pmid:28516402
Ferreira A et al. Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus. 2017 Am. J. Nephrol. pmid:28511172
Kim YJ et al. Two cases of hydroa vacciniforme-like lymphoproliferative disease controlled by anti-inflammatory agents. 2017 Photodermatol Photoimmunol Photomed pmid:28543883
Zanjani H et al. Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. 2017 Cornea pmid:28399035
Piñana JL et al. A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis. 2017 Biol. Blood Marrow Transplant. pmid:28396159
Gnarra M et al. Low-Dose Cyclosporine A in the Treatment of Severe Atopic Dermatitis Complicated by Chronic Hepatitis C Virus Infection. 2017 Pediatr Dermatol pmid:28382768
Zhang H et al. Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. 2017 J. Am. Soc. Nephrol. pmid:28760751
Salgüero Fernández I et al. Rapidly progressive infiltrated plaques in a transplant recipient. 2017 Actas Dermosifiliogr pmid:27677210
Hettiarachchi PVKS et al. Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. 2017 J Investig Clin Dent pmid:27633647
Wen Y et al. Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction. 2017 Neurochem. Res. pmid:28299629
Forns X et al. Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study. 2017 Transpl Infect Dis pmid:28295849
Wojciechowski D et al. Early post-transplant conversion from tacrolimus to belatacept for prolonged delayed graft function improves renal function in kidney transplant recipients. 2017 Clin Transplant pmid:28190259
Lum EL et al. Acute Kidney Allograft Rejection Precipitated by Lenalidomide Treatment for Multiple Myeloma. 2017 Am. J. Kidney Dis. pmid:28189378
Xie Y et al. Delayed Donor Bone Marrow Infusion Induces Liver Transplant Tolerance. 2017 Transplantation pmid:28187014
Koster RA et al. Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. 2017 Bioanalysis pmid:28300419
Sepaskhah M et al. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. 2017 Mycoses pmid:28120351
Arroyo Hornero R et al. CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression. 2017 Transplantation pmid:28118317
Liu MZ et al. IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients. 2017 Acta Pharmacol. Sin. pmid:28112181
Zhao YT et al. Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. 2017 Cardiovasc. Res. pmid:28077437
Dun H et al. ASP0028 in combination with suboptimal-dose of tacrolimus in Cynomolgus monkey renal transplantation model. 2017 Transpl. Immunol. pmid:28077266
Herskovitz J et al. Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. 2017 AAPS J pmid:28070711
Liberal R et al. Expert clinical management of autoimmune hepatitis in the real world. 2017 Aliment. Pharmacol. Ther. pmid:28004405
Størset E et al. Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. 2017 Br J Clin Pharmacol pmid:28008657
Segal JP et al. Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. 2017 Aliment. Pharmacol. Ther. pmid:28008631
Ishida R et al. The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. 2017 Mol. Cancer Res. pmid:28710230
Bauer JS et al. dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome. 2017 RNA Biol pmid:28665778
Kalam MA and Alshamsan A Poly (d, l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. 2017 Biomed. Pharmacother. pmid:28772219
Kapoor A et al. Posterior Reversible Encephalopathy Syndrome after Heart Transplantation: Diagnosis and Immunosuppressive Therapy. 2017 Tex Heart Inst J pmid:28761402
Goldsmith PM et al. Impact of intrapatient variability (IPV) in tacrolimus trough levels on long-term renal transplant function: multicentre collaborative retrospective cohort study protocol. 2017 BMJ Open pmid:28756385
Parrow NL and Fleming RE Releasing the FKBP12 brake on hepcidin. 2017 Blood pmid:29122771
Kalt DA Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use. 2017 Lab Med pmid:29096030
Andrews LM et al. Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. 2017 Expert Opin Drug Metab Toxicol pmid:29084469
Noceti O et al. Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. 2017 Clin. Chem. pmid:29054923
Barau C et al. Pharmacokinetics of Mycophenolic Acid and Dose Optimization in Children After Intestinal Transplantation. 2017 Ther Drug Monit pmid:27898598
Kobayashi I et al. Tacrolimus in combination with methotrexate and corticosteroid for the treatment of child-onset anti-signal recognition particle antibody-positive necrotizing myopathy. 2017 Scand. J. Rheumatol. pmid:27897449
Theile D et al. Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice. 2017 Eur J Pharm Sci pmid:27890698
Iwayama T et al. Granulomatous reaction to permanent eyebrow makeup successfully treated with topical steroids in combination with topical tacrolimus. 2017 Eur J Dermatol pmid:29311043
Grinyó JM et al. Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial. 2017 Am. J. Kidney Dis. pmid:27889299