| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang C et al. | Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28776273 |
| Béland MA et al. | Higher calcineurin inhibitor levels predict better kidney graft survival in patients with de novo donor-specific anti-HLA antibodies: a cohort study. | 2017 | Transpl. Int. | pmid:28186642 |
| Lim SW et al. | Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. | 2017 | Cell Death Dis | pmid:28771227 |
| Colombo M et al. | Influence of Drug Brittleness, Nanomilling Time, and Freeze-Drying on the Crystallinity of Poorly Water-Soluble Drugs and Its Implications for Solubility Enhancement. | 2017 | AAPS PharmSciTech | pmid:28168626 |
| Kumai Y et al. | Reversible Cerebral Vasoconstriction Syndrome After Heart Transplantation: A Case Report. | 2017 | Transplant. Proc. | pmid:29198694 |
| Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
| Miyake M et al. | Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice. | 2017 | PLoS ONE | pmid:28644884 |
| Song L et al. | ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys. | 2017 | Am. J. Transplant. | pmid:27598231 |
| Zizzo AN et al. | Second-line Agents in Pediatric Patients With Autoimmune Hepatitis: A Systematic Review and Meta-analysis. | 2017 | J. Pediatr. Gastroenterol. Nutr. | pmid:28644343 |
| Sopko NA et al. | Ex Vivo Model of Human Penile Transplantation and Rejection: Implications for Erectile Tissue Physiology. | 2017 | Eur. Urol. | pmid:27432525 |
| Al-Uzri A et al. | Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. | 2017 | Pediatr Transplant | pmid:28635157 |
| Ruiz S et al. | Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology. | 2017 | Hum. Mol. Genet. | pmid:28973643 |
| Saburi M et al. | Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:28516402 |
| Ferreira A et al. | Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus. | 2017 | Am. J. Nephrol. | pmid:28511172 |
| Kim YJ et al. | Two cases of hydroa vacciniforme-like lymphoproliferative disease controlled by anti-inflammatory agents. | 2017 | Photodermatol Photoimmunol Photomed | pmid:28543883 |
| Zanjani H et al. | Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. | 2017 | Cornea | pmid:28399035 |
| Piñana JL et al. | A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis. | 2017 | Biol. Blood Marrow Transplant. | pmid:28396159 |
| Gnarra M et al. | Low-Dose Cyclosporine A in the Treatment of Severe Atopic Dermatitis Complicated by Chronic Hepatitis C Virus Infection. | 2017 | Pediatr Dermatol | pmid:28382768 |
| Zhang H et al. | Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. | 2017 | J. Am. Soc. Nephrol. | pmid:28760751 |
| Salgüero Fernández I et al. | Rapidly progressive infiltrated plaques in a transplant recipient. | 2017 | Actas Dermosifiliogr | pmid:27677210 |
| Hettiarachchi PVKS et al. | Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. | 2017 | J Investig Clin Dent | pmid:27633647 |
| Wen Y et al. | Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction. | 2017 | Neurochem. Res. | pmid:28299629 |
| Forns X et al. | Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study. | 2017 | Transpl Infect Dis | pmid:28295849 |
| Wojciechowski D et al. | Early post-transplant conversion from tacrolimus to belatacept for prolonged delayed graft function improves renal function in kidney transplant recipients. | 2017 | Clin Transplant | pmid:28190259 |
| Lum EL et al. | Acute Kidney Allograft Rejection Precipitated by Lenalidomide Treatment for Multiple Myeloma. | 2017 | Am. J. Kidney Dis. | pmid:28189378 |
| Xie Y et al. | Delayed Donor Bone Marrow Infusion Induces Liver Transplant Tolerance. | 2017 | Transplantation | pmid:28187014 |
| Koster RA et al. | Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. | 2017 | Bioanalysis | pmid:28300419 |
| Sepaskhah M et al. | Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. | 2017 | Mycoses | pmid:28120351 |
| Arroyo Hornero R et al. | CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression. | 2017 | Transplantation | pmid:28118317 |
| Liu MZ et al. | IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients. | 2017 | Acta Pharmacol. Sin. | pmid:28112181 |
| Zhao YT et al. | Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. | 2017 | Cardiovasc. Res. | pmid:28077437 |
| Dun H et al. | ASP0028 in combination with suboptimal-dose of tacrolimus in Cynomolgus monkey renal transplantation model. | 2017 | Transpl. Immunol. | pmid:28077266 |
| Herskovitz J et al. | Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. | 2017 | AAPS J | pmid:28070711 |
| Liberal R et al. | Expert clinical management of autoimmune hepatitis in the real world. | 2017 | Aliment. Pharmacol. Ther. | pmid:28004405 |
| Størset E et al. | Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. | 2017 | Br J Clin Pharmacol | pmid:28008657 |
| Segal JP et al. | Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. | 2017 | Aliment. Pharmacol. Ther. | pmid:28008631 |
| Ishida R et al. | The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. | 2017 | Mol. Cancer Res. | pmid:28710230 |
| Bauer JS et al. | dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome. | 2017 | RNA Biol | pmid:28665778 |
| Kalam MA and Alshamsan A | Poly (d, l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. | 2017 | Biomed. Pharmacother. | pmid:28772219 |
| Kapoor A et al. | Posterior Reversible Encephalopathy Syndrome after Heart Transplantation: Diagnosis and Immunosuppressive Therapy. | 2017 | Tex Heart Inst J | pmid:28761402 |
| Goldsmith PM et al. | Impact of intrapatient variability (IPV) in tacrolimus trough levels on long-term renal transplant function: multicentre collaborative retrospective cohort study protocol. | 2017 | BMJ Open | pmid:28756385 |
| Parrow NL and Fleming RE | Releasing the FKBP12 brake on hepcidin. | 2017 | Blood | pmid:29122771 |
| Kalt DA | Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use. | 2017 | Lab Med | pmid:29096030 |
| Andrews LM et al. | Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 2017 | Expert Opin Drug Metab Toxicol | pmid:29084469 |
| Noceti O et al. | Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. | 2017 | Clin. Chem. | pmid:29054923 |
| Barau C et al. | Pharmacokinetics of Mycophenolic Acid and Dose Optimization in Children After Intestinal Transplantation. | 2017 | Ther Drug Monit | pmid:27898598 |
| Kobayashi I et al. | Tacrolimus in combination with methotrexate and corticosteroid for the treatment of child-onset anti-signal recognition particle antibody-positive necrotizing myopathy. | 2017 | Scand. J. Rheumatol. | pmid:27897449 |
| Theile D et al. | Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice. | 2017 | Eur J Pharm Sci | pmid:27890698 |
| Iwayama T et al. | Granulomatous reaction to permanent eyebrow makeup successfully treated with topical steroids in combination with topical tacrolimus. | 2017 | Eur J Dermatol | pmid:29311043 |
| Grinyó JM et al. | Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27889299 |