| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fuseler JW et al. | FK506 attenuates developing and established joint inflammation and suppresses interleukin 6 and nitric oxide expression in bacterial cell wall induced polyarthritis. | 2000 | J. Rheumatol. | pmid:10648038 |
| Bekersky I et al. | Dose linearity after oral administration of tacrolimus 1-mg capsules at doses of 3, 7, and 10 mg. | 1999 | Clin Ther | pmid:10645753 |
| Richter-Hintz D et al. | Topical tacrolimus (FK 506) is effective in the treatment of pyoderma gangrenosum. | 2000 | J. Am. Acad. Dermatol. | pmid:10642695 |
| Lipper GM et al. | Recent therapeutic advances in dermatology. | 2000 | JAMA | pmid:10634322 |
| Thiers BH | Topical tacrolimus: treatment failure in a patient with alopecia areata. | 2000 | Arch Dermatol | pmid:10632221 |
| Furutani M et al. | FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro. | 2000 | Biochemistry | pmid:10631007 |
| Wang-Fan W et al. | Application of centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues. I. Selection of solvent systems based on solubility and partition coefficient investigations. | 1999 | J Chromatogr A | pmid:10630872 |
| Vanrenterghem YF | Which calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine? | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630811 |
| Paul LC | Dialysis and transplantation. | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630810 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Shapiro R et al. | Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 1999 | Transplantation | pmid:10628763 |
| Mehta P et al. | Increased clearance of tacrolimus in children: need for higher doses and earlier initiation prior to bone marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10627642 |
| Patella V et al. | HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. | 2000 | J. Immunol. | pmid:10623799 |
| Uchino T et al. | Effect of FK 506 and lipo prostaglandin E1 on heart allograft survival in rats. | 1999 | Scand. Cardiovasc. J. | pmid:10622549 |
| Hashii M et al. | cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells. | 2000 | Biochem. J. | pmid:10620496 |
| Hida H et al. | Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats. | 1999 | Neurosci. Res. | pmid:10616914 |
| Land W | Mycophenolate mofetil-based immunosuppressive therapy: induction, maintenance, and conversion protocols in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616558 |
| Gaston RS | Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. | 1999 | Transplant. Proc. | pmid:10616556 |
| Kindt MV et al. | Tacrolimus toxicity in rhesus monkey: model for clinical side effects. | 1999 | Transplant. Proc. | pmid:10616519 |
| Charco R et al. | CD28 regulation in liver transplant recipients treated with two different immunosuppressive regimens. | 1999 | Transplant. Proc. | pmid:10616508 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Crétolle-Vastel C et al. | [Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]. | 1999 | Chirurgie | pmid:10615777 |
| Bitker MO et al. | [Combined renal and pancreas transplantation as treatment for chronic renal insufficiency of diabetic origin: a series of 50 consecutive transplantations]. | 1999 | Chirurgie | pmid:10615774 |
| Yen MT et al. | Oscillopsia and pseudonystagmus in kidney transplant patients. | 1999 | Am. J. Ophthalmol. | pmid:10612521 |
| Freudenberger R et al. | Antithrombotic effect of FK506 vs cyclosporine in cardiac transplant recipients: potential implications in transplant arteriopathy. | 1999 | J. Heart Lung Transplant. | pmid:10612383 |
| Olyaei AJ et al. | Immunosuppressant-induced nephropathy: pathophysiology, incidence and management. | 1999 | Drug Saf | pmid:10612271 |
| Qi Z et al. | Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts. | 1999 | Transpl. Immunol. | pmid:10608300 |
| Wright DC et al. | A comparison of the sensitivity of pig and human peripheral blood mononuclear cells to the antiproliferative effects of traditional and newer immunosuppressive agents. | 1999 | Transpl. Immunol. | pmid:10608297 |
| MacFarlane GD et al. | Analysis of whole blood tacrolimus concentrations in liver transplant patients exhibiting impaired liver function. | 1999 | Ther Drug Monit | pmid:10604816 |
| Bers DM et al. | Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603944 |
| Xu L et al. | Potential for pharmacology of ryanodine receptor/calcium release channels. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603942 |
| Briggs CJ et al. | Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1. | 1999 | Arch. Virol. | pmid:10603169 |
| Camacho R et al. | Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation. | 1999 | Immunopharmacology | pmid:10598882 |
| Shimoyama M et al. | Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. | 1999 | Circulation | pmid:10595959 |
| Yamashita N et al. | Nuclear factor kappa B mediates interleukin-8 production in eosinophils. | 1999 | Int. Arch. Allergy Immunol. | pmid:10592469 |
| Dickenmann MJ et al. | Blood eosinophilia in tacrolimus-treated patients: an indicator of Pneumocystis carinii pneumonia. | 1999 | Transplantation | pmid:10589963 |
| Batten P et al. | Human T cell responses to human and porcine endothelial cells are highly sensitive to cyclosporin A and FK506 in vitro. | 1999 | Transplantation | pmid:10589954 |
| Fernandez LA et al. | The effects of maintenance doses of FK506 versus cyclosporin A on glucose and lipid metabolism after orthotopic liver transplantation. | 1999 | Transplantation | pmid:10589951 |
| Maes BD et al. | Differences in gastric motor activity in renal transplant recipients treated with FK-506 versus cyclosporine. | 1999 | Transplantation | pmid:10589943 |
| von Baum H et al. | Prevalence of vancomycin-resistant enterococci among children with end-stage renal failure. Mid-European Pediatric Peritoneal Dialysis Study Group. | 1999 | Clin. Infect. Dis. | pmid:10589909 |
| Agarwala S et al. | Co-administration of co-trimoxazole does not augment tacrolimus-induced impairment in kidney function in rats. | 1999 | Ren Fail | pmid:10586426 |
| Tsuchida M et al. | T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. | 1999 | J. Immunol. | pmid:10586059 |
| Miyamoto S and Safer B | Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation. | 1999 | Biochem. J. | pmid:10585867 |
| Le Bricon T et al. | Changes in plasma cystatin C after renal transplantation and acute rejection in adults. | 1999 | Clin. Chem. | pmid:10585359 |
| Wong TY et al. | Parvovirus B19 infection causing red cell aplasia in renal transplantation on tacrolimus. | 1999 | Am. J. Kidney Dis. | pmid:10585325 |
| Busque S et al. | [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. | 1999 | Ann Chir | pmid:10584376 |
| Horigome A et al. | Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients. | 1999 | Br J Clin Pharmacol | pmid:10583028 |
| Mathieu P et al. | Conversion of cyclosporine A to tacrolimus following heart transplantation. | 1999 | Can J Cardiol | pmid:10579737 |
| Lowry PW et al. | Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. | 1999 | Inflamm. Bowel Dis. | pmid:10579116 |
| Bush WW | Overview of transplantation immunology and the pharmacotherapy of adult solid organ transplant recipients: focus on immunosuppression. | 1999 | AACN Clin Issues | pmid:10578712 |
| Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
| Manu MA et al. | Tacrolimus rescue for resistant rejection, chronic rejection, and immunoglobulin A nephropathy of renal allografts under primary cyclosporine A immunosuppression. | 1999 | Transplant. Proc. | pmid:10578313 |
| Uchida H et al. | Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. | 1999 | Transplant. Proc. | pmid:10578297 |
| Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
| Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Tamura A et al. | Combination effect of tacrolimus and FTY720 in liver transplantation in rats. | 1999 | Transplant. Proc. | pmid:10578290 |
| Hairhara Y et al. | Effect of fluconazole on blood levels of tacrolimus. | 1999 | Transplant. Proc. | pmid:10578284 |
| Tojimbara T et al. | Oral vs intravenous tacrolimus-based induction therapy in renal transplantation. | 1999 | Transplant. Proc. | pmid:10578282 |
| Ishibashi M et al. | Elimination of the adverse effects of tacrolimus-based induction therapy by a 5-day exposure of optimal steady-state blood concentration in renal transplant patients in the early postoperative period. | 1999 | Transplant. Proc. | pmid:10578281 |
| Hampel G et al. | Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors. | 1999 | Transplant. Proc. | pmid:10578279 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK 506 with FK 506 (tacrolimus) with and without anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578277 |
| Uchida H et al. | Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile. | 1999 | Transplant. Proc. | pmid:10578276 |
| Sawai T et al. | A successful induction of tolerance by perioperative intrathymic injection in rat "high-responder" heart transplantation. | 1999 | Transplant. Proc. | pmid:10578275 |
| Moffatt SD and Metcalfe SM | FK 506 versus cyclosporine in combination with anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578271 |
| Fukushima N et al. | Role of endothelial apoptosis in delayed xenograft rejection in pig-to-baboon cardiac transplantation. | 1999 | Transplant. Proc. | pmid:10578268 |
| Watanabe Y et al. | The expression of nonmuscle myosin heavy chain in rat renal transplantation. | 1999 | Transplant. Proc. | pmid:10578260 |
| Przepiorka D et al. | Practical considerations in the use of tacrolimus for allogeneic marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10578154 |
| Villaverde V et al. | Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506) | 1999 | Ann. Rheum. Dis. | pmid:10577370 |
| Vanrenterghem Y | Vascular rejection with tacrolimus and potential long-term graft outcome. | 1999 | Transplant. Proc. | pmid:10576054 |
| Woodle ES et al. | Corticosteroid withdrawal under tacrolimus primary and rescue therapy in renal transplantation: the Chicago experience. | 1999 | Transplant. Proc. | pmid:10576053 |
| Jordan ML et al. | Outcome of tacrolimus conversion therapy for renal allograft rejection: 5-year follow-up. | 1999 | Transplant. Proc. | pmid:10576052 |
| Morales JM et al. | Tacrolimus, mycophenolate mofetil and corticosteroids as primary immunosuppression after renal transplantation at the Hospital 12 de Octubre, Madrid. | 1999 | Transplant. Proc. | pmid:10576051 |
| Squifflet JP et al. | The Benelux experience with the combination of tacrolimus and mycophenolate mofetil. | 1999 | Transplant. Proc. | pmid:10576050 |
| Forsythe J | Tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. The European Multicentre Tacrolimus/MMF Study Group. | 1999 | Transplant. Proc. | pmid:10576049 |
| Jurewicz WA | Immunological and nonimmunological risk factors with tacrolimus and Neoral in renal transplant recipients: an interim report. | 1999 | Transplant. Proc. | pmid:10576048 |
| Oliveira DB and Chang R | Report of the first 118 tacrolimus-treated patients at St George's Hospital, London. | 1999 | Transplant. Proc. | pmid:10576047 |
| van Hooff JP et al. | Dosing and management guidelines for tacrolimus in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10576046 |
| Soriano S et al. | Single-center experience with initial intravenous dosing of tacrolimus after kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576045 |
| van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
| Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
| Friemann S et al. | Conversion to tacrolimus in hyperlipidemic patients. | 1999 | Transplant. Proc. | pmid:10576042 |
| Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
| Jordan ML et al. | Tacrolimus-based immunosuppression in pediatric renal transplantation. | 1999 | Transplant. Proc. | pmid:10576039 |
| Mayer AD | Four-year follow-up of the European Tacrolimus Multicenter Renal Study. | 1999 | Transplant. Proc. | pmid:10576038 |
| Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
| Zhang Y et al. | Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites. | 1999 | J. Biol. Chem. | pmid:10574930 |
| Rao SK et al. | Limbal allografting using FK-506. | 1999 | Br J Ophthalmol | pmid:10574824 |
| Young AL et al. | Allo-limbal transplantation in patients with limbal stem cell deficiency. | 1999 | Br J Ophthalmol | pmid:10574823 |
| Burke GW et al. | Microangiopathy in kidney and simultaneous pancreas/kidney recipients treated with tacrolimus: evidence of endothelin and cytokine involvement. | 1999 | Transplantation | pmid:10573073 |
| Shiratori T et al. | [Immunosuppressive treatment of ulcerative colitis]. | 1999 | Nippon Rinsho | pmid:10572417 |
| Fujiki M et al. | Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10572064 |
| Asai A et al. | High level calcineurin activity predisposes neuronal cells to apoptosis. | 1999 | J. Biol. Chem. | pmid:10567426 |
| Shaw LM et al. | Current opinions on therapeutic drug monitoring of immunosuppressive drugs. | 1999 | Clin Ther | pmid:10566561 |
| Fansa H et al. | [Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK 506]. | 1999 | Handchir Mikrochir Plast Chir | pmid:10566134 |
| Müschen A et al. | Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. | 1999 | Inflamm. Res. | pmid:10563471 |
| Myers JN et al. | Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome. | 1999 | J. Heart Lung Transplant. | pmid:10561115 |
| Gremillion RB et al. | Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: initial experience in 12 patients. | 1999 | J. Rheumatol. | pmid:10555886 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Mizuta K et al. | Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. | 1999 | Transpl. Int. | pmid:10551996 |