| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mollison KW et al. | Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. | 1998 | Toxicology | pmid:9570331 |
| Salerno A et al. | The effect of cyclosporin A, FK506 and rapamycin on the murine contact sensitivity reaction. | 1998 | Clin. Exp. Immunol. | pmid:9566798 |
| Pizzolato GP et al. | Cerebral vasculitis during FK 506 treatment in a liver transplant patient. | 1998 | Neurology | pmid:9566415 |
| Kennedy AP et al. | Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. | 1998 | J. Biol. Chem. | pmid:9565564 |
| Yuzawa K and Fukao K | Topical FK506 ointment for skin grafting. | 1998 | Transplantation | pmid:9565111 |
| Hayashi M et al. | Allograft rejection after liver transplantation for autoimmune liver diseases. | 1998 | Liver Transpl Surg | pmid:9563959 |
| Jain A et al. | Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon. | 1998 | Liver Transpl Surg | pmid:9563957 |
| Fernández-Miranda C et al. | Lipid abnormalities in stable liver transplant recipients--effects of cyclosporin, tacrolimus, and steroids. | 1998 | Transpl. Int. | pmid:9561680 |
| Cicalese L et al. | Phenotypic and functional characteristics of intestinal intraepithelial lymphocytes during acute rejection of small intestinal allografts. | 1998 | Transpl. Int. | pmid:9561676 |
| Takaoka Y et al. | Cyclosporin A and FK-506 inhibit development of superantigen-potentiated collagen-induced arthritis in mice. | 1998 | Gen. Pharmacol. | pmid:9559334 |
| Main ER et al. | Context-dependent nature of destabilizing mutations on the stability of FKBP12. | 1998 | Biochemistry | pmid:9558354 |
| Taylor PJ et al. | Therapeutic drug monitoring of tacrolimus (FK506) using tandem mass spectrometry. | 1998 | Ther Drug Monit | pmid:9558142 |
| Jubran RF and Dinndorf PA | Successful therapy of refractory graft versus host disease with tacrolimus and Psoralen plus ultraviolet light. | 1998 | Ther Drug Monit | pmid:9558141 |
| Ku YM and Min DI | An abbreviated area-under-the-curve monitoring for tacrolimus in patients with liver transplants. | 1998 | Ther Drug Monit | pmid:9558138 |
| Antonysamy MA et al. | Flt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients. | 1998 | J. Immunol. | pmid:9558122 |
| D'Incà R et al. | Tacrolimus to treat pyoderma gangrenosum resistant to cyclosporine. | 1998 | Ann. Intern. Med. | pmid:9556483 |
| Terashima A et al. | Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. | 1998 | Brain Res. | pmid:9555045 |
| Wiederrecht GJ et al. | Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. | 1995 | Prog Cell Cycle Res | pmid:9552353 |
| Hashimoto T et al. | [Involvement of calcineurin A alpha and A beta in neuronal death in a gerbil model of cerebral ischemia]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551469 |
| Matsuda T and Baba A | [Response of Na+/Ca2+ antiporter to ischemia and glial/neuronal death]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551468 |
| Epstein A et al. | Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction. | 1998 | Surgery | pmid:9551073 |
| ten Berge RJ and Schellekens PT | [Immunology in clinical practice. VI. Current immunosuppressive drugs]. | 1997 | Ned Tijdschr Geneeskd | pmid:9550813 |
| Trull AK | Therapeutic monitoring of tacrolimus. | 1998 | Ann. Clin. Biochem. | pmid:9547889 |
| Endrich MM and Gehring H | The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood. | 1998 | Eur. J. Biochem. | pmid:9546659 |
| Matsuoka S et al. | [Severe hepatic veno-occlusive disease (VOD) which was successfully treated with supportive therapy, but subsequently developed late-recurrence]. | 1998 | Rinsho Ketsueki | pmid:9545827 |
| Lopez-Ilasaca M et al. | Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. | 1998 | J. Biol. Chem. | pmid:9545268 |
| Bassing CH et al. | FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. | 1998 | Cell Growth Differ. | pmid:9543388 |
| Hiroi J et al. | Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice. | 1998 | Jpn. J. Pharmacol. | pmid:9541280 |
| Anderson PO | Tacrolimus and breastfeeding. | 1998 | Transplantation | pmid:9539100 |
| Schäffer MR et al. | Tacrolimus impairs wound healing: a possible role of decreased nitric oxide synthesis. | 1998 | Transplantation | pmid:9539093 |
| Cichon G and Strauss M | Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer. | 1998 | Gene Ther. | pmid:9536268 |
| Mattoo AK | Peptidylprolyl cis-trans-isomerases from plant organelles. | 1998 | Meth. Enzymol. | pmid:9534153 |
| Wiederrecht G and Siekierka JJ | Yeast immunophilins: purification and assay of yeast FKBP12. | 1998 | Meth. Enzymol. | pmid:9534152 |
| Ochiai M et al. | Islet toxicity of FK506 measured in canine autografts. | 1998 | Transplant. Proc. | pmid:9532224 |
| Burke GW et al. | Tacrolimus-related microangiopathy in kidney and simultaneous pancreas-kidney recipients: evidence of endothelin and cytokine involvement. | 1998 | Transplant. Proc. | pmid:9532223 |
| Elmer DS et al. | Metabolic effects of FK 506 (tacrolimus) versus cyclosporine in portally drained pancreas allografts. | 1998 | Transplant. Proc. | pmid:9532159 |
| Corry RJ et al. | Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients. | 1998 | Transplant. Proc. | pmid:9532157 |
| Gruessner RW et al. | Mycophenolate mofetil and tacrolimus for induction and maintenance therapy after pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532156 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
| Corry RJ et al. | Pancreas transplantation without antibody therapy. | 1998 | Transplant. Proc. | pmid:9532050 |
| First MR | Clinical application of immunosuppressive agents in renal transplantation. | 1998 | Surg. Clin. North Am. | pmid:9531936 |
| Walensky LD et al. | The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. | 1998 | J. Cell Biol. | pmid:9531554 |
| Venkataraman C et al. | Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes. | 1998 | J. Immunol. | pmid:9531290 |
| Briffa N and Morris RE | Immunosuppressive drugs after lung transplantation. | 1998 | BMJ | pmid:9529396 |
| Matsuda T et al. | Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats. | 1998 | J Trauma | pmid:9529174 |
| Mizunuma M et al. | Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. | 1998 | Nature | pmid:9521328 |
| Moxey-Mims MM et al. | Increased incidence of insulin-dependent diabetes mellitus in pediatric renal transplant patients receiving tacrolimus (FK506) | 1998 | Transplantation | pmid:9521193 |
| MacCorkle RA et al. | Synthetic activation of caspases: artificial death switches. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520421 |
| Sequeira M et al. | New-onset Majocchi's granuloma in two kidney transplant recipients under tacrolimus treatment. | 1998 | J. Am. Acad. Dermatol. | pmid:9520033 |
| Schuppe HC et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Lancet | pmid:9519983 |
| Carreau A et al. | Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons. | 1997 Nov-Dec | Neuropharmacology | pmid:9517448 |
| Uchida J et al. | Renal endothelin in FK506-induced nephrotoxicity in spontaneously hypertensive rats. | 1998 | Jpn. J. Pharmacol. | pmid:9517403 |
| Pham H et al. | Occurrence of gammopathies and lymphoproliferative disorders in liver transplant recipients randomized to tacrolimus (FK506)- or cyclosporine-based immunosuppression. | 1998 | Liver Transpl Surg | pmid:9516567 |
| de la Pompa JL et al. | Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. | 1998 | Nature | pmid:9515963 |
| Corry RJ and Starzl TE | Pancreas transplantation. | 1998 | J. Am. Coll. Surg. | pmid:9510273 |
| Dumont FJ et al. | Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. | 1998 | J. Immunol. | pmid:9510155 |
| Snyder SH et al. | Neural actions of immunophilin ligands. | 1998 | Trends Pharmacol. Sci. | pmid:9509898 |
| Ikeda E et al. | Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis. | 1997 Nov-Dec | Jpn. J. Ophthalmol. | pmid:9509307 |
| Lukyanenko V et al. | Termination of Ca2+ release during Ca2+ sparks in rat ventricular myocytes. | 1998 | J. Physiol. (Lond.) | pmid:9508828 |
| Healey MC et al. | Bovine fallopian tube epithelial cells, adult C57BL/6 mice, and non-neonatal pigs as models for cryptosporidiosis. | 1997 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9508447 |
| Radermacher J et al. | Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506. | 1998 | Transpl. Int. | pmid:9503547 |
| Hatanaka H and Shimomura K | [Immunosuppressive activity of a microbial product]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503409 |
| Gold BG et al. | The immunosuppressant FK506 increases GAP-43 mRNA levels in axotomized sensory neurons. | 1998 | Neurosci. Lett. | pmid:9502207 |
| Bielefeldt K et al. | Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle. | 1997 | Cell Calcium | pmid:9502200 |
| Nagai H et al. | Immunopharmacological studies on experimental allergic encephalomyelitis in DA rats. | 1998 | Gen. Pharmacol. | pmid:9502169 |
| Finn L et al. | Epstein-Barr virus infections in children after transplantation of the small intestine. | 1998 | Am. J. Surg. Pathol. | pmid:9500771 |
| Misra S et al. | Red cell aplasia in children on tacrolimus after liver transplantation. | 1998 | Transplantation | pmid:9500636 |
| Neylan JF | Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group. | 1998 | Transplantation | pmid:9500626 |
| Gayowski T et al. | Orthotopic liver transplantation in high-risk patients: risk factors associated with mortality and infectious morbidity. | 1998 | Transplantation | pmid:9500623 |
| Khanna A et al. | Donor bone marrow potentiates the effect of tacrolimus on nonvascularized heart allograft survival: association with microchimerism and growth of donor dendritic cell progenitors from recipient bone marrow. | 1998 | Transplantation | pmid:9500620 |
| Chen H et al. | Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes. | 1998 | FEBS Lett. | pmid:9498805 |
| Boytim ML et al. | Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. | 1998 | J. Immunol. | pmid:9498760 |
| Jindal RM | Post-transplant hyperlipidaemia. | 1997 | Postgrad Med J | pmid:9497947 |
| Lhoëst G et al. | In vitro immunosuppressive activity, isolation from pig liver microsomes and identification by electrospray ms-ms of a new FK-506 C19-C20 epoxide metabolite. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495869 |
| Roche, FDA announce new drug-interaction warnings for mibefradil. | 1998 | Am J Health Syst Pharm | pmid:9492249 | |
| Witzke O et al. | Tacrolimus rescue therapy in patients with rejection and long-term dialysis after kidney transplantation. | 1998 | Clin. Nephrol. | pmid:9491282 |
| Tezcan H et al. | Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. | 1998 | Bone Marrow Transplant. | pmid:9486505 |
| Boswell GW et al. | Tacrolimus pharmacokinetics in BMT patients. | 1998 | Bone Marrow Transplant. | pmid:9486490 |
| Satterthwaite R et al. | Incidence of new-onset hypercholesterolemia in renal transplant patients treated with FK506 or cyclosporine. | 1998 | Transplantation | pmid:9484771 |
| Furlan V et al. | Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient. | 1998 | Transplant. Proc. | pmid:9474996 |
| Resch B et al. | FK 506 and successful pregnancy in a patient after renal transplantation. | 1998 | Transplant. Proc. | pmid:9474990 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Egawa H et al. | Lymphoproliferative disorders in patients undergoing living-related liver transplantation. | 1998 | Transplant. Proc. | pmid:9474982 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
| Watanabe K et al. | Synergistic effect of short-term fractionated lymphoid irradiation with initial high doses of FK506 on the induction of tolerance to kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9474940 |
| Shaw LM et al. | Prospective investigations of concentration-clinical response for immunosuppressive drugs provide the scientific basis for therapeutic drug monitoring. | 1998 | Clin. Chem. | pmid:9474049 |
| Kihira H et al. | Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation. | 1998 | Int. J. Oncol. | pmid:9472103 |
| Redrup AC et al. | Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. | 1998 | J. Immunol. | pmid:9469459 |
| Woo M et al. | Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. | 1997 | Bone Marrow Transplant. | pmid:9466284 |
| Miyazawa Y et al. | Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice. | 1998 | Hepatology | pmid:9462649 |
| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
| Zeng B et al. | Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506. | 1998 | Biochem. J. | pmid:9461498 |
| Roth D et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil for renal allograft recipients. | 1998 | Transplantation | pmid:9458023 |