| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garg V et al. | Proglycosomes: A novel nano-vesicle for ocular delivery of tacrolimus. | 2017 | Colloids Surf B Biointerfaces | pmid:28575739 |
| Jogiraju VK et al. | Application of physiologically based pharmacokinetic modeling to predict drug disposition in pregnant populations. | 2017 | Biopharm Drug Dispos | pmid:28474821 |
| Hu YN et al. | High-dose calcineurin inhibitor-free everolimus as a maintenance regimen for heart transplantation may be a risk factor for Pneumocystis pneumonia. | 2017 | Transpl Infect Dis | pmid:28425200 |
| Trasi NS et al. | Non-Sink Dissolution Behavior and Solubility Limit of Commercial Tacrolimus Amorphous Formulations. | 2017 | J Pharm Sci | pmid:27816263 |
| David-Neto E et al. | Longitudinal Pharmacokinetics of Everolimus When Combined With Low-level of Tacrolimus in Elderly Renal Transplant Recipients. | 2017 | Transplantation | pmid:27798513 |
| Lim SW et al. | Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. | 2017 | Lab. Invest. | pmid:28759009 |
| Alloway RR | Mounting Clinical Evidence With Tacrolimus Generic Products. | 2017 | Transplantation | pmid:28749820 |
| Solmaz S et al. | Tacrolimus-Induced Diabetic Ketoacidosis After Allogeneic Bone Marrow Transplant. | 2017 | Exp Clin Transplant | pmid:26643544 |
| Rhu J et al. | Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. | 2017 | Ann. Transplant. | pmid:29180612 |
| Wei L et al. | Therapeutic Effects of FK506 on IgA Nephropathy Rat. | 2017 | Kidney Blood Press. Res. | pmid:29179182 |
| Baluch A et al. | Successful management of Mycobacterium haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient. | 2017 | Transpl Infect Dis | pmid:27775824 |
| An Q et al. | High Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis. | 2017 | Chin. Med. J. | pmid:28685715 |
| Wang Y et al. | Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans. | 2017 | Molecules | pmid:28672869 |
| Lee D et al. | Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression. | 2017 | Transplantation | pmid:27779572 |
| Li X et al. | Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28669722 |
| Yuan D et al. | Effect of Vitamin D and Tacrolimus Combination Therapy on IgA Nephropathy. | 2017 | Med. Sci. Monit. | pmid:28659572 |
| Devaux S et al. | RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis. | 2017 | Mol. Cell Proteomics | pmid:28659490 |
| Qazi Y et al. | Efficacy and Safety of Everolimus Plus Low-Dose Tacrolimus Versus Mycophenolate Mofetil Plus Standard-Dose Tacrolimus in De Novo Renal Transplant Recipients: 12-Month Data. | 2017 | Am. J. Transplant. | pmid:27775865 |
| Arns W et al. | Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial. | 2017 | Transplantation | pmid:28658202 |
| Li X et al. | Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. | 2017 | J. Am. Soc. Nephrol. | pmid:27807213 |
| Agarwal SK et al. | Impact of type of calcineurin inhibitor on post-transplant tuberculosis: Single-center study from India. | 2017 | Transpl Infect Dis | pmid:27775825 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Sharma N et al. | Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort. | 2017 | J. Rheumatol. | pmid:28864644 |
| Asada A et al. | The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. | 2017 | Dig Liver Dis | pmid:27717793 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Park SS et al. | Beneficial Role of Low-Dose Antithymocyte Globulin in Unrelated Stem Cell Transplantation for Adult Patients with Acquired Severe Aplastic Anemia: Reduction of Graft-versus-Host Disease and Improvement of Graft-versus-Host Disease-Free, Failure-Free Survival Rate. | 2017 | Biol. Blood Marrow Transplant. | pmid:28554856 |
| Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
| Kim HS et al. | The Protective Effect of Febuxostat on Chronic Tacrolimus-Induced Nephrotoxicity in Rats. | 2017 | Nephron | pmid:27701176 |
| Pinsk V et al. | Complete Reversion of Familial Adenomatous Polyposis Phenotype Associated with Tacrolimus and Mycophenolate Mofetil Treatment Following Kidney Transplantation. | 2017 | Anticancer Res. | pmid:28551651 |
| Jin SE et al. | Evaluation of tacrolimus sorption to PVC- and non-PVC-based tubes in administration sets: Pump method vs. drip method. | 2017 | Int J Pharm | pmid:28549974 |
| Zaza G et al. | Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen. | 2017 | PLoS ONE | pmid:28542523 |
| Neustadtl AL et al. | Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. | 2017 | Neuroreport | pmid:28542068 |
| Berntsen HF et al. | The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | 2017 | Toxicology | pmid:29037868 |
| Eleftheriadis T et al. | In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity. | 2017 | Int Urol Nephrol | pmid:28508247 |
| Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
| Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
| Chen B et al. | Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. | 2017 | Sci Rep | pmid:28400553 |
| Banovic F et al. | Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. | 2017 | Vet. Dermatol. | pmid:28439997 |
| Vanhove T et al. | Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. | 2017 | Clin. Pharmacol. Ther. | pmid:28437851 |
| Alvarez-ElÃas AC et al. | A Retrospective Study on Mycophenolic Acid Drug Interactions: Effect of Prednisone, Sirolimus, and Tacrolimus With MPA. | 2017 | Ther Drug Monit | pmid:28437284 |
| Alhamad T et al. | Targeting High Calcineurin Inhibitor Levels After Acute Rejection With Less Tremor: A New Strategy. | 2017 | Transplantation | pmid:28422926 |
| Kanate AS et al. | Recipient Immune Modulation with Atorvastatin for Acute Graft-versus-Host Disease Prophylaxis after Allogeneic Transplantation. | 2017 | Biol. Blood Marrow Transplant. | pmid:28412518 |
| Labroo P et al. | Effect Of combining FK506 and neurotrophins on neurite branching and elongation. | 2017 | Muscle Nerve | pmid:27503321 |
| Bhari N et al. | Tacrolimus induced dermatophyte infection overlying a plaque morphea. | 2017 | Dermatol Ther | pmid:27502443 |
| Zhang H et al. | Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. | 2017 | J. Am. Soc. Nephrol. | pmid:28760751 |
| Calo S et al. | A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. | 2017 | PLoS Genet. | pmid:28339467 |
| Peng T et al. | Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats. | 2017 | Mol Med Rep | pmid:28339051 |
| Huang TQ et al. | Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury. | 2017 | Mol Med Rep | pmid:28339015 |
| Varela-Veiga A et al. | Long-standing Papules on the Scrotum. | 2017 | Actas Dermosifiliogr | pmid:27328825 |
| Saeki H | Management of Atopic Dermatitis in Japan. | 2017 | J Nippon Med Sch | pmid:28331140 |
| Ito A et al. | Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. | 2017 | Biochem. Genet. | pmid:28324194 |
| Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
| Truffinet O et al. | Tacrolimus Exerts Only a Transient Effectiveness in Refractory Pediatric Crohn Disease: A Case Series. | 2017 | J. Pediatr. Gastroenterol. Nutr. | pmid:27429426 |
| Xiang DM et al. | [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. | 2017 | Zhonghua Yan Ke Za Zhi | pmid:28412805 |
| Vanhove T et al. | Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients. | 2017 | Am. J. Transplant. | pmid:28224698 |
| Spallanzani V et al. | Red blood cell exchange as an approach for treating a case of severe tacrolimus overexposure. | 2017 | Transfus. Apher. Sci. | pmid:28223040 |
| Kasahara M et al. | Living donor liver transplantation during the first 3 months of life. | 2017 | Liver Transpl. | pmid:28220684 |
| Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
| Lepelley M et al. | [Pharmacokinetic drug interaction between miconazole mucoadhesive tablet and tacrolimus: About 3Â case-reports in transplant patients]. | 2017 | Therapie | pmid:28214069 |
| Shihab F et al. | Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:28141897 |
| Son SY et al. | Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients. | 2017 | Drug Des Devel Ther | pmid:28138224 |
| Regunath H et al. | Early diagnosis of Ehrlichia ewingii infection in a lung transplant recipient by peripheral blood smear. | 2017 | Transpl Infect Dis | pmid:28036138 |
| Shoughy SS and Tabbara KF | Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis. | 2017 | Br J Ophthalmol | pmid:28137823 |
| Onodera M et al. | ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis. | 2017 | J. Gastroenterol. Hepatol. | pmid:28135009 |
| Ayar Y et al. | Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. | 2017 | Transplant. Proc. | pmid:28219583 |
| Keller F et al. | Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
. | 2017 | Clin. Nephrol. | pmid:28025957 |
| Chu CH et al. | Radiation recall dermatitis induced by topical tacrolimus for post-irradiation morphea. | 2017 | J Eur Acad Dermatol Venereol | pmid:27256845 |
| Kirpalani A et al. | Idiosyncratic drug reactions and membranous glomerulopathy. | 2017 | BMJ Case Rep | pmid:28137906 |
| Sommer W et al. | Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. | 2017 | Transpl. Int. | pmid:28095640 |
| Classen J et al. | Seasonal leukotrichia in a German shepherd dog. A case report. | 2017 | Tierarztl Prax Ausg K Kleintiere Heimtiere | pmid:28094416 |
| Kim JM et al. | Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients. | 2017 | Med Princ Pract | pmid:28092916 |
| Viklicky O et al. | Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial. | 2017 | PLoS ONE | pmid:28085915 |
| Ren L et al. | Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients. | 2017 | Pharmacogenomics | pmid:28084894 |
| Naniwa T et al. | Efficacy of add-on tacrolimus on methotrexate to maintain clinical remission after rediscontinuation of a tumor necrosis factor inhibitor in rheumatoid arthritis patients who relapsed shortly after discontinuation of the same tumor necrosis factor inhibitor due to clinical remission. | 2017 | Mod Rheumatol | pmid:27143107 |
| Pimentel AL et al. | Diagnostic accuracy of glycated hemoglobin for post-transplantation diabetes mellitus after kidney transplantation: systematic review and meta-analysis. | 2017 | Nephrol. Dial. Transplant. | pmid:28088775 |
| Li R et al. | Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. | 2017 | Photodermatol Photoimmunol Photomed | pmid:27696531 |
| Srivastava AK et al. | Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis. | 2017 | Exp. Neurol. | pmid:28038988 |
| Yang D et al. | JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature. | 2017 | Transpl Infect Dis | pmid:28036142 |
| Billing H et al. | Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial. | 2017 | Ther Drug Monit | pmid:28030534 |
| Xu D et al. | Tacrolimus improves proteinuria remission in adults with cyclosporine A-resistant or -dependent minimal change disease. | 2017 | Nephrology (Carlton) | pmid:28035723 |
| Igata S et al. | Acute right heart failure caused by tacrolimus after renal transplantation: Serial observation by speckle tracking and Doppler echocardiography. | 2017 | Echocardiography | pmid:29178293 |
| Spiekerkoetter E et al. | Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension. | 2017 | Eur. Respir. J. | pmid:28893866 |
| Sathyasaikumar KV et al. | Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. | 2017 | Neuroscience | pmid:29031603 |
| Li J et al. | Wuzhi Tablet ( Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. | 2017 | Drug Metab. Dispos. | pmid:28864749 |
| Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
| Van Laecke S et al. | Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. | 2017 | Ann. Transplant. | pmid:28848225 |
| Cohen L et al. | A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report. | 2017 | J Med Case Rep | pmid:28844207 |
| Watanabe M et al. | Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. | 2017 | Ann. Hematol. | pmid:28508935 |
| Dang W et al. | Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. | 2017 | Antimicrob. Agents Chemother. | pmid:28807916 |
| Dabrowska-Zamojcin E et al. | KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus. | 2017 | Folia Biol. (Praha) | pmid:28805561 |
| Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
| Noceti O et al. | Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. | 2017 | Clin. Chem. | pmid:29054923 |
| Soiffer RJ et al. | Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. | 2017 | J. Clin. Oncol. | pmid:29040031 |
| Hasegawa J et al. | Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients. | 2017 | Int. J. Infect. Dis. | pmid:28986314 |
| Olariu R et al. | Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation. | 2017 | J. Surg. Res. | pmid:28985877 |
| Furukawa T et al. | A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. | 2017 | Rinsho Shinkeigaku | pmid:28132975 |
| Wang Y et al. | FK506 protects heart function via increasing autophagy after myocardial infarction in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28965948 |
| Whitehouse G et al. | IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584086 |
| Al-Kadhimi Z et al. | Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28581472 |
| Dardis G et al. | Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. | 2017 | Dev. Dyn. | pmid:28577298 |