| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Openshaw H | Peripheral neuropathy after bone marrow transplantation. | 1997 | Biol. Blood Marrow Transplant. | pmid:9360782 |
| Firdaous I et al. | Excretion of tacrolimus glucuronides in human bile. | 1997 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:9358202 |
| Wang JH and Kelly PT | Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. | 1997 | J. Neurophysiol. | pmid:9356420 |
| Ishida H et al. | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. | 1997 | Toxicology | pmid:9355935 |
| Karlsson H and Nässberger L | FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli. | 1997 | Transplantation | pmid:9355847 |
| Sheiner PA et al. | Increased risk of early rejection correlates with recovery of CD3 cell count after liver transplant in patients receiving OKT3 induction. | 1997 | Transplantation | pmid:9355846 |
| Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
| Lang P and Baron C | Molecular mechanisms of immunosuppressive chemical agents recently introduced in clinical transplantation protocols. | 1997 | Nephrol. Dial. Transplant. | pmid:9351062 |
| Saitoh O et al. | Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29). | 1997 | J. Gastroenterol. | pmid:9349985 |
| Prokisch H et al. | Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient. | 1997 | Mol. Gen. Genet. | pmid:9349701 |
| Krüger M et al. | Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9349628 |
| Hosoi R et al. | Isoform-specific up-regulation by ouabain of Na+,K+-ATPase in cultured rat astrocytes. | 1997 | J. Neurochem. | pmid:9349566 |
| Cameron AM et al. | FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. | 1997 | J. Biol. Chem. | pmid:9346894 |
| Wong PY et al. | FK506 in liver transplantation for chronic hepatitis B: in vitro studies on lymphocyte activation and virus replication. | 1995 | Liver Transpl Surg | pmid:9346613 |
| Klintmalm GB and Gonwa TA | Nephrotoxicity associated with cyclosporine and FK506. | 1995 | Liver Transpl Surg | pmid:9346596 |
| Gold BG et al. | A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. | 1997 | Exp. Neurol. | pmid:9344552 |
| Wallemacq PE et al. | IMx tacrolimus II vs IMx tacrolimus microparticle enzyme immunoassay evaluated in renal and hepatic transplant patients. | 1997 | Clin. Chem. | pmid:9342026 |
| Harihara Y and Makuuchi M | [Partial liver transplantation]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340350 |
| Vella JP and Sayegh MH | Maintenance pharmacological immunosuppressive strategies in renal transplantation. | 1997 | Postgrad Med J | pmid:9338020 |
| Nagai H et al. | FK-506 and cyclosporin A potentiate the IgE antibody production by contact sensitization with hapten in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336339 |
| Hara K et al. | Implantation of xenogeneic transgenic neural plate tissues into parkinsonian rat brain. | 1997 Sep-Oct | Cell Transplant | pmid:9331504 |
| Ilan Y et al. | Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat. | 1997 | Hepatology | pmid:9328318 |
| McGhee B et al. | Therapeutic use of an extemporaneously prepared oral suspension of tacrolimus in pediatric patients. | 1997 | Transplantation | pmid:9326429 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation. | 1997 | Transplantation | pmid:9326428 |
| Fujita T et al. | Prolonged survival of rat skin allograft by treatment with FK506 ointment. | 1997 | Transplantation | pmid:9326422 |
| Denecker G et al. | Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. | 1997 | Cytokine | pmid:9325011 |
| Arbustini E et al. | Acute rejection and heart infection rates in FK 506- versus cyclosporine A-treated heart transplant recipients: an endomyocardial biopsy pathologic study. | 1997 | J. Heart Lung Transplant. | pmid:9322152 |
| Ko WJ et al. | Hypomagnesia and arrhythmia corrected by replacing cyclosporine with FK506 in a heart transplant recipient. | 1997 | J. Heart Lung Transplant. | pmid:9322151 |
| Kesten S et al. | Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. | 1997 | J. Heart Lung Transplant. | pmid:9322139 |
| Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
| Goodyear N et al. | The 37 kDa immunophilin has uracil DNA glycosylase but not rotamase activity. | 1997 | Clin. Biochem. | pmid:9316745 |
| Alarcón CM and Heitman J | FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. | 1997 | Mol. Cell. Biol. | pmid:9315655 |
| Reynolds KA et al. | Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. | 1997 | J. Antibiot. | pmid:9315087 |
| Kageyama M et al. | FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release. | 1997 | Eur. J. Pharmacol. | pmid:9314039 |
| Wong BR et al. | TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. | 1997 | J. Biol. Chem. | pmid:9312132 |
| Graef IA et al. | Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. | 1997 | EMBO J. | pmid:9312021 |
| Atkison PR et al. | Arteritis and increased intracellular calcium as a possible mechanism for tacrolimus-related cardiac toxicity in a pediatric transplant recipient. | 1997 | Transplantation | pmid:9311719 |
| Ito A et al. | Donor-specific tolerance by perioperative intrathymic injection of bone marrow cells in the rat cardiac allograft model: use of FK506 can shorten the necessary duration of pretransplant intrathymic conditioning. | 1997 | Transplantation | pmid:9311715 |
| Kamada H et al. | Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats. | 1997 | Jpn. J. Pharmacol. | pmid:9307327 |
| Tanaka H et al. | [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. | 1997 | Yakugaku Zasshi | pmid:9306728 |
| Tze WJ et al. | Prolongation of pig islet xenograft survival in rats immunosuppressed with FK506. | 1997 | Diabetes Res. Clin. Pract. | pmid:9306035 |
| Jonas S et al. | De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin. | 1997 | Cancer | pmid:9305716 |
| Izuishi K et al. | Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9304807 |
| Sperr WR et al. | Inhibition of allergen-induced histamine release from human basophils by cyclosporine A and FK-506. | 1997 | Int. Arch. Allergy Immunol. | pmid:9303333 |
| Milićević NM and Milićević Z | Stereological study of splenic tissue compartments in FK506-treated rats. | 1997 | Histol. Histopathol. | pmid:9302561 |
| Lal SM et al. | De novo membranous glomerulopathy in a renal transplant patient treated with FK 506. The first reported case. | 1997 | Int J Artif Organs | pmid:9298410 |
| Alevizopoulos A et al. | Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV. | 1997 | J. Biol. Chem. | pmid:9295299 |
| Ruzicka T et al. | A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. | 1997 | N. Engl. J. Med. | pmid:9295241 |
| Alvaro D et al. | Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. | 1997 | J. Clin. Invest. | pmid:9294100 |
| Suzuki H et al. | Induction of transplantation tolerance in adult rats by vascularized spleen transplantation. | 1997 | Transplantation | pmid:9293881 |
| Garcia-Criado FJ et al. | Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. | 1997 | Transplantation | pmid:9293871 |
| Jain A et al. | Pregnancy after liver transplantation under tacrolimus. | 1997 | Transplantation | pmid:9293865 |
| Yoshikawa H et al. | Fc gammaRIII-mediated regulation of hematopoiesis in murine bone marrow cells by interleukin-3 and CD95 (Fas/Apo-1). | 1997 | Blood | pmid:9292524 |
| de-la-Serna-Higuera C et al. | Tacrolimus-induced bone marrow suppression. | 1997 | Lancet | pmid:9291912 |
| Shapiro R et al. | Reversibility of tacrolimus-induced posttransplant diabetes: an illustrative case and review of the literature. | 1997 | Transplant. Proc. | pmid:9290809 |
| Kramer MR et al. | Dose adjustment and cost of itraconazole prophylaxis in lung transplant recipients receiving cyclosporine and tacrolimus (FK 506). | 1997 | Transplant. Proc. | pmid:9290780 |
| Yagi M et al. | Effect of a glutamine-enriched diet on small bowel allograft during immunosuppressive therapy. | 1997 | Nutrition | pmid:9290090 |
| Brunet M | [Tacrolimus (FK506): clinical, pharmacological and analytical aspects]. | 1997 | Med Clin (Barc) | pmid:9289523 |
| Michel MC et al. | Comparison of old and new IMX assays for monitoring of tacrolimus levels. | 1997 | Transpl. Int. | pmid:9287412 |
| Gerlach J et al. | Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation. | 1997 | Transpl. Int. | pmid:9287409 |
| Morris-Stiff G et al. | Conversion from cyclosporin to tacrolimus in a patient with prolonged acute tubular necrosis. | 1997 | Transpl. Int. | pmid:9287408 |
| Meiser BM et al. | Tacrolimus: a superior agent to OKT3 for treating cases of persistent rejection after intrathoracic transplantation. | 1997 | J. Heart Lung Transplant. | pmid:9286771 |
| Weppler D et al. | Status of liver and gastrointestinal transplantation at the University of Miami. | 1996 | Clin Transpl | pmid:9286568 |
| Vaden SL | Cyclosporine and tacrolimus. | 1997 | Semin. Vet. Med. Surg. Small Anim. | pmid:9283240 |
| Butcher SP et al. | Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. | 1997 | J. Neurosci. | pmid:9278529 |
| Guérette B et al. | Prevention by anti-LFA-1 of acute myoblast death following transplantation. | 1997 | J. Immunol. | pmid:9278346 |
| Mayer AD et al. | Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group. | 1997 | Transplantation | pmid:9275110 |
| Rolfe FG et al. | Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9271313 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |
| Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
| Alak AM and Moy S | Biological activity of tacrolimus (FK506) and its metabolites from whole blood of kidney transplant patients. | 1997 | Transplant. Proc. | pmid:9270821 |
| Filler G et al. | Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants. | 1997 | Nephrol. Dial. Transplant. | pmid:9269646 |
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| Sherrington PD et al. | TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. | 1997 | J. Biol. Chem. | pmid:9268302 |
| Gruessner RW | Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group. | 1997 | Clin Transplant | pmid:9267719 |
| Singh N et al. | Bloodstream infections in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9267715 |
| Ahsan N et al. | Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation. | 1997 | Clin Transplant | pmid:9267713 |
| Woodle ES et al. | Reversal of accelerated renal allograft rejection with FK 506. | 1997 | Clin Transplant | pmid:9267710 |
| Yoshimoto T et al. | [Leukoencephalopathy probably caused by tacrolimus hydrate after stem cell transplantation in a girl with MDS 7 monosomy]. | 1997 | Rinsho Ketsueki | pmid:9267167 |
| Paterson DL et al. | Could a herpesvirus mimic tacrolimus-induced leukoencephalopathy? | 1997 | Ann. Neurol. | pmid:9266742 |
| Hickman PE et al. | Clinical chemistry and post-liver-transplant monitoring. | 1997 | Clin. Chem. | pmid:9265907 |
| Zhang Q et al. | A specific method for the measurement of tacrolimus in human whole blood by liquid chromatography/tandem mass spectrometry. | 1997 | Ther Drug Monit | pmid:9263391 |
| Wang MS et al. | Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9262378 |
| Frezza EE et al. | Non-lymphoid cancer after liver transplantation. | 1997 Jul-Aug | Hepatogastroenterology | pmid:9261620 |
| Trede NS et al. | Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. | 1997 | Bone Marrow Transplant. | pmid:9257897 |
| Tsamandas AC et al. | Adult heart transplantation under tacrolimus (FK506) immunosuppression: histopathologic observations and comparison to a cyclosporine-based regimen with lympholytic (ATG) induction. | 1997 | J. Heart Lung Transplant. | pmid:9257254 |
| Sher LS et al. | Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. | 1997 | Transplantation | pmid:9256184 |
| Tsamandas AC et al. | Central venulitis in the allograft liver: a clinicopathologic study. | 1997 | Transplantation | pmid:9256183 |
| Newell KA et al. | Association between liver transplantation for Langerhans cell histiocytosis, rejection, and development of posttransplant lymphoproliferative disease in children. | 1997 | J. Pediatr. | pmid:9255199 |
| Lacaille F et al. | Life-threatening food allergy in a child treated with FK506. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9252915 |
| Bragado MJ et al. | p70s6k is activated by CCK in rat pancreatic acini. | 1997 | Am. J. Physiol. | pmid:9252447 |
| Dhawan A et al. | Tacrolimus (FK506) malabsorption: management with fluconazole coadministration. | 1997 | Transpl. Int. | pmid:9249946 |
| Neuhaus P et al. | Tacrolimus-based immunosuppression after liver transplantation: a randomised study comparing dual versus triple low-dose oral regimens. | 1997 | Transpl. Int. | pmid:9249934 |
| Newstead CG | Tacrolimus in renal transplantation. | 1997 | Nephrol. Dial. Transplant. | pmid:9249761 |
| Massicot F et al. | Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line. | 1997 | Arch. Toxicol. | pmid:9248632 |
| Marienfeld R et al. | Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells. | 1997 | Eur. J. Immunol. | pmid:9247567 |
| McKee M et al. | Steroid withdrawal in tacrolimus (FK506)-treated pediatric liver transplant recipients. | 1997 | J. Pediatr. Surg. | pmid:9247215 |
| Cao S et al. | Potential effect of cyclosporin A in formation of cholesterol gallstones in pediatric liver transplant recipients. | 1997 | Dig. Dis. Sci. | pmid:9246038 |
| Floren LC et al. | Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. | 1997 | Clin. Pharmacol. Ther. | pmid:9246018 |
| Yu C et al. | Glucocorticoids fail to enhance the effect of FK506 and methotrexate in prevention of graft-versus-host disease after DLA-nonidentical, unrelated marrow transplantation. | 1997 | Bone Marrow Transplant. | pmid:9244417 |