| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Durham HD et al. | The immunosuppressant FK506 prolongs transgene expression in brain following adenovirus-mediated gene transfer. | 1997 | Neuroreport | pmid:9243594 |
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| Kogi M et al. | Effects of calyculin A and FK506 on the O2- generation of rat peritoneal macrophages. | 1996 | Tokai J. Exp. Clin. Med. | pmid:9239803 |
| Sawabe T et al. | Sinus arrest during tacrolimus (FK506) and digitalis treatment in a bone marrow transplant recipient. | 1997 | Transplantation | pmid:9233725 |
| Yamagami S et al. | Mechanism of concordant corneal xenograft rejection in mice: synergistic effects of anti-leukocyte function-associated antigen-1 monoclonal antibody and FK506. | 1997 | Transplantation | pmid:9233699 |
| Wingard JR et al. | Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients. | 1997 | Bone Marrow Transplant. | pmid:9232256 |
| Birnbaum AH et al. | Recurrence of autoimmune hepatitis in children after liver transplantation. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9226522 |
| Rejto PA and Verkhivker GM | Mean field analysis of FKBP12 complexes with FK506 and rapamycin: implications for a role of crystallographic water molecules in molecular recognition and specificity. | 1997 | Proteins | pmid:9223178 |
| Hebebrand D et al. | Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443. | 1997 | J Hand Surg Br | pmid:9222906 |
| duBell WH et al. | Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes. | 1997 | J. Physiol. (Lond.) | pmid:9218211 |
| Maeda T | [Experimental study of the effectiveness of immunosuppression therapy using FK506 and 15-deoxyspergualin in concordant xenotransplantation]. | 1997 | Nihon Kyobu Geka Gakkai Zasshi | pmid:9217381 |
| Su Y et al. | Cyclosporin A but not FK506 inhibits thyroid hormone-induced apoptosis in tadpole intestinal epithelium. | 1997 | FASEB J. | pmid:9212079 |
| Devine SM et al. | The outcome of unrelated donor bone marrow transplantation in patients with hematologic malignancies using tacrolimus (FK506) and low dose methotrexate for graft-versus-host disease prophylaxis. | 1997 | Biol. Blood Marrow Transplant. | pmid:9209738 |
| Ellouk-Achard S et al. | Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture. | 1997 | Arch. Toxicol. | pmid:9209689 |
| Uberti JP et al. | Tacrolimus and methotrexate for the prophylaxis of acute graft-versus-host disease in allogeneic bone marrow transplantation in patients with hematologic malignancies. | 1997 | Bone Marrow Transplant. | pmid:9208118 |
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| Moroda T et al. | Self-reactive forbidden clones are confined to pathways of intermediate T-cell receptor cell differentiation even under immunosuppressive conditions. | 1997 | Immunology | pmid:9203970 |
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| Raufman JP et al. | Regulation of calcium-induced exocytosis from gastric chief cells by protein phosphatase-2B (calcineurin). | 1997 | Biochim. Biophys. Acta | pmid:9202177 |
| Alak AM | Measurement of tacrolimus (FK506) and its metabolites: a review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies. | 1997 | Ther Drug Monit | pmid:9200777 |
| Rouviere N et al. | Immunosuppressor binding to the immunophilin FKBP59 affects the local structural dynamics of a surface beta-strand: time-resolved fluorescence study. | 1997 | Biochemistry | pmid:9200682 |
| Guerini D | Calcineurin: not just a simple protein phosphatase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199180 |
| Sugitani A et al. | En bloc pancreas and kidney transplantation in a patient with limited vascular access. | 1997 | Transplantation | pmid:9197366 |
| Koneru B et al. | Blood transfusions in liver recipients: a conundrum or a clear benefit in the cyclosporine/tacrolimus era? | 1997 | Transplantation | pmid:9197350 |
| Ciancio G et al. | Post-transplant lymphoproliferative disease in kidney transplant patients in the new immunosuppressive era. | 1997 | Clin Transplant | pmid:9193850 |
| Katari SR et al. | Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193849 |
| Hohage H et al. | Effects of cyclosporin A and FK 506 on lipid metabolism and fibrinogen in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193847 |
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| Scott JE et al. | Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells. | 1997 | Biochem. J. | pmid:9182723 |
| Prasad NV et al. | Metabolism of tacrolimus (FK 506) in rat liver microsomes. Effect of rifampin and dexamethasone. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9178371 |
| Aoki Y and Kao PN | Cyclosporin A-sensitive calcium signaling represses NFkappaB activation in human bronchial epithelial cells and enhances NFkappaB activation in Jurkat T-cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9177287 |
| Rezeig MA et al. | Kaposi's sarcoma in liver transplant recipients on FK506: two case reports. | 1997 | Transplantation | pmid:9175820 |
| Savoldi E et al. | [Dental and oral aspects in pediatric liver transplant patients. A comparison between the effects of cyclosporine A and FK 506]. | 1997 | Minerva Stomatol | pmid:9173223 |
| Dodd DA | Rapid resolution of gingival hyperplasia after switching from cyclosporine A to tacrolimus. | 1997 | J. Heart Lung Transplant. | pmid:9171281 |
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| Freiberg RA et al. | Transcriptional control in keratinocytes and fibroblasts using synthetic ligands. | 1997 | J. Clin. Invest. | pmid:9169490 |
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| Min DI et al. | Time-dependent disposition of tacrolimus and its effect on endothelin-1 in liver allograft recipients. | 1997 May-Jun | Pharmacotherapy | pmid:9165550 |
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| Siddiqui MA et al. | Lymphomatoid papulosis and FK 506. | 1997 | Int. J. Dermatol. | pmid:9159004 |
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| Delehanty LL et al. | Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone. | 1997 | Immunology | pmid:9155645 |
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| Chow FS et al. | Effect of hematocrit and albumin concentration on hepatic clearance of tacrolimus (FK506) during rabbit liver perfusion. | 1997 | Drug Metab. Dispos. | pmid:9152601 |
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| Yamagami S et al. | Rejection mechanism and immunosuppression by FK 506 and anti-leukocyte function associated antigen-1 antibody in concordant corneal xenotransplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123598 |
| Ohdan H et al. | Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123589 |
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| Iacona I et al. | Mycophenolic acid in combination with FK 506: a pharmacokinetic study in piglets after small-bowel transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123489 |
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