| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
| Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
| Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
| Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
| Assan R et al. | FK 506/fluconazole interaction enhances FK 506 nephrotoxicity. | 1994 Jan-Feb | Diabete Metab | pmid:7520007 |
| Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
| Funauchi M et al. | Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. | 1994 | Neurosci. Res. | pmid:7520143 |
| Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
| Zeniya A et al. | Anti-ulcer effect of FK 506, immunosuppressive agent, in rats. | 1994 | J. Gastroenterol. | pmid:7520322 |
| Yamamoto S et al. | Inhibition of anthralin-caused skin tumor promotion and interleukin-1 alpha production by potent immunosuppressant FK506. | 1994 | Cancer Lett. | pmid:7520353 |
| Enslen H and Soderling TR | Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. | 1994 | J. Biol. Chem. | pmid:7520433 |
| Sewell TJ et al. | Inhibition of calcineurin by a novel FK-506-binding protein. | 1994 | J. Biol. Chem. | pmid:7520438 |
| Oyanagui Y | Nitric oxide- and hydrogen peroxide-mediated gene expression by glucocorticoids and FK506 in histamine paw edema of mice. | 1994 | Life Sci. | pmid:7520521 |
| Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
| Nakata S et al. | Immunosuppressive mechanisms of deoxymethylspergualin and FK 506 on in vitro cytotoxic T lymphocytes. | 1994 | Transplant. Proc. | pmid:7520613 |
| Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
| Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
| Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
| Sun CK et al. | Intensive care after orthotopic liver transplantation. | 1994 | Transplant. Proc. | pmid:7520627 |
| Sato K et al. | Effectiveness of triple regimen immunosuppression in canine pancreatic allotransplantation. | 1994 | Transplant. Proc. | pmid:7520628 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Jiang H et al. | FK 506 and deoxyspergualin: additive immunosuppressive effect on rat cardiac allograft rejection in vivo and mitogen-stimulated human lymphocyte responses in vitro. | 1994 | Transplant. Proc. | pmid:7520631 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
| Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
| Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
| Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
| Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
| Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
| Stancato LF et al. | The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. | 1994 | J. Biol. Chem. | pmid:7520912 |
| Hirano Y et al. | Mechanism of FK506-induced glucose intolerance in rats. | 1994 | J Toxicol Sci | pmid:7520947 |
| Tacrolimus (FK506) for organ transplants. | 1994 | Med Lett Drugs Ther | pmid:7520968 | |
| Malyszko J et al. | FK 506 affects platelet aggregation in vitro. | 1994 | Thromb. Res. | pmid:7521072 |
| Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
| Chen Y et al. | A putative sirolimus (rapamycin) effector protein. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7521160 |
| Tai PK et al. | Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. | 1994 | Biochemistry | pmid:7521210 |
| Akita K et al. | Suppression of nitric oxide production by cyclosporin A and FK506A in rat vascular smooth muscle cells. | 1994 | Clin. Exp. Pharmacol. Physiol. | pmid:7521274 |
| Weaver JL et al. | The interaction of immunosuppressive compounds in tandem stimulated peripheral human lymphocytes. | 1994 | Immunopharmacol Immunotoxicol | pmid:7521360 |
| Hibbins M et al. | Inhibition of PHA induced mononuclear cell proliferation by FK506 in combination with cyclosporine, methylprednisolone, 6-mercaptopurine and mycophenolic acid. | 1993 | Transpl. Immunol. | pmid:7521736 |
| Thomson AW et al. | Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. | 1993 | Transpl. Immunol. | pmid:7521738 |
| Matsuura T et al. | Organ-specific unresponsiveness induced by intrathymic injection of donor bone marrow cells and a short course of immunosuppression in the rat heart transplantation model. | 1993 | Transpl. Immunol. | pmid:7521742 |
| Woo J et al. | FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo. | 1994 | Transpl. Immunol. | pmid:7521743 |
| Kasiske BL | The effects of immunosuppressive agents on plasma lipoproteins after organ transplantation. | 1994 | J. Lab. Clin. Med. | pmid:7521894 |
| Krentz AJ et al. | Serum lipids and apolipoproteins in liver transplant recipients: a comparative study of cyclosporin A and FK 506. | 1994 | J. Lab. Clin. Med. | pmid:7521895 |
| Jensen C et al. | Interaction between tacrolimus and erythromycin. | 1994 | Lancet | pmid:7521928 |
| Winkler M et al. | Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. | 1994 | Ther Drug Monit | pmid:7521978 |
| D'Ambrosio R et al. | Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction. | 1994 | Ther Drug Monit | pmid:7521979 |
| Renoir JM et al. | Immunological identification of a 50 kDa Mr FK506-binding immunophilin as a component of the non-DNA binding, hsp90 and hsp70 containing, heterooligomeric form of the chick oviduct progesterone receptor. | 1993 | C. R. Acad. Sci. III, Sci. Vie | pmid:7522118 |
| Jung-Testas I et al. | [Inhibition of the anti-glucocorticosteroid effect of RU486 on the growth of mouse fibroblasts in culture by the immunosuppressor kf506]]. | 1993 | C. R. Acad. Sci. III, Sci. Vie | pmid:7522119 |
| Metcalfe S et al. | FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. | 1994 | Cell. Immunol. | pmid:7522130 |
| Nichols RA et al. | Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. | 1994 | J. Biol. Chem. | pmid:7522234 |
| Nakagawa H et al. | Tacrolimus ointment for atopic dermatitis. | 1994 | Lancet | pmid:7522297 |
| Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
| Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
| Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
| Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Lebeau MC et al. | Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7522447 |
| Abu-Elmagd K et al. | Recent advances in hepatic transplantation at the University of Pittsburgh. | 1993 | Clin Transpl | pmid:7522528 |
| Mouzaki A and Rungger D | Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory T-helper cells. | 1994 | Blood | pmid:7522636 |
| Abu-Elmagd K et al. | Three years clinical experience with intestinal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522850 |
| Shapiro R et al. | Improving results of pediatric renal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522851 |
| Moia LJ et al. | Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. | 1994 | Brain Res. | pmid:7522929 |
| Pai SY et al. | Cross-linking CD28 leads to activation of 70-kDa S6 kinase. | 1994 | Eur. J. Immunol. | pmid:7523138 |
| Schmidt B et al. | A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila. | 1994 | FEBS Lett. | pmid:7523184 |
| Hakamata Y et al. | Involvement of the brain type of ryanodine receptor in T-cell proliferation. | 1994 | FEBS Lett. | pmid:7523185 |
| Ahern GP et al. | Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506. | 1994 | FEBS Lett. | pmid:7523191 |
| Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
| Clipstone NA et al. | Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. | 1994 | J. Biol. Chem. | pmid:7523407 |
| Karmann K et al. | Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. | 1994 | J. Immunol. | pmid:7523510 |
| Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
| Ohtomo Y et al. | Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. | 1994 | Kidney Int. | pmid:7523751 |
| Moore R and Lord R | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523805 |
| Krentz AJ et al. | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523806 |
| Collins RH | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523807 |
| Schmidt A et al. | Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. | 1994 | Mol. Cell. Biol. | pmid:7523855 |
| A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. | 1994 | N. Engl. J. Med. | pmid:7523946 | |
| Calne RY | Immunosuppression in liver transplantation. | 1994 | N. Engl. J. Med. | pmid:7523947 |
| Schleuning M et al. | Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7523957 |
| Perotti BY et al. | HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. | 1994 | Pharm. Res. | pmid:7524055 |
| FDA approved new drug bulletin: aprotinin injection (trasylol), tacrolimus (prograf). | 1994 | RN | pmid:7524131 | |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
| Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
| Kattner A et al. | Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption. | 1994 | Transplant. Proc. | pmid:7524225 |
| Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
| Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
| Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |