| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burnett D et al. | Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. | 1994 | Biochem. Pharmacol. | pmid:7524504 |
| Bierer BE | Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. | 1994 | Chem. Immunol. | pmid:7524531 |
| Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
| Yu L and Fesik SW | pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands. | 1994 | Biochim. Biophys. Acta | pmid:7524680 |
| von Asmuth EJ et al. | IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. | 1994 May-Jun | Eur. Cytokine Netw. | pmid:7524716 |
| Papaccio G et al. | The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. | 1994 | Cell Tissue Res. | pmid:7525068 |
| Milan D et al. | The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. | 1994 | Cell | pmid:7525078 |
| Tamir H et al. | Secretogogue-induced gating of chloride channels in the secretory vesicles of parafollicular cells. | 1994 | Endocrinology | pmid:7525261 |
| Shafiee A et al. | Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858. | 1994 | Eur. J. Biochem. | pmid:7525282 |
| Benton BM et al. | A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. | 1994 | J. Cell Biol. | pmid:7525596 |
| Gruber SA et al. | Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation. | 1994 | J Clin Pharmacol | pmid:7525661 |
| Funk JO and Maibach HI | Horizons in pharmacologic intervention in allergic contact dermatitis. | 1994 | J. Am. Acad. Dermatol. | pmid:7525668 |
| Mukaida N et al. | Molecular mechanism of interleukin-8 gene expression. | 1994 | J. Leukoc. Biol. | pmid:7525815 |
| Hiromatsu Y et al. | Inhibitory effect of FK506 on intercellular adhesion molecule-1 (ICAM-1) expression on cultured thyroid cells. | 1994 | Kurume Med J | pmid:7526029 |
| Hacker J and Fischer G | Immunophilins: structure-function relationship and possible role in microbial pathogenicity. | 1993 | Mol. Microbiol. | pmid:7526121 |
| Kinoshita I et al. | Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. | 1994 | Muscle Nerve | pmid:7526208 |
| Cullen BR and Heitman J | Human immunodeficiency virus. Chaperoning a pathogen. | 1994 | Nature | pmid:7526224 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Radanyi C et al. | The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7526392 |
| Ko S et al. | The pharmacokinetic benefits of newly developed liposome-incorporated FK506. | 1994 | Transplantation | pmid:7526494 |
| Holländer GA et al. | Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | 1994 | Transplantation | pmid:7526495 |
| Ishioka M et al. | FK506 treatment of noninfectious uveitis. | 1994 | Am. J. Ophthalmol. | pmid:7526689 |
| Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
| Akamine S et al. | Monitoring canine lung allograft rejection using Ia antigen expression by bronchoalveolar lymphocytes. | 1994 | Surg. Today | pmid:7526914 |
| Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
| Alnemri ES et al. | FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. | 1994 | J. Biol. Chem. | pmid:7527037 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Shaw LM and Brayman KL | FK-506 therapeutic drug monitoring. | 1994 | Clin. Chem. | pmid:7527305 |
| Winkler M et al. | Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. | 1994 | Clin. Chem. | pmid:7527306 |
| Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
| Chen SR et al. | Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7527548 |
| Calmus Y | [Rejection of a liver allograft. Diagnosis and treatment]. | 1994 | Ann Radiol (Paris) | pmid:7527621 |
| Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
| Winkler M et al. | The use of plasma levels for FK 506 dosing in liver-grafted patients. | 1994 | Transpl. Int. | pmid:7527638 |
| Stark JH et al. | Sensitivity of baboon lymphocytes to cyclosporin A and FK 506: relative resistance of alloactivated cells to CyA. | 1994 | Transpl. Int. | pmid:7527639 |
| Abdalla AH et al. | FK 506 as an alternative in cyclosporin-induced hemolytic uremic syndrome in a kidney transplant recipient. | 1994 | Transpl. Int. | pmid:7527640 |
| Cooper MH et al. | Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. | 1994 | Bone Marrow Transplant. | pmid:7527689 |
| Lea JP et al. | Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin. | 1994 | Kidney Int. | pmid:7527873 |
| Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Mathieu C et al. | Potential role of 1,25(OH)2 vitamin D3 as a dose-reducing agent for cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7527950 |
| Mueller AR et al. | Severe neurotoxicity after liver transplantation: association between FK 506 therapy and hepatitis C virus disease. | 1994 | Transplant. Proc. | pmid:7527951 |
| Platz KP et al. | Causes of death following liver transplantation in FK 506- and cyclosporine-treated patients. | 1994 | Transplant. Proc. | pmid:7527952 |
| Christe W | Neurological disorders in liver and kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7527953 |
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
| Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Asselin I et al. | Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. | 1994 | Transplant. Proc. | pmid:7527970 |
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
| Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
| Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
| Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
| Hossain M et al. | Eosinophil viability-enhancing activity in mite-sensitive bronchial asthma. | 1994 | Intern. Med. | pmid:7528071 |
| Suzuki S | FK506 and deoxyspergualin: experimental studies and clinical applications. | 1994 | Transpl. Immunol. | pmid:7528087 |
| Yli-Kauhaluoma J and Janda KD | Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: synthesis of the immunoconjugates. | 1994 | Bioorg. Med. Chem. | pmid:7528089 |
| Stan R et al. | Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. | 1994 | J. Biol. Chem. | pmid:7528205 |
| Hachida M et al. | [The rescue effect of FK506 in refractory rejection after cardiac transplantation]. | 1994 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7528255 |
| Sugiyama E et al. | FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. | 1994 | J. Rheumatol. | pmid:7528280 |
| Monfar M et al. | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. | 1995 | Mol. Cell. Biol. | pmid:7528328 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Nephrol. Dial. Transplant. | pmid:7528363 |
| Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
| Moudgil A et al. | Inhibition of in vitro immunoglobulin production by a novel immunosuppressive drug brequinar sodium. | 1994 | Transplant Sci | pmid:7528627 |
| Klaus GG et al. | Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca(++)-dependent, FK506-sensitive pathway. | 1994 | Eur. J. Immunol. | pmid:7528676 |
| Chaudhuri B et al. | The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. | 1995 | FEBS Lett. | pmid:7528690 |
| Sandborn WJ et al. | Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue. | 1995 | Hepatology | pmid:7528712 |
| Douglas CM et al. | The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7528927 |
| Coghlan VM et al. | Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. | 1995 | Science | pmid:7528941 |
| Kraus-Friedmann N and Feng L | Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. | 1994 | Biochem. Pharmacol. | pmid:7529023 |
| Cardenas ME et al. | Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. | 1994 | EMBO J. | pmid:7529175 |
| Burkhalter EL et al. | Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. | 1994 | J. Hepatol. | pmid:7529272 |
| Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
| Alamartine E et al. | In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7529381 |
| Clardy J | The chemistry of signal transduction. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7529414 |
| Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
| Braun W et al. | Three-dimensional structure and actions of immunosuppressants and their immunophilins. | 1995 | FASEB J. | pmid:7529736 |
| Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Zarnt T et al. | Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. | 1995 | Biochem. J. | pmid:7529995 |
| Wera S et al. | Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression. | 1995 | FEBS Lett. | pmid:7530217 |
| Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
| Petros AM and Fesik SW | Nuclear magnetic resonance methods for studying protein-ligand complexes. | 1994 | Meth. Enzymol. | pmid:7530321 |
| Dawson TM et al. | The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. | 1994 | Neuroscience | pmid:7530348 |
| Karanam BV et al. | FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7530623 |
| Tsuchida M et al. | Effects of irradiation, glucocorticoid and FK506 on cell-surface antigen expression by rat thymocytes: a three-colour flow cytofluorometric analysis. | 1994 | Immunology | pmid:7530693 |
| Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |