| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fauvel H et al. | Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11850335 |
| Baboolal K et al. | Molecular and structural consequences of early renal allograft injury. | 2002 | Kidney Int. | pmid:11849412 |
| Tada H et al. | Effects of thymic hormone on reactive oxygen species-scavengers and renal function in tacrolimus-induced nephrotoxicity. | 2002 | Life Sci. | pmid:11848304 |
| Cruz MC et al. | Calcineurin is essential for survival during membrane stress in Candida albicans. | 2002 | EMBO J. | pmid:11847103 |
| Brenner BC et al. | Mechanisms of L-selectin-induced activation of the nuclear factor of activated T lymphocytes (NFAT). | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846396 |
| Tsoulfas G and Geller DA | NF-kappaB in transplantation: friend or foe? | 2001 | Transpl Infect Dis | pmid:11844153 |
| Clemons PA et al. | Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. | 2002 | Chem. Biol. | pmid:11841938 |
| Takeda Y et al. | Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. | 2002 | Circulation | pmid:11839620 |
| Kruszka SJ and Gherman RB | Successful pregnancy outcome in a lung transplant recipient with tacrolimus immunosuppression. A case report. | 2002 | J Reprod Med | pmid:11838314 |
| Garcia M et al. | Efficacy of early immunosuppressive therapy in a child with carbamazepine-associated vanishing bile duct and Stevens-Johnson syndromes. | 2002 | Dig. Dis. Sci. | pmid:11837721 |
| Lü L et al. | [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. | 1999 | Zhonghua Yan Ke Za Zhi | pmid:11835769 |
| Van Leent EJ et al. | Low systemic exposure after repeated topical application of Pimecrolimus (Elidel), SD Z ASM 981) in patients with atopic dermatitis. | 2002 | Dermatology (Basel) | pmid:11834853 |
| Kato Y et al. | Effect of epidermal growth factor on intestinal adaptation after allogeneic small bowel transplantation in rats. | 2002 | Life Sci. | pmid:11833743 |
| MacDonald A | Improving tolerability of immunosuppressive regimens. | 2001 | Transplantation | pmid:11833142 |
| Okabe H et al. | Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction. | 2002 | J. Pharm. Pharmacol. | pmid:11829131 |
| Mazzone PJ et al. | The humoral immune response to influenza vaccination in lung transplant patients. | 2001 | Eur. Respir. J. | pmid:11829104 |
| Zhang W | Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. | 2002 | Cardiovasc. Res. | pmid:11827679 |
| Yoshida EM | Post-liver transplantation immunosuppression: the song does not remain the same. | 2002 | Can. J. Gastroenterol. | pmid:11826341 |
| Ponseti JM et al. | [Tacrolimus (FK506) in the treatment of prednisone-resistant myasthenia gravis. Preliminary results of 20 cases]. | 2002 | Med Clin (Barc) | pmid:11825555 |
| Hopt UT | [New developments in immunosuppressive therapy]. | 2001 | Kongressbd Dtsch Ges Chir Kongr | pmid:11824327 |
| Homma M et al. | Effects of lansoprazole and rabeprazole on tacrolimus blood concentration: case of a renal transplant recipient with CYP2C19 gene mutation. | 2002 | Transplantation | pmid:11821750 |
| Bennett PC et al. | Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick. | 2002 | Brain Res. | pmid:11821011 |
| Iyer KR et al. | Late graft loss and long-term outcome after isolated intestinal transplantation in children. | 2002 | J. Pediatr. Surg. | pmid:11819189 |
| Kotanko P et al. | Rhabdomyolysis and acute renal graft impairment in a patient treated with simvastatin, tacrolimus, and fusidic acid. | 2002 | Nephron | pmid:11818715 |
| Sugden PH | Signalling pathways in cardiac myocyte hypertrophy. | 2001 | Ann. Med. | pmid:11817656 |
| Cho ML et al. | Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes. | 2002 | Arthritis Rheum. | pmid:11817607 |
| Peces R et al. | [Hemolytic anemia caused by graft-versus-host reaction in ABO-nonidentical renal transplants from blood group O donors]. | 2001 Jul-Aug | Nefrologia | pmid:11816517 |
| Pascual MA et al. | Progress in understanding humoral rejection in kidney transplantation: implications for patient management. | 2001 Jul-Aug | Nefrologia | pmid:11816504 |
| Li TK et al. | Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin. | 2002 | J. Cell. Biochem. | pmid:11813252 |
| Yoshimasu T et al. | Topical FK506 (tacrolimus) therapy for facial erythematous lesions of cutaneous lupus erythematosus and dermatomyositis. | 2002 Jan-Feb | Eur J Dermatol | pmid:11809595 |
| Suga Y et al. | Topical tacrolimus for chronic actinic dermatitis. | 2002 | J. Am. Acad. Dermatol. | pmid:11807453 |
| Nghiem P et al. | Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. | 2002 | J. Am. Acad. Dermatol. | pmid:11807435 |
| Holt DW et al. | International Federation of Clinical Chemistry/International Association of Therapeutic Drug Monitoring and Clinical Toxicology working group on immunosuppressive drug monitoring. | 2002 | Ther Drug Monit | pmid:11805724 |
| Olyaei AJ et al. | Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies. | 2001 | Curr Opin Crit Care | pmid:11805539 |
| Girman P et al. | The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats. | 2001 | Ann. Transplant. | pmid:11803619 |
| Espino G et al. | Assessment of myocardial hypertrophy by echocardiography in adult patients receiving tacrolimus or cyclosporine therapy for prevention of acute GVHD. | 2001 | Bone Marrow Transplant. | pmid:11803349 |
| Zylber-Katz E and Granot E | Abrupt increase of tacrolimus blood levels during an episode of Shigella infection in a child after liver transplantation. | 2001 | Ther Drug Monit | pmid:11802098 |
| Itagaki F et al. | Effect of ascites on tacrolimus disposition in a liver transplant recipient. | 2001 | Ther Drug Monit | pmid:11802097 |
| Turvey SE | Atopic diseases of childhood. | 2001 | Curr. Opin. Pediatr. | pmid:11801897 |
| Jain A et al. | A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis C. | 2002 | Liver Transpl. | pmid:11799484 |
| Tacrolimus. | 2001 | Am J Health Syst Pharm | pmid:11794952 | |
| Tanaka K et al. | Effects of immunophilin ligands on hydrogen peroxide-induced apoptosis in C6 glioma cells. | 2002 | Synapse | pmid:11793428 |
| Hymes LC and Warshaw BL | Tacrolimus rescue therapy for children with acute renal transplant rejection. | 2001 | Pediatr. Nephrol. | pmid:11793086 |
| Venkiteswaran K et al. | Tacrolimus, cyclosporine and plasma lipoproteins in renal transplant recipients. | 2001 | Transpl. Int. | pmid:11793038 |
| Lo A et al. | Initial clinical experience with interleukin-2 receptor antagonist induction in combination with tacrolimus, mycophenolate mofetil and steroids in simultaneous kidney-pancreas transplantation. | 2001 | Transpl. Int. | pmid:11793037 |
| Chang RW et al. | European randomised trial of dual versus triple tacrolimus-based regimens for control of acute rejection in renal allograft recipients. | 2001 | Transpl. Int. | pmid:11793035 |
| Boots JM et al. | Single-center experience with tacrolimus versus cyclosporine-Neoral in renal transplant recipients. | 2001 | Transpl. Int. | pmid:11793034 |
| Butani L et al. | Effect of felodipine on tacrolimus pharmacokinetics in a renal transplant recipient. | 2002 | Transplantation | pmid:11793001 |
| D'Antiga L et al. | Late cellular rejection in paediatric liver transplantation: aetiology and outcome. | 2002 | Transplantation | pmid:11792983 |
| Iguchi S et al. | Intratubular calcification in a post-renal transplanted patient with secondary hyperparathyroidism. | 2001 | Clin Transplant | pmid:11791796 |
| Oka K et al. | A case of tacrolimus nephrotoxicity appearing in a second renal transplantation patient. | 2001 | Clin Transplant | pmid:11791792 |
| Aitio ML | [Is it possible to prevent kidney problems caused by immunosuppression?]. | 2000 | Duodecim | pmid:11787104 |
| Uchida T et al. | Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation. | 2002 | Int. J. Mol. Med. | pmid:11786924 |
| Holtmeier J and Leuschner U | Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. | 2001 | Digestion | pmid:11786661 |
| Reeves CD et al. | A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus. | 2002 | J. Biol. Chem. | pmid:11786554 |
| Menillo SA et al. | Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation. | 2001 | Bone Marrow Transplant. | pmid:11781637 |
| Jacobson P et al. | Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients. | 2001 | Bone Marrow Transplant. | pmid:11781626 |
| Limke TL and Atchison WD | Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells. | 2002 | Toxicol. Appl. Pharmacol. | pmid:11781080 |
| Tang L et al. | FK506 enhanced osteoblastic differentiation in mesenchymal cells. | 2002 | Cell Biol. Int. | pmid:11779223 |
| Boucher M | Tacrolimus ointment for the treatment of atopic dermatitis. | 2001 | Issues Emerg Health Technol | pmid:11776288 |
| Kamiya H et al. | Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder. | 2001 | Can J Cardiol | pmid:11773940 |
| Gonwa TA et al. | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | 2001 | Transplantation | pmid:11773892 |
| Ling MR | Topical tacrolimus and pimecrolimus: future directions. | 2001 | Semin Cutan Med Surg | pmid:11770914 |
| Hebert AA et al. | Pimecrolimus cream 1%: a new development in nonsteroid topical treatment of inflammatory skin diseases. | 2001 | Semin Cutan Med Surg | pmid:11770913 |
| Bergman J and Rico MJ | Tacrolimus clinical studies for atopic dermatitis and other conditions. | 2001 | Semin Cutan Med Surg | pmid:11770912 |
| Robinson N et al. | Safety of the new macrolide immunomodulators. | 2001 | Semin Cutan Med Surg | pmid:11770911 |
| Stuetz A et al. | Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. | 2001 | Semin Cutan Med Surg | pmid:11770910 |
| Bekersky I et al. | Tacrolimus pharmacology and nonclinical studies: from FK506 to protopic. | 2001 | Semin Cutan Med Surg | pmid:11770909 |
| Eichenfield LF | Tacrolimus and pimecrolimus. Introduction. | 2001 | Semin Cutan Med Surg | pmid:11770907 |
| Tang S et al. | Necrotizing fasciitis in a renal transplant recipient treated with FK 506: the first reported case. | 2001 | Clin. Nephrol. | pmid:11770800 |
| Cheer SM and Plosker GL | Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. | 2001 | Am J Clin Dermatol | pmid:11770393 |
| Dudzik B et al. | [Use of Cyclosporine A and new immunosuppressive drugs in the therapy of glomerulonephritis]. | 2001 | Prz. Lek. | pmid:11769390 |
| Wondimu B et al. | Oral health in liver transplant children administered cyclosporin A or tacrolimus. | 2001 | Int J Paediatr Dent | pmid:11759102 |
| Schnopp C et al. | Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. | 2002 | J. Am. Acad. Dermatol. | pmid:11756949 |
| Kaliakatsou F et al. | Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus. | 2002 | J. Am. Acad. Dermatol. | pmid:11756943 |
| Rozycki TW et al. | Topical tacrolimus in the treatment of symptomatic oral lichen planus: a series of 13 patients. | 2002 | J. Am. Acad. Dermatol. | pmid:11756942 |
| Evoli A et al. | Successful treatment of myasthenia gravis with tacrolimus. | 2002 | Muscle Nerve | pmid:11754194 |
| Sakamoto Y et al. | Higher intracerebral concentration of tacrolimus after intermittent than continuous administration to rats. | 2001 | Liver Transpl. | pmid:11753909 |
| Takamatsu H et al. | FK506 attenuates early ischemic neuronal death in a monkey model of stroke. | 2001 | J. Nucl. Med. | pmid:11752082 |
| Boots JM et al. | Glucose metabolism in renal transplant recipients on tacrolimus: the effect of steroid withdrawal and tacrolimus trough level reduction. | 2002 | J. Am. Soc. Nephrol. | pmid:11752041 |
| van Duijnhoven EM et al. | Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. | 2002 | J. Am. Soc. Nephrol. | pmid:11752040 |
| Scheel AK et al. | Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: two case reports. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750573 |
| Tanabe K et al. | Prospective analysis and successful treatment of thrombotic microangiopathy in renal allografts under tacrolimus immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750571 |
| Risaliti A et al. | Cardiovascular and metabolic complications after liver transplantation: Neoral- versus tacrolimus-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750569 |
| Garcia CD et al. | Renal transplantation in children less than six years old. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750527 |
| Ferraresso M et al. | Conversion from cyclosporine to tacrolimus for refractory acute rejection in pediatric kidney transplant recipients: a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750525 |
| Tolba RH et al. | Conversion to Neoral for tacrolimus-related adverse effects in liver transplant recipients and improvement in quality of life. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750475 |
| Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
| Meier-Kriesche HU and Kaplan B | Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared to Sandimmune. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750465 |
| Miura S et al. | Long-term results of spousal renal donor transplants with donor-specific blood transfusions. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750463 |
| Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
| Sterneck M et al. | Steroid withdrawal in long-term liver transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750398 |
| Diekmann F et al. | Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor-induced nephrotoxicity. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750386 |
| Pridöhl O et al. | Low-dose immunosuppression with FK 506 and sirolimus after liver transplantation: 1-year results. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750384 |
| Hartwig T et al. | Low-dose sirolimus and tacrolimus in kidney transplantation: first results of a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750383 |
| Lawen J et al. | Sirolimus and low-dose tacrolimus with antibody induction in kidney transplantation: preliminary results of a pilot study. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750382 |
| Boggi U et al. | Use of basiliximab in conjunction with either Neora/MMF/steroids or Prograf/MMF/steroids in simultaneous pancreas-kidney transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750373 |
| Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
| Jørgensen KA et al. | Optimal time for determination of blood tacrolimus level. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750358 |
| Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |