tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
IgG Deficiency D017099 1 associated lipids
Deltaretrovirus Infections D006800 1 associated lipids
Dendritic Cell Sarcoma, Interdigitating D054739 1 associated lipids
Polymyositis D017285 1 associated lipids
Scorpion Stings D065008 1 associated lipids
Rotavirus Infections D012400 1 associated lipids
Netherton Syndrome D056770 1 associated lipids
Pseudohypoaldosteronism D011546 1 associated lipids
Arm Injuries D001134 1 associated lipids
Intussusception D007443 1 associated lipids
Per page 10 20 50 100 | Total 613

PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Mott JL et al. Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A. 2004 Biochem. Biophys. Res. Commun. pmid:15194495
Cryan J et al. FKBP, the binding protein for the immunosuppressive drug, FK-506, is not an inhibitor of protein kinase C activity. 1991 Biochem. Biophys. Res. Commun. pmid:1719972
Beppu K et al. Inhibition of interferon-gamma-activated nuclear factor-kappa B by cyclosporin A: A possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells. 2003 Biochem. Biophys. Res. Commun. pmid:12767900
Panyi G et al. Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes. 1996 Biochem. Biophys. Res. Commun. pmid:8619842
Li X et al. Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE. 2017 Biochem. Biophys. Res. Commun. pmid:28669722
Guerini D Calcineurin: not just a simple protein phosphatase. 1997 Biochem. Biophys. Res. Commun. pmid:9199180
Kim HY et al. Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. 2016 Biochem. Biophys. Res. Commun. pmid:26820537
Wang H et al. Different roles of Loop 7 in inhibition of calcineurin. 2007 Biochem. Biophys. Res. Commun. pmid:17707777
Yamamoto S et al. A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae. 2005 Biochem. Biophys. Res. Commun. pmid:15796929
Cobbs SL and Gooch JL NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin. 2007 Biochem. Biophys. Res. Commun. pmid:17719012
Nakamura T et al. Co-stimulation with bone morphogenetic protein-9 and FK506 induces remarkable osteoblastic differentiation in rat dedifferentiated fat cells. 2013 Biochem. Biophys. Res. Commun. pmid:24064349
Pancer Z et al. cDNA cloning of a putative protochordate FK506-binding protein. 1993 Biochem. Biophys. Res. Commun. pmid:7505578
Wiederrecht G et al. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. 1992 Biochem. Biophys. Res. Commun. pmid:1376117
Arie Y et al. Developmental changes in the regulation of calcium-dependent neurite outgrowth. 2009 Biochem. Biophys. Res. Commun. pmid:19068207
Tamura K et al. Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin. 1994 Biochem. Biophys. Res. Commun. pmid:7518678
Kochel I et al. Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004. 2005 Biochem. Biophys. Res. Commun. pmid:16051191
Tanaka S et al. Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells. 2005 Biochem. Biophys. Res. Commun. pmid:16055081
Ocain TD et al. A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase. 1993 Biochem. Biophys. Res. Commun. pmid:7685167
Asami M et al. Detection of the FK506-FKBP-calcineurin complex by a simple binding assay. 1993 Biochem. Biophys. Res. Commun. pmid:7685169
Hofbauer LC et al. Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. 2001 Biochem. Biophys. Res. Commun. pmid:11162519
Ke H and Huai Q Structures of calcineurin and its complexes with immunophilins-immunosuppressants. 2003 Biochem. Biophys. Res. Commun. pmid:14623295
Jeong JH et al. Effects of surface camouflaged islet transplantation on pathophysiological progression in a db/db type 2 diabetic mouse model. 2013 Biochem. Biophys. Res. Commun. pmid:23523788
Leiva MC and Lyttle CR Leukocyte chemotactic activity of FKBP and inhibition by FK506. 1992 Biochem. Biophys. Res. Commun. pmid:1379802
Kugimiya F et al. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. 2005 Biochem. Biophys. Res. Commun. pmid:16246307
Antoni FA et al. Inhibitory role for calcineurin in stimulus-secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells. 1993 Biochem. Biophys. Res. Commun. pmid:7687429
Denesyuk AI et al. Comparison of conformations of cyclosporin A and macrolide FK506 fragments: localization of putative binding sites with phosphatase calcineurin. 1993 Biochem. Biophys. Res. Commun. pmid:7687433
Krasowska A et al. Cell ATP level of Saccharomyces cerevisiae sensitively responds to culture growth and drug-inflicted variations in membrane integrity and PDR pump activity. 2010 Biochem. Biophys. Res. Commun. pmid:20346916
Lochmüller H et al. Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice. 1995 Biochem. Biophys. Res. Commun. pmid:7544122
Zhou N et al. Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway. 2010 Biochem. Biophys. Res. Commun. pmid:20580688
Davis DL and Soldin SJ Identification of ubiquitin as an immunophilin. 2000 Biochem. Biophys. Res. Commun. pmid:11032725
Ishizuka T et al. Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. 1997 Biochem. Biophys. Res. Commun. pmid:9016789
Marquis-Omer D et al. Stabilization of the FK506 binding protein by ligand binding. 1991 Biochem. Biophys. Res. Commun. pmid:1716886
Wang Y et al. FK506 protects heart function via increasing autophagy after myocardial infarction in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28965948
Sata M and Walsh K Cyclosporine downregulates Fas ligand expression on vascular endothelial cells: implication for accelerated vasculopathy by immunosuppressive therapy. 1999 Biochem. Biophys. Res. Commun. pmid:10491310
Hempen CM et al. Hematocrit-independent recovery of immunosuppressants from DBS using heated flow-through desorption. 2015 Bioanalysis pmid:26327182
Taillon MP et al. Challenges of developing a bioanalytical method for a macrolide immunosuppressant compound by LC-MS/MS. 2011 Bioanalysis pmid:21649497
Yuan C et al. A simple and robust LC-MS/MS method for measuring sirolimus and everolimus in whole blood. 2014 Bioanalysis pmid:25077621
Koster RA et al. Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems. 2017 Bioanalysis pmid:28300419
Koster RA et al. The performance of five different dried blood spot cards for the analysis of six immunosuppressants. 2015 Bioanalysis pmid:26045003
Zhang CW et al. [Establishment of a real-time PCR assay for simultaneously detecting human BKV and CMV DNA and its application in renal transplantation recipients]. 2013 Bing Du Xue Bao pmid:23895006
Holler E Risk assessment in haematopoietic stem cell transplantation: GvHD prevention and treatment. 2007 Best Pract Res Clin Haematol pmid:17448962
de Mare-Bredemeijer EL and Metselaar HJ Optimization of the use of Calcineurin inhibitors in liver transplantation. 2012 Best Pract Res Clin Gastroenterol pmid:22482528
Koutroubakis IE The patient with persistent perianal fistulae. 2007 Best Pract Res Clin Gastroenterol pmid:17544114
Xie ZQ et al. [Effect of topical tacrolimus ointment on expression of Toll-like receptors 2 and 4 in lesional atopic dermatitis skin]. 2006 Beijing Da Xue Xue Bao pmid:16892151
Sun W et al. [Association factors analysis of diarrhea in patients receiving kidney transplantation]. 2013 Beijing Da Xue Xue Bao pmid:24136278
Xie ZQ et al. [Expression of nuclear factor kappaB and the effect of topical tacrolimus ointment on lesional atopic dermatitis skin]. 2004 Beijing Da Xue Xue Bao pmid:15489928
Taglialatela G et al. Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. 2009 Behav. Brain Res. pmid:19162087
Clift DE et al. Effects of embryonic cyclosporine exposures on brain development and behavior. 2015 Behav. Brain Res. pmid:25591474
Arora RB et al. FK506 attenuates intracerebroventricular streptozotocin-induced neurotoxicity in rats. 2013 Behav Pharmacol pmid:26057771
Homayoun H et al. The effects of FK506 on the development and expression of morphine tolerance and dependence in mice. 2003 Behav Pharmacol pmid:12658072
Wu Q et al. Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation. 2014 Behav Neurol pmid:24970980
Cumming DV et al. Pharmacological preconditioning of primary rat cardiac myocytes by FK506. 1996 Sep-Oct Basic Res. Cardiol. pmid:8922254
Ikeda Y et al. Activation of ERK and suppression of calcineurin are interacting mechanisms of cardioprotection afforded by delta-opioid receptor activation. 2006 Basic Res. Cardiol. pmid:16619106
Kise H et al. Cardiac and haemodynamic effects of tacrolimus in the halothane-anaesthetized dog. 2010 Basic Clin. Pharmacol. Toxicol. pmid:19912168
Zhang H et al. Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. 2018 Basic Clin. Pharmacol. Toxicol. pmid:28945011
Han N et al. Population pharmacokinetic-pharmacogenetic model of tacrolimus in the early period after kidney transplantation. 2014 Basic Clin. Pharmacol. Toxicol. pmid:24238261
Huang F et al. Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study. 2018 Basic Clin. Pharmacol. Toxicol. pmid:29427400
Quteineh L et al. Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipients. 2008 Basic Clin. Pharmacol. Toxicol. pmid:19067682
Kagaya H et al. Correlation of IMPDH1 gene polymorphisms with subclinical acute rejection and mycophenolic acid exposure parameters on day 28 after renal transplantation. 2010 Basic Clin. Pharmacol. Toxicol. pmid:20136638
Kim IW et al. Identification of factors affecting tacrolimus level and 5-year clinical outcome in kidney transplant patients. 2012 Basic Clin. Pharmacol. Toxicol. pmid:22469198
Panahi Y et al. Comparison of clinical efficacy of topical pimecrolimus with betamethasone in chronic skin lesions due to sulfur mustard exposure: a randomized, investigator-blind study. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19143752
Velickovic-Radovanovic RM et al. Clinical pharmacokinetics of tacrolimus after the first oral administration in renal transplant recipients on triple immunosuppressive therapy. 2010 Basic Clin. Pharmacol. Toxicol. pmid:20102364
Hisamura F et al. Protective effect of green tea extract and tea polyphenols against FK506-induced cytotoxicity in renal cells. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16445594
Hu R et al. CYP3A5*3 and ABCB1 61A>G Significantly Influence Dose-adjusted Trough Blood Tacrolimus Concentrations in the First Three Months Post-Kidney Transplantation. 2018 Basic Clin. Pharmacol. Toxicol. pmid:29603629
Ekici Günay N et al. Administration of Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy. 2018 Balkan Med J pmid:29553465
Gates T Atopic dermatitis: diagnosis, treatment, and aeromedical implications. 2007 Aviat Space Environ Med pmid:17225479
Nakagaki T et al. FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. 2013 Autophagy pmid:23800841
Matsumura C et al. Differential effects of FK506 and cyclosporin A on catecholamine release from bovine adrenal chromaffin cells. 2004 Auton Autacoid Pharmacol pmid:15541012
Shinkura N et al. Autoantibodies to FK506 binding protein 12 (FKBP12) in autoimmune diseases. 1999 Autoimmunity pmid:10433096
Maalej A et al. Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. 2004 Autoimmunity pmid:15497458
Thomson AW et al. ICAM-1 and E-selectin expression in lesional biopsies of psoriasis patients responding to systemic FK 506 therapy. 1993 Autoimmunity pmid:7505632
Lemster B et al. Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. 1994 Autoimmunity pmid:7539635
Thomson AW and Starzl TE FK 506 and autoimmune disease: perspective and prospects. 1992 Autoimmunity pmid:1382646
Mochizuki M and Kawashima H Effects of FK506, 15-deoxyspergualin, and cyclosporine on experimental autoimmune uveoretinitis in the rat. 1990 Autoimmunity pmid:1717007
Ni M et al. FR900506 (FK506) and 15-deoxyspergualin (15-DSG) modulate the kinetics of infiltrating cells in eyes with experimental autoimmune uveoretinitis. 1990 Autoimmunity pmid:1717008
Hannah J et al. Tacrolimus use in lupus nephritis: A systematic review and meta-analysis. 2016 Autoimmun Rev pmid:26427983
Dall'Olio E et al. Erosive pustular dermatosis of the leg: long-term control with topical tacrolimus. 2011 Australas. J. Dermatol. pmid:21332681
Shamsudin N et al. Objective assessment of vitiligo with a computerised digital imaging analysis system. 2015 Australas. J. Dermatol. pmid:25367709
Dar NR and Rao SU Facial lichen nitidus actinicus. 2012 Australas. J. Dermatol. pmid:22571575
Milcic D and Nikolic M Clinical effects of topical pimecrolimus in a patient with Fox-Fordyce disease. 2012 Australas. J. Dermatol. pmid:22571582
Lee FJ et al. Poor efficacy of oral tacrolimus in the treatment of severe generalized atopic eczema in adults: a small retrospective case series. 2012 Australas. J. Dermatol. pmid:23157781
Zirbs M et al. Demodicidosis associated with psoriasis therapy--two case reports. 2013 Australas. J. Dermatol. pmid:23905976
Patterson C and Coutts I Granuloma faciale successfully treated with topical tacrolimus. 2009 Australas. J. Dermatol. pmid:19659988
Cassis TB and Callen JP Bupropion-induced subacute cutaneous lupus erythematosus. 2005 Australas. J. Dermatol. pmid:16197429
Wilson LM and Reid CM Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointment. 2004 Australas. J. Dermatol. pmid:15250900
Christophers E Psoriasis: mechanisms and entry points for possible therapeutic interventions. 1996 Australas. J. Dermatol. pmid:8713012
Pirmez R et al. Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus. 2016 Australas. J. Dermatol. pmid:27124649
Starritt E and Lee S Erythroplasia of Queyrat of the glans penis on a background of Zoon's plasma cell balanitis. 2008 Australas. J. Dermatol. pmid:18412812
Black M and Marshman G Dermatomyositis and pemphigus vulgaris: association or coincidence? 2011 Australas. J. Dermatol. pmid:21605086
Chung TH et al. Topical tacrolimus (FK506) for the treatment of feline idiopathic facial dermatitis. 2009 Aust. Vet. J. pmid:19796164
Cooley HM et al. Resolution of pyoderma gangrenosum using tacolimus (FK-506) 1996 Aust N Z J Med pmid:8744629
Grillo E et al. Necrobiosis lipoidica. 2014 Aust Fam Physician pmid:24600675
Grillo E et al. Skin rash associated with limb weakness. 2012 Aust Fam Physician pmid:23210105
Ichimaru N et al. Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. 2001 Atherosclerosis pmid:11583721
Hamada N et al. Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/NFAT signaling in porcine coronary artery model. 2010 Atherosclerosis pmid:19682688
Matsumoto T et al. Influence of FK506 on experimental atherosclerosis in cholesterol-fed rabbits. 1998 Atherosclerosis pmid:9699896
Riba Torrecillas D et al. [Use of topical tacrolimus and its side-effects]. 2005 Aten Primaria pmid:15946616
Clark K et al. Oxidative Stress Induces Disruption of the Axon Initial Segment. ASN Neuro pmid:29228786
Labcharoenwongs P et al. A double-masked comparison of 0.1% tacrolimus ointment and 2% cyclosporine eye drops in the treatment of vernal keratoconjunctivitis in children. 2012 Asian Pac. J. Allergy Immunol. pmid:23156846
Manuyakorn W et al. In vitro cytokine changes after pediatric liver transplantation. 2015 Asian Pac. J. Allergy Immunol. pmid:25840634