| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ascites | D001201 | 25 associated lipids |
| Ataxia | D001259 | 20 associated lipids |
| Ataxia Telangiectasia | D001260 | 6 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Autonomic Nervous System Diseases | D001342 | 4 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Balanitis | D001446 | 4 associated lipids |
| Beckwith-Wiedemann Syndrome | D001506 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dickerson JA et al. | Tacrolimus and sirolimus in capillary dried blood spots allows for remote monitoring. | 2015 | Pediatr Transplant | pmid:25414084 |
| Jahan A et al. | Clinical efficacy and pharmacokinetics of tacrolimus in children with steroid-resistant nephrotic syndrome. | 2015 | Pediatr. Nephrol. | pmid:26135137 |
| Marquezan MC et al. | Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. | 2015 | Am. J. Ophthalmol. | pmid:26133248 |
| Izumi Y et al. | Two cases of refractory polymyositis accompanied with steroid myopathy. | 2015 | Mod Rheumatol | pmid:24533547 |
| Li H et al. | Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata. | 2015 | J. Med. Microbiol. | pmid:25355935 |
| Gallon L et al. | Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. | 2015 | Kidney Int. | pmid:25354238 |
| Pamuk F et al. | Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. | 2015 | J. Periodont. Res. | pmid:25399832 |
| Koreth J et al. | A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. | 2015 | Biol. Blood Marrow Transplant. | pmid:26055298 |
| Sikma MA et al. | Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation. | 2015 | Am. J. Transplant. | pmid:26053114 |
| Huang X and Xu B | Efficacy and Safety of Tacrolimus versus Pimecrolimus for the Treatment of Atopic Dermatitis in Children: A Network Meta-Analysis. | 2015 | Dermatology (Basel) | pmid:26043855 |
| Rozman Peterka T et al. | Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. | 2015 | J Pharm Biomed Anal | pmid:25804434 |
| Pardi C and Oltean M | An unusual case of red blood cell immunisation following liver transplantation. | 2015 | Blood Transfus | pmid:26057497 |
| Xia Z et al. | Refractory Dyslipidemia After Liver Transplant: Case Study With Successive Histologic Investigations. | 2015 | Exp Clin Transplant | pmid:25924105 |
| Zheng L et al. | Simultaneous determination of cortisol, cortisone, 6β-hydroxycortisol and 6β-hydroxycortisone by HPLC. | 2015 | J Chromatogr Sci | pmid:25628347 |
| Cortes X et al. | Successful use of infliximab and tacrolimus in a patient with Crohn's disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25997551 |
| Takahashi N et al. | Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. | 2015 | Rheumatol. Int. | pmid:25991396 |
| Gupta G et al. | Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction. | 2015 | Am. J. Transplant. | pmid:25988397 |
| Brännström M et al. | Livebirth after uterus transplantation. | 2015 | Lancet | pmid:25301505 |
| de Weerd AE et al. | ABO-incompatible kidney transplant recipients have a higher bleeding risk after antigen-specific immunoadsorption. | 2015 | Transpl. Int. | pmid:25070762 |
| Yahng SA et al. | A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:25300871 |
| Lin YK et al. | Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs. | 2015 | PLoS ONE | pmid:26355594 |
| Andrews LM et al. | Dosing algorithms for initiation of immunosuppressive drugs in solid organ transplant recipients. | 2015 | Expert Opin Drug Metab Toxicol | pmid:25865963 |
| de Sandes-Freitas TV et al. | Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus. | 2015 | Transplantation | pmid:25929604 |
| Cheng S and Rodier F | Manipulating senescence in health and disease: emerging tools. | 2015 | Cell Cycle | pmid:25928330 |
| Hricik DE et al. | Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients. | 2015 | J. Am. Soc. Nephrol. | pmid:25925687 |
| Matas AJ and Gaston RS | Moving Beyond Minimization Trials in Kidney Transplantation. | 2015 | J. Am. Soc. Nephrol. | pmid:25925686 |
| Bogéa TH et al. | Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26720441 |
| Hiraoka S et al. | The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients. | 2015 | BMC Gastroenterol | pmid:25925267 |
| Cuervas-Mons V et al. | Impact of tacrolimus and mycophenolate mofetil regimen vs. a conventional therapy with steroids on cardiovascular risk in liver transplant patients. | 2015 | Clin Transplant | pmid:25924549 |
| Falloon K et al. | Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. | 2015 | PLoS ONE | pmid:26366742 |
| Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
| Nashan B et al. | Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus-facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial. | 2015 | Trials | pmid:25873064 |
| Ramachandran R et al. | Chronic nephrotoxicity limits successful use of Tacrolimus in the management of adult steroid-dependent minimal change disease. | 2015 | Nephrology (Carlton) | pmid:25872662 |
| Shahraki M et al. | Influence of Tacrolimus (FK506) on Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model. | 2015 | J. Oral Maxillofac. Surg. | pmid:25869987 |
| Zijlstra LE et al. | [Heart transplantation in the 21st century in Netherlands: improved survival in the last decade]. | 2015 | Ned Tijdschr Geneeskd | pmid:26648576 |
| Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
| Dastgheib L et al. | Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial. | 2015 | J Dermatolog Treat | pmid:24552352 |
| RodrÃguez-RodrÃguez AE et al. | Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus. | 2015 | Nefrologia | pmid:26299169 |
| Dave V et al. | Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. | 2015 | Nephrology (Carlton) | pmid:25807849 |
| Hlavaty KA et al. | Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. | 2015 | Clin. Immunol. | pmid:25805659 |
| Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
| Sigurgeirsson B et al. | Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. | 2015 | Pediatrics | pmid:25802354 |
| Kurita T et al. | The efficacy of calcineurin inhibitors for the treatment of interstitial lung disease associated with polymyositis/dermatomyositis. | 2015 | Lupus | pmid:25297551 |
| Birdwell KA et al. | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. | 2015 | Clin. Pharmacol. Ther. | pmid:25801146 |
| Shokati T et al. | Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. | 2015 | J Vis Exp | pmid:26575262 |
| La Placa M et al. | Disfiguring papular sarcoidosis of the face: dramatic improvement with pimecrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:25073484 |
| Garritsen FM et al. | Ten years experience with oral immunosuppressive treatment in adult patients with atopic dermatitis in two academic centres. | 2015 | J Eur Acad Dermatol Venereol | pmid:25752497 |
| Qian G et al. | Successful treatment of recalcitrant granulomatous rosacea with oral thalidomide and topical pimecrolimus. | 2015 | J. Dermatol. | pmid:25753523 |
| Wu D et al. | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. | 2015 | Exp Clin Transplant | pmid:25748726 |
| Jo GA et al. | Isolation and characterization of a 17-kDa FKBP-type peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2015 | Protein Expr. Purif. | pmid:25747528 |
| Tachibana T et al. | Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure. | 2015 | Intern. Med. | pmid:26521905 |
| Liu J et al. | Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods. | 2015 | Clin Ther | pmid:26519232 |
| Guerra Júnior AA et al. | Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. | 2015 | Rev Saude Publica | pmid:25741648 |
| Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
| Schwarz C et al. | Tacrolimus, Mycophenolate Mofetil, and Low-Dose Steroids With or Without Interleukin-2 Receptor Antibody Induction Therapy: A Retrospective Cohort Analysis. | 2015 | Transplant. Proc. | pmid:26518948 |
| Ko MS et al. | Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25740263 |
| Cotton D | Celebrating the ACP centennial: from the Annals archive. | 2015 | Ann. Intern. Med. | pmid:25560715 |
| Shuker N et al. | Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management. | 2015 | Transplant Rev (Orlando) | pmid:25687818 |
| Kawakami K et al. | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. | 2015 | World J. Gastroenterol. | pmid:25684955 |
| Al Gain M et al. | [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. | 2015 | Ann Dermatol Venereol | pmid:25683011 |
| Ikeya K et al. | Tacrolimus for remission induction in ulcerative colitis: Mayo endoscopic subscore 0 and 1 predict long-term prognosis. | 2015 | Dig Liver Dis | pmid:25682993 |
| Zhao L et al. | Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. | 2015 | Int J Pharm | pmid:25681723 |
| Ramesh M et al. | A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. | 2015 | J. Biol. Chem. | pmid:25681440 |
| Matsushima M et al. | [A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome]. | 2015 | Rinsho Shinkeigaku | pmid:26458569 |
| Kim S et al. | Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. | 2015 | Neurobiol. Aging | pmid:26455952 |
| Fukuta T et al. | Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions. | 2015 | Eur J Pharm Biopharm | pmid:26455340 |
| BuendÃa JA et al. | Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients. | 2015 | Exp Clin Transplant | pmid:26450467 |
| Ceberio I et al. | Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant. | 2015 | Leuk. Lymphoma | pmid:24913499 |
| Luo X et al. | Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. | 2015 | J Pharm Sci | pmid:26150050 |
| Herbst S et al. | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. | 2015 | EMBO Mol Med | pmid:25637383 |
| Cuellar-Rodriguez J et al. | Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. | 2015 | Biol. Blood Marrow Transplant. | pmid:25636378 |
| Schoettler M et al. | Treatment and outcomes of immune cytopenias following solid organ transplant in children. | 2015 | Pediatr Blood Cancer | pmid:25308853 |
| Chung H et al. | Renal transplantation: better fat than thin. | 2015 | J. Surg. Res. | pmid:25634827 |
| Ustundag UV et al. | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. | 2015 | Reprod Biol | pmid:26370456 |
| Pennington CA and Park JM | Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. | 2015 | Am J Health Syst Pharm | pmid:25631834 |
| Mok CC | Mycophenolate mofetil for lupus nephritis: an update. | 2015 | Expert Rev Clin Immunol | pmid:26364748 |
| Satake K et al. | Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats. | 2015 | Eur. J. Pharmacol. | pmid:26362749 |
| Farhangian ME et al. | Treatment of Alopecia Areata in the United States: A Retrospective Cross-Sectional Study. | 2015 | J Drugs Dermatol | pmid:26355621 |
| Gao L and Sun Y | In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms. | 2015 | Antimicrob. Agents Chemother. | pmid:26303797 |
| Kawahara T et al. | The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion. | 2015 | Prostate | pmid:25631176 |
| Iwamoto T et al. | Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation. | 2015 | Ther Drug Monit | pmid:25565672 |
| Ruiz J et al. | Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation. | 2015 | Int J Mol Sci | pmid:26307985 |
| Yao X et al. | Limited Sampling Strategy for Mycophenolic Acid in Chinese Kidney Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus During the Early Posttransplantation Phase. | 2015 | Ther Drug Monit | pmid:25565669 |
| Nelson R et al. | Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. | 2015 | Bone Marrow Transplant. | pmid:26301969 |
| Lemaitre F et al. | Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells. | 2015 | Clin. Biochem. | pmid:25562187 |
| Tedesco-Silva H et al. | Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses. | 2015 | Am. J. Transplant. | pmid:25988935 |
| Bauters T et al. | Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients. | 2015 | J Oncol Pharm Pract | pmid:24748582 |
| Tornatore KM et al. | Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian renal transplant recipients. | 2015 | Clin Pharmacokinet | pmid:25511793 |
| Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
| Zhu LQ et al. | Posterior reversible encephalopathy syndrome and graft-versus-host disease after liver transplantation: a case report and review of the literature. | 2015 | Int J Clin Pharmacol Ther | pmid:26227100 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
| Zhang JJ et al. | The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2015 | Int J Clin Pharmacol Ther | pmid:26227094 |
| Jung JW et al. | Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease. | 2015 | Am. J. Ophthalmol. | pmid:25498356 |
| Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
| Kloster-Jensen K et al. | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. | 2015 | Transpl. Int. | pmid:26046470 |
| Koster RA et al. | The performance of five different dried blood spot cards for the analysis of six immunosuppressants. | 2015 | Bioanalysis | pmid:26045003 |
| Peake RW et al. | Multicenter evaluation of the thermo scientific prelude for measurement of immunosuppressant drugs using sample preparation liquid chromatography-tandem mass spectrometry. | 2015 | Ther Drug Monit | pmid:25072947 |
| Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
| Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |
| Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |