Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
Liang J et al. | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. | 1999 | Acta Crystallogr. D Biol. Crystallogr. | pmid:10089303 |
Bracher A et al. | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. | 2011 | Acta Crystallogr. D Biol. Crystallogr. | pmid:21636895 |
Li P et al. | Structure of the N-terminal domain of human FKBP52. | 2003 | Acta Crystallogr. D Biol. Crystallogr. | pmid:12499534 |
Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
Segura S et al. | Eczema herpeticum during treatment of atopic dermatitis with 1% pimecrolimus cream. | 2005 | Acta Derm. Venereol. | pmid:16396803 |
Mercader P et al. | Treatment of protein contact dermatitis with topical tacrolimus. | 2005 | Acta Derm. Venereol. | pmid:16396818 |
Campione E et al. | Combination of low-dosage cyclosporine and topical pimecrolimus in severe atopic dermatitis with chronic hepatitis B. | 2008 | Acta Derm. Venereol. | pmid:18176762 |
Bovenschen HJ | Novel treatment for cheilitis glandularis. | 2009 | Acta Derm. Venereol. | pmid:19197557 |
Pagliarello C and Paradisi A | Topical tacrolimus is useful for avoiding suction-blister epidermal grafting depigmentation in non-segmental vitiligo: a case report. | 2012 | Acta Derm. Venereol. | pmid:22101735 |
Hamade Y et al. | Lichen planus in childhood showing various cutaneous features. | 2012 | Acta Derm. Venereol. | pmid:22101991 |
Mandelin J et al. | Leg ulcers treated with topical tacrolimus in patients with rheumatoid arthritis. | 2010 | Acta Derm. Venereol. | pmid:21057750 |
Nakamizo S et al. | Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin. | 2010 | Acta Derm. Venereol. | pmid:21057761 |
Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
Cunha PR | Pimecrolimus cream 1% is effective in seborrhoeic dermatitis refractory to treatment with topical corticosteroids. | 2006 | Acta Derm. Venereol. | pmid:16585998 |
Cunha PR and Rossi AB | Pimecrolimus cream 1% is effective in a case of granulomatous rosacea. | 2006 | Acta Derm. Venereol. | pmid:16585999 |
Ambo M | Relapsing Kaposi's varicelliform eruption and herpes simplex following facial tacrolimus treatment for atopic dermatitis. | 2002 | Acta Derm. Venereol. | pmid:12353724 |
De Rie MA et al. | Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. | 1996 | Acta Derm. Venereol. | pmid:8891007 |
Pagliarello C et al. | Topical tacrolimus and 50% zinc oxide paste for Hailey-Hailey disease: less is more. | 2012 | Acta Derm. Venereol. | pmid:22293917 |
Kim TW et al. | Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial. | 2013 | Acta Derm. Venereol. | pmid:23388687 |