tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prescott TA et al. | A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. | 2014 | FEBS Lett. | pmid:24374339 |
| Perlman RL and Rao PS | Quality of life of older patients undergoing renal transplantation: finding the right immunosuppressive treatment. | 2014 | Drugs Aging | pmid:24399579 |
| Tanaka K et al. | Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. | 2014 | J. Hum. Genet. | pmid:24352002 |
| Erdinest N and Solomon A | Topical immunomodulators in the management of allergic eye diseases. | 2014 | Curr Opin Allergy Clin Immunol | pmid:25054831 |
| Mo D et al. | In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. | 2014 | Mycopathologia | pmid:25052248 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Ünlüsoy Aksu A et al. | Immune thrombocytopenic purpura in a liver transplant patient. | 2014 | Exp Clin Transplant | pmid:24635822 |
| Bakkour W et al. | Successful use of dapsone for the management of circinate balanitis. | 2014 | Clin. Exp. Dermatol. | pmid:24635073 |
| Kapoor K et al. | Lip hypertrophy due to cyclosporine therapy. | 2014 | Clin. Exp. Nephrol. | pmid:23615783 |
| Alloway RR et al. | Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): phase 2 trial of stable liver transplant recipients. | 2014 | Liver Transpl. | pmid:24493215 |
| Hartmann A et al. | Treatment of generalised vitiligo with tacrolimus 0.1% ointment vs. UVB intense pulsed light phototherapy: a pilot study. | 2014 | Acta Derm. Venereol. | pmid:24473666 |
| Xu H et al. | The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. | 2014 | Am. J. Transplant. | pmid:24472192 |
| Tsuchimoto A et al. | Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. | 2014 | PLoS ONE | pmid:25329716 |
| Lankarani KB et al. | Response to: Comment on: New-onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:24471728 |
| Qi H et al. | The antiaging activity and cerebral protection of rapamycin at micro-doses. | 2014 | CNS Neurosci Ther | pmid:25327787 |
| Kuypers DR et al. | Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients. | 2014 | Pharmacogenet. Genomics | pmid:25322286 |
| Balato A et al. | Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes. | 2014 | Mycoses | pmid:24512536 |
| Li CJ et al. | Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients. | 2014 | PLoS ONE | pmid:24465960 |
| Silva-Cunha A et al. | Evaluation of the pharmacokinetics and ocular tolerance of a microemulsion containing tacrolimus. | 2014 | J Ocul Pharmacol Ther | pmid:24199740 |
| Diémé B et al. | Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling. | 2014 | Transplantation | pmid:24598938 |
| Grillo E et al. | Necrobiosis lipoidica. | 2014 | Aust Fam Physician | pmid:24600675 |
| Kimura Y et al. | Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. | 2014 | Toxicol In Vitro | pmid:24603311 |
| Daher Abdi Z et al. | Exposure to mycophenolic acid better predicts immunosuppressive efficacy than exposure to calcineurin inhibitors in renal transplant patients. | 2014 | Clin. Pharmacol. Ther. | pmid:24968086 |
| Sapir-Pichhadze R et al. | Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure. | 2014 | Kidney Int. | pmid:24336032 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Kato H et al. | Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Bone Marrow Transplant. | pmid:24317130 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Urbanowicz T et al. | Induction therapy, tacrolimus plasma concentration, and duration if intensive care unit stay are risk factors for peripheral leucopenia following heart transplantation. | 2014 | Ann. Transplant. | pmid:25274118 |
| Stifft F et al. | Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation. | 2014 | Transplantation | pmid:24686426 |
| Funaro D et al. | A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in patients with vulvar lichen sclerosus. | 2014 | J. Am. Acad. Dermatol. | pmid:24704090 |
| Demmers MW et al. | Limited efficacy of immunosuppressive drugs on CD8+ T cell-mediated and natural killer cell-mediated lysis of human renal tubular epithelial cells. | 2014 | Transplantation | pmid:24704664 |
| Størset E et al. | Importance of hematocrit for a tacrolimus target concentration strategy. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24071959 |
| Peloso LJ et al. | The serum concentration of tacrolimus after ingesting omeprazole: a pilot study. | 2014 | Transplantation | pmid:25221905 |
| Posadas Salas MA and Srinivas TR | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2014 | Drug Des Devel Ther | pmid:25210441 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Keniya MV et al. | Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. | 2014 | Mol. Pharm. | pmid:25115303 |
| Sun Z et al. | Co-administration of Wuzhi capsules and tacrolimus in patients with idiopathic membranous nephropathy: clinical efficacy and pharmacoeconomics. | 2014 | Int Urol Nephrol | pmid:25145781 |
| Dannhorn E et al. | De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | 2014 | Clin Transplant | pmid:25142496 |
| Chatterjea A et al. | Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats. | 2014 | J. Cell. Mol. Med. | pmid:24237965 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Størset E et al. | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. | 2014 | Br J Clin Pharmacol | pmid:25279405 |
| Ko SF et al. | Therapeutic potential of tacrolimus on acute myocardial infarction in minipigs: analysis with serial cardiac magnetic resonance and changes at histological and protein levels. | 2014 | Biomed Res Int | pmid:25114905 |
| Grossman J et al. | Nonmyeloablative allogeneic hematopoietic stem cell transplantation for GATA2 deficiency. | 2014 | Biol. Blood Marrow Transplant. | pmid:25111582 |
| Sethna CB and Gipson DS | Treatment of FSGS in Children. | 2014 | Adv Chronic Kidney Dis | pmid:24602468 |
| Bercaw-Pratt JL et al. | Clinical recommendation: pediatric lichen sclerosus. | 2014 | J Pediatr Adolesc Gynecol | pmid:24602304 |
| Kaieda S et al. | Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus. | 2014 | Mod Rheumatol | pmid:24593214 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Little JA et al. | The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood. | 2014 | J. Rheumatol. | pmid:24085549 |
| Hostettler KE et al. | Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. | 2014 | Eur. Respir. J. | pmid:23645405 |
| Oh CK et al. | Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation. | 2014 | Yonsei Med. J. | pmid:25048494 |
| Matin M et al. | The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. | 2014 | J Cosmet Laser Ther | pmid:25046236 |
| de la Fuente V et al. | Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation. | 2014 | Hippocampus | pmid:25043904 |
| Kluk J et al. | Follicular mucinosis treated with topical 0.1% tacrolimus ointment. | 2014 | Clin. Exp. Dermatol. | pmid:24252117 |
| Ohe M et al. | Successful treatment with tacrolimus of refractory adult-onset Still's disease. | 2014 | Korean J. Intern. Med. | pmid:24648814 |
| Friedrich RB et al. | Nanoencapsulation of tacrolimus in lipid-core nanocapsules showed similar immunosuppressive activity after oral and intraperitoneal administrations. | 2014 | J Biomed Nanotechnol | pmid:25016659 |
| Rostaing L et al. | The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. | 2014 | Ann. Transplant. | pmid:25017487 |
| Qi H et al. | Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24965502 |
| Jannot M et al. | Early conversion from twice-daily tacrolimus to once-daily extended formulation in renal transplant patients before hospital discharge. | 2014 | Ann. Transplant. | pmid:24999809 |
| Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
| Toniutto P et al. | Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated. | 2014 | Int J Surg | pmid:25219480 |
| Boonyapredee M et al. | Increased BK viremia and progression to BK-virus nephropathy following high-dose intravenous immunoglobulin for acute cellular rejection. | 2014 | Mil Med | pmid:24902140 |
| Langone A et al. | Long-term dosing patterns of enteric-coated mycophenolate sodium or mycophenolate mofetil with tacrolimus after renal transplantation. | 2014 | Clin Transplant | pmid:24893821 |
| Nafar M et al. | Prevalence and risk factors of recurrent cytomegalovirus infection in kidney transplant recipients. | 2014 | Iran J Kidney Dis | pmid:24878947 |
| van Gelder T | Within-patient variability in immunosuppressive drug exposure as a predictor for poor outcome after transplantation. | 2014 | Kidney Int. | pmid:24875549 |
| Tümgör G et al. | A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment. | 2014 | Turk J Gastroenterol | pmid:25599790 |
| Stifft F et al. | Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24809233 |
| Korbel L et al. | Clinically relevant pharmacogenomic testing in pediatric practice. | 2014 | Clin Pediatr (Phila) | pmid:24803633 |
| Kallash M and Aviles D | Efficacy of tacrolimus in the treatment of children with focal segmental glomerulosclerosis. | 2014 | World J Pediatr | pmid:24801235 |
| Maeda H et al. | Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine. | 2014 | PLoS ONE | pmid:24796859 |
| Du W et al. | Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24788378 |
| Nkongolo S et al. | Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. | 2014 | J. Hepatol. | pmid:24295872 |
| Levy G et al. | REFINE: a randomized trial comparing cyclosporine A and tacrolimus on fibrosis after liver transplantation for hepatitis C. | 2014 | Am. J. Transplant. | pmid:24456049 |
| Parashos SA et al. | Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. | 2014 | JAMA Neurol | pmid:24711047 |
| Gillard P et al. | Early alteration of kidney function in nonuremic type 1 diabetic islet transplant recipients under tacrolimus-mycophenolate therapy. | 2014 | Transplantation | pmid:24770614 |
| Pandey S et al. | Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A-dependent manner in non-neuronal and neuronal cell lines. | 2014 | J. Neurochem. | pmid:25113668 |
| Supe-Markovina K et al. | Alemtuzumab with corticosteroid minimization for pediatric deceased donor renal transplantation: a seven-yr experience. | 2014 | Pediatr Transplant | pmid:24712738 |
| Chung BH et al. | Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression. | 2014 | Transpl. Immunol. | pmid:24709525 |
| Al-Kadhimi Z et al. | High incidence of severe acute graft-versus-host disease with tacrolimus and mycophenolate mofetil in a large cohort of related and unrelated allogeneic transplantation patients. | 2014 | Biol. Blood Marrow Transplant. | pmid:24709007 |
| Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
| Indriolo A and Ravelli P | Clinical management of inflammatory bowel disease in the organ recipient. | 2014 | World J. Gastroenterol. | pmid:24707135 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
| Li DW et al. | Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis. | 2015 | World J. Gastroenterol. | pmid:26034369 |
| Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
| Bruckmueller H et al. | Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus. | 2015 | Ther Drug Monit | pmid:25271728 |
| Moscovici BK et al. | Treatment of Sjögren's syndrome dry eye using 0.03% tacrolimus eye drop: Prospective double-blind randomized study. | 2015 | Cont Lens Anterior Eye | pmid:25956572 |
| Torres-EspÃn A et al. | Immunosuppression of allogenic mesenchymal stem cells transplantation after spinal cord injury improves graft survival and beneficial outcomes. | 2015 | J. Neurotrauma | pmid:25203134 |
| Hur J et al. | Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | 2015 | Chem. Res. Toxicol. | pmid:25811541 |
| Malvezzi P and Rostaing L | The safety of calcineurin inhibitors for kidney-transplant patients. | 2015 | Expert Opin Drug Saf | pmid:26329325 |
| Pidala J et al. | Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease. | 2015 | Haematologica | pmid:25840599 |
| Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
| Lehman N et al. | Left subconjunctival hemorrhage · renal dysfunction · international normalized ratio of 4.5 · Dx? | 2015 | J Fam Pract | pmid:26551480 |
| TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
| Chen QQ et al. | Kaposi's Varicelliform Eruption During Long-term Treatment of Rosacea with 0.03% Tacrolimus Ointment. | 2015 | Chin. Med. J. | pmid:26481759 |
| Shengyou Y et al. | Influence of tacrolimus on podocyte injury inducted by angiotensin II. | 2015 | J Renin Angiotensin Aldosterone Syst | pmid:25650384 |
| Yang F et al. | A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases. | 2015 | Int Urol Nephrol | pmid:25539617 |
| Seeling W et al. | Knowledge-based immunosuppressive therapy for kidney transplant patients--from theoretical model to clinical integration. | 2015 | Stud Health Technol Inform | pmid:26262418 |