tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Yashima J et al. | Successful conversion from tacrolimus to cyclosporine after kidney transplantation. | 2000 | Transplant. Proc. | pmid:11119895 |
| Gibbs JF et al. | Outcome analysis of FK 506 therapy for acute and chronic rejection. | 1993 | Transplant. Proc. | pmid:7679823 |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Siekierka JJ et al. | Potential roles of other FK 506-binding proteins in mediating the effects of FK 506. | 1991 | Transplant. Proc. | pmid:1721256 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Kumai Y et al. | Reversible Cerebral Vasoconstriction Syndrome After Heart Transplantation: A Case Report. | 2017 | Transplant. Proc. | pmid:29198694 |
| Shapiro R et al. | The side effects of FK 506 in humans. | 1990 | Transplant. Proc. | pmid:1689892 |
| Machado PG et al. | Use of reduced dose of OKT3 (2.5 mg) after renal transplantation. | 2002 | Transplant. Proc. | pmid:11959207 |
| Asensio M et al. | Experience with tacrolimus as primary immunosuppressor in pediatric liver transplant. | 2002 | Transplant. Proc. | pmid:11959208 |
| Zervos XA et al. | Comparison of tacrolimus with neoral as primary immunosuppression in hepatitis C patients after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636568 |
| Millis JM et al. | Successful use of tacrolimus for initial rejection episodes after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636569 |
| Matevossian E et al. | Liver transplantation in the rat: single-center experience with technique, long-term survival, and functional and histologic findings. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715990 |
| Videla CO | Two-year experience with tacrolimus in renal transplantation after late conversion from cyclosporine therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715995 |
| Mazali FC et al. | Posttransplant diabetes mellitus: incidence and risk factors. | 2008 | Transplant. Proc. | pmid:18455010 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Francavilla A et al. | The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo. | 1991 | Transplant. Proc. | pmid:1721287 |
| Carobbi A et al. | Synergism of splenectomy and immunosuppressive drugs in prolongation of cardiac xenograft survival. | 1992 | Transplant. Proc. | pmid:1373543 |
| Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
| Blanc P et al. | Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture. | 1991 | Transplant. Proc. | pmid:1721288 |
| Ueno M et al. | Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1373546 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Meçule A et al. | Once daily tacrolimus formulation: monitoring of plasma levels, graft function, and cardiovascular risk factors. | 2010 | Transplant. Proc. | pmid:20534290 |
| Comuzzi C et al. | Safety of conversion from twice-daily tacrolimus (Prograf) to once-daily prolonged-release tacrolimus (Advagraf) in stable liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20534291 |
| Tellis V et al. | No-load sirolimus with tacrolimus and steroids is safe and effective in renal transplantation. | 2005 | Transplant. Proc. | pmid:15848571 |
| Burke GW et al. | Use of tacrolimus and mycophenolate mofetil for pancreas-kidney transplantation with or without OKT3 induction. | 1998 | Transplant. Proc. | pmid:9636627 |
| Basu A et al. | Reversal of acute cellular rejection after renal transplantation with Campath-1H. | 2005 | Transplant. Proc. | pmid:15848576 |
| Akbas SH et al. | Evaluation of the new EMIT tacrolimus assay in kidney and liver transplant recipients. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013308 |
| Bakar F et al. | Low-density lipoprotein oxidizability and the alteration of its fatty acid content in renal transplant recipients treated with cyclosporine/tacrolimus. | 2009 | Transplant. Proc. | pmid:19545695 |
| Töz H et al. | Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013324 |
| Marchewka Z et al. | Kidney graft function in long-term cyclosporine and tacrolimus treatment: comparative study with nephrotoxicity markers. | 2009 | Transplant. Proc. | pmid:19545703 |
| Marcén R et al. | Effects of the new immunosuppressive agents on the occurrence of malignancies after renal transplantation. | 2010 | Transplant. Proc. | pmid:20970609 |
| Herrero MJ et al. | Clinical interest of pharmacogenetic polymorphisms in the immunosuppressive treatment after heart transplantation. | 2010 | Transplant. Proc. | pmid:20970643 |
| Bachetoni A et al. | Preliminary evaluation of the new TACR flex method versus MEIA method in the therapeutic monitoring of tacrolimus in organ transplantation. | 2007 Jul-Aug | Transplant. Proc. | pmid:17692678 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Demetris AJ et al. | Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. | 1993 | Transplant. Proc. | pmid:7505503 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Mucha K et al. | 36-month follow-up of 75 renal allograft recipients treated with steroids, tacrolimus, and azathioprine or mycophenolate mofetil. | 2003 | Transplant. Proc. | pmid:14529880 |
| Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
| Falkiewicz K et al. | Tacrolimus decreases tubular phosphate wasting in renal allograft recipients. | 2003 | Transplant. Proc. | pmid:14529892 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Lang T et al. | Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. | 1995 | Transplant. Proc. | pmid:7533367 |
| Chen-Woan M et al. | Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721320 |
| Ito Y et al. | Inhibition of epithelial replacement by nonspecific immunosuppressants accelerates rat orthotopic tracheal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176430 |
| Shibutani S et al. | FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen. | 2002 | Transplant. Proc. | pmid:12176432 |
| Hoshinaga K et al. | Regimen of tacrolimus-based immunosuppression with basiliximab, mycophenolate mofetil, and low-dose steroid reduces acute rejection in kidney transplants. | 2005 | Transplant. Proc. | pmid:15919457 |
| Signorell J et al. | Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. | 2010 | Transplant. Proc. | pmid:21094874 |
| Kumano K et al. | Role of endothelin in FK 506-induced renal hypoperfusion in rats. | 1995 | Transplant. Proc. | pmid:7533423 |
| Green M et al. | Infectious complications of pediatric liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721352 |
| Altaca G et al. | Effect of low-dose calcineurin inhibitors on acute rejection and graft survival. | 2002 | Transplant. Proc. | pmid:12270320 |
| Squifflet JP et al. | Safe withdrawal of corticosteroids or mycophenolate mofetil: results of a large, prospective, multicenter, randomized study. | 2002 | Transplant. Proc. | pmid:12176495 |
| Ko WJ et al. | Clinical trial of FK506 in heart transplant patients in Taiwan: report of 7 cases with immunosuppression switch from cyclosporine to FK506. | 1998 | Transplant. Proc. | pmid:9838474 |
| Borda B et al. | Functional and histopathologic changes in renal transplant patients with new-onset diabetes and dyslipidemia. | 2011 | Transplant. Proc. | pmid:21620104 |
| Cho JH et al. | Chronic rejection in pediatric liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123078 |
| Marino IR et al. | Preoperative assessment of risk in liver transplantation: a multivariate analysis in 2376 cases of the UW era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123079 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| McCauley J et al. | Changes in renal function after liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721385 |
| Zmonarski S et al. | Expression of PBMC TLR4 in Renal Graft Recipients Who Experienced Delayed Graft Function Reflects Dynamic Balance Between Blood and Tissue Compartments and Helps Select a Problematic Patient. | Transplant. Proc. | pmid:30056893 | |
| Morris RE et al. | Immunopharmacology of FK-506. | 1989 | Transplant. Proc. | pmid:2468201 |
| Tauxe WN et al. | A comparison of the renal effects (ERPF, GFR, and FF) of FK 506 and cyclosporine in patients with liver transplantation. | 1991 | Transplant. Proc. | pmid:1721386 |
| Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
| Boots JM et al. | Risk of adrenal insufficiency with steroid maintenance therapy in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176541 |
| Klupp J et al. | Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083497 |
| Kim JM et al. | Preemptive therapy in adult liver transplant recipients in CMV-endemic area. | 2010 | Transplant. Proc. | pmid:20430182 |
| Alessiani M et al. | Morphological and functional changes in small-bowel allografts of pigs under combined tacrolimus and mycophenolate mofetil immunosuppression. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123483 |
| Saber LT et al. | Posttransplantation conversion to sirolimus-based immunosuppression: a single center experience. | 2007 | Transplant. Proc. | pmid:18089330 |
| Kimura O et al. | Influence of bombesin on the intestinal mucosal immunologic response under immunosuppression. | 2000 | Transplant. Proc. | pmid:10995942 |
| Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
| Cai W et al. | Limited Sampling Strategy for Estimating Mycophenolic Acid Exposure on Day 7 Post-Transplant for Two Mycophenolate Mofetil Formulations Derived From 20 Chinese Renal Transplant Recipients. | 2018 | Transplant. Proc. | pmid:29735215 |
| Karamperis N et al. | Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. | 2003 | Transplant. Proc. | pmid:12826146 |
| Fukuzaki T et al. | Induction of tolerance to islet allografts with preoperative donor spleen cell injection and a short course of FK 506 treatment. | 1991 | Transplant. Proc. | pmid:1721415 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Dette K et al. | Daclizumab and ATG versus ATG in combination with tacrolimus, mycophenolate mofetil, and steroids in simultaneous [correction of simultaneus] pancreas-kidney transplantation: analysis of early outcome. | 2002 | Transplant. Proc. | pmid:12176624 |
| Land W et al. | Tacrolimus versus cyclosporine in primary simultaneous pancreas-kidney transplantation: preliminary results at 1 year of a large multicenter trial. | 2002 | Transplant. Proc. | pmid:12176625 |
| Zhang J et al. | Chemotherapy for De Novo Gastric Adenocarcinoma After Deceased Orthotopic Liver Transplantation: A Case Report. | Transplant. Proc. | pmid:28104131 | |
| Zaltzman J et al. | Tacrolimus, MMF, steroid, and ALG immunotherapy for high immunological risk renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267183 |
| Zamauskaite A et al. | FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267184 |
| Yoshimura R et al. | Hepatocyte growth factor: a sensitive indicator for CsA-induced nephropathy. | 1998 | Transplant. Proc. | pmid:9723373 |
| Burrows L et al. | Conversion to tacrolimus to ameliorate cyclosporine toxicity in kidney recipients. | 1998 | Transplant. Proc. | pmid:9723378 |
| Donadio C et al. | Tubular damage and impairment of renal function in transplanted kidneys. | 1998 | Transplant. Proc. | pmid:9723381 |
| Fabrega AJ et al. | FK 506 enhances the beneficial effects of donor-specific blood transfusion on allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1721447 |
| Winkler M et al. | Plasma level-guided low-dose FK 506 therapy in patients with early liver dysfunction after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689277 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| Rabkin JM et al. | Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267411 |
| McAlister VC | Liposomal tacrolimus: drug migration within blood compartments. | 1998 | Transplant. Proc. | pmid:9636404 |
| Zhang J et al. | Value of CYP3A5 genotyping on determining initial dosages of tacrolimus for Chinese renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21094797 |
| Ciancio G et al. | Randomized trial of thymoglobulin versus alemtuzumab (with lower dose maintenance immunosuppression) versus daclizumab in living donor renal transplantation. | 2010 | Transplant. Proc. | pmid:21094804 |
| Barak S et al. | Alveolar bone height in patients after liver transplantation. | 2000 | Transplant. Proc. | pmid:10856558 |
| Gotsman I et al. | Effect of peripheral immune tolerance on liver-associated lymphocytes expressing NK1.1. | 2000 | Transplant. Proc. | pmid:10856569 |
| Guleria S et al. | Tacrolimus (Pan Graf) as de novo therapy in renal transplant recipients in India. | 2006 | Transplant. Proc. | pmid:16979989 |
| Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |
| Busque S et al. | Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. | 1998 | Transplant. Proc. | pmid:9636507 |