tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hossain MA et al. | Immunosuppression in auxiliary partial liver transplantation with FK506 in rats. | 1997 | Transplant. Proc. | pmid:9414861 |
| Weber M et al. | Decreased rejection episodes in African-American renal transplant recipients receiving mycophenolate mofetil/tacrolimus therapy. | 1997 | Transplant. Proc. | pmid:9414883 |
| Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
| Gruessner RW et al. | Solitary pancreas transplantation for nonuremic patients with labile insulin-dependent diabetes mellitus. | 1997 | Transplantation | pmid:9415558 |
| Lang T et al. | Cholic acid synthesis is reduced in pediatric liver recipients during graft dysfunction due to ischemic injury and allograft rejection. | 1997 | Transplantation | pmid:9415561 |
| Gruessner RW and Sharp HL | Living-related intestinal transplantation: first report of a standardized surgical technique. | 1997 | Transplantation | pmid:9415566 |
| Talbot D et al. | Alopecia as a consequence of tacrolimus therapy in renal transplantation? | 1997 | Transplantation | pmid:9415574 |
| Braun F et al. | Pitfalls in monitoring tacrolimus (FK 506). | 1997 | Ther Drug Monit | pmid:9421102 |
| Salm P et al. | High-performance liquid chromatography-tandem mass spectrometry as a reference for analysis of tacrolimus to assess two immunoassays in patients with liver and renal transplants. | 1997 | Ther Drug Monit | pmid:9421113 |
| Nicoletti F et al. | Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats. | 1998 | Diabetes | pmid:9421371 |
| Spencer CM et al. | Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation. | 1997 | Drugs | pmid:9421697 |
| Stegall MD et al. | Mycophenolate mofetil decreases rejection in simultaneous pancreas-kidney transplantation when combined with tacrolimus or cyclosporine. | 1997 | Transplantation | pmid:9422404 |
| Shield CF et al. | Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9422413 |
| Stegall MD et al. | Prednisone withdrawal 14 days after liver transplantation with mycophenolate: a prospective trial of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9422416 |
| Shihab FS et al. | Mechanism of fibrosis in experimental tacrolimus nephrotoxicity. | 1997 | Transplantation | pmid:9422427 |
| Vu MD et al. | Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat. | 1997 | Transplantation | pmid:9422432 |
| Yang J et al. | Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. | 1998 | Curr. Biol. | pmid:9427627 |
| DiMartini AF et al. | Neuropsychiatric side effects of FK506 vs. cyclosporine A. First-week postoperative findings. | 1997 Nov-Dec | Psychosomatics | pmid:9427854 |
| Kitagaki K et al. | Facilitation of apoptosis by cyclosporins A and H, but not FK506 in mouse bronchial eosinophils. | 1997 | Eur. J. Pharmacol. | pmid:9430427 |
| Midtvedt K et al. | Successful pregnancies in a combined pancreas and renal allograft recipient and in a renal graft recipient on tacrolimus treatment. | 1997 | Nephrol. Dial. Transplant. | pmid:9430893 |
| Paterson DL and Singh N | Interactions between tacrolimus and antimicrobial agents. | 1997 | Clin. Infect. Dis. | pmid:9431391 |
| Alessiani M et al. | [Flexibility of the surgical model of intestinal transplantation in swine]. | 1997 | Minerva Chir | pmid:9432575 |
| Ito E and Tanaka Y | Influences of immunosuppressive agents, FK506 and cyclosporin on systemic Candida albicans infection in mice. | 1997 | Mycopathologia | pmid:9433807 |
| Boucek MM et al. | The Registry of the International Society of Heart and Lung Transplantation: first official pediatric report--1997. | 1997 | J. Heart Lung Transplant. | pmid:9436131 |
| Billaud EM et al. | [Immunosuppression: a case of mucoviscidosis]. | 1997 Jul-Aug | Therapie | pmid:9437888 |
| Garraffo R | [Clinical pharmacokinetics and therapeutic monitoring of tacrolimus]. | 1997 Jul-Aug | Therapie | pmid:9437890 |
| Furutani M et al. | Biochemical and genetic characterization of an FK506-sensitive peptidyl prolyl cis-trans isomerase from a thermophilic archaeon, Methanococcus thermolithotrophicus. | 1998 | J. Bacteriol. | pmid:9440528 |
| Yokoyama I et al. | Fas antigen expression of hepatocytes and its modification by immunosuppressants. | 1997 | Dig. Dis. Sci. | pmid:9440622 |
| Davis EC et al. | Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway. | 1998 | J. Cell Biol. | pmid:9442105 |
| Rühlmann A and Nordheim A | Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. | 1997 | Immunobiology | pmid:9442391 |
| Garattini S | Are me-too drugs justified? | 1997 Nov-Dec | J. Nephrol. | pmid:9442441 |
| McDiarmid SV | The use of tacrolimus in pediatric liver transplantation. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9443127 |
| Jin L et al. | Stimulating cell proliferation through the pharmacologic activation of c-kit. | 1998 | Blood | pmid:9446649 |
| [Transplantation medicine. Tacrolimus increases survival chances after organ transplantation. XVI International Congress of the Transplantation Society. 25-30 August 1996 Barcelona]. | 1996 | Dtsch. Med. Wochenschr. | pmid:9447224 | |
| Alak AM et al. | An HPLC/MS/MS assay for tacrolimus in patient blood samples. Correlation with results of an ELISA assay. | 1997 | J Pharm Biomed Anal | pmid:9447546 |
| Singh N et al. | Predictors and outcome of early- versus late-onset major bacterial infections in liver transplant recipients receiving tacrolimus (FK506) as primary immunosuppression. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447904 |
| Peterson LB et al. | A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. | 1998 | Transplantation | pmid:9448137 |
| Dumont FJ et al. | A tacrolimus-related immunosuppressant with reduced toxicity. | 1998 | Transplantation | pmid:9448138 |
| Miyauchi T et al. | Effect of donor-specific splenocytes via portal vein and FK506 in rat small bowel transplantation. | 1998 | Transplantation | pmid:9448139 |
| Rosen HR et al. | Significance of early aminotransferase elevation after liver transplantation. | 1998 | Transplantation | pmid:9448146 |
| McCune TR et al. | Effects of tacrolimus on hyperlipidemia after successful renal transplantation: a Southeastern Organ Procurement Foundation multicenter clinical study. | 1998 | Transplantation | pmid:9448150 |
| Mentzer RM et al. | Tacrolimus as a rescue immunosuppressant after heart and lung transplantation. The U.S. Multicenter FK506 Study Group. | 1998 | Transplantation | pmid:9448154 |
| Ernst A et al. | Lung abcess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review. | 1998 | Transplantation | pmid:9448158 |
| Cavaillé-Coll MW and Elashoff MR | Commentary on a comparison of tacrolimus and cyclosporine for immunosuppression after cadaveric renal transplantation. | 1998 | Transplantation | pmid:9448161 |
| Alaiti S et al. | Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children. | 1998 | J. Am. Acad. Dermatol. | pmid:9448208 |
| Fletcher L | Specific neuroimmunophilin ligands to treat neurodegenerative disease. | 1997 | Mol Med Today | pmid:9449119 |
| Lauerma AI et al. | Absorption of topical tacrolimus (FK506) in vitro through human skin: comparison with cyclosporin A. | 1997 | Skin Pharmacol. | pmid:9449161 |
| Egner R et al. | Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. | 1998 | Mol. Biol. Cell | pmid:9450972 |
| Sikorski R and Peters R | Droplet discovery. | 1998 | Science | pmid:9454334 |
| Gold BG | FK506 and the role of immunophilins in nerve regeneration. | 1997 | Mol. Neurobiol. | pmid:9457703 |
| Eckhoff DE et al. | Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantation. | 1998 | Transplantation | pmid:9458011 |
| Roth D et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil for renal allograft recipients. | 1998 | Transplantation | pmid:9458023 |
| Zeng B et al. | Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506. | 1998 | Biochem. J. | pmid:9461498 |
| Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Miyazawa Y et al. | Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice. | 1998 | Hepatology | pmid:9462649 |
| Woo M et al. | Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. | 1997 | Bone Marrow Transplant. | pmid:9466284 |
| Redrup AC et al. | Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. | 1998 | J. Immunol. | pmid:9469459 |
| Kihira H et al. | Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation. | 1998 | Int. J. Oncol. | pmid:9472103 |
| Shaw LM et al. | Prospective investigations of concentration-clinical response for immunosuppressive drugs provide the scientific basis for therapeutic drug monitoring. | 1998 | Clin. Chem. | pmid:9474049 |
| Watanabe K et al. | Synergistic effect of short-term fractionated lymphoid irradiation with initial high doses of FK506 on the induction of tolerance to kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9474940 |
| Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| Egawa H et al. | Lymphoproliferative disorders in patients undergoing living-related liver transplantation. | 1998 | Transplant. Proc. | pmid:9474982 |
| Murata M et al. | Unrelated donor bone marrow transplantation in Japanese patients is facilitated by the National Marrow Donor Program of the United States. | 1998 | Transplant. Proc. | pmid:9474987 |
| Resch B et al. | FK 506 and successful pregnancy in a patient after renal transplantation. | 1998 | Transplant. Proc. | pmid:9474990 |
| Furlan V et al. | Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient. | 1998 | Transplant. Proc. | pmid:9474996 |
| Satterthwaite R et al. | Incidence of new-onset hypercholesterolemia in renal transplant patients treated with FK506 or cyclosporine. | 1998 | Transplantation | pmid:9484771 |
| Boswell GW et al. | Tacrolimus pharmacokinetics in BMT patients. | 1998 | Bone Marrow Transplant. | pmid:9486490 |
| Tezcan H et al. | Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506. | 1998 | Bone Marrow Transplant. | pmid:9486505 |
| Witzke O et al. | Tacrolimus rescue therapy in patients with rejection and long-term dialysis after kidney transplantation. | 1998 | Clin. Nephrol. | pmid:9491282 |
| Roche, FDA announce new drug-interaction warnings for mibefradil. | 1998 | Am J Health Syst Pharm | pmid:9492249 | |
| Lhoëst G et al. | In vitro immunosuppressive activity, isolation from pig liver microsomes and identification by electrospray ms-ms of a new FK-506 C19-C20 epoxide metabolite. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495869 |
| Jindal RM | Post-transplant hyperlipidaemia. | 1997 | Postgrad Med J | pmid:9497947 |
| Boytim ML et al. | Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. | 1998 | J. Immunol. | pmid:9498760 |
| Chen H et al. | Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes. | 1998 | FEBS Lett. | pmid:9498805 |
| Khanna A et al. | Donor bone marrow potentiates the effect of tacrolimus on nonvascularized heart allograft survival: association with microchimerism and growth of donor dendritic cell progenitors from recipient bone marrow. | 1998 | Transplantation | pmid:9500620 |
| Gayowski T et al. | Orthotopic liver transplantation in high-risk patients: risk factors associated with mortality and infectious morbidity. | 1998 | Transplantation | pmid:9500623 |
| Neylan JF | Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group. | 1998 | Transplantation | pmid:9500626 |
| Misra S et al. | Red cell aplasia in children on tacrolimus after liver transplantation. | 1998 | Transplantation | pmid:9500636 |
| Finn L et al. | Epstein-Barr virus infections in children after transplantation of the small intestine. | 1998 | Am. J. Surg. Pathol. | pmid:9500771 |
| Nagai H et al. | Immunopharmacological studies on experimental allergic encephalomyelitis in DA rats. | 1998 | Gen. Pharmacol. | pmid:9502169 |
| Bielefeldt K et al. | Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle. | 1997 | Cell Calcium | pmid:9502200 |
| Gold BG et al. | The immunosuppressant FK506 increases GAP-43 mRNA levels in axotomized sensory neurons. | 1998 | Neurosci. Lett. | pmid:9502207 |
| Hatanaka H and Shimomura K | [Immunosuppressive activity of a microbial product]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503409 |
| Radermacher J et al. | Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506. | 1998 | Transpl. Int. | pmid:9503547 |
| Healey MC et al. | Bovine fallopian tube epithelial cells, adult C57BL/6 mice, and non-neonatal pigs as models for cryptosporidiosis. | 1997 Nov-Dec | J. Eukaryot. Microbiol. | pmid:9508447 |
| Lukyanenko V et al. | Termination of Ca2+ release during Ca2+ sparks in rat ventricular myocytes. | 1998 | J. Physiol. (Lond.) | pmid:9508828 |
| Ikeda E et al. | Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis. | 1997 Nov-Dec | Jpn. J. Ophthalmol. | pmid:9509307 |
| Snyder SH et al. | Neural actions of immunophilin ligands. | 1998 | Trends Pharmacol. Sci. | pmid:9509898 |
| Dumont FJ et al. | Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. | 1998 | J. Immunol. | pmid:9510155 |
| Corry RJ and Starzl TE | Pancreas transplantation. | 1998 | J. Am. Coll. Surg. | pmid:9510273 |
| de la Pompa JL et al. | Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. | 1998 | Nature | pmid:9515963 |
| Pham H et al. | Occurrence of gammopathies and lymphoproliferative disorders in liver transplant recipients randomized to tacrolimus (FK506)- or cyclosporine-based immunosuppression. | 1998 | Liver Transpl Surg | pmid:9516567 |
| Uchida J et al. | Renal endothelin in FK506-induced nephrotoxicity in spontaneously hypertensive rats. | 1998 | Jpn. J. Pharmacol. | pmid:9517403 |
| Carreau A et al. | Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons. | 1997 Nov-Dec | Neuropharmacology | pmid:9517448 |
| Schuppe HC et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Lancet | pmid:9519983 |
| Sequeira M et al. | New-onset Majocchi's granuloma in two kidney transplant recipients under tacrolimus treatment. | 1998 | J. Am. Acad. Dermatol. | pmid:9520033 |
| MacCorkle RA et al. | Synthetic activation of caspases: artificial death switches. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520421 |